| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.166575 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.10038 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.080513 |
| AHNAK | AHNAK nucleoprotein | 0.0768428 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0675365 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0661914 |
| LAMB3 | laminin, beta 3 | 0.0648513 |
| ENO1 | enolase 1, (alpha) | 0.0575128 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0545219 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0542038 |
| FLNB | filamin B, beta | 0.0539889 |
| JUN | jun proto-oncogene | 0.0498528 |
| MCL1 | myeloid cell leukemia 1 | 0.0496774 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0492214 |
| LAMC2 | laminin, gamma 2 | 0.0488398 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0480545 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0480062 |
| RPS27A | ribosomal protein S27a | 0.0478429 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0477489 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0435717 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0427882 |
| VGLL3 | vestigial-like family member 3 | 0.0426855 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0421427 |
| INTS6 | integrator complex subunit 6 | 0.0419138 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0412724 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0403734 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0398905 |
| FNIP1 | folliculin interacting protein 1 | 0.0396641 |
| PTK2 | protein tyrosine kinase 2 | 0.0393018 |
| DUSP10 | dual specificity phosphatase 10 | 0.0387486 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0384184 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0381024 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0380139 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0378559 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0373216 |
| SDC4 | syndecan 4 | 0.0371951 |
| SMAD3 | SMAD family member 3 | 0.0363902 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0357328 |
| HDAC9 | histone deacetylase 9 | 0.0353466 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0347473 |
| PLEC | plectin | 0.0345532 |
| EZR | ezrin | 0.0335302 |
| ADM | adrenomedullin | 0.0326199 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0324358 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0316179 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0315241 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0308954 |
| DTNA | dystrobrevin, alpha | 0.0308766 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.030698 |
| NABP1 | nucleic acid binding protein 1 | 0.0306359 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0305388 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0304629 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0303429 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0298028 |
| FAM107B | family with sequence similarity 107, member B | 0.0297167 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.029533 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0291585 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0291579 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.02885 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0288362 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0282479 |
| TUFT1 | tuftelin 1 | 0.0279745 |
| CALU | calumenin | 0.0279636 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0273388 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0270173 |
| FLNA | filamin A, alpha | 0.027017 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0266542 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.026576 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0263477 |
| MYO6 | myosin VI | 0.0262733 |
| RNF213 | ring finger protein 213 | 0.0261864 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0260301 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0259244 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0254453 |
| CD44 | CD44 molecule (Indian blood group) | 0.0250983 |
| SGMS2 | sphingomyelin synthase 2 | 0.0250914 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0250903 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0250083 |
| TJP1 | tight junction protein 1 | 0.0249417 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0248527 |
| SEPTIN11 | septin 11 | 0.0246263 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0244996 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.024106 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0240738 |
| RNF10 | ring finger protein 10 | 0.0238392 |
| SAFB2 | scaffold attachment factor B2 | 0.0237179 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0233289 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0232382 |
| VMP1 | vacuole membrane protein 1 | 0.0232096 |
| MED13 | mediator complex subunit 13 | 0.0230973 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0230131 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0229871 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.022975 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0227678 |
| NAV2 | neuron navigator 2 | 0.0227459 |
| ANO6 | anoctamin 6 | 0.0226756 |
| EFNA5 | ephrin-A5 | 0.022663 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0224843 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0224214 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0223794 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.182573 |
| S100A6 | S100 calcium binding protein A6 | -0.138721 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.129461 |
| RPL35A | ribosomal protein L35a | -0.117571 |
| PTMA | prothymosin, alpha | -0.116609 |
| RPS6 | ribosomal protein S6 | -0.110562 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107161 |
| RPLP1 | ribosomal protein, large, P1 | -0.0968964 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0950894 |
| TMSB4X | thymosin beta 4, X-linked | -0.0931507 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0926846 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0926803 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0828024 |
| S100A10 | S100 calcium binding protein A10 | -0.0812424 |
| RPS19 | ribosomal protein S19 | -0.0700265 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0688673 |
| GOLGA4 | golgin A4 | -0.0675089 |
| RPL34 | ribosomal protein L34 | -0.0662515 |
| RPS23 | ribosomal protein S23 | -0.0661059 |
| RPS8 | ribosomal protein S8 | -0.0645516 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0614311 |
| POTEF | POTE ankyrin domain family, member F | -0.0605841 |
| RPL8 | ribosomal protein L8 | -0.0599667 |
| RPL19 | ribosomal protein L19 | -0.0587184 |
| ACTG1 | actin gamma 1 | -0.0581153 |
| HMGA1 | high mobility group AT-hook 1 | -0.0576669 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0572079 |
| RPS27 | ribosomal protein S27 | -0.0557075 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0549424 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0529004 |
| NDRG1 | N-myc downstream regulated 1 | -0.0503504 |
| RPL11 | ribosomal protein L11 | -0.0491732 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0475931 |
| RNF145 | ring finger protein 145 | -0.0466704 |
| RPS14 | ribosomal protein S14 | -0.0457879 |
| RPLP0 | ribosomal protein, large, P0 | -0.0457121 |
| FAM3C | family with sequence similarity 3, member C | -0.0456352 |
| RPL32 | ribosomal protein L32 | -0.0455176 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0451072 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0450236 |
| RPLP2 | ribosomal protein, large, P2 | -0.044116 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0437433 |
| DSTN | destrin (actin depolymerizing factor) | -0.0437011 |
| FTL | ferritin, light polypeptide | -0.0435048 |
| GNAS | GNAS complex locus | -0.0424979 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0421142 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0420213 |
| RPL12 | ribosomal protein L12 | -0.0414843 |
| FAM162A | family with sequence similarity 162, member A | -0.041099 |
| TXNRD1 | thioredoxin reductase 1 | -0.0410122 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0409879 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0408409 |
| TPM4 | tropomyosin 4 | -0.0403569 |
| TKT | transketolase | -0.0403432 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0393027 |
| RPS21 | ribosomal protein S21 | -0.0392184 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0388003 |
| ANXA2 | annexin A2 | -0.0385858 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0381495 |
| CCND1 | cyclin D1 | -0.0379982 |
| RPL28 | ribosomal protein L28 | -0.0377993 |
| RPS13 | ribosomal protein S13 | -0.0369939 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0368602 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0363767 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0363239 |
| MAP4 | microtubule-associated protein 4 | -0.0356734 |
| ADAR | adenosine deaminase, RNA-specific | -0.0348754 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.034687 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0340676 |
| RPS29 | ribosomal protein S29 | -0.0337705 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0336602 |
| YBX1 | Y box binding protein 1 | -0.0335984 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0331668 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0331351 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0330973 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0327895 |
| KRT19 | keratin 19, type I | -0.0326661 |
| EPCAM | epithelial cell adhesion molecule | -0.0322682 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0321222 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0320745 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0320017 |
| MATR3 | matrin 3 | -0.0314939 |
| SLMAP | sarcolemma associated protein | -0.0313616 |
| CD47 | CD47 molecule | -0.0313319 |
| AREG | amphiregulin | -0.0313151 |
| TMEM123 | transmembrane protein 123 | -0.0311284 |
| CTSD | cathepsin D | -0.0311096 |
| RPS25 | ribosomal protein S25 | -0.0310297 |
| CBX3 | chromobox homolog 3 | -0.0310284 |
| YBX3 | Y box binding protein 3 | -0.0308582 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0308102 |
| RPS5 | ribosomal protein S5 | -0.0303142 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0301935 |
| S100A11 | S100 calcium binding protein A11 | -0.0299794 |
| TRAM1 | translocation associated membrane protein 1 | -0.0298422 |
| RPL27A | ribosomal protein L27a | -0.0297561 |
| RIOK3 | RIO kinase 3 | -0.0295057 |
| KRT18 | keratin 18, type I | -0.0293607 |
| TOP1 | topoisomerase (DNA) I | -0.0293122 |
| RPL36A | ribosomal protein L36a | -0.0289377 |
