| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ENO1 | enolase 1, (alpha) | 0.135765 |
| UBC | ubiquitin C | 0.100616 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0886062 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0764258 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0736733 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0728862 |
| RPS27A | ribosomal protein S27a | 0.0710742 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0557502 |
| PCBP2 | poly(rC) binding protein 2 | 0.0510661 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0448974 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0433333 |
| SFPQ | splicing factor proline/glutamine-rich | 0.042394 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0416502 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0408176 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0393333 |
| RPS3 | ribosomal protein S3 | 0.0351939 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0338602 |
| CALR | calreticulin | 0.0338078 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0336045 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.031767 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0315307 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0309613 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0303313 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.030094 |
| CALU | calumenin | 0.028898 |
| JUN | jun proto-oncogene | 0.0271882 |
| SET | SET nuclear proto-oncogene | 0.0269065 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0264812 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0263472 |
| ASPH | aspartate beta-hydroxylase | 0.0259639 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0255392 |
| FTL | ferritin, light polypeptide | 0.0252857 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0250829 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0248522 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0246887 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0246044 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0243641 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0240853 |
| SEPTIN9 | septin 9 | 0.0239973 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0239589 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0238602 |
| HTATSF1 | HIV-1 Tat specific factor 1 | 0.0232761 |
| RPL37A | ribosomal protein L37a | 0.0220023 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0218143 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0214373 |
| ARRDC3 | arrestin domain containing 3 | 0.0209063 |
| HLA-E | major histocompatibility complex, class I, E | 0.0206099 |
| TMF1 | TATA element modulatory factor 1 | 0.0202175 |
| RPS8 | ribosomal protein S8 | 0.0197135 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0194656 |
| NRDC | nardilysin convertase | 0.0193949 |
| CERS2 | ceramide synthase 2 | 0.0192358 |
| PUS7 | pseudouridylate synthase 7 (putative) | 0.0191467 |
| ATF3 | activating transcription factor 3 | 0.0189403 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0189129 |
| RPS12 | ribosomal protein S12 | 0.018801 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0185492 |
| PURA | purine-rich element binding protein A | 0.0183959 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0180783 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0178081 |
| HYOU1 | hypoxia up-regulated 1 | 0.0177138 |
| RPL15 | ribosomal protein L15 | 0.0176675 |
| ATXN1 | ataxin 1 | 0.0175954 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0175425 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0174739 |
| RLF | rearranged L-myc fusion | 0.0174482 |
| CANX | calnexin | 0.0172344 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.017012 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0168676 |
| SSRP1 | structure specific recognition protein 1 | 0.0167612 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0166201 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0160252 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0160142 |
| FOXP1 | forkhead box P1 | 0.0160011 |
| POTEF | POTE ankyrin domain family, member F | 0.0158537 |
| JAK1 | Janus kinase 1 | 0.0156056 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0155586 |
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 | 0.0155502 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0154774 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.015438 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.0153766 |
| EFL1 | elongation factor like GTPase 1 | 0.0149984 |
| NEBL | nebulette | 0.0147671 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0147638 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0147429 |
| FN1 | fibronectin 1 | 0.0146664 |
| AMOTL2 | angiomotin like 2 | 0.01466 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0145777 |
| INSIG2 | insulin induced gene 2 | 0.0144985 |
| KIAA1217 | KIAA1217 | 0.0144882 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0144488 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0143822 |
| CEP250 | centrosomal protein 250kDa | 0.0141995 |
| ICAM1 | intercellular adhesion molecule 1 | 0.014062 |
| CFAP96 | cilia and flagella associated protein 96 | 0.014036 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0140355 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0139741 |
| C11ORF58 | chromosome 11 open reading frame 58 | 0.0139159 |
| AREG | amphiregulin | 0.0138524 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 0.0138014 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.230157 |
| PTMA | prothymosin, alpha | -0.136676 |
| MKI67 | marker of proliferation Ki-67 | -0.117954 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.112333 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.10185 |
| SERINC5 | serine incorporator 5 | -0.0959262 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0830998 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0756442 |
| RAD51B | RAD51 paralog B | -0.0699718 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0670206 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0661849 |
| DIAPH3 | diaphanous-related formin 3 | -0.0628275 |
| KRT18 | keratin 18, type I | -0.0622417 |
| TPM4 | tropomyosin 4 | -0.0562772 |
| MSI2 | musashi RNA-binding protein 2 | -0.053707 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0530444 |
| TENM3 | teneurin transmembrane protein 3 | -0.0529174 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0527189 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0513996 |
| VCL | vinculin | -0.0510943 |
| CLTC | clathrin, heavy chain (Hc) | -0.0494769 |
| JMJD1C | jumonji domain containing 1C | -0.0489183 |
| SLC38A2 | solute carrier family 38, member 2 | -0.048604 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.048599 |
| S100A9 | S100 calcium binding protein A9 | -0.047043 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0464833 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0463672 |
| EZR | ezrin | -0.0454716 |
| FHIT | fragile histidine triad | -0.0442148 |
| SETD5 | SET domain containing 5 | -0.0440011 |
| EGR1 | early growth response 1 | -0.0424299 |
| NF1 | neurofibromin 1 | -0.0423887 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0422015 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0421559 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0419591 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0417114 |
| RPL35A | ribosomal protein L35a | -0.0413991 |
| SBF2 | SET binding factor 2 | -0.0404053 |
| KRT8 | keratin 8, type II | -0.0397662 |
| SHROOM3 | shroom family member 3 | -0.0395494 |
| FRMD5 | FERM domain containing 5 | -0.0394449 |
| LMO7 | LIM domain 7 | -0.0393455 |
| TUBB | tubulin, beta class I | -0.0392676 |
| PRELID2 | PRELI domain containing 2 | -0.0391191 |
| CENPF | centromere protein F, 350/400kDa | -0.0388987 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0380238 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0377261 |
| MED13L | mediator complex subunit 13-like | -0.0377186 |
| TBC1D4 | TBC1 domain family, member 4 | -0.0376088 |
| TCF12 | transcription factor 12 | -0.0373152 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0369952 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0364483 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.036257 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0357524 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0357297 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0355315 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0351536 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0351152 |
| BCL2L1 | BCL2-like 1 | -0.0347264 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0346621 |
| CTBP2 | C-terminal binding protein 2 | -0.0345434 |
| RRBP1 | ribosome binding protein 1 | -0.0343129 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0342537 |
| RBM39 | RNA binding motif protein 39 | -0.0342115 |
| CCND1 | cyclin D1 | -0.0341955 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.034066 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0339031 |
| ANKRD17 | ankyrin repeat domain 17 | -0.033741 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0335925 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0335389 |
| GNAS | GNAS complex locus | -0.0332592 |
| CD2AP | CD2-associated protein | -0.0324392 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0323616 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0322008 |
| EGFR | epidermal growth factor receptor | -0.0315701 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0315655 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.03117 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0311576 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.030968 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0308769 |
| PKP2 | plakophilin 2 | -0.0308239 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0307233 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.030454 |
| MAP4 | microtubule-associated protein 4 | -0.0302592 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0296787 |
| DSPP | dentin sialophosphoprotein | -0.0295884 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0295613 |
| HMGA2 | high mobility group AT-hook 2 | -0.0295586 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0294411 |
| KLF6 | Kruppel-like factor 6 | -0.0293266 |
| VMP1 | vacuole membrane protein 1 | -0.0292216 |
| PCM1 | pericentriolar material 1 | -0.0292204 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0288918 |
| WASF2 | WAS protein family, member 2 | -0.0288567 |
| DSG2 | desmoglein 2 | -0.0286296 |
| ZFHX3 | zinc finger homeobox 3 | -0.0286186 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0285798 |
| WWOX | WW domain containing oxidoreductase | -0.0285643 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0284999 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.028468 |
