| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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194 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ENO1 | enolase 1, (alpha) | 0.198538 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.186622 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.139434 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.134033 |
| EGFR | epidermal growth factor receptor | 0.129524 |
| DOCK5 | dedicator of cytokinesis 5 | 0.126294 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.124284 |
| UBC | ubiquitin C | 0.117769 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.107133 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.103171 |
| COL5A2 | collagen, type V, alpha 2 | 0.101704 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.100337 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.100279 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0984169 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0937827 |
| CD44 | CD44 molecule (Indian blood group) | 0.0910178 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0898193 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0833912 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0813372 |
| ACTG1 | actin gamma 1 | 0.0799844 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0795047 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0792591 |
| CANX | calnexin | 0.0788596 |
| B2M | beta-2-microglobulin | 0.077279 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0723874 |
| FN1 | fibronectin 1 | 0.0723772 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0722795 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0708928 |
| JMJD1C | jumonji domain containing 1C | 0.0683251 |
| PTK2 | protein tyrosine kinase 2 | 0.0660564 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0596547 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0574099 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0550913 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0544758 |
| RPS24 | ribosomal protein S24 | 0.05342 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0522061 |
| AHNAK | AHNAK nucleoprotein | 0.0514646 |
| RUNX1 | runt-related transcription factor 1 | 0.0507932 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0507211 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.050715 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0501396 |
| FNIP1 | folliculin interacting protein 1 | 0.0468002 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0460551 |
| TXNRD1 | thioredoxin reductase 1 | 0.0419748 |
| FLNB | filamin B, beta | 0.0397561 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.037831 |
| ACTN4 | actinin, alpha 4 | 0.0376678 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0368561 |
| MYOF | myoferlin | 0.036635 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0319504 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0312468 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0286962 |
| RPS3 | ribosomal protein S3 | 0.0261351 |
| CD2AP | CD2-associated protein | 0.0253385 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0248557 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0245395 |
| RPS27A | ribosomal protein S27a | 0.0244178 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0220143 |
| TPI1 | triosephosphate isomerase 1 | 0.0211765 |
| PKM | pyruvate kinase, muscle | 0.0207958 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.020683 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0197869 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0190613 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.018781 |
| GPC6 | glypican 6 | 0.0181912 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0178489 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.016704 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0161538 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0160598 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0150659 |
| HLA-B | major histocompatibility complex, class I, B | 0.0142591 |
| PGK1 | phosphoglycerate kinase 1 | 0.0108426 |
| RPL37 | ribosomal protein L37 | 0.00994903 |
| MAP4 | microtubule-associated protein 4 | 0.00933888 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0084599 |
| PRRC2C | proline-rich coiled-coil 2C | 0.00835883 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.0081776 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.00722224 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.00597724 |
| LAMA4 | laminin, alpha 4 | 0.00591271 |
| PTMA | prothymosin, alpha | 0.00555214 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.00511782 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.00486867 |
| INTS6 | integrator complex subunit 6 | 0.00420601 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00411221 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.00365189 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.00343619 |
| NF1 | neurofibromin 1 | 0.0026393 |
| RPLP1 | ribosomal protein, large, P1 | 0.00207919 |
| RPLP0 | ribosomal protein, large, P0 | 0.00181463 |
| STC1 | stanniocalcin 1 | 0.00162643 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00161193 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.00137508 |
| NDRG1 | N-myc downstream regulated 1 | 8.73962E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RORA | RAR-related orphan receptor A | -0.152148 |
| NAV2 | neuron navigator 2 | -0.138746 |
| PDE10A | phosphodiesterase 10A | -0.133462 |
| CDH13 | cadherin 13 | -0.115784 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.112345 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.112313 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.102259 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0977186 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0926799 |
| HMGA2 | high mobility group AT-hook 2 | -0.0924449 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0907523 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0877066 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0875074 |
| SETD5 | SET domain containing 5 | -0.0859078 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0803927 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0752387 |
| VIM | vimentin | -0.0744644 |
| COL5A1 | collagen, type V, alpha 1 | -0.0738976 |
| NHSL1 | NHS-like 1 | -0.0736605 |
| RPS25 | ribosomal protein S25 | -0.0730309 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0723927 |
| PARD3 | par-3 family cell polarity regulator | -0.0705615 |
| STAG2 | stromal antigen 2 | -0.0687308 |
| MYO1E | myosin IE | -0.068116 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0671727 |
| MT2A | metallothionein 2A | -0.0661798 |
| RPS6 | ribosomal protein S6 | -0.0656009 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0653322 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.06515 |
| SMYD3 | SET and MYND domain containing 3 | -0.0650075 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0642982 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0642137 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0638296 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0615089 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0614229 |
| S100A9 | S100 calcium binding protein A9 | -0.0608455 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0579313 |
| RPS12 | ribosomal protein S12 | -0.056235 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0517725 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.050889 |
| RPL11 | ribosomal protein L11 | -0.0486989 |
| FRMD5 | FERM domain containing 5 | -0.0477757 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0477673 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0473149 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0461161 |
| SLC38A1 | solute carrier family 38, member 1 | -0.045968 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0449855 |
| PFN1 | profilin 1 | -0.044826 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0445484 |
| BPTF | bromodomain PHD finger transcription factor | -0.0440751 |
| PRKCA | protein kinase C, alpha | -0.0438545 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.043418 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0434056 |
| CUX1 | cut-like homeobox 1 | -0.0413165 |
| RPLP2 | ribosomal protein, large, P2 | -0.0407147 |
| IGF2 | insulin-like growth factor 2 | -0.0386953 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.036938 |
| MCL1 | myeloid cell leukemia 1 | -0.0360534 |
| RPS17 | ribosomal protein S17 | -0.035798 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0355069 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.035214 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0340528 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0337833 |
| LAMB3 | laminin, beta 3 | -0.0334554 |
| ATXN1 | ataxin 1 | -0.0332307 |
| RPL23 | ribosomal protein L23 | -0.0326888 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0314675 |
| VCL | vinculin | -0.0314093 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0310335 |
| RPS19 | ribosomal protein S19 | -0.0309322 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0307475 |
| RACK1 | receptor for activated C kinase 1 | -0.0305317 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.030249 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0301524 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0291802 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0283334 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.028184 |
| PCBP3 | poly(rC) binding protein 3 | -0.0280384 |
| ASPH | aspartate beta-hydroxylase | -0.0276097 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0275914 |
| TMSB10 | thymosin beta 10 | -0.0272697 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0271131 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0269968 |
| RPS8 | ribosomal protein S8 | -0.0268688 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0267504 |
| RPL19 | ribosomal protein L19 | -0.0260513 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0242294 |
| VMP1 | vacuole membrane protein 1 | -0.0242271 |
| EFNA5 | ephrin-A5 | -0.0236873 |
| LDHA | lactate dehydrogenase A | -0.0236564 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0219956 |
| PRELID2 | PRELI domain containing 2 | -0.0200762 |
| RPS13 | ribosomal protein S13 | -0.0194689 |
| RPL35A | ribosomal protein L35a | -0.0190265 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0185177 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0177479 |
| LOXL2 | lysyl oxidase-like 2 | -0.0176794 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0176267 |
| DOCK4 | dedicator of cytokinesis 4 | -0.016685 |
| RPL37A | ribosomal protein L37a | -0.0166456 |
