| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0888462 |
| AHNAK | AHNAK nucleoprotein | 0.071605 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0682106 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.049443 |
| STC1 | stanniocalcin 1 | 0.0401436 |
| INTS6 | integrator complex subunit 6 | 0.0373174 |
| PRELID2 | PRELI domain containing 2 | 0.0368225 |
| ASPH | aspartate beta-hydroxylase | 0.03656 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0365293 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0331291 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0330969 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0319842 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0317863 |
| VCL | vinculin | 0.0313817 |
| ATXN1 | ataxin 1 | 0.0313607 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0284872 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0283211 |
| PHF3 | PHD finger protein 3 | 0.0279541 |
| FNIP1 | folliculin interacting protein 1 | 0.0267967 |
| ACTN1 | actinin, alpha 1 | 0.025537 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.025483 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0239484 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0238149 |
| COL5A1 | collagen, type V, alpha 1 | 0.0237951 |
| MCL1 | myeloid cell leukemia 1 | 0.0235256 |
| UBC | ubiquitin C | 0.0233461 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0233003 |
| HELZ | helicase with zinc finger | 0.0232173 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0230646 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0229158 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0225159 |
| VMP1 | vacuole membrane protein 1 | 0.0222229 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0221562 |
| ZNF638 | zinc finger protein 638 | 0.0221159 |
| GPATCH2L | G patch domain containing 2-like | 0.0220947 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0220923 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0218898 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0218333 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0213312 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0210869 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0207226 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0201591 |
| CLIC4 | chloride intracellular channel 4 | 0.0198561 |
| ANO6 | anoctamin 6 | 0.0196441 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0193321 |
| OGA | O-GlcNAcase | 0.0191924 |
| FAM13A | family with sequence similarity 13, member A | 0.0191434 |
| CORO1C | coronin, actin binding protein, 1C | 0.0189313 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.01879 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.018783 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0185598 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0184248 |
| GLIS3 | GLIS family zinc finger 3 | 0.0182341 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0179923 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.017735 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0177254 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0176608 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0175772 |
| FLNA | filamin A, alpha | 0.0173269 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | 0.0171548 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0170646 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0170533 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.017034 |
| HMGA2 | high mobility group AT-hook 2 | 0.0169879 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0167817 |
| ANK2 | ankyrin 2, neuronal | 0.0166738 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0164721 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0164659 |
| RUNX1 | runt-related transcription factor 1 | 0.0164381 |
| CALR | calreticulin | 0.0163752 |
| ZNF841 | zinc finger protein 841 | 0.0163703 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0162382 |
| COG5 | component of oligomeric golgi complex 5 | 0.0162108 |
| PMM2 | phosphomannomutase 2 | 0.0160816 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0159603 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0159573 |
| SUN1 | Sad1 and UNC84 domain containing 1 | 0.0159409 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0158672 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0158423 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0158343 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0158225 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0157275 |
| CDK13 | cyclin-dependent kinase 13 | 0.0156675 |
| ZNF292 | zinc finger protein 292 | 0.0156153 |
| DENND1A | DENN/MADD domain containing 1A | 0.0154908 |
| ERI3 | ERI1 exoribonuclease family member 3 | 0.0154804 |
| DIAPH2 | diaphanous-related formin 2 | 0.0154683 |
| MYO1B | myosin IB | 0.0154004 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | 0.0153816 |
| SUCO | SUN domain containing ossification factor | 0.0153021 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0152813 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0152626 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0151702 |
| EGFR | epidermal growth factor receptor | 0.0151513 |
| ATP13A3 | ATPase type 13A3 | 0.0150921 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 0.0150775 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0150115 |
| GPR107 | G protein-coupled receptor 107 | 0.014973 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0149441 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0148774 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.153331 |
| FN1 | fibronectin 1 | -0.146307 |
| FTL | ferritin, light polypeptide | -0.13464 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126345 |
| VIM | vimentin | -0.124099 |
| MT2A | metallothionein 2A | -0.123301 |
| HLA-B | major histocompatibility complex, class I, B | -0.0959186 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0885395 |
| PTMA | prothymosin, alpha | -0.0810169 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0801269 |
| B2M | beta-2-microglobulin | -0.0778423 |
| TPM4 | tropomyosin 4 | -0.0664661 |
| RPS6 | ribosomal protein S6 | -0.0618999 |
| MKI67 | marker of proliferation Ki-67 | -0.0555881 |
| PRSS23 | protease, serine, 23 | -0.0475378 |
| MAP1B | microtubule-associated protein 1B | -0.0469912 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0464236 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0462592 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0450233 |
| RPL35A | ribosomal protein L35a | -0.0432169 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.042141 |
| IGF2 | insulin-like growth factor 2 | -0.0409225 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0393324 |
| RPLP2 | ribosomal protein, large, P2 | -0.0387292 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0384463 |
| TPI1 | triosephosphate isomerase 1 | -0.0380727 |
| RPS13 | ribosomal protein S13 | -0.0374765 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0372317 |
| GNAS | GNAS complex locus | -0.0368191 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.036771 |
| CENPF | centromere protein F, 350/400kDa | -0.0361381 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.035473 |
| RPS8 | ribosomal protein S8 | -0.0350391 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0350067 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0348353 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0348162 |
| HLA-A | major histocompatibility complex, class I, A | -0.0341765 |
| RPLP1 | ribosomal protein, large, P1 | -0.033821 |
| NAV3 | neuron navigator 3 | -0.0332894 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0327193 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0326216 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0325599 |
| PGK1 | phosphoglycerate kinase 1 | -0.0324922 |
| S100A10 | S100 calcium binding protein A10 | -0.0320976 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0318317 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0317272 |
| ANXA2 | annexin A2 | -0.0317023 |
| RPL34 | ribosomal protein L34 | -0.0314399 |
| LMNA | lamin A/C | -0.0310608 |
| RPL19 | ribosomal protein L19 | -0.030881 |
| H3-3B | H3.3 histone B | -0.0305836 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0304562 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0302936 |
| RPS19 | ribosomal protein S19 | -0.0302291 |
| ACTG1 | actin gamma 1 | -0.0288022 |
| CD63 | CD63 molecule | -0.028565 |
| S100A9 | S100 calcium binding protein A9 | -0.0285442 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0284544 |
| S100A6 | S100 calcium binding protein A6 | -0.0282581 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0276843 |
| CLMP | CXADR-like membrane protein | -0.0274706 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0273946 |
| RPL32 | ribosomal protein L32 | -0.0273692 |
| RPLP0 | ribosomal protein, large, P0 | -0.0271772 |
| RPL36 | ribosomal protein L36 | -0.027146 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0269747 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.026751 |
| SEPTIN7 | septin 7 | -0.0267437 |
| TUBA1B | tubulin, alpha 1b | -0.0264142 |
| RPL11 | ribosomal protein L11 | -0.0263395 |
| TXNRD1 | thioredoxin reductase 1 | -0.0262409 |
| NLGN1 | neuroligin 1 | -0.0259593 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0257984 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0257657 |
| RPL31 | ribosomal protein L31 | -0.0256957 |
| TUBB | tubulin, beta class I | -0.0255383 |
| PXDN | peroxidasin | -0.0254851 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0251836 |
| RPS16 | ribosomal protein S16 | -0.0251538 |
| RPL37A | ribosomal protein L37a | -0.0251335 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0245381 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0244633 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0244208 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0243661 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0240526 |
| POTEF | POTE ankyrin domain family, member F | -0.0239497 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0238532 |
| RPS21 | ribosomal protein S21 | -0.0236564 |
| CD99 | CD99 molecule | -0.0236093 |
| RPS3 | ribosomal protein S3 | -0.0236018 |
| RACK1 | receptor for activated C kinase 1 | -0.0235779 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0234433 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0233232 |
| RPS14 | ribosomal protein S14 | -0.0232724 |
| PKM | pyruvate kinase, muscle | -0.0231968 |
| TENM3 | teneurin transmembrane protein 3 | -0.0231185 |
| HLA-C | major histocompatibility complex, class I, C | -0.0230155 |
| RPS25 | ribosomal protein S25 | -0.0229445 |
| RPS11 | ribosomal protein S11 | -0.0228198 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0228039 |
