Ritonavir_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.128313
NAMPT nicotinamide phosphoribosyltransferase 0.10523
FNDC3B fibronectin type III domain containing 3B 0.096632
SLTM SAFB-like, transcription modulator 0.09314
NABP1 nucleic acid binding protein 1 0.0856289
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0844918
ELL2 elongation factor, RNA polymerase II, 2 0.0825321
ADARB1 adenosine deaminase, RNA-specific, B1 0.0819932
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.077229
RCOR1 REST corepressor 1 0.0749335
DOCK5 dedicator of cytokinesis 5 0.0749144
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0745605
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0743267
MACF1 microtubule-actin crosslinking factor 1 0.071788
RUNX1 runt-related transcription factor 1 0.0706523
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0706199
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0700652
TRPS1 trichorhinophalangeal syndrome I 0.0692386
DIAPH3 diaphanous-related formin 3 0.0659318
PGK1 phosphoglycerate kinase 1 0.06399
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0627743
ARHGAP32 Rho GTPase activating protein 32 0.0618955
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0614518
LMO7 LIM domain 7 0.060925
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0602689
ANKRD12 ankyrin repeat domain 12 0.0599927
EXT1 exostosin glycosyltransferase 1 0.0599531
AKAP12 A kinase (PRKA) anchor protein 12 0.0597792
BASP1 brain abundant, membrane attached signal protein 1 0.057774
CYRIB CYFIP related Rac1 interactor B 0.0573108
CALU calumenin 0.0549895
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0540101
SPAG9 sperm associated antigen 9 0.0527095
MSI2 musashi RNA-binding protein 2 0.0526015
MBNL1 muscleblind-like splicing regulator 1 0.0522612
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0513937
TRAPPC9 trafficking protein particle complex 9 0.0510944
CSNK1A1 casein kinase 1, alpha 1 0.0490412
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0457908
HELZ helicase with zinc finger 0.0457401
FBXO11 F-box protein 11 0.0455124
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0444319
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0442595
EIF1 eukaryotic translation initiation factor 1 0.0433229
WAC WW domain containing adaptor with coiled-coil 0.0428138
RSF1 remodeling and spacing factor 1 0.0404179
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.040114
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0399417
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0398939
THSD4 thrombospondin, type I, domain containing 4 0.0398752
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0395709
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0392935
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0387905
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0378969
TAOK1 TAO kinase 1 0.0373384
PCBP3 poly(rC) binding protein 3 0.0366891
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0352447
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0329011
ZBTB20 zinc finger and BTB domain containing 20 0.0317693
YBX3 Y box binding protein 3 0.0310596
STK24 serine/threonine kinase 24 0.0309299
DLG1 discs, large homolog 1 (Drosophila) 0.0306506
BPTF bromodomain PHD finger transcription factor 0.0294357
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0284
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0280228
USP34 ubiquitin specific peptidase 34 0.0277384
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0275846
SMYD3 SET and MYND domain containing 3 0.0273764
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0259966
TRIO trio Rho guanine nucleotide exchange factor 0.0250308
MED13L mediator complex subunit 13-like 0.0247995
NDRG1 N-myc downstream regulated 1 0.0236281
JMJD1C jumonji domain containing 1C 0.0223698
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0221538
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0216993
DGKD diacylglycerol kinase, delta 130kDa 0.0205825
RPS6 ribosomal protein S6 0.020308
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.019678
RAB7A RAB7A, member RAS oncogene family 0.0196072
RPL23 ribosomal protein L23 0.0195558
ENO1 enolase 1, (alpha) 0.0183772
ADGRB3 adhesion G protein-coupled receptor B3 0.0161187
CSNK1E casein kinase 1, epsilon 0.0161078
RPL31 ribosomal protein L31 0.0158008
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0145227
SLC38A2 solute carrier family 38, member 2 0.0142134
CUX1 cut-like homeobox 1 0.0115107
ITGA6 integrin, alpha 6 0.0114778
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0110861
ACTG1 actin gamma 1 0.0108153
COL6A3 collagen, type VI, alpha 3 0.0105432
WDFY3 WD repeat and FYVE domain containing 3 0.0100976
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.00993893
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0093348
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0093225
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0084079
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00823311
RACK1 receptor for activated C kinase 1 0.00810456
RPLP0 ribosomal protein, large, P0 0.00739669
GOLGA4 golgin A4 0.00637454

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.252998
EFNA5 ephrin-A5 -0.1473
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135263
PDE10A phosphodiesterase 10A -0.130865
NKD1 naked cuticle homolog 1 (Drosophila) -0.125203
FN1 fibronectin 1 -0.124321
VIM vimentin -0.115981
PTPRM protein tyrosine phosphatase, receptor type, M -0.0997811
ASPH aspartate beta-hydroxylase -0.0978982
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.092524
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0909409
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0873631
RORA RAR-related orphan receptor A -0.0824354
PSD3 pleckstrin and Sec7 domain containing 3 -0.0731835
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0719477
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0674819
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0673964
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.064403
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0632263
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0624755
VCL vinculin -0.0588729
SETD5 SET domain containing 5 -0.0564664
CDH13 cadherin 13 -0.0547049
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0527428
GPC6 glypican 6 -0.051389
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0509596
FNDC3A fibronectin type III domain containing 3A -0.0504877
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0470343
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0469441
NAV2 neuron navigator 2 -0.046802
MT2A metallothionein 2A -0.0455954
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0440818
VMP1 vacuole membrane protein 1 -0.043822
PTMA prothymosin, alpha -0.0424522
RAD51B RAD51 paralog B -0.0418524
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0414481
TMSB10 thymosin beta 10 -0.040683
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0391073
WSB1 WD repeat and SOCS box containing 1 -0.0384793
DOCK4 dedicator of cytokinesis 4 -0.038271
ATXN1 ataxin 1 -0.0378977
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0361751
STAG2 stromal antigen 2 -0.0360401
MYOF myoferlin -0.0359155
RPL35A ribosomal protein L35a -0.035198
KTN1 kinectin 1 (kinesin receptor) -0.0351496
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0337658
STC1 stanniocalcin 1 -0.0330606
PRKCA protein kinase C, alpha -0.0327391
KMT2E lysine (K)-specific methyltransferase 2E -0.0324244
AREG amphiregulin -0.0322542
ZMYND8 zinc finger, MYND-type containing 8 -0.0321514
MBNL2 muscleblind-like splicing regulator 2 -0.0290956
NPAS2 neuronal PAS domain protein 2 -0.0287763
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0283756
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0282859
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.02731
AKAP13 A kinase (PRKA) anchor protein 13 -0.0256908
MYO1E myosin IE -0.0256659
PARD3 par-3 family cell polarity regulator -0.0253184
CD44 CD44 molecule (Indian blood group) -0.02316
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.021943
ESYT2 extended synaptotagmin-like protein 2 -0.0219056
RPS3 ribosomal protein S3 -0.0214752
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0208554
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0204352
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0181481
DST dystonin -0.0180537
RPS19 ribosomal protein S19 -0.0176486
DSCAM Down syndrome cell adhesion molecule -0.0168908
RPS8 ribosomal protein S8 -0.0165025
PKM pyruvate kinase, muscle -0.0161687
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0160595
RPLP1 ribosomal protein, large, P1 -0.0154377
GPHN gephyrin -0.0150114
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0145532
SEC31A SEC31 homolog A (S. cerevisiae) -0.0136006
TPT1 tumor protein, translationally-controlled 1 -0.0108822
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0105526
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0105467
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.00985567
LDHA lactate dehydrogenase A -0.00931873
IGF2 insulin-like growth factor 2 -0.00929956
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.00884114
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00847722
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.00794991
EGFR epidermal growth factor receptor -0.00748789
COL6A1 collagen, type VI, alpha 1 -0.00730665
NHSL1 NHS-like 1 -0.00664791
FTL ferritin, light polypeptide -0.00597353
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.00536036
LRP1B low density lipoprotein receptor-related protein 1B -0.00499281
RPL12 ribosomal protein L12 -0.00481876
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.00447726
SLC38A1 solute carrier family 38, member 1 -0.00413273
MAML3 mastermind-like 3 (Drosophila) -0.00325348
CAMTA1 calmodulin binding transcription activator 1 -0.00288975
TBC1D22A TBC1 domain family, member 22A -0.0028616
NIPBL Nipped-B homolog (Drosophila) -0.00196305
RPL26 ribosomal protein L26 -0.00131165