Ritonavir_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 0.108075
COL5A2 collagen, type V, alpha 2 0.10518
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0866679
ANK2 ankyrin 2, neuronal 0.0579876
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0571038
ADGRL2 adhesion G protein-coupled receptor L2 0.0519474
ADGRL3 adhesion G protein-coupled receptor L3 0.0439562
PEG10 paternally expressed 10 0.0417738
PCLO piccolo presynaptic cytomatrix protein 0.0405756
CSMD3 CUB and Sushi multiple domains 3 0.0396327
PARD3B par-3 family cell polarity regulator beta 0.0395923
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0384484
FOXP2 forkhead box P2 0.0375995
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0370297
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0364278
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0358167
THBS1 thrombospondin 1 0.0347348
ITGAV integrin, alpha V 0.0346561
PCBP2 poly(rC) binding protein 2 0.0329187
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0312541
PDGFC platelet derived growth factor C 0.0310803
ADGRV1 adhesion G protein-coupled receptor V1 0.0294152
USP9X ubiquitin specific peptidase 9, X-linked 0.0267075
ZNF608 zinc finger protein 608 0.0260978
SLIT2 slit homolog 2 (Drosophila) 0.0252412
NCAM2 neural cell adhesion molecule 2 0.0246977
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0246474
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0241614
NFIB nuclear factor I/B 0.0241271
SFPQ splicing factor proline/glutamine-rich 0.0237868
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0235094
DOCK5 dedicator of cytokinesis 5 0.0235048
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0230926
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0225935
CDC73 cell division cycle 73 0.0213449
CDH19 cadherin 19, type 2 0.0213238
TCF12 transcription factor 12 0.0213099
TSC22D2 TSC22 domain family, member 2 0.0212475
CADM2 cell adhesion molecule 2 0.0210589
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.020982
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.020735
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0204892
SHROOM3 shroom family member 3 0.0203213
NCKAP1 NCK-associated protein 1 0.020219
NPAS3 neuronal PAS domain protein 3 0.0201039
SLC44A5 solute carrier family 44, member 5 0.019972
USP25 ubiquitin specific peptidase 25 0.0198809
EPHA5 EPH receptor A5 0.0198183
GLS2 glutaminase 2 (liver, mitochondrial) 0.0195185
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0193959
MBIP MAP3K12 binding inhibitory protein 1 0.0191624
ZFP30 ZFP30 zinc finger protein 0.0189043
POTEF POTE ankyrin domain family, member F 0.0186223
YAP1 Yes-associated protein 1 0.0184588
USP3 ubiquitin specific peptidase 3 0.0181449
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0180147
NBAS neuroblastoma amplified sequence 0.0178189
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0178157
MEMO1 mediator of cell motility 1 0.0178145
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0178136
PDE4D phosphodiesterase 4D, cAMP-specific 0.0175895
CELF2 CUGBP, Elav-like family member 2 0.0175767
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0174802
ADAM9 ADAM metallopeptidase domain 9 0.0173845
NONO non-POU domain containing, octamer-binding 0.0173603
TTC28 tetratricopeptide repeat domain 28 0.0173271
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0173134
KMT2E lysine (K)-specific methyltransferase 2E 0.017259
EVI5 ecotropic viral integration site 5 0.0171016
DST dystonin 0.0170673
APLP2 amyloid beta (A4) precursor-like protein 2 0.0170486
JMJD1C jumonji domain containing 1C 0.0170459
NTM neurotrimin 0.0169083
DENND4A DENN/MADD domain containing 4A 0.016878
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0168658
SPIDR scaffolding protein involved in DNA repair 0.0168542
OSBPL10 oxysterol binding protein-like 10 0.0167839
FXR1 fragile X mental retardation, autosomal homolog 1 0.0167758
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0167116
APP amyloid beta (A4) precursor protein 0.0165234
OLA1 Obg-like ATPase 1 0.0164855
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0164544
CALCR calcitonin receptor 0.016447
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0161652
KDM6A lysine (K)-specific demethylase 6A 0.0160737
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0159995
PM20D1 peptidase M20 domain containing 1 0.0159413
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0159293
RIMS2 regulating synaptic membrane exocytosis 2 0.0158616
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0158192
MDFIC MyoD family inhibitor domain containing 0.0157391
MYO6 myosin VI 0.0157054
SET SET nuclear proto-oncogene 0.0154722
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0154523
ZMYM2 zinc finger, MYM-type 2 0.015409
MEIS2 Meis homeobox 2 0.0153159
ABI2 abl-interactor 2 0.0152011
SAFB scaffold attachment factor B 0.0151837
ETNK1 ethanolamine kinase 1 0.0151397
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.015107

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.184896
TMSB10 thymosin beta 10 -0.160655
RPS16 ribosomal protein S16 -0.139748
PTMA prothymosin, alpha -0.127934
RPS6 ribosomal protein S6 -0.112411
RPS8 ribosomal protein S8 -0.110242
TPT1 tumor protein, translationally-controlled 1 -0.102813
RPL35A ribosomal protein L35a -0.100753
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.096492
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.091564
RPL23 ribosomal protein L23 -0.0782439
RPS12 ribosomal protein S12 -0.0747185
GNAS GNAS complex locus -0.0684991
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0649854
RPS19 ribosomal protein S19 -0.0636947
EIF1 eukaryotic translation initiation factor 1 -0.0618273
RPL37A ribosomal protein L37a -0.0607473
RPL37 ribosomal protein L37 -0.0589939
RPLP1 ribosomal protein, large, P1 -0.0587146
RPL31 ribosomal protein L31 -0.0585668
FTL ferritin, light polypeptide -0.0576653
RPL12 ribosomal protein L12 -0.0558859
WSB1 WD repeat and SOCS box containing 1 -0.0548005
B2M beta-2-microglobulin -0.053937
ANKRD33B ankyrin repeat domain 33B -0.0533628
MT2A metallothionein 2A -0.0521821
RPS3 ribosomal protein S3 -0.052134
SNX6 sorting nexin 6 -0.0518806
RPL11 ribosomal protein L11 -0.0497462
COL3A1 collagen, type III, alpha 1 -0.0493473
RPL34 ribosomal protein L34 -0.0481512
ISG15 ISG15 ubiquitin-like modifier -0.0474481
RPL36A ribosomal protein L36a -0.047011
RPL26 ribosomal protein L26 -0.0462162
COL1A2 collagen, type I, alpha 2 -0.0456843
RPS24 ribosomal protein S24 -0.0453368
MDK midkine (neurite growth-promoting factor 2) -0.0449203
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0448214
RPL19 ribosomal protein L19 -0.0443321
RPLP2 ribosomal protein, large, P2 -0.0439994
RPL28 ribosomal protein L28 -0.0426427
CNRIP1 cannabinoid receptor interacting protein 1 -0.0425608
RPLP0 ribosomal protein, large, P0 -0.0415022
RPS21 ribosomal protein S21 -0.0413073
MAP4 microtubule-associated protein 4 -0.0398062
NACA nascent polypeptide-associated complex alpha subunit -0.0394416
APOE apolipoprotein E -0.0384225
HSPB1 heat shock 27kDa protein 1 -0.0381841
RPL5 ribosomal protein L5 -0.0373964
RPS13 ribosomal protein S13 -0.0371814
FAM177A1 family with sequence similarity 177, member A1 -0.0371386
MYL12B myosin, light chain 12B, regulatory -0.0367161
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0363353
RPS25 ribosomal protein S25 -0.0355308
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0354292
RPL9 ribosomal protein L9 -0.0350056
RPS14 ribosomal protein S14 -0.0349702
PGK1 phosphoglycerate kinase 1 -0.0342457
RPS27A ribosomal protein S27a -0.0334006
CENPF centromere protein F, 350/400kDa -0.0328234
RACK1 receptor for activated C kinase 1 -0.032622
PHIP pleckstrin homology domain interacting protein -0.0324661
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0316802
RPS29 ribosomal protein S29 -0.0307291
RPS27 ribosomal protein S27 -0.0306552
RPL30 ribosomal protein L30 -0.0300729
RPL18 ribosomal protein L18 -0.0300676
DLG1 discs, large homolog 1 (Drosophila) -0.0299625
ANKRD12 ankyrin repeat domain 12 -0.0298086
RPL36 ribosomal protein L36 -0.0292792
RAI1 retinoic acid induced 1 -0.0290078
ACTG1 actin gamma 1 -0.0289373
LDHA lactate dehydrogenase A -0.0288627
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0288613
RPS10 ribosomal protein S10 -0.0288397
ZNF217 zinc finger protein 217 -0.0288064
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.028732
CAVIN1 caveolae associated protein 1 -0.0285102
RPL27 ribosomal protein L27 -0.0283967
TNRC6B trinucleotide repeat containing 6B -0.0280503
FST follistatin -0.0278619
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0276596
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0267579
S100A9 S100 calcium binding protein A9 -0.0267145
PFN1 profilin 1 -0.0266721
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0266229
TRIO trio Rho guanine nucleotide exchange factor -0.0264092
SERF2 small EDRK-rich factor 2 -0.0263076
ATF4 activating transcription factor 4 -0.0262079
EAPP E2F-associated phosphoprotein -0.026052
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260384
SLC38A2 solute carrier family 38, member 2 -0.025587
GARS1 glycyl-tRNA synthetase 1 -0.0253365
SYT1 synaptotagmin I -0.0247695
RPL35 ribosomal protein L35 -0.0242282
CALR calreticulin -0.0240533
RPS23 ribosomal protein S23 -0.0236788
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0236441
RPL38 ribosomal protein L38 -0.0236071
RSL1D1 ribosomal L1 domain containing 1 -0.0235474