| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.141536 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.117822 |
| UBC | ubiquitin C | 0.117544 |
| RPS27A | ribosomal protein S27a | 0.100967 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0988775 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0961862 |
| MCL1 | myeloid cell leukemia 1 | 0.0871168 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0853162 |
| IER3 | immediate early response 3 | 0.079389 |
| WAC | WW domain containing adaptor with coiled-coil | 0.077895 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0762116 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0749983 |
| ASPH | aspartate beta-hydroxylase | 0.0710143 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0709178 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0709163 |
| RBM39 | RNA binding motif protein 39 | 0.0694953 |
| AHNAK | AHNAK nucleoprotein | 0.0685326 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0682594 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0672338 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0671856 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0666221 |
| CALU | calumenin | 0.0642215 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0638792 |
| BRD2 | bromodomain containing 2 | 0.0625667 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0622462 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0622453 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0617755 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0607677 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0605005 |
| TMSB10 | thymosin beta 10 | 0.0604581 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0584447 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0566502 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0565694 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0559978 |
| FAM107B | family with sequence similarity 107, member B | 0.0546135 |
| FUS | FUS RNA binding protein | 0.0540285 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0535356 |
| PCBP2 | poly(rC) binding protein 2 | 0.0534325 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.053199 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0531881 |
| APP | amyloid beta (A4) precursor protein | 0.050963 |
| CALR | calreticulin | 0.0501871 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0499165 |
| LDHA | lactate dehydrogenase A | 0.049915 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0494201 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0478601 |
| MYOF | myoferlin | 0.04767 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0474872 |
| RPS12 | ribosomal protein S12 | 0.0466522 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0463074 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.046068 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0454533 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0446878 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0446533 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0441457 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0435433 |
| FLNA | filamin A, alpha | 0.0430054 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0427579 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0425561 |
| TPM3 | tropomyosin 3 | 0.0417547 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.041499 |
| COPA | coatomer protein complex, subunit alpha | 0.0413536 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0412106 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0404346 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0400724 |
| CUL3 | cullin 3 | 0.0400552 |
| TOP1 | topoisomerase (DNA) I | 0.039484 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0392044 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0388327 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0386944 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0383731 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0383256 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0376067 |
| BMP6 | bone morphogenetic protein 6 | 0.0371962 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0368742 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0365623 |
| RPS3 | ribosomal protein S3 | 0.0363721 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.036281 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0357595 |
| NUMB | numb homolog (Drosophila) | 0.0350795 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0348919 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0346268 |
| MT2A | metallothionein 2A | 0.0345416 |
| FMNL2 | formin-like 2 | 0.0344924 |
| NCKAP1 | NCK-associated protein 1 | 0.0340025 |
| STC1 | stanniocalcin 1 | 0.0338947 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0338284 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0338252 |
| INTS6 | integrator complex subunit 6 | 0.0333679 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0332755 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0332056 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0330338 |
| JUN | jun proto-oncogene | 0.0328901 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0327913 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0323883 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0322326 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0322207 |
| GLG1 | golgi glycoprotein 1 | 0.0321297 |
| COG5 | component of oligomeric golgi complex 5 | 0.0316263 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0314515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.150886 |
| GRAMD1B | GRAM domain containing 1B | -0.120381 |
| IGF2 | insulin-like growth factor 2 | -0.119595 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0997967 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0943978 |
| VIM | vimentin | -0.0847998 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0663599 |
| RPS6 | ribosomal protein S6 | -0.058922 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0574915 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0536725 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0497614 |
| BICC1 | BicC family RNA binding protein 1 | -0.0463697 |
| MAP1B | microtubule-associated protein 1B | -0.0457864 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0421407 |
| MKI67 | marker of proliferation Ki-67 | -0.041773 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.041003 |
| HDAC9 | histone deacetylase 9 | -0.0400696 |
| AK1 | adenylate kinase 1 | -0.039086 |
| PRR16 | proline rich 16 | -0.0364533 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0356398 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0353863 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0343238 |
| TPM4 | tropomyosin 4 | -0.0338741 |
| PFN1 | profilin 1 | -0.0337986 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0333495 |
| S100A6 | S100 calcium binding protein A6 | -0.0324495 |
| NRG1 | neuregulin 1 | -0.0322388 |
| RPS21 | ribosomal protein S21 | -0.0321122 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0312224 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0303115 |
| RPLP1 | ribosomal protein, large, P1 | -0.0286694 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0285914 |
| RPL35A | ribosomal protein L35a | -0.027323 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0269444 |
| NEBL | nebulette | -0.0268245 |
| NAV3 | neuron navigator 3 | -0.0264729 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0261411 |
| SRGN | serglycin | -0.0260926 |
| RAD51B | RAD51 paralog B | -0.0249247 |
| TUBB | tubulin, beta class I | -0.0245639 |
| SERF2 | small EDRK-rich factor 2 | -0.024423 |
| EFNA5 | ephrin-A5 | -0.0242659 |
| EGR1 | early growth response 1 | -0.0241338 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0237734 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233704 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0233135 |
| DCLK2 | doublecortin-like kinase 2 | -0.0230863 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0230225 |
| CENPF | centromere protein F, 350/400kDa | -0.0228511 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0219333 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.021865 |
| ZNF804A | zinc finger protein 804A | -0.02181 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0214666 |
| DST | dystonin | -0.0214018 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.021163 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0204847 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0202331 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0197353 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0193256 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0191188 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.018927 |
| TAGLN2 | transgelin 2 | -0.0185499 |
| HMGB1 | high mobility group box 1 | -0.0181469 |
| PTEN | phosphatase and tensin homolog | -0.0180927 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0177387 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0175535 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0174812 |
| RPS14 | ribosomal protein S14 | -0.0174804 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0174759 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0174413 |
| GNAS | GNAS complex locus | -0.0174319 |
| ECT2 | epithelial cell transforming 2 | -0.0173051 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0172904 |
| TPX2 | TPX2, microtubule-associated | -0.0172847 |
| CBX5 | chromobox homolog 5 | -0.0170729 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0168529 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0166308 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.016616 |
| SRBD1 | S1 RNA binding domain 1 | -0.0166122 |
| RIN2 | Ras and Rab interactor 2 | -0.016413 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0163393 |
| MYADM | myeloid-associated differentiation marker | -0.016334 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | -0.0163103 |
| NRP1 | neuropilin 1 | -0.0162118 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0162002 |
| UTRN | utrophin | -0.0161334 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0160425 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0160295 |
| TANGO6 | transport and golgi organization 6 homolog (Drosophila) | -0.016025 |
| JMJD1C | jumonji domain containing 1C | -0.0159545 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | -0.0158751 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0158703 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0157259 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0155442 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0155174 |
| TBC1D19 | TBC1 domain family, member 19 | -0.015407 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0154003 |
| POTEF | POTE ankyrin domain family, member F | -0.0151851 |
| S100A11 | S100 calcium binding protein A11 | -0.0150061 |
| SVIL | supervillin | -0.0147841 |
