| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/449193 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Roflumilast relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 3.09 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 2.23 |
| FTL | ferritin, light polypeptide | 1.6 |
| SBSN | suprabasin | 1.54 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | 1.38 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.91 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.85 |
| PIP | prolactin-induced protein | 0.82 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.81 |
| TBX3 | T-box 3 | 0.75 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.72 |
| PDE7A | phosphodiesterase 7A | 0.71 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.7 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.64 |
| CMC4 | C-x(9)-C motif containing 4 | 0.61 |
| METTL7A | methyltransferase like 7A | 0.61 |
| MEGF6 | multiple EGF-like-domains 6 | 0.59 |
| CPE | carboxypeptidase E | 0.57 |
| TUB | tubby bipartite transcription factor | 0.56 |
| TTC30B | tetratricopeptide repeat domain 30B | 0.54 |
| CDK18 | cyclin-dependent kinase 18 | 0.54 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.54 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.53 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.53 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.5 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.5 |
| TRMO | tRNA methyltransferase O | 0.49 |
| DENND5B | DENN/MADD domain containing 5B | 0.49 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.49 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.48 |
| WDR5B | WD repeat domain 5B | 0.46 |
| PDIK1L | PDLIM1 interacting kinase 1 like | 0.46 |
| PTGES | prostaglandin E synthase | 0.44 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | 0.44 |
| CHRD | chordin | 0.44 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.43 |
| FOXC1 | forkhead box C1 | 0.42 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.42 |
| RNF19B | ring finger protein 19B | 0.42 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.41 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.41 |
| ARG2 | arginase 2 | 0.41 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.41 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.4 |
| F8 | coagulation factor VIII, procoagulant component | 0.4 |
| ABHD14A | abhydrolase domain containing 14A | 0.4 |
| CMIP | c-Maf inducing protein | 0.4 |
| SYTL2 | synaptotagmin-like 2 | 0.4 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.4 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | 0.39 |
| CD320 | CD320 molecule | 0.39 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.38 |
| ZNF611 | zinc finger protein 611 | 0.38 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.37 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.37 |
| HOXA10 | homeobox A10 | 0.37 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.37 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.37 |
| ZNF503 | zinc finger protein 503 | 0.37 |
| TEN1 | TEN1 CST complex subunit | 0.36 |
| STK40 | serine/threonine kinase 40 | 0.36 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.36 |
| PDLIM3 | PDZ and LIM domain 3 | 0.35 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 0.35 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.35 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.35 |
| TSC22D4 | TSC22 domain family, member 4 | 0.34 |
| TJP3 | tight junction protein 3 | 0.34 |
| RBM47 | RNA binding motif protein 47 | 0.34 |
| ZNF226 | zinc finger protein 226 | 0.34 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.34 |
| KYAT1 | kynurenine aminotransferase 1 | 0.33 |
| CNTLN | centlein, centrosomal protein | 0.33 |
| KLHL17 | kelch-like family member 17 | 0.32 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.32 |
| GDF15 | growth differentiation factor 15 | 0.32 |
| ZNF700 | zinc finger protein 700 | 0.32 |
| APLF | aprataxin and PNKP like factor | 0.32 |
| SLC16A10 | solute carrier family 16 (aromatic amino acid transporter), member 10 | 0.32 |
| TMEM131L | transmembrane 131 like | 0.31 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.31 |
| FAM171A2 | family with sequence similarity 171, member A2 | 0.31 |
| CHMP1B | charged multivesicular body protein 1B | 0.31 |
| CCPG1 | cell cycle progression 1 | 0.31 |
| TRIM9 | tripartite motif containing 9 | 0.31 |
| ZNF100 | zinc finger protein 100 | 0.31 |
| ADCK1 | aarF domain containing kinase 1 | 0.31 |
| BAIAP3 | BAI1-associated protein 3 | 0.31 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.3 |
| DENND4B | DENN/MADD domain containing 4B | 0.3 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | 0.3 |
| GRAMD4 | GRAM domain containing 4 | 0.3 |
| ANK2 | ankyrin 2, neuronal | 0.3 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.3 |
| ABHD3 | abhydrolase domain containing 3 | 0.3 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.29 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.29 |
| CFAP410 | cilia and flagella associated protein 410 | 0.29 |
| ATXN1L | ataxin 1-like | 0.29 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POF1B | premature ovarian failure, 1B | -1.79 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.83 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.76 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.69 |
| CHST7 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 | -0.58 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.54 |
| TRIB3 | tribbles pseudokinase 3 | -0.51 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.5 |
| TSPAN5 | tetraspanin 5 | -0.5 |
| DEPDC7 | DEP domain containing 7 | -0.49 |
| ALOXE3 | arachidonate lipoxygenase 3 | -0.47 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.44 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.43 |
| BSN | bassoon presynaptic cytomatrix protein | -0.43 |
| BMP8A | bone morphogenetic protein 8a | -0.42 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.42 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.41 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.41 |
| FOSL1 | FOS-like antigen 1 | -0.41 |
| ZNF142 | zinc finger protein 142 | -0.4 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.4 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.39 |
| GAS6 | growth arrest-specific 6 | -0.39 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | -0.39 |
| ZNF3 | zinc finger protein 3 | -0.38 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.37 |
| GPATCH4 | G patch domain containing 4 | -0.37 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.37 |
| GLMP | glycosylated lysosomal membrane protein | -0.36 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -0.36 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.36 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.35 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.35 |
| SLC38A2 | solute carrier family 38, member 2 | -0.35 |
| TMEM64 | transmembrane protein 64 | -0.35 |
| MGLL | monoglyceride lipase | -0.34 |
| ABHD15 | abhydrolase domain containing 15 | -0.34 |
| JUNB | jun B proto-oncogene | -0.33 |
| RPLP1 | ribosomal protein, large, P1 | -0.33 |
| LAMC2 | laminin, gamma 2 | -0.33 |
| H1-4 | H1.4 linker histone, cluster member | -0.32 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.31 |
| ANKRD13B | ankyrin repeat domain 13B | -0.3 |
| METRNL | meteorin, glial cell differentiation regulator-like | -0.29 |
| NAV3 | neuron navigator 3 | -0.29 |
| NKAPD1 | NKAP domain containing 1 | -0.29 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.29 |
| KCTD6 | potassium channel tetramerization domain containing 6 | -0.28 |
| H1-0 | H1.0 linker histone | -0.28 |
| AXL | AXL receptor tyrosine kinase | -0.28 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.27 |
| ARL4D | ADP-ribosylation factor-like 4D | -0.27 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.27 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | -0.26 |
| CD3EAP | CD3e molecule, epsilon associated protein | -0.26 |
| CRTC2 | CREB regulated transcription coactivator 2 | -0.26 |
| TRIB1 | tribbles pseudokinase 1 | -0.26 |
| ANKRD10 | ankyrin repeat domain 10 | -0.26 |
| ITGA6 | integrin, alpha 6 | -0.26 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.26 |
| ZNF567 | zinc finger protein 567 | -0.26 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.25 |
| CMC1 | C-x(9)-C motif containing 1 | -0.25 |
| ARL6IP4 | ADP-ribosylation factor-like 6 interacting protein 4 | -0.25 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.25 |
| H1-5 | H1.5 linker histone, cluster member | -0.24 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.24 |
| CCND3 | cyclin D3 | -0.24 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -0.23 |
| HMGA2 | high mobility group AT-hook 2 | -0.23 |
| CPA4 | carboxypeptidase A4 | -0.23 |
| C19ORF44 | chromosome 19 open reading frame 44 | -0.23 |
| ZNF576 | zinc finger protein 576 | -0.23 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | -0.23 |
| NRP1 | neuropilin 1 | -0.23 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.23 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | -0.23 |
| IER2 | immediate early response 2 | -0.23 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.23 |
| NKAP | NFKB activating protein | -0.22 |
| AEN | apoptosis enhancing nuclease | -0.22 |
| PRMT6 | protein arginine methyltransferase 6 | -0.22 |
| ZNF600 | zinc finger protein 600 | -0.22 |
| EYS | eyes shut homolog (Drosophila) | -0.22 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.22 |
| SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3 | -0.22 |
| PXN | paxillin | -0.21 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | -0.21 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.21 |
| FAM122B | family with sequence similarity 122B | -0.21 |
| CST6 | cystatin E/M | -0.21 |
| BCL2L1 | BCL2-like 1 | -0.21 |
| SATB1 | SATB homeobox 1 | -0.21 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | -0.21 |
| SESN2 | sestrin 2 | -0.21 |
| FAM133B | family with sequence similarity 133, member B | -0.21 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.21 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.21 |
| PLAUR | plasminogen activator, urokinase receptor | -0.21 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.21 |
