Ropivacaine (hydrochloride monohydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ropivacaine (hydrochloride monohydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.13386
VIM vimentin 0.078788
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.077911
EEF2 eukaryotic translation elongation factor 2 0.0669532
RPS27A ribosomal protein S27a 0.062917
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0611802
MYH9 myosin, heavy chain 9, non-muscle 0.0585768
NALF1 NALCN channel auxiliary factor 1 0.0585732
PCBP2 poly(rC) binding protein 2 0.0575438
MCL1 myeloid cell leukemia 1 0.0569392
TLE4 transducin-like enhancer of split 4 0.0522627
VMP1 vacuole membrane protein 1 0.0495397
ZSWIM6 zinc finger, SWIM-type containing 6 0.0494669
UBC ubiquitin C 0.0480844
PDE4D phosphodiesterase 4D, cAMP-specific 0.0466831
MSI2 musashi RNA-binding protein 2 0.0444476
PTPRM protein tyrosine phosphatase, receptor type, M 0.0443569
ENO1 enolase 1, (alpha) 0.0433572
RPL23 ribosomal protein L23 0.042965
ATXN1 ataxin 1 0.0423012
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0422166
DSCAM Down syndrome cell adhesion molecule 0.0377271
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0376908
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0359708
LIMCH1 LIM and calponin homology domains 1 0.0359457
SMAD3 SMAD family member 3 0.0358094
ACTG1 actin gamma 1 0.0356381
TIMP3 TIMP metallopeptidase inhibitor 3 0.0353315
FMN1 formin 1 0.0346646
INTS6 integrator complex subunit 6 0.032693
AHNAK AHNAK nucleoprotein 0.0326894
SFPQ splicing factor proline/glutamine-rich 0.0322176
NAP1L1 nucleosome assembly protein 1-like 1 0.0321444
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0318971
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0304732
FERMT2 fermitin family member 2 0.0304578
NDRG1 N-myc downstream regulated 1 0.0302327
TPM1 tropomyosin 1 (alpha) 0.0301898
ACTN1 actinin, alpha 1 0.0292038
SLIT2 slit homolog 2 (Drosophila) 0.0291009
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0290741
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0286787
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0286425
SENP6 SUMO1/sentrin specific peptidase 6 0.0285659
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0283532
ASPH aspartate beta-hydroxylase 0.0282829
MEF2A myocyte enhancer factor 2A 0.0282432
RPS3 ribosomal protein S3 0.0282363
MBNL1 muscleblind-like splicing regulator 1 0.0282118
TMSB10 thymosin beta 10 0.0279303
RERE arginine-glutamic acid dipeptide (RE) repeats 0.027479
TIMP2 TIMP metallopeptidase inhibitor 2 0.0271846
PRKCA protein kinase C, alpha 0.0271837
PLAT plasminogen activator, tissue 0.0270047
STC1 stanniocalcin 1 0.0269416
AUTS2 autism susceptibility candidate 2 0.0264938
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0261035
PRRC2C proline-rich coiled-coil 2C 0.0260338
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0260134
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0259078
SET SET nuclear proto-oncogene 0.025577
RPS12 ribosomal protein S12 0.0254337
RPL31 ribosomal protein L31 0.0252475
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0250568
RPL37A ribosomal protein L37a 0.0249143
EFNA5 ephrin-A5 0.0248843
APP amyloid beta (A4) precursor protein 0.0247348
KTN1 kinectin 1 (kinesin receptor) 0.0245921
CUL3 cullin 3 0.0244723
MYO6 myosin VI 0.0244109
CTNND1 catenin (cadherin-associated protein), delta 1 0.0241653
SPDYA speedy/RINGO cell cycle regulator family member A 0.0240323
PTK2 protein tyrosine kinase 2 0.02366
CDK12 cyclin-dependent kinase 12 0.0236137
SRRM2 serine/arginine repetitive matrix 2 0.0234508
APLP2 amyloid beta (A4) precursor-like protein 2 0.0234182
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0233138
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0230799
PRRC2B proline-rich coiled-coil 2B 0.0230652
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0230479
RPS17 ribosomal protein S17 0.0230399
ZMIZ1 zinc finger, MIZ-type containing 1 0.0230281
IQGAP1 IQ motif containing GTPase activating protein 1 0.0228929
SMYD3 SET and MYND domain containing 3 0.0227493
ZYX zyxin 0.022552
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0225236
TPM3 tropomyosin 3 0.0224723
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.022445
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0223158
TPR translocated promoter region, nuclear basket protein 0.022045
JUN jun proto-oncogene 0.0220184
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0219513
TRA2A transformer 2 alpha homolog (Drosophila) 0.0219304
KDM4C lysine (K)-specific demethylase 4C 0.0218751
FN1 fibronectin 1 0.0218518
PKM pyruvate kinase, muscle 0.0218078
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0216135
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0215903
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0215006
MACF1 microtubule-actin crosslinking factor 1 0.0214981

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.325815
NRG1 neuregulin 1 -0.115373
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0596054
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0493895
SYT1 synaptotagmin I -0.0358179
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0280894
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0273408
PTPRD protein tyrosine phosphatase, receptor type, D -0.0271961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0269068
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0266768
NCAM2 neural cell adhesion molecule 2 -0.0266137
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.026575
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0234376
HAND2 heart and neural crest derivatives expressed 2 -0.0234228
SREBF2 sterol regulatory element binding transcription factor 2 -0.0232312
PTPRK protein tyrosine phosphatase, receptor type, K -0.0229287
ZNF804A zinc finger protein 804A -0.0224038
MAPK10 mitogen-activated protein kinase 10 -0.0216971
NPEPPS aminopeptidase puromycin sensitive -0.0207824
DENND4A DENN/MADD domain containing 4A -0.020504
AOPEP aminopeptidase O (putative) -0.0202295
ZNF33B zinc finger protein 33B -0.0202243
GPC5 glypican 5 -0.0200248
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0196228
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.01896
COL4A6 collagen, type IV, alpha 6 -0.0188572
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0188148
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0186722
TRIB2 tribbles pseudokinase 2 -0.0186354
TNRC6B trinucleotide repeat containing 6B -0.0185322
ARF1 ADP-ribosylation factor 1 -0.0179382
GAB2 GRB2-associated binding protein 2 -0.0176672
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0175148
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.017384
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0172124
MON2 MON2 homolog (S. cerevisiae) -0.0172041
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0169796
BICD1 bicaudal D homolog 1 (Drosophila) -0.0169447
TRIO trio Rho guanine nucleotide exchange factor -0.016835
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0166198
TCERG1 transcription elongation regulator 1 -0.0164679
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0164639
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0162725
RPS6 ribosomal protein S6 -0.0160931
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0160056
MATR3 matrin 3 -0.0159616
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0157594
RPL34 ribosomal protein L34 -0.0157354
CDC27 cell division cycle 27 -0.0157256
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0156399
ADAR adenosine deaminase, RNA-specific -0.0155459
PDZRN3 PDZ domain containing ring finger 3 -0.0155276
PTPRE protein tyrosine phosphatase, receptor type, E -0.0154885
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0153502
CLINT1 clathrin interactor 1 -0.015002
ZNF33A zinc finger protein 33A -0.0148465
PCNX1 pecanex 1 -0.0147963
H1-0 H1.0 linker histone -0.0145692
MTDH metadherin -0.0144759
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0144584
PEG10 paternally expressed 10 -0.0143285
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0142397
ANK2 ankyrin 2, neuronal -0.0142221
CD46 CD46 molecule, complement regulatory protein -0.0142003
STOX2 storkhead box 2 -0.0141564
NREP neuronal regeneration related protein -0.0140683
LONRF2 LON peptidase N-terminal domain and ring finger 2 -0.013986
INTS2 integrator complex subunit 2 -0.0139306
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0139291
SOS1 son of sevenless homolog 1 (Drosophila) -0.0139096
ATXN2 ataxin 2 -0.0138317
TENT5A terminal nucleotidyltransferase 5A -0.0138064
BCL2L13 BCL2-like 13 (apoptosis facilitator) -0.0137041
RBBP6 retinoblastoma binding protein 6 -0.0136655
EIF1 eukaryotic translation initiation factor 1 -0.0136015
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0135929
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0135475
KLHL5 kelch-like family member 5 -0.0133908
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0131889
AKAP9 A kinase (PRKA) anchor protein 9 -0.0131657
UBE2O ubiquitin-conjugating enzyme E2O -0.0131345
PRR11 proline rich 11 -0.0131043
TMEM39A transmembrane protein 39A -0.0130661
NSD3 nuclear receptor binding SET domain protein 3 -0.0130482
CLTC clathrin, heavy chain (Hc) -0.0129364
RNF150 ring finger protein 150 -0.0128485
IKBIP IKBKB interacting protein -0.0128258
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0127282
ANKRD17 ankyrin repeat domain 17 -0.0126043
IARS1 isoleucyl-tRNA synthetase 1 -0.0125659
SOD2 superoxide dismutase 2, mitochondrial -0.0125196
ARHGAP24 Rho GTPase activating protein 24 -0.0125001
GLI3 GLI family zinc finger 3 -0.0124904
SSBP2 single-stranded DNA binding protein 2 -0.0124446
IFIH1 interferon induced with helicase C domain 1 -0.0124327
FAM204A family with sequence similarity 204, member A -0.0123453
PRRC1 proline-rich coiled-coil 1 -0.0122986
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0122486
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0122393
PMP22 peripheral myelin protein 22 -0.0122207