Ritonavir_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ritonavir_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BICC1 BicC family RNA binding protein 1 0.0301256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0224089
AHR aryl hydrocarbon receptor 0.0190671
CENPF centromere protein F, 350/400kDa 0.0167166
DUSP5 dual specificity phosphatase 5 0.0161352
ZBTB38 zinc finger and BTB domain containing 38 0.0152457
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0138325
INTS6 integrator complex subunit 6 0.013782
MKI67 marker of proliferation Ki-67 0.0131552
EIF4B eukaryotic translation initiation factor 4B 0.0122024
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0121035
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0120611
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0120303
ZC3H12B zinc finger CCCH-type containing 12B 0.0117085
USP9X ubiquitin specific peptidase 9, X-linked 0.0113166
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0111926
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0111517
CKAP5 cytoskeleton associated protein 5 0.010611
HSPH1 heat shock 105kDa/110kDa protein 1 0.00955217
APLP2 amyloid beta (A4) precursor-like protein 2 0.00946084
HSPA8 heat shock 70kDa protein 8 0.00936303
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.00931927
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.00908299
PGM3 phosphoglucomutase 3 0.00899137
KIF4A kinesin family member 4A 0.00898617
NONO non-POU domain containing, octamer-binding 0.00897221
KLHL15 kelch-like family member 15 0.00883389
ATM ATM serine/threonine kinase 0.00870882
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00864904
ANKHD1 ankyrin repeat and KH domain containing 1 0.00857806
KYNU kynureninase 0.00851217
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.00825871
PCBP2 poly(rC) binding protein 2 0.00821009
TPX2 TPX2, microtubule-associated 0.00814248
DIAPH3 diaphanous-related formin 3 0.00810869
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.00809816
CD47 CD47 molecule 0.00806662
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.00749585
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00740145
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.00738952
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00737936
NCAPG2 non-SMC condensin II complex, subunit G2 0.00731412
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00725761
NAV2 neuron navigator 2 0.0072471
NUP58 nucleoporin 58 0.0072301
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00705313
KIF11 kinesin family member 11 0.00703016
NRIP1 nuclear receptor interacting protein 1 0.00697888
AHI1 Abelson helper integration site 1 0.00696723
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00696397
PDE5A phosphodiesterase 5A, cGMP-specific 0.00694534
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 0.00663493
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.00659349
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00650585
ANLN anillin, actin binding protein 0.00650408
CDC25C cell division cycle 25C 0.00647272
IPO7 importin 7 0.00635846
NPR2 natriuretic peptide receptor 2 0.00633794
TRA2A transformer 2 alpha homolog (Drosophila) 0.00627674
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.00618608
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.00613183
CPNE1 copine I 0.00605848
GAS2L3 growth arrest-specific 2 like 3 0.00601773
HJURP Holliday junction recognition protein 0.00601328
MTERF1 mitochondrial transcription termination factor 1 0.00597543
TTC21B tetratricopeptide repeat domain 21B 0.00592938
ATP10D ATPase, class V, type 10D 0.0059233
ECT2 epithelial cell transforming 2 0.00592243
CKAP2 cytoskeleton associated protein 2 0.00591798
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.00586906
SND1 staphylococcal nuclease and tudor domain containing 1 0.00586446
DUSP10 dual specificity phosphatase 10 0.00578932
AURKA aurora kinase A 0.00575214
ELOVL5 ELOVL fatty acid elongase 5 0.0057518
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00574555
KIF18A kinesin family member 18A 0.00573019
BBS9 Bardet-Biedl syndrome 9 0.00571055
CENPE centromere protein E, 312kDa 0.00569246
TGM2 transglutaminase 2 0.00568304
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.00567893
HBEGF heparin-binding EGF-like growth factor 0.00566939
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.00564984
KIF14 kinesin family member 14 0.00563267
LURAP1L leucine rich adaptor protein 1-like 0.00553854
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.00553629
KSR1 kinase suppressor of ras 1 0.00551439
RFC3 replication factor C (activator 1) 3, 38kDa 0.0055114
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00549696
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.00547413
NEK7 NIMA-related kinase 7 0.00543682
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.00543549
STAU2 staufen double-stranded RNA binding protein 2 0.00538364
IQGAP3 IQ motif containing GTPase activating protein 3 0.00537356
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.00535731
KIF2C kinesin family member 2C 0.00530519
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00526747
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.00523988
FAM3C family with sequence similarity 3, member C 0.00521876
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.00521376
CKS2 CDC28 protein kinase regulatory subunit 2 0.00521258

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.176307
FRMD4A FERM domain containing 4A -0.114595
FTL ferritin, light polypeptide -0.103267
AKAP12 A kinase (PRKA) anchor protein 12 -0.0956774
TMSB10 thymosin beta 10 -0.0921916
TRIO trio Rho guanine nucleotide exchange factor -0.0898131
HLA-B major histocompatibility complex, class I, B -0.0866307
NDRG1 N-myc downstream regulated 1 -0.0863451
MT2A metallothionein 2A -0.0862032
PDE10A phosphodiesterase 10A -0.081331
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0782755
GLIS3 GLIS family zinc finger 3 -0.0775126
IGFBP3 insulin-like growth factor binding protein 3 -0.0758161
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0758013
TPT1 tumor protein, translationally-controlled 1 -0.0714399
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0669235
COL6A3 collagen, type VI, alpha 3 -0.0652719
CD44 CD44 molecule (Indian blood group) -0.0613102
CADM1 cell adhesion molecule 1 -0.0606445
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0606207
MARCKS myristoylated alanine-rich protein kinase C substrate -0.059384
IER3 immediate early response 3 -0.0586679
ZMYND8 zinc finger, MYND-type containing 8 -0.0584547
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0583841
PGK1 phosphoglycerate kinase 1 -0.0567737
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0554215
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.054851
HLA-A major histocompatibility complex, class I, A -0.0539339
RAI14 retinoic acid induced 14 -0.0533835
RPS12 ribosomal protein S12 -0.053176
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0528888
B2M beta-2-microglobulin -0.0523199
CDH13 cadherin 13 -0.0509708
FN1 fibronectin 1 -0.0479104
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0473723
VCAN versican -0.0456365
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0453291
SOD2 superoxide dismutase 2, mitochondrial -0.0440631
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0435404
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0428716
CTSD cathepsin D -0.0424697
DST dystonin -0.0410409
FNDC3B fibronectin type III domain containing 3B -0.0407713
FTH1 ferritin, heavy polypeptide 1 -0.04048
DIAPH2 diaphanous-related formin 2 -0.0397349
ANXA2 annexin A2 -0.0389715
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0384148
MYH9 myosin, heavy chain 9, non-muscle -0.0382083
HMGA2 high mobility group AT-hook 2 -0.0379446
TMSB4X thymosin beta 4, X-linked -0.0376637
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0373588
SDK1 sidekick cell adhesion molecule 1 -0.0369933
RPL35A ribosomal protein L35a -0.0369358
RPL37A ribosomal protein L37a -0.0368796
RPS6 ribosomal protein S6 -0.0366943
BASP1 brain abundant, membrane attached signal protein 1 -0.0366859
DLG1 discs, large homolog 1 (Drosophila) -0.0363637
SMYD3 SET and MYND domain containing 3 -0.0362578
TGFBI transforming growth factor, beta-induced, 68kDa -0.0359936
RPLP2 ribosomal protein, large, P2 -0.0359522
EGR1 early growth response 1 -0.0355083
LDHA lactate dehydrogenase A -0.0349013
VCL vinculin -0.0348592
NAV1 neuron navigator 1 -0.0345876
EGFR epidermal growth factor receptor -0.0345421
RPS3 ribosomal protein S3 -0.034253
COL5A1 collagen, type V, alpha 1 -0.0341227
RPL23 ribosomal protein L23 -0.0340683
ENO1 enolase 1, (alpha) -0.0338091
PTMA prothymosin, alpha -0.0338073
IFITM3 interferon induced transmembrane protein 3 -0.0336595
IFI6 interferon, alpha-inducible protein 6 -0.0334526
FLNB filamin B, beta -0.0333712
VEGFA vascular endothelial growth factor A -0.0327506
RNF213 ring finger protein 213 -0.0326907
RPS8 ribosomal protein S8 -0.0321765
WSB1 WD repeat and SOCS box containing 1 -0.0315891
ADM adrenomedullin -0.0311806
PTPRK protein tyrosine phosphatase, receptor type, K -0.0297639
RPL36A ribosomal protein L36a -0.0297381
SFRP1 secreted frizzled-related protein 1 -0.0295208
RPS24 ribosomal protein S24 -0.029508
RAB7A RAB7A, member RAS oncogene family -0.0291195
FRMPD4 FERM and PDZ domain containing 4 -0.0290557
FMNL2 formin-like 2 -0.0288107
ATXN1 ataxin 1 -0.0287028
ADAM12 ADAM metallopeptidase domain 12 -0.0284589
BNC2 basonuclin 2 -0.0282069
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0278683
RPS19 ribosomal protein S19 -0.0270455
RPL12 ribosomal protein L12 -0.0267786
TNS3 tensin 3 -0.0265414
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0264133
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0263819
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0263428
RPL26 ribosomal protein L26 -0.0261109
SLC38A1 solute carrier family 38, member 1 -0.0260116
CCBE1 collagen and calcium binding EGF domains 1 -0.0259464
AFF3 AF4/FMR2 family, member 3 -0.0258265
LPP LIM domain containing preferred translocation partner in lipoma -0.0254587