Ropivacaine (hydrochloride monohydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ropivacaine (hydrochloride monohydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNA filamin A, alpha 0.0618948
ANKRD36 ankyrin repeat domain 36 0.0489151
UBC ubiquitin C 0.0482205
SMAD3 SMAD family member 3 0.0457795
FLNB filamin B, beta 0.04477
EEF2 eukaryotic translation elongation factor 2 0.0408369
TTC3 tetratricopeptide repeat domain 3 0.0368599
SFPQ splicing factor proline/glutamine-rich 0.0340029
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0331365
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0321813
EIF4A2 eukaryotic translation initiation factor 4A2 0.0319885
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0304999
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0281323
DSCAM Down syndrome cell adhesion molecule 0.02801
RANBP2 RAN binding protein 2 0.0273725
MYH9 myosin, heavy chain 9, non-muscle 0.0263454
AFDN afadin, adherens junction formation factor 0.0257927
BIRC6 baculoviral IAP repeat containing 6 0.0246419
GARS1 glycyl-tRNA synthetase 1 0.0240864
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0237412
USP9X ubiquitin specific peptidase 9, X-linked 0.023713
RBM5 RNA binding motif protein 5 0.0234981
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0234282
SRSF1 serine/arginine-rich splicing factor 1 0.0233663
ACTN4 actinin, alpha 4 0.0228669
ECPAS Ecm29 proteasome adaptor and scaffold 0.0224215
PCBP2 poly(rC) binding protein 2 0.0220162
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0219796
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.021684
FUBP1 far upstream element (FUSE) binding protein 1 0.0216832
APLP2 amyloid beta (A4) precursor-like protein 2 0.0215088
KDM6A lysine (K)-specific demethylase 6A 0.0213683
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0212227
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0209959
OGA O-GlcNAcase 0.0209659
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0209557
CCNL1 cyclin L1 0.0208542
CEP192 centrosomal protein 192kDa 0.0208151
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0206651
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0202578
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0202029
RNF213 ring finger protein 213 0.019787
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0195459
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0193772
AMOTL2 angiomotin like 2 0.0192102
PICALM phosphatidylinositol binding clathrin assembly protein 0.0189771
ZFC3H1 zinc finger, C3H1-type containing 0.0189502
TRIO trio Rho guanine nucleotide exchange factor 0.0186573
PTEN phosphatase and tensin homolog 0.0184023
ANKRD36C ankyrin repeat domain 36C 0.0182623
HELZ helicase with zinc finger 0.0182239
SETX senataxin 0.0181868
ECT2 epithelial cell transforming 2 0.0177702
RBM25 RNA binding motif protein 25 0.0176674
POTEF POTE ankyrin domain family, member F 0.0176348
SON SON DNA binding protein 0.0175932
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0174872
EZR ezrin 0.0173661
RPSA ribosomal protein SA 0.0173633
XPO6 exportin 6 0.0173281
ZNF638 zinc finger protein 638 0.0172854
TBCD tubulin folding cofactor D 0.0172462
CTBP2 C-terminal binding protein 2 0.0172148
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0171651
KIF1B kinesin family member 1B 0.01713
CCDC93 coiled-coil domain containing 93 0.0170309
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0168838
MYEOV myeloma overexpressed 0.0168651
ANKHD1 ankyrin repeat and KH domain containing 1 0.0166379
FNDC3B fibronectin type III domain containing 3B 0.0165386
AKAP9 A kinase (PRKA) anchor protein 9 0.0164065
UBA6 ubiquitin-like modifier activating enzyme 6 0.0162571
PRRC2C proline-rich coiled-coil 2C 0.0161685
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0161421
GIGYF2 GRB10 interacting GYF protein 2 0.0160981
CEMIP2 cell migration inducing hyaluronidase 2 0.016046
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0159921
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0159017
PDIA4 protein disulfide isomerase family A, member 4 0.0158772
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0158517
COPA coatomer protein complex, subunit alpha 0.0157863
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.015689
ZFAND3 zinc finger, AN1-type domain 3 0.0154407
SCFD1 sec1 family domain containing 1 0.0154343
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0153513
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0152698
CCNY cyclin Y 0.0152106
SEC16A SEC16 homolog A (S. cerevisiae) 0.0151838
CALU calumenin 0.015158
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0151414
ZC3H11A zinc finger CCCH-type containing 11A 0.0150731
DIAPH1 diaphanous-related formin 1 0.0149454
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0148265
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0147875
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0147295
ZNF644 zinc finger protein 644 0.0147067
UBP1 upstream binding protein 1 (LBP-1a) 0.0146203
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0144952
ZNF207 zinc finger protein 207 0.0144729
CALR calreticulin 0.0143773

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201559
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.119723
RPS6 ribosomal protein S6 -0.118121
RPL35A ribosomal protein L35a -0.110269
TPT1 tumor protein, translationally-controlled 1 -0.0877055
PTMA prothymosin, alpha -0.0780304
TMSB10 thymosin beta 10 -0.0776223
RPS8 ribosomal protein S8 -0.0772785
ALCAM activated leukocyte cell adhesion molecule -0.0723034
FTL ferritin, light polypeptide -0.0715699
MKI67 marker of proliferation Ki-67 -0.0705552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0675164
RPL12 ribosomal protein L12 -0.067253
RPL23 ribosomal protein L23 -0.0666601
RPLP1 ribosomal protein, large, P1 -0.0665167
S100A10 S100 calcium binding protein A10 -0.0649896
RPL34 ribosomal protein L34 -0.0617898
RPLP0 ribosomal protein, large, P0 -0.0614753
TMSB4X thymosin beta 4, X-linked -0.0583482
RPL19 ribosomal protein L19 -0.055646
IGFBP3 insulin-like growth factor binding protein 3 -0.0536834
S100A9 S100 calcium binding protein A9 -0.0495878
CCND1 cyclin D1 -0.0492116
MT2A metallothionein 2A -0.0492115
RPS19 ribosomal protein S19 -0.0468397
TPM4 tropomyosin 4 -0.0468343
B2M beta-2-microglobulin -0.0464103
RPL31 ribosomal protein L31 -0.0456157
S100A6 S100 calcium binding protein A6 -0.0451518
RPL26 ribosomal protein L26 -0.045127
PKM pyruvate kinase, muscle -0.044958
GNAS GNAS complex locus -0.0448185
VCL vinculin -0.04434
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.043709
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0413843
TPI1 triosephosphate isomerase 1 -0.0413278
RPL32 ribosomal protein L32 -0.0406604
ANXA2 annexin A2 -0.0390087
RACK1 receptor for activated C kinase 1 -0.0385843
RPL35 ribosomal protein L35 -0.0385401
RPS14 ribosomal protein S14 -0.0385244
MACROD2 MACRO domain containing 2 -0.0379279
RPS24 ribosomal protein S24 -0.0371878
ACTG1 actin gamma 1 -0.0360681
BPTF bromodomain PHD finger transcription factor -0.0358656
RPS27 ribosomal protein S27 -0.035847
RPLP2 ribosomal protein, large, P2 -0.0356029
PSD3 pleckstrin and Sec7 domain containing 3 -0.0347902
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0345055
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0344747
FTH1 ferritin, heavy polypeptide 1 -0.0344528
LPP LIM domain containing preferred translocation partner in lipoma -0.0344062
EIF1 eukaryotic translation initiation factor 1 -0.0340161
DSG2 desmoglein 2 -0.0329069
RPS2 ribosomal protein S2 -0.0326699
SSH2 slingshot protein phosphatase 2 -0.03261
H1-0 H1.0 linker histone -0.0325497
HMGB1 high mobility group box 1 -0.0322709
AKAP12 A kinase (PRKA) anchor protein 12 -0.0321819
RPS25 ribosomal protein S25 -0.03197
RPS16 ribosomal protein S16 -0.0318664
RPL11 ribosomal protein L11 -0.0315913
RPS5 ribosomal protein S5 -0.0312484
LDHA lactate dehydrogenase A -0.0309497
ASPH aspartate beta-hydroxylase -0.0303317
LAMB3 laminin, beta 3 -0.0298272
AHNAK AHNAK nucleoprotein -0.0295132
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0295024
RPS13 ribosomal protein S13 -0.0290267
RPS21 ribosomal protein S21 -0.0286183
RPS11 ribosomal protein S11 -0.028488
RPS12 ribosomal protein S12 -0.0284363
RAD51B RAD51 paralog B -0.0283758
PRELID2 PRELI domain containing 2 -0.0282209
ENO1 enolase 1, (alpha) -0.0281755
DLC1 DLC1 Rho GTPase activating protein -0.0281599
FAM162A family with sequence similarity 162, member A -0.0273972
SVIL supervillin -0.0273781
PCED1B PC-esterase domain containing 1B -0.0272435
RPS20 ribosomal protein S20 -0.0272005
SH3KBP1 SH3-domain kinase binding protein 1 -0.0269937
KPNB1 karyopherin (importin) beta 1 -0.026865
RPS4X ribosomal protein S4, X-linked -0.0265822
RPS29 ribosomal protein S29 -0.0265175
LAMA4 laminin, alpha 4 -0.026406
WWOX WW domain containing oxidoreductase -0.0263354
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0261046
RPS23 ribosomal protein S23 -0.026089
BICD1 bicaudal D homolog 1 (Drosophila) -0.0260039
VDAC1 voltage-dependent anion channel 1 -0.0259577
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0258934
RPL28 ribosomal protein L28 -0.0255573
CDCP1 CUB domain containing protein 1 -0.025444
CD44 CD44 molecule (Indian blood group) -0.0250626
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0246241
RPL7A ribosomal protein L7a -0.024394
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0242465
HMGA2 high mobility group AT-hook 2 -0.0241803
RPL36A ribosomal protein L36a -0.0240369
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0237916