| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS27A | ribosomal protein S27a | 0.132618 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132318 |
| UBC | ubiquitin C | 0.100378 |
| VIM | vimentin | 0.0820586 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0805937 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.08048 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0698055 |
| AHNAK | AHNAK nucleoprotein | 0.0667548 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0564229 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0497608 |
| TXNRD1 | thioredoxin reductase 1 | 0.0493227 |
| PCBP2 | poly(rC) binding protein 2 | 0.0487426 |
| ASPH | aspartate beta-hydroxylase | 0.0447458 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0428543 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0393919 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0384241 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0362315 |
| SET | SET nuclear proto-oncogene | 0.0360441 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.033717 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0303888 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0292652 |
| TPM3 | tropomyosin 3 | 0.0291299 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0291161 |
| RPS12 | ribosomal protein S12 | 0.0286857 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0282733 |
| ENO1 | enolase 1, (alpha) | 0.0282608 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0280361 |
| RPS3 | ribosomal protein S3 | 0.0277755 |
| VMP1 | vacuole membrane protein 1 | 0.0275737 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0273985 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0272307 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0265976 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0264965 |
| ZNF292 | zinc finger protein 292 | 0.0263739 |
| RPL37A | ribosomal protein L37a | 0.0260155 |
| EXOC6B | exocyst complex component 6B | 0.0256389 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0255134 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0254916 |
| JUN | jun proto-oncogene | 0.0253387 |
| XPOT | exportin, tRNA | 0.023629 |
| EZR | ezrin | 0.0235697 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0230587 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0227717 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0224081 |
| CALR | calreticulin | 0.021964 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0219612 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0216776 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0212796 |
| SQSTM1 | sequestosome 1 | 0.0207161 |
| PREPL | prolyl endopeptidase-like | 0.0201112 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.01998 |
| HSPA8 | heat shock 70kDa protein 8 | 0.019907 |
| FMNL2 | formin-like 2 | 0.0195807 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0194722 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0193375 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0193154 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0187633 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.018654 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0184884 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0184428 |
| PEG10 | paternally expressed 10 | 0.0182563 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0181952 |
| APP | amyloid beta (A4) precursor protein | 0.0180831 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0180002 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0179494 |
| ITSN2 | intersectin 2 | 0.0178992 |
| CEP250 | centrosomal protein 250kDa | 0.0177112 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0176674 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0176336 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0175985 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0175788 |
| PCBP3 | poly(rC) binding protein 3 | 0.017335 |
| RPL15 | ribosomal protein L15 | 0.0173259 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0169001 |
| ZNF148 | zinc finger protein 148 | 0.0168564 |
| ZNF638 | zinc finger protein 638 | 0.0168033 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0164462 |
| CCNY | cyclin Y | 0.0164243 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0163898 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0163318 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0162763 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.016207 |
| SSH2 | slingshot protein phosphatase 2 | 0.0161458 |
| CLPTM1L | CLPTM1-like | 0.0160044 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0160008 |
| ATP11A | ATPase, class VI, type 11A | 0.015857 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0158185 |
| RHOA | ras homolog family member A | 0.0156752 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.015495 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0154819 |
| XPO1 | exportin 1 | 0.0154529 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0153648 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0153103 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0152507 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0151582 |
| YTHDC1 | YTH domain containing 1 | 0.0151392 |
| OGA | O-GlcNAcase | 0.0150558 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0150518 |
| PLK2 | polo-like kinase 2 | 0.0149591 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.014829 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.208095 |
| NLGN1 | neuroligin 1 | -0.137337 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.100084 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0994783 |
| RPL35A | ribosomal protein L35a | -0.0948091 |
| RPS6 | ribosomal protein S6 | -0.0886124 |
| ACTG1 | actin gamma 1 | -0.0801354 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0756251 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0742528 |
| MKI67 | marker of proliferation Ki-67 | -0.073968 |
| EGR1 | early growth response 1 | -0.0685573 |
| BCHE | butyrylcholinesterase | -0.0624057 |
| NHSL1 | NHS-like 1 | -0.0592082 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0572089 |
| TPI1 | triosephosphate isomerase 1 | -0.0540251 |
| PFN1 | profilin 1 | -0.0528202 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0521754 |
| RPS21 | ribosomal protein S21 | -0.0510308 |
| HMGA1 | high mobility group AT-hook 1 | -0.0493766 |
| TUBA1B | tubulin, alpha 1b | -0.0461312 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0459727 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0451863 |
| TUBB | tubulin, beta class I | -0.0448187 |
| RPLP1 | ribosomal protein, large, P1 | -0.0441844 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0436594 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.043272 |
| HMGA2 | high mobility group AT-hook 2 | -0.0421345 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0419569 |
| RPL19 | ribosomal protein L19 | -0.0404194 |
| RPS19 | ribosomal protein S19 | -0.0404117 |
| YBX3 | Y box binding protein 3 | -0.0398303 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0397804 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0396442 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0389125 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0382934 |
| RPL11 | ribosomal protein L11 | -0.0373783 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0372585 |
| RPS14 | ribosomal protein S14 | -0.036482 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0357705 |
| RPL34 | ribosomal protein L34 | -0.0357023 |
| PDGFC | platelet derived growth factor C | -0.0346609 |
| MGAT4C | MGAT4 family, member C | -0.0342895 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0342742 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0342664 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0336879 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0335796 |
| PCDH7 | protocadherin 7 | -0.033507 |
| GCG | glucagon | -0.0331508 |
| RPLP0 | ribosomal protein, large, P0 | -0.0325248 |
| RPS23 | ribosomal protein S23 | -0.0321638 |
| TMEM123 | transmembrane protein 123 | -0.0305814 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0302691 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.0297103 |
| HMGB1 | high mobility group box 1 | -0.029622 |
| AREG | amphiregulin | -0.0295525 |
| GNAS | GNAS complex locus | -0.0295224 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0294994 |
| CCN2 | cellular communication network factor 2 | -0.0293826 |
| RPS24 | ribosomal protein S24 | -0.0292659 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0287146 |
| RPLP2 | ribosomal protein, large, P2 | -0.028449 |
| CBX3 | chromobox homolog 3 | -0.0279142 |
| ZNF804A | zinc finger protein 804A | -0.0276819 |
| S100A10 | S100 calcium binding protein A10 | -0.0276613 |
| TENM3 | teneurin transmembrane protein 3 | -0.0273736 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0268616 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0264492 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0263277 |
| TUBA1C | tubulin, alpha 1c | -0.025759 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.025675 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0250407 |
| RPL12 | ribosomal protein L12 | -0.0248973 |
| YBX1 | Y box binding protein 1 | -0.0246436 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0241256 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0241148 |
| YAP1 | Yes-associated protein 1 | -0.023345 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0232665 |
| KIF18B | kinesin family member 18B | -0.0230822 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0227843 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0225366 |
| CENPF | centromere protein F, 350/400kDa | -0.0225225 |
| TGM2 | transglutaminase 2 | -0.0222861 |
| TBCA | tubulin folding cofactor A | -0.0222211 |
| PTMS | parathymosin | -0.0221793 |
| RPS26 | ribosomal protein S26 | -0.0221767 |
| RPS15 | ribosomal protein S15 | -0.0220147 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0219965 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0217354 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0217289 |
| RPS13 | ribosomal protein S13 | -0.021692 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0216522 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0215202 |
| CDK6 | cyclin-dependent kinase 6 | -0.0214761 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0213207 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0210778 |
| MTAP | methylthioadenosine phosphorylase | -0.0210175 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0209215 |
| FTL | ferritin, light polypeptide | -0.0207978 |
| VCL | vinculin | -0.0205141 |
| KIF4A | kinesin family member 4A | -0.0203727 |
