Ritonavir_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.109511
NRG1 neuregulin 1 0.0993681
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0753059
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.049258
STC2 stanniocalcin 2 0.0458262
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0375584
LIMCH1 LIM and calponin homology domains 1 0.0346562
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0335822
PLIN2 perilipin 2 0.0325216
HMGA2 high mobility group AT-hook 2 0.0283705
HILPDA hypoxia inducible lipid droplet-associated 0.0281687
PTMA prothymosin, alpha 0.028111
MRPS6 mitochondrial ribosomal protein S6 0.0274934
INTS6 integrator complex subunit 6 0.0225402
FTH1 ferritin, heavy polypeptide 1 0.0218337
AHNAK AHNAK nucleoprotein 0.0211429
IGFBP3 insulin-like growth factor binding protein 3 0.0196495
H1-0 H1.0 linker histone 0.0195436
BZW1 basic leucine zipper and W2 domains 1 0.0191011
ENO1 enolase 1, (alpha) 0.017875
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0164625
SLC35F3 solute carrier family 35, member F3 0.0159504
PDIA4 protein disulfide isomerase family A, member 4 0.0154633
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.014766
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.014745
ZFP36L1 ZFP36 ring finger protein-like 1 0.014248
HSPH1 heat shock 105kDa/110kDa protein 1 0.0128637
MYOF myoferlin 0.0128183
ATF3 activating transcription factor 3 0.0126761
CADM1 cell adhesion molecule 1 0.0126414
JUN jun proto-oncogene 0.0123916
INHBA inhibin, beta A 0.0120578
TPT1 tumor protein, translationally-controlled 1 0.0120402
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0120198
STC1 stanniocalcin 1 0.0119466
GRB10 growth factor receptor-bound protein 10 0.0119368
SOX4 SRY (sex determining region Y)-box 4 0.0116896
FLNB filamin B, beta 0.0116115
MTSS1 metastasis suppressor 1 0.0112946
DENND1A DENN/MADD domain containing 1A 0.0110599
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0108627
DNAH5 dynein, axonemal, heavy chain 5 0.0107571
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0104211
SLC38A2 solute carrier family 38, member 2 0.0103286
AKAP12 A kinase (PRKA) anchor protein 12 0.0102489
RPL35A ribosomal protein L35a 0.0101184
SFRP1 secreted frizzled-related protein 1 0.0100344
BHLHE40 basic helix-loop-helix family, member e40 0.00998665
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.00994825
CLIC4 chloride intracellular channel 4 0.00993689
GPC5 glypican 5 0.00992995
FAM193B family with sequence similarity 193, member B 0.0098564
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.00983167
RPS8 ribosomal protein S8 0.00969621
MAML3 mastermind-like 3 (Drosophila) 0.00961957
MARCKS myristoylated alanine-rich protein kinase C substrate 0.00957827
FAM107B family with sequence similarity 107, member B 0.0095263
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00940171
EFCAB13 EF-hand calcium binding domain 13 0.00929674
FBN1 fibrillin 1 0.00923132
ZHX2 zinc fingers and homeoboxes 2 0.00914932
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0090443
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00897263
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00895102
TKT transketolase 0.0089244
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00886873
FRMD6 FERM domain containing 6 0.00877223
COL6A3 collagen, type VI, alpha 3 0.0086284
KPNB1 karyopherin (importin) beta 1 0.00857268
ELOVL5 ELOVL fatty acid elongase 5 0.00856594
PRSS23 protease, serine, 23 0.00856384
FLRT2 fibronectin leucine rich transmembrane protein 2 0.00855046
WARS1 tryptophanyl-tRNA synthetase 1 0.00849909
BTG1 B-cell translocation gene 1, anti-proliferative 0.00848209
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.00846743
IER3 immediate early response 3 0.0084321
FAM162A family with sequence similarity 162, member A 0.00842378
HMGB1 high mobility group box 1 0.00835844
CCND1 cyclin D1 0.00831373
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00830384
TCF12 transcription factor 12 0.00829684
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.00828991
PRKG1 protein kinase, cGMP-dependent, type I 0.00823864
SAMD4A sterile alpha motif domain containing 4A 0.00823577
AEBP2 AE binding protein 2 0.0082186
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.00820814
ABLIM1 actin binding LIM protein 1 0.0081897
CDK6 cyclin-dependent kinase 6 0.00815321
GJA1 gap junction protein, alpha 1, 43kDa 0.00813592
LTBP1 latent transforming growth factor beta binding protein 1 0.00812753
SOD2 superoxide dismutase 2, mitochondrial 0.0080076
SLIT2 slit homolog 2 (Drosophila) 0.00797899
DIAPH2 diaphanous-related formin 2 0.00792559
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.00792171
IGFBP5 insulin-like growth factor binding protein 5 0.0078504
IFRD1 interferon-related developmental regulator 1 0.00783395
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.00775471
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.00774762
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.00765322
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00762871

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.294343
NAMPT nicotinamide phosphoribosyltransferase -0.176274
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.136287
PRRC2C proline-rich coiled-coil 2C -0.0944684
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0841091
MT2A metallothionein 2A -0.0808255
FNDC3B fibronectin type III domain containing 3B -0.0786179
OSMR oncostatin M receptor -0.0763443
EXT1 exostosin glycosyltransferase 1 -0.0720015
CENPF centromere protein F, 350/400kDa -0.069336
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0612996
NDRG1 N-myc downstream regulated 1 -0.0612506
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0611571
FNBP1 formin binding protein 1 -0.0482616
CD44 CD44 molecule (Indian blood group) -0.0461797
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0457266
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.045135
JMJD1C jumonji domain containing 1C -0.0448333
SMAD3 SMAD family member 3 -0.0446502
SMOX spermine oxidase -0.0441008
AHR aryl hydrocarbon receptor -0.0439344
SFTPA2 surfactant protein A2 -0.0434787
KMT2E lysine (K)-specific methyltransferase 2E -0.0432733
OGA O-GlcNAcase -0.0426214
SMYD3 SET and MYND domain containing 3 -0.0417225
ETNK1 ethanolamine kinase 1 -0.0415345
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0414754
ITGA1 integrin, alpha 1 -0.0413913
TXNIP thioredoxin interacting protein -0.0410733
TMEM165 transmembrane protein 165 -0.0407949
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0403528
GOLGA4 golgin A4 -0.0399768
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0397395
RBM39 RNA binding motif protein 39 -0.0393241
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0391021
VCL vinculin -0.0382884
ETV6 ets variant 6 -0.0375518
MYH9 myosin, heavy chain 9, non-muscle -0.037447
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0364983
NEK7 NIMA-related kinase 7 -0.0361975
CLTC clathrin, heavy chain (Hc) -0.0361234
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0359162
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0354661
NRP1 neuropilin 1 -0.0353685
MKI67 marker of proliferation Ki-67 -0.0349482
AKAP9 A kinase (PRKA) anchor protein 9 -0.034908
ELL2 elongation factor, RNA polymerase II, 2 -0.0348919
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0339845
RB1CC1 RB1-inducible coiled-coil 1 -0.0337122
TPR translocated promoter region, nuclear basket protein -0.03362
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0334912
NIPBL Nipped-B homolog (Drosophila) -0.0328678
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0327395
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0321183
FRY furry homolog (Drosophila) -0.0317408
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0316573
ANKRD28 ankyrin repeat domain 28 -0.0311074
RPS2 ribosomal protein S2 -0.0308035
CAB39 calcium binding protein 39 -0.0307456
IL6ST interleukin 6 signal transducer -0.0304382
TAS2R14 taste receptor, type 2, member 14 -0.0303637
EREG epiregulin -0.0300559
MCTP2 multiple C2 domains, transmembrane 2 -0.0299751
SVIL supervillin -0.0299572
VIM vimentin -0.0297286
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0295777
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0295268
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0293705
CDCP1 CUB domain containing protein 1 -0.0292181
GLIS3 GLIS family zinc finger 3 -0.0290378
LOXL2 lysyl oxidase-like 2 -0.0288368
ADAR adenosine deaminase, RNA-specific -0.0286808
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0282475
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0278857
ACBD3 acyl-CoA binding domain containing 3 -0.0278503
RPS12 ribosomal protein S12 -0.0277269
DUSP5 dual specificity phosphatase 5 -0.027699
NPC1 Niemann-Pick disease, type C1 -0.0276869
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0275379
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0274237
GOLT1B golgi transport 1B -0.0271526
ZMYND8 zinc finger, MYND-type containing 8 -0.0268853
TXNRD1 thioredoxin reductase 1 -0.026798
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0267898
SPAG9 sperm associated antigen 9 -0.026682
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0266668
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0265791
MBD5 methyl-CpG binding domain protein 5 -0.0265631
GPC6 glypican 6 -0.0262738
TENT2 terminal nucleotidyltransferase 2 -0.0259577
RTN4 reticulon 4 -0.0258697
UBXN4 UBX domain protein 4 -0.025742
RAB2A RAB2A, member RAS oncogene family -0.0256716
DOCK5 dedicator of cytokinesis 5 -0.0254699
VEGFA vascular endothelial growth factor A -0.025433
PKM pyruvate kinase, muscle -0.0253903
MAP1B microtubule-associated protein 1B -0.0253243
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0252423
RUNX1 runt-related transcription factor 1 -0.0252022
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0251972