| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | 0.149329 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.126803 |
| ENO1 | enolase 1, (alpha) | 0.121166 |
| JUN | jun proto-oncogene | 0.103467 |
| ASPH | aspartate beta-hydroxylase | 0.0898303 |
| LDHA | lactate dehydrogenase A | 0.0889897 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0820565 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0756724 |
| INTS6 | integrator complex subunit 6 | 0.0737663 |
| NDRG1 | N-myc downstream regulated 1 | 0.0735787 |
| CD44 | CD44 molecule (Indian blood group) | 0.0685804 |
| NAV2 | neuron navigator 2 | 0.0676873 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0594335 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0591862 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0589364 |
| ANXA2 | annexin A2 | 0.0581939 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0581737 |
| FLNA | filamin A, alpha | 0.0578594 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0576896 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0542374 |
| ADM | adrenomedullin | 0.0526726 |
| ANXA1 | annexin A1 | 0.0526007 |
| RPS27A | ribosomal protein S27a | 0.0520427 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.051734 |
| POTEF | POTE ankyrin domain family, member F | 0.0487009 |
| TMSB10 | thymosin beta 10 | 0.0481784 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0480842 |
| FLNB | filamin B, beta | 0.0477351 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0463741 |
| RPS3 | ribosomal protein S3 | 0.0458576 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0451168 |
| MT2A | metallothionein 2A | 0.0438508 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0434123 |
| RND3 | Rho family GTPase 3 | 0.0418205 |
| CALU | calumenin | 0.0410749 |
| VIM | vimentin | 0.040079 |
| TLE4 | transducin-like enhancer of split 4 | 0.0390281 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.038182 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0378482 |
| ACTG1 | actin gamma 1 | 0.0369331 |
| EGFR | epidermal growth factor receptor | 0.0363437 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0356878 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0355675 |
| MCL1 | myeloid cell leukemia 1 | 0.034996 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347809 |
| MYO10 | myosin X | 0.0346607 |
| DTNA | dystrobrevin, alpha | 0.0346385 |
| MLPH | melanophilin | 0.0345134 |
| COL5A1 | collagen, type V, alpha 1 | 0.0343671 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0343031 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0328758 |
| ATXN1 | ataxin 1 | 0.0327066 |
| RUNX1 | runt-related transcription factor 1 | 0.0324004 |
| APP | amyloid beta (A4) precursor protein | 0.0322163 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0311551 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0307158 |
| ZNF841 | zinc finger protein 841 | 0.0304639 |
| DST | dystonin | 0.0302204 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0295481 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0293015 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.029198 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0291098 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0289149 |
| BRD2 | bromodomain containing 2 | 0.0288692 |
| ACTN4 | actinin, alpha 4 | 0.0287812 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0286317 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0281168 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0277936 |
| CEP250 | centrosomal protein 250kDa | 0.0276746 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0270817 |
| PODXL | podocalyxin-like | 0.0264387 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0263705 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0260101 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0258235 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.025744 |
| HDAC9 | histone deacetylase 9 | 0.0257417 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0256254 |
| DIAPH2 | diaphanous-related formin 2 | 0.0255558 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0251978 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0251128 |
| WDR1 | WD repeat domain 1 | 0.0248596 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0244047 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0243743 |
| ERBIN | erbb2 interacting protein | 0.024251 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0241181 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0239072 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0237349 |
| PRELID2 | PRELI domain containing 2 | 0.023666 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0235039 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0234625 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.023236 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0231175 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0230581 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0226676 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0225523 |
| NABP1 | nucleic acid binding protein 1 | 0.0222228 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0221343 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0221184 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0220358 |
| FAM107B | family with sequence similarity 107, member B | 0.0220311 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.1484 |
| HLA-B | major histocompatibility complex, class I, B | -0.14058 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0999461 |
| SLC12A8 | solute carrier family 12, member 8 | -0.0854523 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0794952 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0767662 |
| FTL | ferritin, light polypeptide | -0.0737711 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0705183 |
| ATP13A3 | ATPase type 13A3 | -0.069684 |
| B2M | beta-2-microglobulin | -0.0691939 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0688387 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0684833 |
| RPS6 | ribosomal protein S6 | -0.0680149 |
| FN1 | fibronectin 1 | -0.0660254 |
| GOLGA4 | golgin A4 | -0.062605 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0619178 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0614295 |
| TXNRD1 | thioredoxin reductase 1 | -0.0604662 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0568244 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.056393 |
| POSTN | periostin, osteoblast specific factor | -0.0538212 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0518643 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0518182 |
| KPNB1 | karyopherin (importin) beta 1 | -0.051015 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0500407 |
| PTMA | prothymosin, alpha | -0.0475131 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0470986 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0460401 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0453354 |
| CTSD | cathepsin D | -0.0449683 |
| MAP4 | microtubule-associated protein 4 | -0.0441555 |
| SULF1 | sulfatase 1 | -0.0424432 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0421311 |
| RPLP2 | ribosomal protein, large, P2 | -0.0406915 |
| OSMR | oncostatin M receptor | -0.0405615 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0393033 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0388481 |
| GLIS3 | GLIS family zinc finger 3 | -0.0384107 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.037465 |
| PLCB4 | phospholipase C, beta 4 | -0.0371304 |
| HLA-A | major histocompatibility complex, class I, A | -0.0370915 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0370447 |
| PFN1 | profilin 1 | -0.0369577 |
| SBF2 | SET binding factor 2 | -0.0368332 |
| DEK | DEK proto-oncogene | -0.0364815 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0361839 |
| RPL35A | ribosomal protein L35a | -0.0361674 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0356166 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0353305 |
| DIAPH3 | diaphanous-related formin 3 | -0.0346712 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0343157 |
| MKI67 | marker of proliferation Ki-67 | -0.0341604 |
| TUBB | tubulin, beta class I | -0.0337868 |
| MT1X | metallothionein 1X | -0.0337431 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0337373 |
| TGFB2 | transforming growth factor, beta 2 | -0.033208 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.0329214 |
| ZXDC | ZXD family zinc finger C | -0.0326417 |
| MAP1B | microtubule-associated protein 1B | -0.0325405 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0324285 |
| AFAP1 | actin filament associated protein 1 | -0.0321492 |
| CENPF | centromere protein F, 350/400kDa | -0.0318297 |
| ANXA5 | annexin A5 | -0.0317838 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0314331 |
| ARF4 | ADP-ribosylation factor 4 | -0.0314194 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0313945 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0310884 |
| GNAS | GNAS complex locus | -0.0310355 |
| RPL35 | ribosomal protein L35 | -0.0304016 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0303808 |
| TMEM41B | transmembrane protein 41B | -0.0300488 |
| TMEM178B | transmembrane protein 178B | -0.0299088 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0297493 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0292829 |
| SUCO | SUN domain containing ossification factor | -0.0289353 |
| SETD5 | SET domain containing 5 | -0.0288791 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0285179 |
| TFG | TRK-fused gene | -0.0282243 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0279489 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0279361 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0277635 |
| FOSL1 | FOS-like antigen 1 | -0.0276341 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0272181 |
| TPD52 | tumor protein D52 | -0.0271413 |
| RPS13 | ribosomal protein S13 | -0.0268263 |
| CLTC | clathrin, heavy chain (Hc) | -0.0266308 |
| COG5 | component of oligomeric golgi complex 5 | -0.0265531 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0263314 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0263176 |
| ZFR | zinc finger RNA binding protein | -0.0262375 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0261762 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.026088 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0260629 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0260072 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0256515 |
| ZNF148 | zinc finger protein 148 | -0.0255252 |
| NUP58 | nucleoporin 58 | -0.0254801 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | -0.0254525 |
| GRAMD2B | GRAM domain containing 2B | -0.0253896 |
| IL6ST | interleukin 6 signal transducer | -0.0249777 |
