| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS27A | ribosomal protein S27a | 0.153507 |
| ENO1 | enolase 1, (alpha) | 0.132565 |
| UBC | ubiquitin C | 0.129773 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.126832 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110681 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.107167 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.10059 |
| SVIL | supervillin | 0.0986028 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0948376 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0909599 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0872695 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0812847 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0790937 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0695896 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0685427 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0681057 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0651204 |
| ATXN1 | ataxin 1 | 0.0545773 |
| TNS1 | tensin 1 | 0.0545291 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0501826 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0468604 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0466248 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0466008 |
| SMAD3 | SMAD family member 3 | 0.0432912 |
| MCL1 | myeloid cell leukemia 1 | 0.043258 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0386493 |
| TF | transferrin | 0.0378506 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.036928 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0366932 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0356913 |
| PCBP2 | poly(rC) binding protein 2 | 0.0348705 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0346887 |
| CANX | calnexin | 0.033574 |
| RPL23 | ribosomal protein L23 | 0.0335621 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0334911 |
| FAM107B | family with sequence similarity 107, member B | 0.0332311 |
| MYO6 | myosin VI | 0.0327876 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0325244 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0319703 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0319003 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0318301 |
| VMP1 | vacuole membrane protein 1 | 0.0311879 |
| FOXP1 | forkhead box P1 | 0.0308075 |
| RPL3 | ribosomal protein L3 | 0.030701 |
| TCIM | transcriptional and immune response regulator | 0.0306223 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0305977 |
| RUNX1 | runt-related transcription factor 1 | 0.03027 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0300459 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0295271 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0291914 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0289916 |
| CCNY | cyclin Y | 0.0282272 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0279975 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0279079 |
| FLNB | filamin B, beta | 0.0277093 |
| ARFGEF3 | ARFGEF family member 3 | 0.0275987 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0275326 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.027465 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0273431 |
| RPS12 | ribosomal protein S12 | 0.0268341 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0266308 |
| JUN | jun proto-oncogene | 0.0263908 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0262871 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0262144 |
| RPL37A | ribosomal protein L37a | 0.0260386 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.025782 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0254935 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0254691 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0252443 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0252109 |
| INSIG2 | insulin induced gene 2 | 0.0251048 |
| ASPH | aspartate beta-hydroxylase | 0.0251018 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0248861 |
| KYNU | kynureninase | 0.0248229 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.024504 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0244485 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0242091 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0238276 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0237772 |
| DUSP16 | dual specificity phosphatase 16 | 0.0236196 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0235156 |
| AFDN | afadin, adherens junction formation factor | 0.0231966 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0230711 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0227784 |
| DIAPH1 | diaphanous-related formin 1 | 0.0225173 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.022421 |
| YME1L1 | YME1-like 1 ATPase | 0.0223987 |
| JAK1 | Janus kinase 1 | 0.022389 |
| GK | glycerol kinase | 0.0221362 |
| GOLGA4 | golgin A4 | 0.0221082 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220481 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0220423 |
| TPM3 | tropomyosin 3 | 0.0217238 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0213846 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.021336 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0212767 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0211754 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0211338 |
| FAM13A | family with sequence similarity 13, member A | 0.0211044 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0210987 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.368865 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.245486 |
| MT2A | metallothionein 2A | -0.15229 |
| APOA2 | apolipoprotein A-II | -0.143448 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.139274 |
| APOB | apolipoprotein B | -0.116983 |
| GPC3 | glypican 3 | -0.0965217 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0706853 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0706103 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0657779 |
| TRIM26 | tripartite motif containing 26 | -0.0653672 |
| C3 | complement component 3 | -0.0644862 |
| RPL11 | ribosomal protein L11 | -0.0518343 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0508976 |
| PTCHD4 | patched domain containing 4 | -0.0456989 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0453222 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0416993 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0400903 |
| A2M | alpha-2-macroglobulin | -0.0399769 |
| RPL35A | ribosomal protein L35a | -0.0384875 |
| RPS21 | ribosomal protein S21 | -0.0367521 |
| GNAS | GNAS complex locus | -0.036595 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0360164 |
| FTL | ferritin, light polypeptide | -0.0355921 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0355434 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0349411 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0347279 |
| HMGA1 | high mobility group AT-hook 1 | -0.0337758 |
| FRMD5 | FERM domain containing 5 | -0.0331073 |
| VCL | vinculin | -0.0328933 |
| LYZ | lysozyme | -0.0319517 |
| EGR1 | early growth response 1 | -0.0308118 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0301482 |
| CST3 | cystatin C | -0.0297555 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0291752 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0288771 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0288605 |
| TMEM123 | transmembrane protein 123 | -0.0288389 |
| RPLP1 | ribosomal protein, large, P1 | -0.0285191 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0280352 |
| SP100 | SP100 nuclear antigen | -0.027844 |
| APOA1 | apolipoprotein A-I | -0.0277876 |
| RNF213 | ring finger protein 213 | -0.0269742 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0269477 |
| RPL34 | ribosomal protein L34 | -0.0267656 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.026746 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0266099 |
| GPC6 | glypican 6 | -0.0261265 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0261113 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0256478 |
| TMSB10 | thymosin beta 10 | -0.0253138 |
| RPLP0 | ribosomal protein, large, P0 | -0.0253044 |
| HMGA2 | high mobility group AT-hook 2 | -0.0251765 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0250993 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0250551 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0250072 |
| APOE | apolipoprotein E | -0.0249888 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.024766 |
| H1-0 | H1.0 linker histone | -0.0247357 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.024678 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0245125 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0241523 |
| MIDN | midnolin | -0.0240061 |
| KRT18 | keratin 18, type I | -0.0237792 |
| PEG10 | paternally expressed 10 | -0.0232077 |
| MT1X | metallothionein 1X | -0.02311 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0227752 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.022597 |
| RPS24 | ribosomal protein S24 | -0.0224286 |
| PFN1 | profilin 1 | -0.0224051 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0222153 |
| METTL9 | methyltransferase like 9 | -0.0221017 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0209723 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0208516 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0205668 |
| CDK6 | cyclin-dependent kinase 6 | -0.0204991 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0204959 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.020394 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0203736 |
| ITGA1 | integrin, alpha 1 | -0.0203118 |
| CCND1 | cyclin D1 | -0.0202331 |
| AGXT | alanine-glyoxylate aminotransferase | -0.0201458 |
| RPS19 | ribosomal protein S19 | -0.01994 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.019866 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0195949 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0195255 |
| TPM4 | tropomyosin 4 | -0.0192913 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0192465 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0192163 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0191617 |
| S100A9 | S100 calcium binding protein A9 | -0.0191472 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0190445 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.018887 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0187772 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0187341 |
| ITGAV | integrin, alpha V | -0.0186244 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0186223 |
| TPI1 | triosephosphate isomerase 1 | -0.0182232 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0181821 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0181639 |
