Ropivacaine (hydrochloride monohydrate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ropivacaine (hydrochloride monohydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBC ubiquitin C 0.247192
FLNB filamin B, beta 0.0745232
PMM2 phosphomannomutase 2 0.0490172
CALU calumenin 0.0457423
THSD4 thrombospondin, type I, domain containing 4 0.0442404
ABTB3 ankyrin repeat and BTB domain containing 3 0.0438221
DOCK5 dedicator of cytokinesis 5 0.0408822
MCL1 myeloid cell leukemia 1 0.0375592
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0363315
TPM3 tropomyosin 3 0.0353378
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0349385
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.034058
SGMS2 sphingomyelin synthase 2 0.0329363
ZSWIM6 zinc finger, SWIM-type containing 6 0.032811
FMNL2 formin-like 2 0.0327277
EXT1 exostosin glycosyltransferase 1 0.0326575
EFNA5 ephrin-A5 0.0311071
EMP1 epithelial membrane protein 1 0.0299618
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0291344
ACTN4 actinin, alpha 4 0.0288504
ZFC3H1 zinc finger, C3H1-type containing 0.0279119
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0277864
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0254771
SEC31A SEC31 homolog A (S. cerevisiae) 0.0251328
RPS27A ribosomal protein S27a 0.0243963
TXNRD1 thioredoxin reductase 1 0.0242663
SFPQ splicing factor proline/glutamine-rich 0.0239812
OGA O-GlcNAcase 0.0232629
TMEM263 transmembrane protein 263 0.0229701
FLNA filamin A, alpha 0.0226239
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0225569
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0220913
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0214206
SPDYA speedy/RINGO cell cycle regulator family member A 0.0211916
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0209721
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0208307
MMP1 matrix metallopeptidase 1 0.0207914
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.020749
BMP6 bone morphogenetic protein 6 0.020547
SAMD4A sterile alpha motif domain containing 4A 0.0205146
XPO6 exportin 6 0.0204113
GRB10 growth factor receptor-bound protein 10 0.0202789
VMP1 vacuole membrane protein 1 0.0201098
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0200044
IQGAP1 IQ motif containing GTPase activating protein 1 0.0198603
RASA3 RAS p21 protein activator 3 0.0194733
AHNAK AHNAK nucleoprotein 0.0191359
HDLBP high density lipoprotein binding protein 0.0191277
RBM25 RNA binding motif protein 25 0.0190862
HSPA8 heat shock 70kDa protein 8 0.0190625
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0189108
APLP2 amyloid beta (A4) precursor-like protein 2 0.018842
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0184461
ARB2A ARB2 cotranscriptional regulator A 0.0184151
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.01801
PDLIM5 PDZ and LIM domain 5 0.0178876
TBC1D15 TBC1 domain family, member 15 0.0178575
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0178425
SET SET nuclear proto-oncogene 0.0175786
SOD2 superoxide dismutase 2, mitochondrial 0.0173991
BCAR3 breast cancer anti-estrogen resistance 3 0.0173903
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0173223
THBD thrombomodulin 0.0173218
MARCHF6 membrane associated ring-CH-type finger 6 0.0172728
SAFB2 scaffold attachment factor B2 0.0171366
TTC3 tetratricopeptide repeat domain 3 0.0167407
KLF5 Kruppel-like factor 5 (intestinal) 0.0164785
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0163312
MBNL1 muscleblind-like splicing regulator 1 0.0161537
CERS2 ceramide synthase 2 0.0161018
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0160817
SEC16A SEC16 homolog A (S. cerevisiae) 0.0160769
APP amyloid beta (A4) precursor protein 0.0160675
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0157502
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0156812
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0156192
PPARD peroxisome proliferator-activated receptor delta 0.0155657
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0154788
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0153233
IRS2 insulin receptor substrate 2 0.0151916
SETX senataxin 0.0150967
CAPRIN2 caprin family member 2 0.0150856
SMAD3 SMAD family member 3 0.0150473
CDK13 cyclin-dependent kinase 13 0.0147575
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0147022
YTHDC1 YTH domain containing 1 0.0146983
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0146732
NOP58 NOP58 ribonucleoprotein 0.0146068
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0145931
SRSF5 serine/arginine-rich splicing factor 5 0.0145352
TM9SF3 transmembrane 9 superfamily member 3 0.0143921
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0143713
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0141572
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0140641
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.0140625
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0139849
PDIA4 protein disulfide isomerase family A, member 4 0.0139302
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0138546
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0138269
AMOTL2 angiomotin like 2 0.0138157

decreased expression

Symbol Name Standardized Value
BAIAP2L1 BAI1-associated protein 2-like 1 -0.157527
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12281
PTMA prothymosin, alpha -0.114843
AKAP12 A kinase (PRKA) anchor protein 12 -0.10301
FTH1 ferritin, heavy polypeptide 1 -0.101712
S100A10 S100 calcium binding protein A10 -0.0964274
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0906455
RPL35A ribosomal protein L35a -0.0902163
POTEF POTE ankyrin domain family, member F -0.0825174
IGFBP3 insulin-like growth factor binding protein 3 -0.0780079
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0769892
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0768089
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0755793
LMO7 LIM domain 7 -0.0740796
FTL ferritin, light polypeptide -0.0738612
RPS6 ribosomal protein S6 -0.0737858
HMGA1 high mobility group AT-hook 1 -0.0690201
TMSB10 thymosin beta 10 -0.0683496
ACTG1 actin gamma 1 -0.0677006
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0649422
TPT1 tumor protein, translationally-controlled 1 -0.0644937
F3 coagulation factor III (thromboplastin, tissue factor) -0.0615145
MUC17 mucin 17, cell surface associated -0.0604369
RPL34 ribosomal protein L34 -0.057509
RPLP1 ribosomal protein, large, P1 -0.0568986
PRSS3 protease, serine, 3 -0.054831
RIOK3 RIO kinase 3 -0.0515273
B2M beta-2-microglobulin -0.049565
EIF1 eukaryotic translation initiation factor 1 -0.0491578
EGR1 early growth response 1 -0.0491305
RPS8 ribosomal protein S8 -0.0490685
EGFR epidermal growth factor receptor -0.0487533
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0482267
RPL11 ribosomal protein L11 -0.0470769
SQSTM1 sequestosome 1 -0.0462624
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0459108
RPL31 ribosomal protein L31 -0.0456235
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0455942
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0452113
VIM vimentin -0.0443592
RPL8 ribosomal protein L8 -0.0443576
RPS25 ribosomal protein S25 -0.0440638
KRT18 keratin 18, type I -0.0433247
RPL12 ribosomal protein L12 -0.04283
ADAM9 ADAM metallopeptidase domain 9 -0.0428071
S100A11 S100 calcium binding protein A11 -0.0426239
RPS21 ribosomal protein S21 -0.0425646
RPL23 ribosomal protein L23 -0.0424592
RPS27 ribosomal protein S27 -0.042446
KRT19 keratin 19, type I -0.0418373
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.041734
RPS13 ribosomal protein S13 -0.0416237
CD2AP CD2-associated protein -0.0413762
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0412271
RPLP2 ribosomal protein, large, P2 -0.04116
RPS16 ribosomal protein S16 -0.0409298
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0392563
GNAS GNAS complex locus -0.038855
SKAP2 src kinase associated phosphoprotein 2 -0.0386073
RPS19 ribosomal protein S19 -0.0383158
VCAN versican -0.0377145
RPS23 ribosomal protein S23 -0.0373932
ITGA6 integrin, alpha 6 -0.0369791
PTPRR protein tyrosine phosphatase, receptor type, R -0.0362123
NPSR1 neuropeptide S receptor 1 -0.0357703
RPL19 ribosomal protein L19 -0.0356596
LDHA lactate dehydrogenase A -0.0343967
VCL vinculin -0.0334191
S100A4 S100 calcium binding protein A4 -0.0330165
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0328992
KTN1 kinectin 1 (kinesin receptor) -0.0328178
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0325366
RPS29 ribosomal protein S29 -0.0322499
DSTN destrin (actin depolymerizing factor) -0.032012
PLEC plectin -0.0315939
DSG2 desmoglein 2 -0.0305413
RPL36 ribosomal protein L36 -0.0304704
JUP junction plakoglobin -0.0303636
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0300496
PLAUR plasminogen activator, urokinase receptor -0.0297347
RPL28 ribosomal protein L28 -0.0297296
RPS20 ribosomal protein S20 -0.0296433
RPS14 ribosomal protein S14 -0.0296093
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.029558
VEZT vezatin, adherens junctions transmembrane protein -0.0293864
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0291543
LAMA4 laminin, alpha 4 -0.0289224
WASF2 WAS protein family, member 2 -0.0287389
S100A6 S100 calcium binding protein A6 -0.0281084
FOSL1 FOS-like antigen 1 -0.0278289
RPS2 ribosomal protein S2 -0.027567
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0273768
TJP2 tight junction protein 2 -0.0273583
ITGB4 integrin, beta 4 -0.0272671
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0272106
PFN1 profilin 1 -0.0270482
SLMAP sarcolemma associated protein -0.0270333
FNDC3B fibronectin type III domain containing 3B -0.0265821
RPL37 ribosomal protein L37 -0.0261431
RPL36A ribosomal protein L36a -0.0261244