| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.244149 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.120185 |
| TMSB10 | thymosin beta 10 | 0.0970144 |
| YBX3 | Y box binding protein 3 | 0.0910351 |
| UBC | ubiquitin C | 0.0712719 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0603564 |
| FMNL2 | formin-like 2 | 0.058632 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.058169 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0575527 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0516975 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0485845 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0473898 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0463247 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0448797 |
| OSMR | oncostatin M receptor | 0.0441793 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0434368 |
| MT2A | metallothionein 2A | 0.0433332 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0423055 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0417871 |
| ACTG1 | actin gamma 1 | 0.0411889 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0398965 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.039407 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0392821 |
| PRKCE | protein kinase C, epsilon | 0.0389295 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0371098 |
| WWOX | WW domain containing oxidoreductase | 0.035396 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0352584 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0349771 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0338617 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0335471 |
| MCL1 | myeloid cell leukemia 1 | 0.0334902 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0314349 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0307752 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0306855 |
| RPS3 | ribosomal protein S3 | 0.0306674 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0306525 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0299057 |
| JUN | jun proto-oncogene | 0.029816 |
| RPS27A | ribosomal protein S27a | 0.0296608 |
| VMP1 | vacuole membrane protein 1 | 0.0283111 |
| PDE10A | phosphodiesterase 10A | 0.027855 |
| HMGA2 | high mobility group AT-hook 2 | 0.026702 |
| KLF6 | Kruppel-like factor 6 | 0.0260576 |
| CUX1 | cut-like homeobox 1 | 0.0259181 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.025238 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0246212 |
| PDE8A | phosphodiesterase 8A | 0.0243788 |
| CALD1 | caldesmon 1 | 0.0238619 |
| VCL | vinculin | 0.0231983 |
| ATP11A | ATPase, class VI, type 11A | 0.0227851 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0225834 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0225711 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0220979 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0218365 |
| EXOC6B | exocyst complex component 6B | 0.021664 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0215939 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0215377 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0214906 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0214251 |
| DIAPH2 | diaphanous-related formin 2 | 0.0209943 |
| GRAMD1B | GRAM domain containing 1B | 0.0205846 |
| ACTN1 | actinin, alpha 1 | 0.0204948 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0204058 |
| STC1 | stanniocalcin 1 | 0.0204024 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0203651 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0203131 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0202173 |
| HLA-B | major histocompatibility complex, class I, B | 0.0200591 |
| TCIM | transcriptional and immune response regulator | 0.0199557 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0199284 |
| TPM2 | tropomyosin 2 (beta) | 0.0198549 |
| RAB7A | RAB7A, member RAS oncogene family | 0.019554 |
| HOMER1 | homer scaffolding protein 1 | 0.01954 |
| FLNA | filamin A, alpha | 0.0193399 |
| PRELID2 | PRELI domain containing 2 | 0.0192897 |
| LOXL2 | lysyl oxidase-like 2 | 0.0192498 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0192152 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.019187 |
| CDK17 | cyclin-dependent kinase 17 | 0.0191289 |
| TRIM9 | tripartite motif containing 9 | 0.0190093 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0187768 |
| SIK3 | SIK family kinase 3 | 0.0187515 |
| EXOC4 | exocyst complex component 4 | 0.018473 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0183806 |
| POTEF | POTE ankyrin domain family, member F | 0.0182177 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0181547 |
| IER3 | immediate early response 3 | 0.017885 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0178103 |
| ETV6 | ets variant 6 | 0.0176386 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0175835 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0175231 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0175099 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0174193 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0173584 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0171979 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0171316 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.017007 |
| FAM13A | family with sequence similarity 13, member A | 0.016887 |
| ANGPTL4 | angiopoietin-like 4 | 0.0168303 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0168263 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.196379 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.117207 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100103 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0867245 |
| RPL35A | ribosomal protein L35a | -0.0765489 |
| VIM | vimentin | -0.0747116 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0726575 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0693596 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0692213 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0682511 |
| MKI67 | marker of proliferation Ki-67 | -0.0602037 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0601582 |
| TXNRD1 | thioredoxin reductase 1 | -0.057345 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0562268 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0513245 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0500104 |
| RPLP1 | ribosomal protein, large, P1 | -0.0484044 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0477774 |
| RPL23 | ribosomal protein L23 | -0.0475557 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0470252 |
| RPS6 | ribosomal protein S6 | -0.0469597 |
| YBX1 | Y box binding protein 1 | -0.0468433 |
| RPS8 | ribosomal protein S8 | -0.0460236 |
| PTMA | prothymosin, alpha | -0.045898 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0442247 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0426297 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0422964 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0421023 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0416024 |
| EGR1 | early growth response 1 | -0.04019 |
| RPS27 | ribosomal protein S27 | -0.0396669 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0392015 |
| GOLGA4 | golgin A4 | -0.0388867 |
| GOLGB1 | golgin B1 | -0.0388196 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0380349 |
| LDHB | lactate dehydrogenase B | -0.0378326 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0366578 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0366101 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0362391 |
| ZFR | zinc finger RNA binding protein | -0.0347841 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0347618 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0341604 |
| PKM | pyruvate kinase, muscle | -0.0340509 |
| RPL3 | ribosomal protein L3 | -0.032876 |
| PGK1 | phosphoglycerate kinase 1 | -0.0327873 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0325839 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0320526 |
| MATR3 | matrin 3 | -0.0319395 |
| RPS29 | ribosomal protein S29 | -0.0315563 |
| CBX3 | chromobox homolog 3 | -0.0314525 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0309912 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.030547 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0302847 |
| RPL12 | ribosomal protein L12 | -0.0302733 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0298023 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0294532 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0293884 |
| PHIP | pleckstrin homology domain interacting protein | -0.029308 |
| RPLP0 | ribosomal protein, large, P0 | -0.0288969 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0288243 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0287866 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0287049 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0286432 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0282104 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0282089 |
| RPL26 | ribosomal protein L26 | -0.028187 |
| TUBB | tubulin, beta class I | -0.0280837 |
| CENPF | centromere protein F, 350/400kDa | -0.0279092 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0278322 |
| RPL5 | ribosomal protein L5 | -0.0274648 |
| RPS20 | ribosomal protein S20 | -0.0273662 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0272055 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0271675 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0271026 |
| PCBP2 | poly(rC) binding protein 2 | -0.0267263 |
| R3HDM1 | R3H domain containing 1 | -0.0264345 |
| TAGLN2 | transgelin 2 | -0.0264134 |
| H1-0 | H1.0 linker histone | -0.026283 |
| RPL37 | ribosomal protein L37 | -0.0261939 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0261463 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0258788 |
| RPS19 | ribosomal protein S19 | -0.0255505 |
| RPL38 | ribosomal protein L38 | -0.0254633 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0254544 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.025384 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0252069 |
| TPX2 | TPX2, microtubule-associated | -0.0251178 |
| RPL34 | ribosomal protein L34 | -0.0249657 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.0249034 |
| RPLP2 | ribosomal protein, large, P2 | -0.024774 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0246279 |
| FBL | fibrillarin | -0.0242374 |
| RPS23 | ribosomal protein S23 | -0.0242179 |
| RPL30 | ribosomal protein L30 | -0.024036 |
| RPL28 | ribosomal protein L28 | -0.0239958 |
| KIF5B | kinesin family member 5B | -0.0239765 |
| COG5 | component of oligomeric golgi complex 5 | -0.0237818 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0236849 |
| RPS2 | ribosomal protein S2 | -0.023575 |
| SRP54 | signal recognition particle 54kDa | -0.0233824 |
