| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.109586 |
| FRMD6 | FERM domain containing 6 | 0.104493 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0918883 |
| HDAC9 | histone deacetylase 9 | 0.082835 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0750067 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0716823 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0691023 |
| INTS6 | integrator complex subunit 6 | 0.0684081 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0662208 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0660937 |
| CALU | calumenin | 0.0468639 |
| UBC | ubiquitin C | 0.0465066 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0435425 |
| RPS27A | ribosomal protein S27a | 0.0425175 |
| MCL1 | myeloid cell leukemia 1 | 0.0414971 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0399849 |
| FRMD4A | FERM domain containing 4A | 0.0372505 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.037141 |
| FKBP15 | FK506 binding protein 15, 133kDa | 0.0369099 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0365062 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0338493 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0333802 |
| RAB7A | RAB7A, member RAS oncogene family | 0.033264 |
| SGMS2 | sphingomyelin synthase 2 | 0.0331344 |
| RCOR1 | REST corepressor 1 | 0.0330497 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0319209 |
| SETX | senataxin | 0.0314824 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.030793 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0307748 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0305701 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0305652 |
| GPATCH2L | G patch domain containing 2-like | 0.0302332 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0302324 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0290739 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0290704 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0285996 |
| CAPRIN2 | caprin family member 2 | 0.0281934 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0281789 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0279557 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0278553 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0275441 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.027525 |
| USP34 | ubiquitin specific peptidase 34 | 0.0274514 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0268526 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0259937 |
| RTN4 | reticulon 4 | 0.0259661 |
| PRELID2 | PRELI domain containing 2 | 0.0259143 |
| JMJD1C | jumonji domain containing 1C | 0.0254282 |
| NAV3 | neuron navigator 3 | 0.0252379 |
| SP100 | SP100 nuclear antigen | 0.0252297 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0250444 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0244968 |
| FMNL2 | formin-like 2 | 0.0244024 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0243462 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.024184 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0241485 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0238378 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0238373 |
| AHI1 | Abelson helper integration site 1 | 0.023719 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0232692 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0230681 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.023017 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0228701 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0226245 |
| RPL7 | ribosomal protein L7 | 0.0225277 |
| ERBIN | erbb2 interacting protein | 0.0224552 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0224358 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0223893 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0219381 |
| VMP1 | vacuole membrane protein 1 | 0.0215854 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0215099 |
| PCBP2 | poly(rC) binding protein 2 | 0.0213989 |
| RPL7A | ribosomal protein L7a | 0.0208306 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0208057 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0206598 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.020509 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.020416 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0200567 |
| FNIP1 | folliculin interacting protein 1 | 0.0199409 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0199364 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0197478 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0196393 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0196345 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.019554 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0193497 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0193111 |
| TUT7 | terminal uridylyl transferase 7 | 0.0191126 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0190325 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0190194 |
| RPS12 | ribosomal protein S12 | 0.0189982 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.01895 |
| COPA | coatomer protein complex, subunit alpha | 0.0185334 |
| ZNF800 | zinc finger protein 800 | 0.0184756 |
| NABP1 | nucleic acid binding protein 1 | 0.0184283 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0183248 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0182891 |
| CCNY | cyclin Y | 0.0182451 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0182408 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0181683 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0180274 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.107574 |
| RPS6 | ribosomal protein S6 | -0.087167 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.069789 |
| RPLP1 | ribosomal protein, large, P1 | -0.0523526 |
| FLNB | filamin B, beta | -0.0506845 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0492415 |
| RPL35A | ribosomal protein L35a | -0.0484322 |
| TTR | transthyretin | -0.0484265 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0414328 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0384178 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0383442 |
| TXNRD1 | thioredoxin reductase 1 | -0.0382454 |
| PFN1 | profilin 1 | -0.0376627 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0372163 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0367241 |
| RPL3 | ribosomal protein L3 | -0.036151 |
| RPL23 | ribosomal protein L23 | -0.0356888 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0318838 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0305045 |
| POTEF | POTE ankyrin domain family, member F | -0.0300922 |
| MTAP | methylthioadenosine phosphorylase | -0.0297821 |
| MATR3 | matrin 3 | -0.0297236 |
| PKM | pyruvate kinase, muscle | -0.0297136 |
| BNC2 | basonuclin 2 | -0.0273341 |
| RPL35 | ribosomal protein L35 | -0.026721 |
| RPS2 | ribosomal protein S2 | -0.0261527 |
| RPS21 | ribosomal protein S21 | -0.0257131 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0256308 |
| MKI67 | marker of proliferation Ki-67 | -0.0256306 |
| HMGA1 | high mobility group AT-hook 1 | -0.0254324 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0253272 |
| S100A2 | S100 calcium binding protein A2 | -0.0251486 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0249333 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0238096 |
| G0S2 | G0/G1 switch 2 | -0.0235111 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0234984 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0226049 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0225358 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0224744 |
| AHNAK | AHNAK nucleoprotein | -0.0217328 |
| CALD1 | caldesmon 1 | -0.0214545 |
| YBX1 | Y box binding protein 1 | -0.0213205 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0207632 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | -0.0203241 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0197209 |
| RPL19 | ribosomal protein L19 | -0.0197121 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0196896 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.019631 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.019504 |
| FHIT | fragile histidine triad | -0.0194353 |
| PTMA | prothymosin, alpha | -0.0192783 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.019236 |
| DIAPH2 | diaphanous-related formin 2 | -0.018855 |
| CCND2 | cyclin D2 | -0.0186985 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0186856 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0184071 |
| RAB3IP | RAB3A interacting protein | -0.0182306 |
| RPS26 | ribosomal protein S26 | -0.0179699 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0179556 |
| PGK1 | phosphoglycerate kinase 1 | -0.0179139 |
| LAMB3 | laminin, beta 3 | -0.0178934 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0176712 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0176401 |
| RPL5 | ribosomal protein L5 | -0.0174834 |
| MAP4 | microtubule-associated protein 4 | -0.0173368 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0173119 |
| RPLP2 | ribosomal protein, large, P2 | -0.0171819 |
| AXL | AXL receptor tyrosine kinase | -0.0168879 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0168836 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0168719 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.016717 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0166372 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0166244 |
| RPS27 | ribosomal protein S27 | -0.0166177 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0164472 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0163677 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0163151 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0162747 |
| FOSL1 | FOS-like antigen 1 | -0.0160855 |
| NUDC | nudC nuclear distribution protein | -0.0159294 |
| S100A6 | S100 calcium binding protein A6 | -0.015824 |
| DST | dystonin | -0.0157169 |
| LDHB | lactate dehydrogenase B | -0.0156629 |
| ADAMTSL1 | ADAMTS-like 1 | -0.0156212 |
| CDCP1 | CUB domain containing protein 1 | -0.0154921 |
| SLMAP | sarcolemma associated protein | -0.0154261 |
| RPL36 | ribosomal protein L36 | -0.0152467 |
| RPS19 | ribosomal protein S19 | -0.0151205 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0150078 |
| NUDCD1 | NudC domain containing 1 | -0.0149068 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0149062 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0147866 |
| CDK6 | cyclin-dependent kinase 6 | -0.0145019 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0144402 |
| CD274 | CD274 molecule | -0.014359 |
| RPL8 | ribosomal protein L8 | -0.0143068 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0142755 |
| TRIM56 | tripartite motif containing 56 | -0.0142703 |
| RPS14 | ribosomal protein S14 | -0.0142195 |
| ZNF121 | zinc finger protein 121 | -0.0142038 |
