| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PHIP | pleckstrin homology domain interacting protein | 0.152364 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.108952 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0998024 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0997895 |
| COL3A1 | collagen, type III, alpha 1 | 0.0975442 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0949697 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.093106 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0920816 |
| HDAC9 | histone deacetylase 9 | 0.090719 |
| COL5A2 | collagen, type V, alpha 2 | 0.0814378 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0784354 |
| APP | amyloid beta (A4) precursor protein | 0.0771321 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0743331 |
| UBC | ubiquitin C | 0.0742742 |
| PTMA | prothymosin, alpha | 0.072039 |
| NTM | neurotrimin | 0.0719581 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0700373 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.068692 |
| ZNF292 | zinc finger protein 292 | 0.0684865 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0675833 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0671533 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0663785 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0631602 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0617358 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0598264 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0588469 |
| SPAG9 | sperm associated antigen 9 | 0.0583052 |
| PDS5A | PDS5 cohesin associated factor A | 0.0578134 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0562532 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0560714 |
| B2M | beta-2-microglobulin | 0.056042 |
| PCBP2 | poly(rC) binding protein 2 | 0.0558939 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0557766 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0552995 |
| PRTG | protogenin | 0.0525864 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0517548 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0515654 |
| CALR | calreticulin | 0.0514145 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0512799 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.050187 |
| FAM171B | family with sequence similarity 171, member B | 0.0494741 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0493429 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0486037 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0475381 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.047352 |
| TCF12 | transcription factor 12 | 0.0473135 |
| LRRC4C | leucine rich repeat containing 4C | 0.0463992 |
| PCDH18 | protocadherin 18 | 0.0452644 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0452032 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0446196 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0441665 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0440359 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0431292 |
| MCL1 | myeloid cell leukemia 1 | 0.0429529 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0426584 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0421577 |
| SETD5 | SET domain containing 5 | 0.0420652 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0420337 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0411795 |
| SNX6 | sorting nexin 6 | 0.041115 |
| THBS1 | thrombospondin 1 | 0.0407965 |
| INTS6 | integrator complex subunit 6 | 0.0407153 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0403037 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0402932 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.040184 |
| PGK1 | phosphoglycerate kinase 1 | 0.0400118 |
| POTEF | POTE ankyrin domain family, member F | 0.0396934 |
| NHSL1 | NHS-like 1 | 0.0386789 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0386366 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0386061 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0383966 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0376419 |
| PLPP1 | phospholipid phosphatase 1 | 0.0376189 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0375618 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0372131 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0367451 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0367358 |
| XPO1 | exportin 1 | 0.0366966 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0366962 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0364276 |
| YAP1 | Yes-associated protein 1 | 0.0360385 |
| UBE3C | ubiquitin protein ligase E3C | 0.0357091 |
| USP34 | ubiquitin specific peptidase 34 | 0.0354626 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0354247 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0353669 |
| JUN | jun proto-oncogene | 0.0351554 |
| DENND5A | DENN/MADD domain containing 5A | 0.0347627 |
| RFPL4B | ret finger protein-like 4B | 0.0346669 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0340132 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0334334 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0333278 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0332077 |
| JMJD1C | jumonji domain containing 1C | 0.0326595 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0322945 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0317062 |
| OGA | O-GlcNAcase | 0.031375 |
| SFPQ | splicing factor proline/glutamine-rich | 0.031079 |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.030994 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0309076 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0308282 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.100333 |
| MKI67 | marker of proliferation Ki-67 | -0.0901245 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0747919 |
| FOXP2 | forkhead box P2 | -0.0631126 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0575944 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.055487 |
| ENAH | enabled homolog (Drosophila) | -0.0504004 |
| CENPF | centromere protein F, 350/400kDa | -0.0495068 |
| HMGA2 | high mobility group AT-hook 2 | -0.0488885 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0484036 |
| DST | dystonin | -0.0476909 |
| CENPE | centromere protein E, 312kDa | -0.0474661 |
| KIF4A | kinesin family member 4A | -0.0420976 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0415255 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0414589 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0412722 |
| TPX2 | TPX2, microtubule-associated | -0.0407913 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0388825 |
| WDR70 | WD repeat domain 70 | -0.0379735 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.036627 |
| SGO2 | shugoshin 2 | -0.0357191 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0355347 |
| CAVIN1 | caveolae associated protein 1 | -0.0351934 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0345861 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0332844 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.0322498 |
| RPS6 | ribosomal protein S6 | -0.0319183 |
| ZNF385D | zinc finger protein 385D | -0.031778 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0314942 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0300444 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0297541 |
| RPLP1 | ribosomal protein, large, P1 | -0.0289575 |
| RPL35A | ribosomal protein L35a | -0.0288365 |
| TTK | TTK protein kinase | -0.0288085 |
| OPHN1 | oligophrenin 1 | -0.0287914 |
| RPS16 | ribosomal protein S16 | -0.0286499 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -0.0284487 |
| CCNA2 | cyclin A2 | -0.0281557 |
| PFN1 | profilin 1 | -0.0277369 |
| VIM | vimentin | -0.0273127 |
| DSTN | destrin (actin depolymerizing factor) | -0.027298 |
| USP3 | ubiquitin specific peptidase 3 | -0.0269118 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0267481 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0266954 |
| ARF1 | ADP-ribosylation factor 1 | -0.0266072 |
| RPL23 | ribosomal protein L23 | -0.0262812 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0256903 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0256669 |
| MEF2C | myocyte enhancer factor 2C | -0.0253638 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0252856 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0252104 |
| CALCR | calcitonin receptor | -0.025047 |
| TMSB4X | thymosin beta 4, X-linked | -0.0250369 |
| S100A9 | S100 calcium binding protein A9 | -0.0248278 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0247857 |
| ACTG1 | actin gamma 1 | -0.0247441 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.024686 |
| KIF5B | kinesin family member 5B | -0.0246664 |
| CLINT1 | clathrin interactor 1 | -0.0246353 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | -0.0245242 |
| RPL37 | ribosomal protein L37 | -0.0245215 |
| RBBP4 | retinoblastoma binding protein 4 | -0.0241172 |
| AK1 | adenylate kinase 1 | -0.0240759 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0238847 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0238276 |
| USP1 | ubiquitin specific peptidase 1 | -0.0236505 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.023391 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0233747 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.023374 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0231539 |
| NUP155 | nucleoporin 155kDa | -0.0229598 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0227708 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0225097 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | -0.0224965 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0223144 |
| POU3F2 | POU class 3 homeobox 2 | -0.0222548 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0222331 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.0221745 |
| SACK1D | scaffolding CK1 anchoring protein D | -0.022124 |
| PRR11 | proline rich 11 | -0.0221015 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0219767 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0219739 |
| YBX1 | Y box binding protein 1 | -0.0217826 |
| CEP350 | centrosomal protein 350kDa | -0.02173 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0217098 |
| ANLN | anillin, actin binding protein | -0.0216383 |
| ANXA1 | annexin A1 | -0.0214129 |
| OLA1 | Obg-like ATPase 1 | -0.0209356 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0208229 |
| WDR43 | WD repeat domain 43 | -0.0207341 |
| GDI2 | GDP dissociation inhibitor 2 | -0.020692 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0206422 |
| NDUFA5 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 | -0.0206252 |
| DIAPH3 | diaphanous-related formin 3 | -0.0205607 |
| BMP5 | bone morphogenetic protein 5 | -0.020525 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0204944 |
| NCAPG | non-SMC condensin I complex, subunit G | -0.0204521 |
| HMGB2 | high mobility group box 2 | -0.0204254 |
| ARHGAP11A | Rho GTPase activating protein 11A | -0.0204187 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0204121 |
