| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.175706 |
| UBC | ubiquitin C | 0.127823 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0881316 |
| RPL23 | ribosomal protein L23 | 0.085018 |
| RPS27A | ribosomal protein S27a | 0.0755711 |
| RPS3 | ribosomal protein S3 | 0.0742669 |
| ENO1 | enolase 1, (alpha) | 0.0680736 |
| SET | SET nuclear proto-oncogene | 0.0657906 |
| NCOA3 | nuclear receptor coactivator 3 | 0.058974 |
| ACTG1 | actin gamma 1 | 0.0583967 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0568537 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0557905 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0551564 |
| INTS6 | integrator complex subunit 6 | 0.0516678 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0497642 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0488127 |
| MCL1 | myeloid cell leukemia 1 | 0.0470046 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0469624 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.045889 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0456785 |
| RPL37A | ribosomal protein L37a | 0.0455808 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0452086 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0445141 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0441173 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0434056 |
| CEP250 | centrosomal protein 250kDa | 0.0423535 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0421454 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0418075 |
| MLPH | melanophilin | 0.0387591 |
| LDHA | lactate dehydrogenase A | 0.0384835 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0382102 |
| CDK12 | cyclin-dependent kinase 12 | 0.0379288 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0373458 |
| ACTN4 | actinin, alpha 4 | 0.0369714 |
| VMP1 | vacuole membrane protein 1 | 0.0363526 |
| PTMA | prothymosin, alpha | 0.0353376 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0351261 |
| TMSB10 | thymosin beta 10 | 0.0349787 |
| CCNY | cyclin Y | 0.0349162 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0343543 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0342783 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0342649 |
| YAP1 | Yes-associated protein 1 | 0.03404 |
| NDRG1 | N-myc downstream regulated 1 | 0.0337965 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0336161 |
| SMYD3 | SET and MYND domain containing 3 | 0.0335068 |
| PRELID2 | PRELI domain containing 2 | 0.0333768 |
| FNBP1L | formin binding protein 1-like | 0.0323535 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0323283 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0316812 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0313814 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0312168 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0310921 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0305154 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0304355 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0300868 |
| TPM3 | tropomyosin 3 | 0.0298422 |
| DTNA | dystrobrevin, alpha | 0.0297278 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0296324 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0296049 |
| DENND5A | DENN/MADD domain containing 5A | 0.029541 |
| LASP1 | LIM and SH3 protein 1 | 0.0291294 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0287936 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0286836 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0286147 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0284641 |
| RPS8 | ribosomal protein S8 | 0.0283618 |
| RPL13A | ribosomal protein L13a | 0.0280823 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0279621 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0277651 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0276164 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0276127 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0275344 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0274296 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0272325 |
| PTK2 | protein tyrosine kinase 2 | 0.0271494 |
| APP | amyloid beta (A4) precursor protein | 0.0271485 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0266209 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0265872 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0265724 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0264657 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.0264626 |
| VIPR2 | vasoactive intestinal peptide receptor 2 | 0.0264615 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0260388 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0260283 |
| JUN | jun proto-oncogene | 0.0260268 |
| RPS12 | ribosomal protein S12 | 0.0255648 |
| RNF10 | ring finger protein 10 | 0.0255505 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0255123 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0254832 |
| FAM219A | family with sequence similarity 219, member A | 0.0249752 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0248201 |
| STK4 | serine/threonine kinase 4 | 0.0248031 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0247837 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0246083 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0244667 |
| RPL9 | ribosomal protein L9 | 0.0243502 |
| RBM39 | RNA binding motif protein 39 | 0.0242553 |
| OGA | O-GlcNAcase | 0.0241486 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0240459 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | -0.132513 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0849283 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0522174 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0516395 |
| TMSB4X | thymosin beta 4, X-linked | -0.0481524 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0464044 |
| S100A8 | S100 calcium binding protein A8 | -0.0440526 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0437947 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0436416 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0433526 |
| NTN4 | netrin 4 | -0.0433444 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0433377 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0410577 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0406415 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.039804 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.0381379 |
| CCND1 | cyclin D1 | -0.037248 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0364542 |
| OSMR | oncostatin M receptor | -0.0349871 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0336423 |
| RPL19 | ribosomal protein L19 | -0.0325932 |
| EGR1 | early growth response 1 | -0.0323988 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.032361 |
| FASN | fatty acid synthase | -0.031469 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0312593 |
| MYO1B | myosin IB | -0.0304824 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.030196 |
| KRT18 | keratin 18, type I | -0.0301174 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0295813 |
| S100A9 | S100 calcium binding protein A9 | -0.0293232 |
| KRT8 | keratin 8, type II | -0.0286455 |
| TENM2 | teneurin transmembrane protein 2 | -0.0285777 |
| GLCCI1 | glucocorticoid induced 1 | -0.0273184 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0272575 |
| DUSP16 | dual specificity phosphatase 16 | -0.0271647 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0270254 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0268171 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0264421 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0262034 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0261941 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0258798 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0254884 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0253577 |
| CD24 | CD24 molecule | -0.0247847 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0246488 |
| HLA-C | major histocompatibility complex, class I, C | -0.0245406 |
| SLC38A1 | solute carrier family 38, member 1 | -0.023936 |
| FGB | fibrinogen beta chain | -0.0238545 |
| DSTN | destrin (actin depolymerizing factor) | -0.0237371 |
| RPS6 | ribosomal protein S6 | -0.0237333 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0232949 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0231137 |
| TUBB | tubulin, beta class I | -0.0230767 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.023003 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0227761 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0224923 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0221348 |
| SHROOM3 | shroom family member 3 | -0.0217725 |
| RPL35A | ribosomal protein L35a | -0.021693 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0214766 |
| ZNF91 | zinc finger protein 91 | -0.0210566 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.021041 |
| RESF1 | retroelement silencing factor 1 | -0.0207165 |
| NRP1 | neuropilin 1 | -0.0204742 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0203824 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0201821 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0200951 |
| UBXN4 | UBX domain protein 4 | -0.0198935 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0196443 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0195332 |
| PLEC | plectin | -0.0195024 |
| KIAA1217 | KIAA1217 | -0.0194657 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0194373 |
| SPTSSB | serine palmitoyltransferase, small subunit B | -0.0192867 |
| NCAM2 | neural cell adhesion molecule 2 | -0.019196 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | -0.0191784 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0190023 |
| TMEM123 | transmembrane protein 123 | -0.0188967 |
| AHR | aryl hydrocarbon receptor | -0.0187895 |
| S100A14 | S100 calcium binding protein A14 | -0.0186585 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0186296 |
| TAPBP | TAP binding protein (tapasin) | -0.0182423 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0180628 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0173748 |
| HLA-B | major histocompatibility complex, class I, B | -0.0173719 |
| SEPTIN11 | septin 11 | -0.017359 |
| TNS3 | tensin 3 | -0.0172972 |
| CFB | complement factor B | -0.0172864 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0171589 |
| FADS2 | fatty acid desaturase 2 | -0.0170532 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0170253 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0169869 |
| IER2 | immediate early response 2 | -0.0169827 |
| MATR3 | matrin 3 | -0.0169625 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0168522 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.01676 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0166815 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0166206 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0165959 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0164621 |
