| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5090 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Rofecoxib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.82 |
| RWDD1 | RWD domain containing 1 | 0.79 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.77 |
| CCDC57 | coiled-coil domain containing 57 | 0.75 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.68 |
| ZNF428 | zinc finger protein 428 | 0.67 |
| SMO | smoothened, frizzled class receptor | 0.65 |
| PTMS | parathymosin | 0.59 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.58 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.56 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.56 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.56 |
| RPL36AL | ribosomal protein L36a-like | 0.55 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.52 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.51 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.49 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.49 |
| RPLP2 | ribosomal protein, large, P2 | 0.46 |
| BAIAP2 | BAI1-associated protein 2 | 0.46 |
| RPL36A | ribosomal protein L36a | 0.46 |
| COMMD8 | COMM domain containing 8 | 0.46 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.44 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.44 |
| SBSN | suprabasin | 0.43 |
| ZXDB | zinc finger, X-linked, duplicated B | 0.43 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.43 |
| RMI2 | RecQ mediated genome instability 2 | 0.41 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.41 |
| RPLP1 | ribosomal protein, large, P1 | 0.4 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.4 |
| GID8 | GID complex subunit 8 | 0.39 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.39 |
| CENPH | centromere protein H | 0.38 |
| SDC1 | syndecan 1 | 0.38 |
| ERMARD | ER membrane-associated RNA degradation | 0.38 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.38 |
| PLCB4 | phospholipase C, beta 4 | 0.37 |
| DES | desmin | 0.36 |
| VIM | vimentin | 0.36 |
| NES | nestin | 0.36 |
| POLQ | polymerase (DNA directed), theta | 0.34 |
| RPS26 | ribosomal protein S26 | 0.34 |
| ZNF273 | zinc finger protein 273 | 0.34 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.33 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.33 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.33 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.32 |
| AAGAB | alpha- and gamma-adaptin binding protein | 0.31 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.31 |
| TPM4 | tropomyosin 4 | 0.31 |
| SLX4 | SLX4 structure-specific endonuclease subunit | 0.31 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | 0.31 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.31 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.31 |
| TBX3 | T-box 3 | 0.3 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.3 |
| CCNF | cyclin F | 0.3 |
| CDC34 | cell division cycle 34 | 0.3 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | 0.3 |
| RPS27A | ribosomal protein S27a | 0.29 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.29 |
| C5ORF22 | chromosome 5 open reading frame 22 | 0.29 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.29 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.29 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | 0.29 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.29 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | 0.29 |
| HSBP1 | heat shock factor binding protein 1 | 0.29 |
| PDCD5 | programmed cell death 5 | 0.29 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.29 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.29 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.29 |
| TULP3 | tubby like protein 3 | 0.29 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.28 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.28 |
| ANKRD13C | ankyrin repeat domain 13C | 0.28 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | 0.28 |
| ATXN2 | ataxin 2 | 0.28 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.27 |
| C1ORF109 | chromosome 1 open reading frame 109 | 0.27 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.27 |
| TPM3 | tropomyosin 3 | 0.27 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | 0.27 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.27 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.27 |
| POMP | proteasome maturation protein | 0.27 |
| LLPH | LLP homolog, long-term synaptic facilitation (Aplysia) | 0.26 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.26 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.26 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.26 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.26 |
| CALU | calumenin | 0.26 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | 0.26 |
| NOP16 | NOP16 nucleolar protein | 0.26 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.26 |
| RPL27A | ribosomal protein L27a | 0.26 |
| FNIP1 | folliculin interacting protein 1 | 0.25 |
| KIF1B | kinesin family member 1B | 0.25 |
| CENPJ | centromere protein J | 0.25 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GREB1 | growth regulation by estrogen in breast cancer 1 | -3.05 |
| CFAP57 | cilia and flagella associated protein 57 | -1.06 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.79 |
| RPAIN | RPA interacting protein | -0.66 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.65 |
| IQCG | IQ motif containing G | -0.6 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.57 |
| RTN2 | reticulon 2 | -0.57 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.57 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.56 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.56 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.55 |
| TTYH3 | tweety family member 3 | -0.53 |
| PAH | phenylalanine hydroxylase | -0.53 |
| VGF | VGF nerve growth factor inducible | -0.53 |
| ZNF175 | zinc finger protein 175 | -0.52 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.51 |
| DCLK2 | doublecortin-like kinase 2 | -0.49 |
| METTL7A | methyltransferase like 7A | -0.47 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.47 |
| ATG13 | autophagy related 13 | -0.47 |
| METTL22 | methyltransferase like 22 | -0.46 |
| TLE5 | TLE family member 5, transcriptional modulator | -0.45 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.45 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.44 |
| CTSB | cathepsin B | -0.44 |
| C20ORF194 | chromosome 20 open reading frame 194 | -0.42 |
| CUX2 | cut-like homeobox 2 | -0.42 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.42 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.42 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.41 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.41 |
| APOE | apolipoprotein E | -0.4 |
| MCEE | methylmalonyl CoA epimerase | -0.4 |
| GALNT4 | polypeptide N-acetylgalactosaminyltransferase 4 | -0.4 |
| AGTRAP | angiotensin II receptor-associated protein | -0.4 |
| ZNF91 | zinc finger protein 91 | -0.4 |
| PLAUR | plasminogen activator, urokinase receptor | -0.39 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.39 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.38 |
| CETN1 | centrin, EF-hand protein, 1 | -0.38 |
| KLK6 | kallikrein-related peptidase 6 | -0.38 |
| ZNF646 | zinc finger protein 646 | -0.38 |
| BPTF | bromodomain PHD finger transcription factor | -0.38 |
| CLDN3 | claudin 3 | -0.38 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.38 |
| PRDX1 | peroxiredoxin 1 | -0.37 |
| TMPO | thymopoietin | -0.37 |
| CETN2 | centrin, EF-hand protein, 2 | -0.37 |
| SMIM19 | small integral membrane protein 19 | -0.37 |
| LRFN4 | leucine rich repeat and fibronectin type III domain containing 4 | -0.36 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.36 |
| STK19 | serine/threonine kinase 19 | -0.36 |
| DST | dystonin | -0.36 |
| GDF15 | growth differentiation factor 15 | -0.35 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.35 |
| STEAP2 | STEAP family member 2, metalloreductase | -0.35 |
| KLK7 | kallikrein-related peptidase 7 | -0.35 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.34 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.34 |
| HYKK | hydroxylysine kinase | -0.34 |
| IFI35 | interferon-induced protein 35 | -0.34 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.33 |
| C17ORF53 | chromosome 17 open reading frame 53 | -0.33 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.33 |
| NCOR1 | nuclear receptor corepressor 1 | -0.33 |
| GLRX5 | glutaredoxin 5 | -0.33 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.33 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.33 |
| LAMA3 | laminin, alpha 3 | -0.32 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.32 |
| LIX1L | Lix1 homolog (chicken) like | -0.32 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.32 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.32 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.32 |
| ATOX1 | antioxidant 1 copper chaperone | -0.31 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.31 |
| MT1X | metallothionein 1X | -0.31 |
| S100A6 | S100 calcium binding protein A6 | -0.31 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.31 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | -0.3 |
| H3C1 | H3 clustered histone 1 | -0.3 |
| RTL6 | retrotransposon Gag like 6 | -0.3 |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa | -0.3 |
| ZNF548 | zinc finger protein 548 | -0.3 |
| GLMP | glycosylated lysosomal membrane protein | -0.3 |
| HAS3 | hyaluronan synthase 3 | -0.3 |
| F2 | coagulation factor II (thrombin) | -0.3 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.3 |
| FUT10 | fucosyltransferase 10 (alpha (1,3) fucosyltransferase) | -0.29 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.29 |
| ARSD | arylsulfatase D | -0.29 |
| GSE1 | Gse1 coiled-coil protein | -0.29 |
| FHIT | fragile histidine triad | -0.29 |
| ATP9A | ATPase, class II, type 9A | -0.29 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.29 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | -0.28 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.28 |
