| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.153502 |
| ASPH | aspartate beta-hydroxylase | 0.12339 |
| ENO1 | enolase 1, (alpha) | 0.11558 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0874016 |
| GRAMD1B | GRAM domain containing 1B | 0.0872708 |
| LDHA | lactate dehydrogenase A | 0.0782534 |
| FAM13A | family with sequence similarity 13, member A | 0.0776723 |
| SMAD3 | SMAD family member 3 | 0.0678297 |
| RPS27A | ribosomal protein S27a | 0.0645116 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0642405 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.063945 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0638831 |
| SMYD3 | SET and MYND domain containing 3 | 0.0560881 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.054402 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0524886 |
| MT2A | metallothionein 2A | 0.0510538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0492018 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0474279 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0463081 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0458904 |
| LAMC2 | laminin, gamma 2 | 0.0457345 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0437144 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0429034 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0426391 |
| EMP1 | epithelial membrane protein 1 | 0.0425304 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0418257 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0416536 |
| AHNAK | AHNAK nucleoprotein | 0.0415465 |
| STC1 | stanniocalcin 1 | 0.041118 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0406932 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0406439 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0398408 |
| SLTM | SAFB-like, transcription modulator | 0.0397881 |
| CANX | calnexin | 0.0393153 |
| FLNB | filamin B, beta | 0.0383699 |
| MYOF | myoferlin | 0.0380842 |
| ARRDC3 | arrestin domain containing 3 | 0.037995 |
| TXNRD1 | thioredoxin reductase 1 | 0.0379825 |
| LAMA4 | laminin, alpha 4 | 0.0376362 |
| TES | testin LIM domain protein | 0.0374578 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0373135 |
| TPM3 | tropomyosin 3 | 0.0371709 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0361421 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0360691 |
| ATP11A | ATPase, class VI, type 11A | 0.0351459 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0345307 |
| PRRC2C | proline-rich coiled-coil 2C | 0.034226 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0337413 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0334234 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0328 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0327937 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0323772 |
| PCBP2 | poly(rC) binding protein 2 | 0.0319264 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0316772 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0315773 |
| SON | SON DNA binding protein | 0.0313492 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0307901 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0304223 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0300685 |
| SEPTIN10 | septin 10 | 0.0295095 |
| ZNF638 | zinc finger protein 638 | 0.0294577 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0292106 |
| KRT18 | keratin 18, type I | 0.02916 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0290975 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0290929 |
| RBM25 | RNA binding motif protein 25 | 0.0285473 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0282134 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0280318 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0279676 |
| OGA | O-GlcNAcase | 0.0276516 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0273551 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0266452 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0261963 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0260908 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0259776 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0258253 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.025722 |
| NF1 | neurofibromin 1 | 0.0256421 |
| PTK2 | protein tyrosine kinase 2 | 0.0256255 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0255209 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0252599 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0252173 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0251874 |
| YBX3 | Y box binding protein 3 | 0.0251742 |
| PGK1 | phosphoglycerate kinase 1 | 0.0250284 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0249469 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0248725 |
| CALR | calreticulin | 0.0247295 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0245301 |
| JUN | jun proto-oncogene | 0.0244695 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0244689 |
| MED13 | mediator complex subunit 13 | 0.0243855 |
| CUL4A | cullin 4A | 0.024361 |
| TOP1 | topoisomerase (DNA) I | 0.0243308 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0241488 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0236513 |
| NGLY1 | N-glycanase 1 | 0.023638 |
| KRT7 | keratin 7, type II | 0.0234311 |
| JMJD1C | jumonji domain containing 1C | 0.0233785 |
| FOXP1 | forkhead box P1 | 0.0233054 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.148371 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.112229 |
| RPL35A | ribosomal protein L35a | -0.110341 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0923126 |
| RPS6 | ribosomal protein S6 | -0.085081 |
| FTL | ferritin, light polypeptide | -0.0732796 |
| EGR1 | early growth response 1 | -0.0731153 |
| RPS8 | ribosomal protein S8 | -0.0671497 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0650148 |
| RPLP1 | ribosomal protein, large, P1 | -0.0630983 |
| RPS25 | ribosomal protein S25 | -0.0626784 |
| PTMA | prothymosin, alpha | -0.062401 |
| RPL34 | ribosomal protein L34 | -0.061362 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0613468 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0573982 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0562944 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0555765 |
| INTS6 | integrator complex subunit 6 | -0.0552966 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.054314 |
| RPS23 | ribosomal protein S23 | -0.0533251 |
| S100A10 | S100 calcium binding protein A10 | -0.0532432 |
| CST3 | cystatin C | -0.0526768 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0508817 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0498558 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0494483 |
| WASF2 | WAS protein family, member 2 | -0.0492101 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0488483 |
| PKM | pyruvate kinase, muscle | -0.0480893 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0465055 |
| RPL31 | ribosomal protein L31 | -0.0444075 |
| RPS27 | ribosomal protein S27 | -0.0435875 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0427634 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0424002 |
| TMSB10 | thymosin beta 10 | -0.0419594 |
| RPL11 | ribosomal protein L11 | -0.0407876 |
| GNAS | GNAS complex locus | -0.0397257 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0369087 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0355676 |
| S100P | S100 calcium binding protein P | -0.0347635 |
| RPS29 | ribosomal protein S29 | -0.0331765 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0324415 |
| HMGA1 | high mobility group AT-hook 1 | -0.0311989 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0311419 |
| RPS13 | ribosomal protein S13 | -0.0309859 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0307408 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0305142 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0305064 |
| NTN4 | netrin 4 | -0.0293313 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.028861 |
| CES1 | carboxylesterase 1 | -0.0285731 |
| HOMER1 | homer scaffolding protein 1 | -0.0283236 |
| B2M | beta-2-microglobulin | -0.0280214 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0279038 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0270247 |
| RPS14 | ribosomal protein S14 | -0.0267438 |
| TNS3 | tensin 3 | -0.0266538 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.026318 |
| MAGT1 | magnesium transporter 1 | -0.0262704 |
| RPL37A | ribosomal protein L37a | -0.0257835 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0257638 |
| AGR2 | anterior gradient 2 | -0.0254911 |
| NDRG1 | N-myc downstream regulated 1 | -0.0254602 |
| RPS19 | ribosomal protein S19 | -0.0246408 |
| RPL37 | ribosomal protein L37 | -0.0243511 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0241049 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0239387 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0236146 |
| RPS17 | ribosomal protein S17 | -0.0230308 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0229981 |
| KIAA1217 | KIAA1217 | -0.0229749 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0228035 |
| CPE | carboxypeptidase E | -0.0225797 |
| RPL36 | ribosomal protein L36 | -0.022532 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0224703 |
| FRY | furry homolog (Drosophila) | -0.022413 |
| RAB10 | RAB10, member RAS oncogene family | -0.022412 |
| RPLP2 | ribosomal protein, large, P2 | -0.0223123 |
| RPL7 | ribosomal protein L7 | -0.0221229 |
| RPS11 | ribosomal protein S11 | -0.0219797 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0219314 |
| NABP1 | nucleic acid binding protein 1 | -0.0218382 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0218316 |
| MGAT4C | MGAT4 family, member C | -0.0213672 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0206183 |
| RPS21 | ribosomal protein S21 | -0.0204831 |
| TAPBP | TAP binding protein (tapasin) | -0.0203957 |
| HDAC9 | histone deacetylase 9 | -0.0201823 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0199669 |
| VEGFA | vascular endothelial growth factor A | -0.0197945 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0196315 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0195758 |
| ACTG1 | actin gamma 1 | -0.0195078 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0194971 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0191099 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.019004 |
| RPL5 | ribosomal protein L5 | -0.0189856 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.01876 |
| FBXO11 | F-box protein 11 | -0.0187263 |
| SCEL | sciellin | -0.0186937 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0185452 |
