| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.235969 |
| ASPH | aspartate beta-hydroxylase | 0.167034 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.144758 |
| RPS27A | ribosomal protein S27a | 0.116598 |
| LAMB3 | laminin, beta 3 | 0.0982118 |
| ENO1 | enolase 1, (alpha) | 0.0952734 |
| JUN | jun proto-oncogene | 0.0806585 |
| AHNAK | AHNAK nucleoprotein | 0.0792329 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0785131 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0731674 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0709966 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0700277 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0697874 |
| KRT19 | keratin 19, type I | 0.0695768 |
| LAMA4 | laminin, alpha 4 | 0.0693142 |
| LAMC2 | laminin, gamma 2 | 0.0655809 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.064527 |
| APP | amyloid beta (A4) precursor protein | 0.0642366 |
| SGMS2 | sphingomyelin synthase 2 | 0.0635846 |
| MYO1E | myosin IE | 0.0621214 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0613318 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0566044 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0540511 |
| EMP1 | epithelial membrane protein 1 | 0.0538861 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0528999 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0523129 |
| CALR | calreticulin | 0.0516622 |
| MCL1 | myeloid cell leukemia 1 | 0.0510026 |
| KLF6 | Kruppel-like factor 6 | 0.050419 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0497424 |
| TMSB10 | thymosin beta 10 | 0.0486725 |
| SMAD3 | SMAD family member 3 | 0.0476432 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0473349 |
| CALU | calumenin | 0.046804 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0462401 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0430143 |
| CANX | calnexin | 0.0400279 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0393223 |
| LCN2 | lipocalin 2 | 0.039296 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0391325 |
| LDHA | lactate dehydrogenase A | 0.0390275 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0384557 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0380547 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0368504 |
| EZR | ezrin | 0.0367974 |
| MEF2A | myocyte enhancer factor 2A | 0.0365894 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0364421 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0361829 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0358937 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0356613 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0351513 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0351171 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0351004 |
| LMO7 | LIM domain 7 | 0.0348401 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0345902 |
| FAM107B | family with sequence similarity 107, member B | 0.0338243 |
| FAM13A | family with sequence similarity 13, member A | 0.0335703 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0326621 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0325332 |
| TPM4 | tropomyosin 4 | 0.0322125 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0321159 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0318224 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0315234 |
| FLNB | filamin B, beta | 0.0312281 |
| TPM3 | tropomyosin 3 | 0.0304161 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0304066 |
| G0S2 | G0/G1 switch 2 | 0.0303449 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.030098 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0288356 |
| PDZD8 | PDZ domain containing 8 | 0.0286001 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0283278 |
| TMEM87A | transmembrane protein 87A | 0.0282756 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0281748 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0278849 |
| RNF10 | ring finger protein 10 | 0.0276868 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0275506 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0272494 |
| EHF | ets homologous factor | 0.027113 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0269765 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0268142 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0266838 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0266167 |
| RNASET2 | ribonuclease T2 | 0.0266162 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0265868 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0261567 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0259221 |
| VMP1 | vacuole membrane protein 1 | 0.0254098 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0252701 |
| FAM3C | family with sequence similarity 3, member C | 0.0252225 |
| PER2 | period circadian clock 2 | 0.0252033 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0251938 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0249196 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0249074 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0248992 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0247861 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0245752 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0243828 |
| AHR | aryl hydrocarbon receptor | 0.0243554 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0242748 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0238834 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.225847 |
| PTMA | prothymosin, alpha | -0.100477 |
| RPL35A | ribosomal protein L35a | -0.0998257 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0859351 |
| MT1X | metallothionein 1X | -0.082651 |
| FTL | ferritin, light polypeptide | -0.077857 |
| CP | ceruloplasmin (ferroxidase) | -0.0733619 |
| RPLP1 | ribosomal protein, large, P1 | -0.0706116 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0695393 |
| RPS6 | ribosomal protein S6 | -0.0610909 |
| RPL19 | ribosomal protein L19 | -0.059417 |
| RPL34 | ribosomal protein L34 | -0.0557859 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0552204 |
| HLA-B | major histocompatibility complex, class I, B | -0.0540081 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0531005 |
| ANXA2 | annexin A2 | -0.0512706 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.051096 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.050618 |
| RPS23 | ribosomal protein S23 | -0.0501589 |
| GNAS | GNAS complex locus | -0.0491351 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0470577 |
| RPL11 | ribosomal protein L11 | -0.0469542 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0463406 |
| RPS19 | ribosomal protein S19 | -0.0458893 |
| DST | dystonin | -0.0445274 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0420503 |
| MT1E | metallothionein 1E | -0.041538 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0414762 |
| RPS29 | ribosomal protein S29 | -0.0402191 |
| RPS25 | ribosomal protein S25 | -0.0393548 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0388442 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0381987 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0370804 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.036 |
| ACTG1 | actin gamma 1 | -0.0348525 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0348272 |
| S100A10 | S100 calcium binding protein A10 | -0.0336983 |
| RPS21 | ribosomal protein S21 | -0.0330819 |
| RPL23 | ribosomal protein L23 | -0.0330002 |
| NABP1 | nucleic acid binding protein 1 | -0.0319035 |
| KRT17 | keratin 17, type I | -0.0317282 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0303518 |
| PLEC | plectin | -0.0303124 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0299701 |
| MKI67 | marker of proliferation Ki-67 | -0.0292979 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0290747 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.0288927 |
| MCU | mitochondrial calcium uniporter | -0.0282593 |
| RPS8 | ribosomal protein S8 | -0.0282025 |
| TPM1 | tropomyosin 1 (alpha) | -0.0278295 |
| SP100 | SP100 nuclear antigen | -0.027684 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0273112 |
| RPL31 | ribosomal protein L31 | -0.0269429 |
| FBXO11 | F-box protein 11 | -0.0267528 |
| RPS16 | ribosomal protein S16 | -0.0264871 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0258595 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0256738 |
| HLA-C | major histocompatibility complex, class I, C | -0.0256448 |
| PCNX4 | pecanex 4 | -0.0254688 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0253403 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0253306 |
| S100P | S100 calcium binding protein P | -0.0252855 |
| RPLP0 | ribosomal protein, large, P0 | -0.0251951 |
| LASP1 | LIM and SH3 protein 1 | -0.0251109 |
| FAM162A | family with sequence similarity 162, member A | -0.0249067 |
| RPS14 | ribosomal protein S14 | -0.024883 |
| RPL26 | ribosomal protein L26 | -0.0244015 |
| PCDH7 | protocadherin 7 | -0.0241913 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0240484 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0237258 |
| PARD3 | par-3 family cell polarity regulator | -0.023367 |
| RTN3 | reticulon 3 | -0.0232625 |
| RPLP2 | ribosomal protein, large, P2 | -0.0231858 |
| RAB7A | RAB7A, member RAS oncogene family | -0.022832 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0227507 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.022744 |
| RPS27 | ribosomal protein S27 | -0.0227234 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0226415 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0224423 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0223656 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0220158 |
| RPS2 | ribosomal protein S2 | -0.0219464 |
| MGLL | monoglyceride lipase | -0.0219063 |
| RPS5 | ribosomal protein S5 | -0.0218907 |
| TMSB4X | thymosin beta 4, X-linked | -0.0216911 |
| RPS10 | ribosomal protein S10 | -0.0213469 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0211704 |
| DEK | DEK proto-oncogene | -0.0211345 |
| RPL27 | ribosomal protein L27 | -0.0211304 |
| BCL2L1 | BCL2-like 1 | -0.0210357 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0207207 |
| RPL9 | ribosomal protein L9 | -0.020585 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0204727 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0204451 |
| SLMAP | sarcolemma associated protein | -0.0204225 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.020347 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0202243 |
| FDPS | farnesyl diphosphate synthase | -0.0200935 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0200109 |
| TAOK3 | TAO kinase 3 | -0.0197971 |
