| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.24422 |
| RPS27A | ribosomal protein S27a | 0.137661 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.129898 |
| MCL1 | myeloid cell leukemia 1 | 0.120262 |
| AHNAK | AHNAK nucleoprotein | 0.108319 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103952 |
| VIM | vimentin | 0.0929365 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0898287 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0872453 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0827519 |
| PCBP2 | poly(rC) binding protein 2 | 0.0735746 |
| TMSB10 | thymosin beta 10 | 0.0728518 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0726214 |
| ENO1 | enolase 1, (alpha) | 0.0719142 |
| ASPH | aspartate beta-hydroxylase | 0.0717867 |
| POTEF | POTE ankyrin domain family, member F | 0.0684677 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0674526 |
| FAM107B | family with sequence similarity 107, member B | 0.0644519 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0631184 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0630228 |
| FLNB | filamin B, beta | 0.0612721 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0592741 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0579488 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0568651 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0567105 |
| ACTN4 | actinin, alpha 4 | 0.0561512 |
| VMP1 | vacuole membrane protein 1 | 0.0540678 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0511775 |
| PKM | pyruvate kinase, muscle | 0.0488297 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0480902 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0471782 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0471707 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0468472 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0468031 |
| EZR | ezrin | 0.0459196 |
| EGFR | epidermal growth factor receptor | 0.0456483 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0453279 |
| STC1 | stanniocalcin 1 | 0.0450107 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0447444 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0446714 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0446196 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0436793 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0424601 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.042079 |
| SET | SET nuclear proto-oncogene | 0.0418222 |
| MSN | moesin | 0.041783 |
| ANXA2 | annexin A2 | 0.0413099 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0412526 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.040551 |
| RPS3 | ribosomal protein S3 | 0.0405468 |
| PARD3 | par-3 family cell polarity regulator | 0.0404467 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0401522 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0398 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0394751 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0380243 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0378892 |
| SMYD3 | SET and MYND domain containing 3 | 0.0378888 |
| TPM3 | tropomyosin 3 | 0.0370162 |
| FLNA | filamin A, alpha | 0.0363754 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0363173 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0358938 |
| PDZD8 | PDZ domain containing 8 | 0.0352808 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0351917 |
| SMAD3 | SMAD family member 3 | 0.0351679 |
| LDHA | lactate dehydrogenase A | 0.0346861 |
| INTS6 | integrator complex subunit 6 | 0.0345474 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0337506 |
| ANXA1 | annexin A1 | 0.0334816 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0328707 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.032669 |
| JUN | jun proto-oncogene | 0.032608 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0323904 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.03204 |
| AXL | AXL receptor tyrosine kinase | 0.0320298 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0318966 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0318587 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.031828 |
| RPS17 | ribosomal protein S17 | 0.0314516 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0312449 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0309787 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0307889 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0305325 |
| FNIP1 | folliculin interacting protein 1 | 0.0304926 |
| CTBP2 | C-terminal binding protein 2 | 0.0302211 |
| RTN4 | reticulon 4 | 0.0300415 |
| CD44 | CD44 molecule (Indian blood group) | 0.0300394 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0299098 |
| FAT1 | FAT atypical cadherin 1 | 0.0295931 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0293942 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0293833 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0293251 |
| EFNA5 | ephrin-A5 | 0.0289048 |
| CUL3 | cullin 3 | 0.0285244 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.028341 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0281443 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0278935 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0273405 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0271168 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0271017 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0270885 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.23414 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.135684 |
| FTL | ferritin, light polypeptide | -0.101282 |
| RPS6 | ribosomal protein S6 | -0.0888776 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0852796 |
| RPLP1 | ribosomal protein, large, P1 | -0.0850766 |
| MT2A | metallothionein 2A | -0.0845471 |
| RPS19 | ribosomal protein S19 | -0.0763438 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0760444 |
| MT1X | metallothionein 1X | -0.0750116 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.070092 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0689369 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0634679 |
| RRBP1 | ribosome binding protein 1 | -0.0625248 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0540935 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.053398 |
| RAI14 | retinoic acid induced 14 | -0.0516559 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0490311 |
| NDRG1 | N-myc downstream regulated 1 | -0.0489444 |
| RPL35A | ribosomal protein L35a | -0.0478479 |
| RNF213 | ring finger protein 213 | -0.0438281 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0424219 |
| OSMR | oncostatin M receptor | -0.0401808 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0398317 |
| RIN2 | Ras and Rab interactor 2 | -0.0393627 |
| ANXA4 | annexin A4 | -0.0392665 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0375527 |
| RIGI | RNA sensor RIG-I | -0.0369937 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0360762 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0351081 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0345734 |
| RPL32 | ribosomal protein L32 | -0.0341118 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0328709 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0323142 |
| TMSB4X | thymosin beta 4, X-linked | -0.0320741 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0316204 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0311931 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0306172 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0304773 |
| RPL38 | ribosomal protein L38 | -0.0295916 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0292626 |
| DENND4C | DENN/MADD domain containing 4C | -0.0291876 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.029142 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0287088 |
| CP | ceruloplasmin (ferroxidase) | -0.0286876 |
| RPS29 | ribosomal protein S29 | -0.0284689 |
| BMERB1 | bMERB domain containing 1 | -0.0284028 |
| GPRIN3 | GPRIN family member 3 | -0.0280388 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0278812 |
| GNAS | GNAS complex locus | -0.0278548 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0273371 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0268532 |
| PYGL | phosphorylase, glycogen, liver | -0.0260663 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0255975 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0255243 |
| EHBP1 | EH domain binding protein 1 | -0.0252247 |
| USP3 | ubiquitin specific peptidase 3 | -0.0250232 |
| WDR45B | WD repeat domain 45B | -0.0249652 |
| TNS3 | tensin 3 | -0.0248311 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0242308 |
| RPL19 | ribosomal protein L19 | -0.0240654 |
| RPLP2 | ribosomal protein, large, P2 | -0.0234012 |
| NRP1 | neuropilin 1 | -0.0233016 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0232322 |
| SFTPA2 | surfactant protein A2 | -0.0230959 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0229668 |
| H1-0 | H1.0 linker histone | -0.0228164 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.022421 |
| RPL11 | ribosomal protein L11 | -0.0222109 |
| MAP1B | microtubule-associated protein 1B | -0.0220986 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0216797 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.021567 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.021235 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.020805 |
| RPL36AL | ribosomal protein L36a-like | -0.0207574 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0205523 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0203535 |
| S100A6 | S100 calcium binding protein A6 | -0.0202414 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0201471 |
| S100A10 | S100 calcium binding protein A10 | -0.02008 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0198646 |
| ARF1 | ADP-ribosylation factor 1 | -0.0198422 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0196496 |
| MKI67 | marker of proliferation Ki-67 | -0.0195405 |
| RNF24 | ring finger protein 24 | -0.0195336 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0195227 |
| HLA-B | major histocompatibility complex, class I, B | -0.0194523 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0193701 |
| CAVIN1 | caveolae associated protein 1 | -0.0193514 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0192733 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0190949 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0189326 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0188651 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0185627 |
| DENND5B | DENN/MADD domain containing 5B | -0.0183456 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0183311 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0181897 |
| EFHD2 | EF-hand domain family, member D2 | -0.0180743 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0180495 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0179839 |
