Ritonavir_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.0860407
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0691646
CPED1 cadherin-like and PC-esterase domain containing 1 0.0691503
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0496281
FOXP1 forkhead box P1 0.0418758
GLI3 GLI family zinc finger 3 0.0262299
PDE7B phosphodiesterase 7B 0.0256275
NAV2 neuron navigator 2 0.0231069
BMP10 bone morphogenetic protein 10 0.0218026
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0199151
INTS6 integrator complex subunit 6 0.0196036
CAMKMT calmodulin-lysine N-methyltransferase 0.0189945
TSC22D1 TSC22 domain family, member 1 0.0171611
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0171209
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0169189
SOX6 SRY (sex determining region Y)-box 6 0.0157576
PRUNE2 prune homolog 2 (Drosophila) 0.0148497
RFC3 replication factor C (activator 1) 3, 38kDa 0.0147233
MKI67 marker of proliferation Ki-67 0.0145545
ZEB1 zinc finger E-box binding homeobox 1 0.0143683
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0142291
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0136675
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0136345
EPS8 epidermal growth factor receptor pathway substrate 8 0.0132139
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0129593
NPAS2 neuronal PAS domain protein 2 0.0128497
DIAPH3 diaphanous-related formin 3 0.0123146
ZSWIM6 zinc finger, SWIM-type containing 6 0.0120779
UNC13A unc-13 homolog A (C. elegans) 0.0120037
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0119645
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0118246
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.011584
SMC4 structural maintenance of chromosomes 4 0.0115802
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0114073
MACROD2 MACRO domain containing 2 0.0110888
CUX1 cut-like homeobox 1 0.0107234
MSRB3 methionine sulfoxide reductase B3 0.0107188
AHCYL2 adenosylhomocysteinase-like 2 0.0105494
HEG1 heart development protein with EGF-like domains 1 0.0105308
EXOC4 exocyst complex component 4 0.0105238
BICD1 bicaudal D homolog 1 (Drosophila) 0.0103248
AEBP2 AE binding protein 2 0.0102622
PDGFC platelet derived growth factor C 0.0102534
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0100863
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0100086
PSPC1 paraspeckle component 1 0.00993465
NABP1 nucleic acid binding protein 1 0.00985544
CFAP44 cilia and flagella associated protein 44 0.00980341
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.00964821
MLIP muscular LMNA-interacting protein 0.00964227
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00963934
APLF aprataxin and PNKP like factor 0.00942871
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.00934393
HDAC9 histone deacetylase 9 0.00933587
FER1L6 fer-1-like family member 6 0.00894448
LGALS12 lectin, galactoside-binding, soluble, 12 0.0089178
TNRC6C trinucleotide repeat containing 6C 0.0087383
FAT1 FAT atypical cadherin 1 0.00872745
KIF11 kinesin family member 11 0.00868526
LRPPRC leucine-rich pentatricopeptide repeat containing 0.00868393
CAB39 calcium binding protein 39 0.00865025
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.00845612
FNIP1 folliculin interacting protein 1 0.00840239
SORBS2 sorbin and SH3 domain containing 2 0.00837868
HELLS helicase, lymphoid-specific 0.00825997
NCOA2 nuclear receptor coactivator 2 0.00825221
SPC25 SPC25, NDC80 kinetochore complex component 0.00804364
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00795759
TXK TXK tyrosine kinase 0.00794212
ATAD2 ATPase family, AAA domain containing 2 0.00789282
MEIS2 Meis homeobox 2 0.00785276
ELMO1 engulfment and cell motility 1 0.00776001
LATS2 large tumor suppressor kinase 2 0.00773214
ATF7IP activating transcription factor 7 interacting protein 0.00768628
ZNF438 zinc finger protein 438 0.00762061
ARID5B AT rich interactive domain 5B (MRF1-like) 0.00761519
PCNX4 pecanex 4 0.00761408
ARID1A AT rich interactive domain 1A (SWI-like) 0.00759406
MRPS6 mitochondrial ribosomal protein S6 0.00757574
VRK1 vaccinia related kinase 1 0.00751667
ZNF407 zinc finger protein 407 0.0075057
WWOX WW domain containing oxidoreductase 0.0075029
N4BP2L2 NEDD4 binding protein 2-like 2 0.00745185
NCAPG2 non-SMC condensin II complex, subunit G2 0.00743031
CREB5 cAMP responsive element binding protein 5 0.00738318
TMEM260 transmembrane protein 260 0.00734659
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00734371
LARP4B La ribonucleoprotein domain family, member 4B 0.00734032
FASN fatty acid synthase 0.00731057
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00730853
DST dystonin 0.00730172
NFE2L2 nuclear factor, erythroid 2-like 2 0.00729447
PDE10A phosphodiesterase 10A 0.00729039
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.00725625
AFG2A AFG2 AAA ATPase homolog A 0.00718542
ATAD5 ATPase family, AAA domain containing 5 0.00716628
NEBL nebulette 0.00715243
CENPE centromere protein E, 312kDa 0.00711609
PBX3 pre-B-cell leukemia homeobox 3 0.00711343
DPH6 diphthamine biosynthesis 6 0.00707725

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.216343
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.213581
PKM pyruvate kinase, muscle -0.0825772
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0822983
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0797165
ADAM10 ADAM metallopeptidase domain 10 -0.0751573
TPT1 tumor protein, translationally-controlled 1 -0.073017
TMSB4X thymosin beta 4, X-linked -0.0721633
GOLGA4 golgin A4 -0.0707973
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0697855
RPS6 ribosomal protein S6 -0.0653088
FLNB filamin B, beta -0.064111
TXNRD1 thioredoxin reductase 1 -0.0588563
S100A6 S100 calcium binding protein A6 -0.0587658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0538093
RPS8 ribosomal protein S8 -0.0536113
RTN4 reticulon 4 -0.0535677
LDHA lactate dehydrogenase A -0.0530942
PGK1 phosphoglycerate kinase 1 -0.051948
B2M beta-2-microglobulin -0.0518815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.046489
ZNF292 zinc finger protein 292 -0.0460169
RBM39 RNA binding motif protein 39 -0.0459157
EIF1 eukaryotic translation initiation factor 1 -0.0455946
RPL11 ribosomal protein L11 -0.0455832
RPL26 ribosomal protein L26 -0.0451821
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0438878
NAMPT nicotinamide phosphoribosyltransferase -0.0435818
RPS2 ribosomal protein S2 -0.0435581
CAMTA1 calmodulin binding transcription activator 1 -0.0404943
AHNAK AHNAK nucleoprotein -0.0394802
EEF2 eukaryotic translation elongation factor 2 -0.0393281
RPS3 ribosomal protein S3 -0.0391905
SQSTM1 sequestosome 1 -0.0390249
RPS12 ribosomal protein S12 -0.037933
GARS1 glycyl-tRNA synthetase 1 -0.0377563
RPL35A ribosomal protein L35a -0.0377284
LOC112694756 uncharaterized LOC112694756 -0.0376206
RPL19 ribosomal protein L19 -0.037399
RPL12 ribosomal protein L12 -0.0370692
ACTG1 actin gamma 1 -0.037064
EZR ezrin -0.0365777
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0364352
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0363937
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0361928
ENO1 enolase 1, (alpha) -0.0358569
DSCAM Down syndrome cell adhesion molecule -0.0356461
RPL37A ribosomal protein L37a -0.034881
KDM3A lysine (K)-specific demethylase 3A -0.0347506
RPS19 ribosomal protein S19 -0.0341415
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0339906
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0336846
ZFAND3 zinc finger, AN1-type domain 3 -0.0331803
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.032953
NBAS neuroblastoma amplified sequence -0.0325096
PYGB phosphorylase, glycogen; brain -0.0320094
RPS13 ribosomal protein S13 -0.0311606
RPL36 ribosomal protein L36 -0.0308239
SMNDC1 survival motor neuron domain containing 1 -0.0304531
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0302193
PNISR PNN-interacting serine/arginine-rich protein -0.0298637
RNF145 ring finger protein 145 -0.0298408
RPLP0 ribosomal protein, large, P0 -0.0290223
RPLP1 ribosomal protein, large, P1 -0.0288852
PRRC2C proline-rich coiled-coil 2C -0.0286008
NF1 neurofibromin 1 -0.0284907
PFN1 profilin 1 -0.0283532
RPL9 ribosomal protein L9 -0.0280309
EML4 echinoderm microtubule associated protein like 4 -0.0278141
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0277594
ANK2 ankyrin 2, neuronal -0.0276953
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0276453
RPL31 ribosomal protein L31 -0.0270628
TPD52 tumor protein D52 -0.0270437
UBC ubiquitin C -0.0268436
TMEM41B transmembrane protein 41B -0.0267965
NUP58 nucleoporin 58 -0.0267449
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0265759
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0265651
RPL5 ribosomal protein L5 -0.0260759
RLF rearranged L-myc fusion -0.0260451
RPS23 ribosomal protein S23 -0.0259867
UBA6 ubiquitin-like modifier activating enzyme 6 -0.025863
RPL32 ribosomal protein L32 -0.0258139
RPL34 ribosomal protein L34 -0.0256972
NCKAP1 NCK-associated protein 1 -0.0254682
COG5 component of oligomeric golgi complex 5 -0.0251821
CCND1 cyclin D1 -0.025167
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0251612
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.025064
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0248088
CCNL1 cyclin L1 -0.0247754
ANKRD12 ankyrin repeat domain 12 -0.0247641
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0247633
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0246102
ADAM9 ADAM metallopeptidase domain 9 -0.0244933
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0241081
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0241007
RHOA ras homolog family member A -0.0240749
PRPF38B pre-mRNA processing factor 38B -0.023888