Ritonavir_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.13073
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.107684
FN1 fibronectin 1 0.0733476
CANX calnexin 0.0413396
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0381931
MYH9 myosin, heavy chain 9, non-muscle 0.0376089
FNDC3B fibronectin type III domain containing 3B 0.0373197
TSC22D2 TSC22 domain family, member 2 0.0329913
LMO7 LIM domain 7 0.0313473
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0310479
ASPH aspartate beta-hydroxylase 0.0300141
AHNAK AHNAK nucleoprotein 0.0284251
DSPP dentin sialophosphoprotein 0.0274319
TRIO trio Rho guanine nucleotide exchange factor 0.0269154
MYO6 myosin VI 0.0253548
PTK2 protein tyrosine kinase 2 0.0248937
FXR1 fragile X mental retardation, autosomal homolog 1 0.0248891
ZFAND3 zinc finger, AN1-type domain 3 0.0244424
MARCHF6 membrane associated ring-CH-type finger 6 0.0240833
ELL2 elongation factor, RNA polymerase II, 2 0.0238759
NAMPT nicotinamide phosphoribosyltransferase 0.0238609
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0238399
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0234353
RAD21 RAD21 homolog (S. pombe) 0.0230313
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.022069
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0218343
ERBIN erbb2 interacting protein 0.0211777
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0209462
IGFBP3 insulin-like growth factor binding protein 3 0.0206403
LAMC2 laminin, gamma 2 0.0205748
HMGB2 high mobility group box 2 0.0204283
ERRFI1 ERBB receptor feedback inhibitor 1 0.0200824
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0198552
USP9X ubiquitin specific peptidase 9, X-linked 0.0198488
KDM3A lysine (K)-specific demethylase 3A 0.0194738
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0193636
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0188152
AKAP13 A kinase (PRKA) anchor protein 13 0.0187222
USP3 ubiquitin specific peptidase 3 0.0186652
RNF145 ring finger protein 145 0.0186017
ADAM9 ADAM metallopeptidase domain 9 0.0184382
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0184324
MATR3 matrin 3 0.0182245
TFG TRK-fused gene 0.0181956
CDC73 cell division cycle 73 0.0181926
KMT2E lysine (K)-specific methyltransferase 2E 0.0177651
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0176245
SPAG9 sperm associated antigen 9 0.0172237
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.016738
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0166949
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0165662
GARS1 glycyl-tRNA synthetase 1 0.0165495
SAMD4A sterile alpha motif domain containing 4A 0.0163113
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0162008
EIF4B eukaryotic translation initiation factor 4B 0.0159727
CD2AP CD2-associated protein 0.0159308
NCKAP1 NCK-associated protein 1 0.0158527
APP amyloid beta (A4) precursor protein 0.0158206
HSPA8 heat shock 70kDa protein 8 0.0157988
RASA2 RAS p21 protein activator 2 0.0156447
DST dystonin 0.015592
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0155111
MEF2A myocyte enhancer factor 2A 0.0154825
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0153929
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0148522
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0146032
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0145291
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0144562
NRIP1 nuclear receptor interacting protein 1 0.0140798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0140321
QKI QKI, KH domain containing, RNA binding 0.0138411
APLP2 amyloid beta (A4) precursor-like protein 2 0.0138294
TOP2B topoisomerase (DNA) II beta 180kDa 0.0138234
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0138056
EPS8 epidermal growth factor receptor pathway substrate 8 0.0137577
RBM39 RNA binding motif protein 39 0.0135301
NPEPPS aminopeptidase puromycin sensitive 0.0135226
PLEC plectin 0.0135205
TXNRD1 thioredoxin reductase 1 0.0135083
SMAD3 SMAD family member 3 0.0133668
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0132154
YTHDC1 YTH domain containing 1 0.0132009
MACF1 microtubule-actin crosslinking factor 1 0.0130536
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0129747
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0129716
NUP58 nucleoporin 58 0.0129415
SEC23A Sec23 homolog A (S. cerevisiae) 0.0127363
ECT2 epithelial cell transforming 2 0.0126612
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0126535
XPO1 exportin 1 0.0125832
PAPOLA poly(A) polymerase alpha 0.0125823
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.012568
KDM6A lysine (K)-specific demethylase 6A 0.0124495
CDK17 cyclin-dependent kinase 17 0.0124472
RHEB Ras homolog enriched in brain 0.0123157
IQGAP1 IQ motif containing GTPase activating protein 1 0.0121909
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0119529
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0118819
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0118387
YAP1 Yes-associated protein 1 0.0117335

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.199106
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165813
TMSB10 thymosin beta 10 -0.14796
IFI27 interferon, alpha-inducible protein 27 -0.0924471
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0866216
ISG15 ISG15 ubiquitin-like modifier -0.0704413
RPL35A ribosomal protein L35a -0.0695879
ACTG1 actin gamma 1 -0.068927
S100A6 S100 calcium binding protein A6 -0.0679874
PTMA prothymosin, alpha -0.0638398
IFI6 interferon, alpha-inducible protein 6 -0.0637708
NDRG1 N-myc downstream regulated 1 -0.0605573
POTEF POTE ankyrin domain family, member F -0.0586961
MT2A metallothionein 2A -0.0585153
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0520912
IFITM3 interferon induced transmembrane protein 3 -0.0520674
TPT1 tumor protein, translationally-controlled 1 -0.0505231
RPS19 ribosomal protein S19 -0.0477886
IFITM1 interferon induced transmembrane protein 1 -0.0446344
RPS3 ribosomal protein S3 -0.0444576
RPL8 ribosomal protein L8 -0.04429
RPLP2 ribosomal protein, large, P2 -0.0440166
CSTB cystatin B (stefin B) -0.0439143
EIF1 eukaryotic translation initiation factor 1 -0.04305
HMGA1 high mobility group AT-hook 1 -0.0428476
RPS13 ribosomal protein S13 -0.042782
RACK1 receptor for activated C kinase 1 -0.0423266
RPL34 ribosomal protein L34 -0.0394716
RPS8 ribosomal protein S8 -0.0393284
FBXO32 F-box protein 32 -0.0388794
TPI1 triosephosphate isomerase 1 -0.0378697
RPS12 ribosomal protein S12 -0.0374864
RPL9 ribosomal protein L9 -0.037215
RPLP1 ribosomal protein, large, P1 -0.0361718
RPL37 ribosomal protein L37 -0.0357514
RPS23 ribosomal protein S23 -0.0352764
RPL19 ribosomal protein L19 -0.035191
RPL37A ribosomal protein L37a -0.0349129
RPL23 ribosomal protein L23 -0.0348564
RPL12 ribosomal protein L12 -0.0342265
RPS14 ribosomal protein S14 -0.0337591
HLA-A major histocompatibility complex, class I, A -0.0323747
RPS29 ribosomal protein S29 -0.0310679
HLA-B major histocompatibility complex, class I, B -0.0304555
RPL15 ribosomal protein L15 -0.0298068
RPL32 ribosomal protein L32 -0.0291902
LDHA lactate dehydrogenase A -0.0289981
RPL30 ribosomal protein L30 -0.0288495
EGR1 early growth response 1 -0.028839
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0288067
KRT7 keratin 7, type II -0.0286551
RPLP0 ribosomal protein, large, P0 -0.0285951
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0285019
RPL27A ribosomal protein L27a -0.0280282
RPS21 ribosomal protein S21 -0.0277972
RPS17 ribosomal protein S17 -0.0267584
IFI16 interferon, gamma-inducible protein 16 -0.0259456
S100A11 S100 calcium binding protein A11 -0.0258931
RPL31 ribosomal protein L31 -0.0257527
SOX4 SRY (sex determining region Y)-box 4 -0.0257029
RPS25 ribosomal protein S25 -0.0256816
RPS24 ribosomal protein S24 -0.0254066
LY6E lymphocyte antigen 6 complex, locus E -0.0248914
FTH1 ferritin, heavy polypeptide 1 -0.024748
RPS16 ribosomal protein S16 -0.0247228
HSPB1 heat shock 27kDa protein 1 -0.0246549
RPS27 ribosomal protein S27 -0.0245769
RPS27A ribosomal protein S27a -0.024184
S100A10 S100 calcium binding protein A10 -0.0241084
H3-3B H3.3 histone B -0.0239833
MDK midkine (neurite growth-promoting factor 2) -0.0238947
RPL11 ribosomal protein L11 -0.0236877
RPL36 ribosomal protein L36 -0.0236052
C15ORF48 chromosome 15 open reading frame 48 -0.0235384
UBC ubiquitin C -0.0223889
ENO1 enolase 1, (alpha) -0.0219143
RPL18 ribosomal protein L18 -0.0216941
RPL28 ribosomal protein L28 -0.0214295
B2M beta-2-microglobulin -0.0209943
LGALS1 lectin, galactoside-binding, soluble, 1 -0.020977
RPS5 ribosomal protein S5 -0.0207288
PFN1 profilin 1 -0.0206909
WSB1 WD repeat and SOCS box containing 1 -0.0204788
RPS10 ribosomal protein S10 -0.0201827
ENO2 enolase 2 (gamma, neuronal) -0.0200778
G0S2 G0/G1 switch 2 -0.0200157
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0200089
RPS6 ribosomal protein S6 -0.019996
KRT19 keratin 19, type I -0.0199535
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0198924
BLZF1 basic leucine zipper nuclear factor 1 -0.0197644
TM4SF1 transmembrane 4 L six family member 1 -0.0196717
RAB7A RAB7A, member RAS oncogene family -0.0195847
RPL36A ribosomal protein L36a -0.0195224
PKM pyruvate kinase, muscle -0.0195096
LMNA lamin A/C -0.0190126
TMSB4X thymosin beta 4, X-linked -0.01899
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0188103
COX6C cytochrome c oxidase subunit VIc -0.0185102
RPL7 ribosomal protein L7 -0.0184147