| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.0965184 |
| AHNAK | AHNAK nucleoprotein | 0.0777992 |
| FLNB | filamin B, beta | 0.0634894 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0605472 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0419811 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.04068 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0399448 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0389146 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0378983 |
| CALR | calreticulin | 0.0365177 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0349071 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0295225 |
| OGA | O-GlcNAcase | 0.0278186 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.027457 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0273136 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0262529 |
| RPS27A | ribosomal protein S27a | 0.0260902 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.025714 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0255062 |
| COL3A1 | collagen, type III, alpha 1 | 0.0253963 |
| RTN4 | reticulon 4 | 0.0250078 |
| STC1 | stanniocalcin 1 | 0.0249477 |
| JUN | jun proto-oncogene | 0.0243905 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0231381 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0230951 |
| CANX | calnexin | 0.0230618 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0227961 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0226263 |
| ANKRD36 | ankyrin repeat domain 36 | 0.022262 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0216167 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0215439 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0213423 |
| SEPTIN9 | septin 9 | 0.0211735 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0207196 |
| CD44 | CD44 molecule (Indian blood group) | 0.0206425 |
| PTK2 | protein tyrosine kinase 2 | 0.0205525 |
| APP | amyloid beta (A4) precursor protein | 0.0205247 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0202427 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0200796 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0198445 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0191915 |
| HDAC9 | histone deacetylase 9 | 0.0181122 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0178209 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0176921 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0175509 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0175159 |
| SET | SET nuclear proto-oncogene | 0.017401 |
| RASA3 | RAS p21 protein activator 3 | 0.0169846 |
| PCBP2 | poly(rC) binding protein 2 | 0.0169369 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0167952 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0166085 |
| PRELID2 | PRELI domain containing 2 | 0.0163434 |
| GOLGA4 | golgin A4 | 0.0160793 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0159891 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0159246 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0156176 |
| RUNX1 | runt-related transcription factor 1 | 0.0154381 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0154336 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0153635 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0153109 |
| MYADM | myeloid-associated differentiation marker | 0.0151973 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0151612 |
| CALU | calumenin | 0.0150722 |
| ARRDC3 | arrestin domain containing 3 | 0.0149456 |
| ZNF638 | zinc finger protein 638 | 0.0148255 |
| ARFGEF3 | ARFGEF family member 3 | 0.0147346 |
| TPM3 | tropomyosin 3 | 0.0145416 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0144394 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0143868 |
| CERS2 | ceramide synthase 2 | 0.0141187 |
| CD99 | CD99 molecule | 0.0139851 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0139125 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0138681 |
| CCNY | cyclin Y | 0.0137774 |
| C1D | C1D nuclear receptor corepressor | 0.0136272 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0135205 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0134516 |
| NEFL | neurofilament, light polypeptide | 0.0134404 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0133679 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0131395 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0131052 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0130825 |
| HLA-E | major histocompatibility complex, class I, E | 0.0130467 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0129493 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0128426 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0128337 |
| ATXN1 | ataxin 1 | 0.0128116 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0127142 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0125084 |
| FMNL2 | formin-like 2 | 0.0125039 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0124464 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0123623 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0123361 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0123333 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.012331 |
| PCM1 | pericentriolar material 1 | 0.0122738 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0121903 |
| HDLBP | high density lipoprotein binding protein | 0.0121462 |
| MEF2A | myocyte enhancer factor 2A | 0.0121097 |
| NGLY1 | N-glycanase 1 | 0.0120204 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.183974 |
| TMSB10 | thymosin beta 10 | -0.135981 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.125279 |
| MAP1B | microtubule-associated protein 1B | -0.0991745 |
| PODXL | podocalyxin-like | -0.0966049 |
| S100A10 | S100 calcium binding protein A10 | -0.088558 |
| FN1 | fibronectin 1 | -0.0835209 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0743042 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0625091 |
| SUCNR1 | succinate receptor 1 | -0.0581621 |
| PRSS23 | protease, serine, 23 | -0.0563768 |
| VIM | vimentin | -0.0560211 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0556068 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.052338 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0520355 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0507298 |
| HLA-B | major histocompatibility complex, class I, B | -0.0501354 |
| CSTB | cystatin B (stefin B) | -0.0494246 |
| B2M | beta-2-microglobulin | -0.0476008 |
| CCND1 | cyclin D1 | -0.0474545 |
| TAGLN2 | transgelin 2 | -0.0446203 |
| PLAT | plasminogen activator, tissue | -0.0429512 |
| RIGI | RNA sensor RIG-I | -0.0429405 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0424472 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0417898 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0415864 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.04141 |
| MT2A | metallothionein 2A | -0.0411712 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0406485 |
| CDH13 | cadherin 13 | -0.0402983 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0399632 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0394781 |
| PFN1 | profilin 1 | -0.0355258 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0351488 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0343575 |
| LMNA | lamin A/C | -0.0341217 |
| LRRC17 | leucine rich repeat containing 17 | -0.0340337 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0337536 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0334418 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0298705 |
| S100A6 | S100 calcium binding protein A6 | -0.0291529 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0280466 |
| S100A4 | S100 calcium binding protein A4 | -0.0278331 |
| MX2 | MX dynamin-like GTPase 2 | -0.0277541 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0276939 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0273918 |
| TUBB4B | tubulin, beta 4B class IVb | -0.027307 |
| CYTH3 | cytohesin 3 | -0.0271061 |
| IL7R | interleukin 7 receptor | -0.027046 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.027021 |
| POTEF | POTE ankyrin domain family, member F | -0.0257846 |
| PKM | pyruvate kinase, muscle | -0.0252912 |
| NAV1 | neuron navigator 1 | -0.0251925 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0246711 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0241135 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0235494 |
| S100A11 | S100 calcium binding protein A11 | -0.0235433 |
| TPM1 | tropomyosin 1 (alpha) | -0.0228606 |
| DCLK2 | doublecortin-like kinase 2 | -0.0227221 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0226861 |
| BSG | basigin (Ok blood group) | -0.0226793 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0223251 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0222863 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.02204 |
| SP100 | SP100 nuclear antigen | -0.0215638 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0215054 |
| RPL35A | ribosomal protein L35a | -0.021318 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0210772 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0207711 |
| HLA-A | major histocompatibility complex, class I, A | -0.0205902 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0203348 |
| FSTL1 | follistatin-like 1 | -0.0202858 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.020239 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0202336 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0199586 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0199169 |
| MT1X | metallothionein 1X | -0.0197416 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0197222 |
| MSI2 | musashi RNA-binding protein 2 | -0.0196128 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0196063 |
| CDK6 | cyclin-dependent kinase 6 | -0.0195482 |
| SEC61G | Sec61 gamma subunit | -0.019387 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0192789 |
| TPI1 | triosephosphate isomerase 1 | -0.0191614 |
| HLA-C | major histocompatibility complex, class I, C | -0.0188329 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0186318 |
| TUBB | tubulin, beta class I | -0.0185938 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0182612 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0182115 |
| KRT81 | keratin 81, type II | -0.0181419 |
| TENM3 | teneurin transmembrane protein 3 | -0.0179735 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0179729 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0177794 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0175074 |
| TNS3 | tensin 3 | -0.0172225 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0170098 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0169979 |
| S100A9 | S100 calcium binding protein A9 | -0.0169739 |
| MEIS2 | Meis homeobox 2 | -0.0166954 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.01667 |
