| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.183567 |
| AHNAK | AHNAK nucleoprotein | 0.153262 |
| EFNA5 | ephrin-A5 | 0.122652 |
| RPS27A | ribosomal protein S27a | 0.120257 |
| JUN | jun proto-oncogene | 0.120019 |
| VIM | vimentin | 0.116328 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.115384 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.106467 |
| INTS6 | integrator complex subunit 6 | 0.104533 |
| MCL1 | myeloid cell leukemia 1 | 0.10355 |
| UBC | ubiquitin C | 0.100474 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0963171 |
| LDHA | lactate dehydrogenase A | 0.0928456 |
| ENO1 | enolase 1, (alpha) | 0.0897219 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0832486 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.077887 |
| FLNA | filamin A, alpha | 0.0743084 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0713727 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0706474 |
| ASPH | aspartate beta-hydroxylase | 0.0706076 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.070205 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.069965 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0650115 |
| DTNA | dystrobrevin, alpha | 0.064358 |
| PRKCE | protein kinase C, epsilon | 0.0643528 |
| SFPQ | splicing factor proline/glutamine-rich | 0.061054 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0606637 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0580207 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0561296 |
| NAV1 | neuron navigator 1 | 0.0553379 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0547008 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0539098 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0512057 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0508721 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0507449 |
| TMSB10 | thymosin beta 10 | 0.0504826 |
| PCBP2 | poly(rC) binding protein 2 | 0.049969 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.049057 |
| FMNL2 | formin-like 2 | 0.0480707 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0456129 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0455838 |
| ZNF638 | zinc finger protein 638 | 0.0454055 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0453676 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.045284 |
| RPL23 | ribosomal protein L23 | 0.0450242 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.045003 |
| SAMD3 | sterile alpha motif domain containing 3 | 0.0436538 |
| EGFR | epidermal growth factor receptor | 0.0434157 |
| AEBP2 | AE binding protein 2 | 0.0432742 |
| FLNB | filamin B, beta | 0.0420701 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0418252 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0413944 |
| RUNX1 | runt-related transcription factor 1 | 0.0391132 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0386718 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0382267 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0374942 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0372073 |
| TLN1 | talin 1 | 0.0364565 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0361624 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0357274 |
| POTEF | POTE ankyrin domain family, member F | 0.0334791 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0331745 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.033097 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0329129 |
| HDAC9 | histone deacetylase 9 | 0.0327533 |
| HMGA2 | high mobility group AT-hook 2 | 0.0326995 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | 0.0324077 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0317936 |
| EFNB2 | ephrin-B2 | 0.0315658 |
| USP34 | ubiquitin specific peptidase 34 | 0.0315623 |
| CORO1C | coronin, actin binding protein, 1C | 0.0315309 |
| PKM | pyruvate kinase, muscle | 0.0314438 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0313765 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.0313003 |
| RPS3 | ribosomal protein S3 | 0.0310241 |
| PRELID2 | PRELI domain containing 2 | 0.0306308 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0304047 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0303507 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0303227 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0302936 |
| HDLBP | high density lipoprotein binding protein | 0.0299649 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0298013 |
| NABP1 | nucleic acid binding protein 1 | 0.0296815 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0294856 |
| RAD51B | RAD51 paralog B | 0.0292769 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0291353 |
| TEX14 | testis expressed 14 | 0.0290229 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.027904 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0276745 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0273777 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0268932 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0268334 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0265783 |
| CALR | calreticulin | 0.0265641 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0263677 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0259461 |
| RCC1 | regulator of chromosome condensation 1 | 0.0259231 |
| EMP1 | epithelial membrane protein 1 | 0.0259053 |
| APP | amyloid beta (A4) precursor protein | 0.0258997 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0257838 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | -0.18808 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.111698 |
| GPC6 | glypican 6 | -0.0991922 |
| MMP12 | matrix metallopeptidase 12 | -0.0811027 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.079101 |
| RPS2 | ribosomal protein S2 | -0.0788686 |
| YBX3 | Y box binding protein 3 | -0.0782289 |
| LSAMP | limbic system-associated membrane protein | -0.0766671 |
| FTL | ferritin, light polypeptide | -0.0754402 |
| RPL35A | ribosomal protein L35a | -0.074579 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0670046 |
| TXNRD1 | thioredoxin reductase 1 | -0.0650359 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0591716 |
| MT2A | metallothionein 2A | -0.057735 |
| VCL | vinculin | -0.0575093 |
| CDK17 | cyclin-dependent kinase 17 | -0.0535392 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0529568 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0523624 |
| CALD1 | caldesmon 1 | -0.0502666 |
| TNNC1 | troponin C type 1 (slow) | -0.0493292 |
| MAP4 | microtubule-associated protein 4 | -0.0490282 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0489311 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0489291 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0486853 |
| HAS2 | hyaluronan synthase 2 | -0.0481668 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0469968 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0446592 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0442193 |
| RBM39 | RNA binding motif protein 39 | -0.0440011 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0432825 |
| RPS19 | ribosomal protein S19 | -0.0432581 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0418854 |
| CAVIN1 | caveolae associated protein 1 | -0.0409337 |
| JMJD1C | jumonji domain containing 1C | -0.0398108 |
| CSTB | cystatin B (stefin B) | -0.0393195 |
| WDR43 | WD repeat domain 43 | -0.0387477 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0381795 |
| RPLP1 | ribosomal protein, large, P1 | -0.0360352 |
| RPS12 | ribosomal protein S12 | -0.0358615 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0356493 |
| KIF5B | kinesin family member 5B | -0.0355311 |
| RPL36 | ribosomal protein L36 | -0.0353108 |
| CTSB | cathepsin B | -0.034656 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.034339 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0342892 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0340962 |
| KYNU | kynureninase | -0.0334364 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0333787 |
| RPL38 | ribosomal protein L38 | -0.0333608 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0331169 |
| CCDC88A | coiled-coil domain containing 88A | -0.0327944 |
| TPM4 | tropomyosin 4 | -0.0325606 |
| RPS21 | ribosomal protein S21 | -0.0324593 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0324306 |
| CDK6 | cyclin-dependent kinase 6 | -0.0322493 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0314218 |
| NUP58 | nucleoporin 58 | -0.0298638 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0297474 |
| SEPTIN7 | septin 7 | -0.0294858 |
| RPL32 | ribosomal protein L32 | -0.0294324 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0292726 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0292641 |
| KLF6 | Kruppel-like factor 6 | -0.0291554 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0289006 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0288843 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0288172 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0287033 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0286955 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0286293 |
| NRP2 | neuropilin 2 | -0.0283646 |
| MATR3 | matrin 3 | -0.0282001 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0277649 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.0275753 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0274516 |
| RPL19 | ribosomal protein L19 | -0.0273859 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0273479 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0269567 |
| WWC1 | WW and C2 domain containing 1 | -0.0267811 |
| WWC2 | WW and C2 domain containing 2 | -0.0266085 |
| RPL8 | ribosomal protein L8 | -0.0265792 |
| RLF | rearranged L-myc fusion | -0.0264676 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0264199 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0263366 |
| NTM | neurotrimin | -0.0262582 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0261811 |
| RPLP2 | ribosomal protein, large, P2 | -0.0260756 |
| H1-0 | H1.0 linker histone | -0.026066 |
| NPC1 | Niemann-Pick disease, type C1 | -0.02601 |
| USP15 | ubiquitin specific peptidase 15 | -0.0259779 |
| OSMR | oncostatin M receptor | -0.025935 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0258483 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0257281 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0257064 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0256935 |
| MAP1B | microtubule-associated protein 1B | -0.0255811 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0255799 |
| GOLGA4 | golgin A4 | -0.02544 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.025362 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0252706 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.025175 |
