Ropivacaine (hydrochloride monohydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBC ubiquitin C 0.136286
PM20D1 peptidase M20 domain containing 1 0.109519
ASPH aspartate beta-hydroxylase 0.0918674
MYOF myoferlin 0.0813726
SMYD3 SET and MYND domain containing 3 0.074353
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.073509
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0679405
GRAMD1B GRAM domain containing 1B 0.0668092
COL5A2 collagen, type V, alpha 2 0.0667104
SPAG9 sperm associated antigen 9 0.0657557
LIMCH1 LIM and calponin homology domains 1 0.0656326
PDE10A phosphodiesterase 10A 0.0642597
CD109 CD109 molecule 0.0636346
TRIO trio Rho guanine nucleotide exchange factor 0.0635969
TXNRD1 thioredoxin reductase 1 0.0606446
ESYT2 extended synaptotagmin-like protein 2 0.0566674
EEF2 eukaryotic translation elongation factor 2 0.0542985
RPS27A ribosomal protein S27a 0.0505104
MCL1 myeloid cell leukemia 1 0.0504511
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.049958
ENO1 enolase 1, (alpha) 0.0488791
ZEB2 zinc finger E-box binding homeobox 2 0.0484827
DOCK5 dedicator of cytokinesis 5 0.0481258
DGKD diacylglycerol kinase, delta 130kDa 0.048035
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0476276
GDA guanine deaminase 0.0458351
TGFBR1 transforming growth factor, beta receptor 1 0.0450004
PCBP2 poly(rC) binding protein 2 0.0430845
RBM39 RNA binding motif protein 39 0.0429389
FLNB filamin B, beta 0.0426965
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0423909
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0420498
KMT2C lysine (K)-specific methyltransferase 2C 0.0394938
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.039418
CSNK1A1 casein kinase 1, alpha 1 0.0393443
NEK7 NIMA-related kinase 7 0.0392291
RBM25 RNA binding motif protein 25 0.039007
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0381076
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0376037
SFPQ splicing factor proline/glutamine-rich 0.0374235
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0373529
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0367693
OGA O-GlcNAcase 0.036526
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0360146
SRPK2 SRSF protein kinase 2 0.0351789
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0346727
COL4A5 collagen, type IV, alpha 5 0.0341376
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0337236
FMNL2 formin-like 2 0.0335558
WSB1 WD repeat and SOCS box containing 1 0.0335256
RTN4 reticulon 4 0.0330327
CDK6 cyclin-dependent kinase 6 0.032597
SAMD4A sterile alpha motif domain containing 4A 0.032556
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0317486
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0316225
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0316161
PERP PERP, TP53 apoptosis effector 0.031589
DOCK4 dedicator of cytokinesis 4 0.0314473
NAP1L1 nucleosome assembly protein 1-like 1 0.0311887
RYR2 ryanodine receptor 2 (cardiac) 0.0309897
TNPO1 transportin 1 0.0309667
DPY19L1 dpy-19-like 1 (C. elegans) 0.0309137
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0308093
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0307292
ATP13A3 ATPase type 13A3 0.0306309
PTEN phosphatase and tensin homolog 0.0305855
SLF1 SMC5-SMC6 complex localization factor 1 0.030312
WARS1 tryptophanyl-tRNA synthetase 1 0.0296976
HELZ helicase with zinc finger 0.0296597
PDIA4 protein disulfide isomerase family A, member 4 0.0291446
ANXA2 annexin A2 0.0290412
TBXT T-box transcription factor T 0.0290406
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0287622
WAC WW domain containing adaptor with coiled-coil 0.0283924
GIGYF2 GRB10 interacting GYF protein 2 0.0283655
FAM13A family with sequence similarity 13, member A 0.0282302
NF1 neurofibromin 1 0.0281367
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0281322
NAMPT nicotinamide phosphoribosyltransferase 0.02797
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0274282
CTIF CBP80/20-dependent translation initiation factor 0.0273272
TM4SF1 transmembrane 4 L six family member 1 0.0272098
TENT5A terminal nucleotidyltransferase 5A 0.0269362
SET SET nuclear proto-oncogene 0.0268758
CALU calumenin 0.0266067
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0263836
PHIP pleckstrin homology domain interacting protein 0.0263088
DDIT4 DNA-damage-inducible transcript 4 0.0261813
ANTXR1 anthrax toxin receptor 1 0.0261048
WDR43 WD repeat domain 43 0.0259596
ITPRID2 ITPR interacting domain containing 2 0.0256281
FNDC3B fibronectin type III domain containing 3B 0.0254688
KDM6A lysine (K)-specific demethylase 6A 0.0254139
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.025358
ZFC3H1 zinc finger, C3H1-type containing 0.0253353
NPAS2 neuronal PAS domain protein 2 0.0252172
ELL2 elongation factor, RNA polymerase II, 2 0.0250253
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0250143
ANKRD28 ankyrin repeat domain 28 0.0249137
XPO1 exportin 1 0.0249067

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.238903
RPS6 ribosomal protein S6 -0.159054
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102657
RPLP1 ribosomal protein, large, P1 -0.0953352
RPL35A ribosomal protein L35a -0.0874226
CDH13 cadherin 13 -0.0863175
RPL23 ribosomal protein L23 -0.0841189
AUTS2 autism susceptibility candidate 2 -0.0801572
RPL26 ribosomal protein L26 -0.0730276
FN1 fibronectin 1 -0.072279
TPT1 tumor protein, translationally-controlled 1 -0.07076
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0676691
RPL34 ribosomal protein L34 -0.0664888
IGFBP3 insulin-like growth factor binding protein 3 -0.063077
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0593227
RPL31 ribosomal protein L31 -0.0591382
ADGRD1 adhesion G protein-coupled receptor D1 -0.0576611
RPS8 ribosomal protein S8 -0.0566626
VIM vimentin -0.056232
EIF1 eukaryotic translation initiation factor 1 -0.053797
RPS23 ribosomal protein S23 -0.0526508
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0518666
RPS24 ribosomal protein S24 -0.0491592
VCL vinculin -0.0467073
RPS19 ribosomal protein S19 -0.0463194
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0448436
RPS27 ribosomal protein S27 -0.0447389
FTH1 ferritin, heavy polypeptide 1 -0.0434207
RACK1 receptor for activated C kinase 1 -0.0408607
PYGL phosphorylase, glycogen, liver -0.0408546
RPL12 ribosomal protein L12 -0.0372511
RPS2 ribosomal protein S2 -0.0372157
RPL19 ribosomal protein L19 -0.0364982
RPS21 ribosomal protein S21 -0.0359913
RPS29 ribosomal protein S29 -0.0355577
RPL37A ribosomal protein L37a -0.035459
RPLP2 ribosomal protein, large, P2 -0.0352167
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0328408
FTL ferritin, light polypeptide -0.0324654
RPL36A ribosomal protein L36a -0.0324021
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0322779
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.032211
RPS14 ribosomal protein S14 -0.0316784
RPS25 ribosomal protein S25 -0.0313081
RPL36 ribosomal protein L36 -0.0312864
RPL38 ribosomal protein L38 -0.0309434
GLRX glutaredoxin (thioltransferase) -0.0308258
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0305491
RPS5 ribosomal protein S5 -0.0303888
RPL27 ribosomal protein L27 -0.0287281
MT2A metallothionein 2A -0.0286416
TFPI2 tissue factor pathway inhibitor 2 -0.0277521
NACA nascent polypeptide-associated complex alpha subunit -0.0274883
RPS13 ribosomal protein S13 -0.0273504
S100A10 S100 calcium binding protein A10 -0.0272651
SOX6 SRY (sex determining region Y)-box 6 -0.0272378
RPL7A ribosomal protein L7a -0.0270977
RPS28 ribosomal protein S28 -0.0269793
RPS11 ribosomal protein S11 -0.0262746
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0262498
RAD51B RAD51 paralog B -0.0262089
RPS20 ribosomal protein S20 -0.0259987
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0258933
RPL32 ribosomal protein L32 -0.0255476
GLCCI1 glucocorticoid induced 1 -0.0255076
HLA-B major histocompatibility complex, class I, B -0.0254502
RPL11 ribosomal protein L11 -0.0253959
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0250441
ATP5F1E ATP synthase F1 subunit epsilon -0.0248307
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0245417
ACTG1 actin gamma 1 -0.0245198
RPS17 ribosomal protein S17 -0.0242927
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0240716
RPL35 ribosomal protein L35 -0.0239606
RPS12 ribosomal protein S12 -0.0235547
RPL37 ribosomal protein L37 -0.0233982
RPLP0 ribosomal protein, large, P0 -0.0228356
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0227339
PTMA prothymosin, alpha -0.0222732
RPL10A ribosomal protein L10a -0.0222581
SDK1 sidekick cell adhesion molecule 1 -0.0215891
S100A6 S100 calcium binding protein A6 -0.021422
CUX1 cut-like homeobox 1 -0.0210941
NDRG1 N-myc downstream regulated 1 -0.0209468
PRKN parkin RBR E3 ubiquitin protein ligase -0.020866
RPS16 ribosomal protein S16 -0.0205906
GNAS GNAS complex locus -0.0202127
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0200036
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0196192
ADGRB3 adhesion G protein-coupled receptor B3 -0.01949
RPL28 ribosomal protein L28 -0.0191079
RPL27A ribosomal protein L27a -0.0187502
PCED1B PC-esterase domain containing 1B -0.0187265
RPL5 ribosomal protein L5 -0.0182765
RPS15 ribosomal protein S15 -0.018195
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0181691
ASTN2 astrotactin 2 -0.0180033
CTSL cathepsin L -0.017855
INTS6 integrator complex subunit 6 -0.0177581
GLIS3 GLIS family zinc finger 3 -0.0174821