| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.120839 |
| UBC | ubiquitin C | 0.0463491 |
| SET | SET nuclear proto-oncogene | 0.0318034 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0310925 |
| ENO1 | enolase 1, (alpha) | 0.0298076 |
| TPM3 | tropomyosin 3 | 0.0283766 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0279524 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0274462 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0268408 |
| FAT1 | FAT atypical cadherin 1 | 0.0258913 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0243906 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0243196 |
| RPS27A | ribosomal protein S27a | 0.0225096 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0224712 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0219537 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0215077 |
| PCBP2 | poly(rC) binding protein 2 | 0.0205432 |
| AUTS2 | autism susceptibility candidate 2 | 0.0202548 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0198402 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0185998 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0184733 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0178463 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0175902 |
| JUN | jun proto-oncogene | 0.0175364 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0174561 |
| XPO1 | exportin 1 | 0.0172081 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0167017 |
| GRB10 | growth factor receptor-bound protein 10 | 0.016588 |
| DUSP4 | dual specificity phosphatase 4 | 0.0163192 |
| SFMBT2 | Scm-like with four mbt domains 2 | 0.0161031 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0159514 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.0158424 |
| ASPH | aspartate beta-hydroxylase | 0.0156885 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0156196 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0155724 |
| UBAC2 | UBA domain containing 2 | 0.0154875 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0153592 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0152917 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0151364 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0150546 |
| AHR | aryl hydrocarbon receptor | 0.0148019 |
| NBAS | neuroblastoma amplified sequence | 0.0147213 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0147126 |
| PDZD8 | PDZ domain containing 8 | 0.0146801 |
| AQR | aquarius intron-binding spliceosomal factor | 0.0146432 |
| TBCD | tubulin folding cofactor D | 0.0146324 |
| TOX | thymocyte selection-associated high mobility group box | 0.0144686 |
| RNGTT | RNA guanylyltransferase and 5'-phosphatase | 0.0143141 |
| RIOK3 | RIO kinase 3 | 0.0140391 |
| RAP2A | RAP2A, member of RAS oncogene family | 0.0140195 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.014015 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0140136 |
| CLEC16A | C-type lectin domain family 16, member A | 0.0138601 |
| PCBP3 | poly(rC) binding protein 3 | 0.0138203 |
| SIN3A | SIN3 transcription regulator family member A | 0.0136278 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0135515 |
| HMGB3 | high mobility group box 3 | 0.0133538 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0133384 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0133359 |
| STX16 | syntaxin 16 | 0.013268 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0131918 |
| RPL3 | ribosomal protein L3 | 0.0129767 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0129233 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.0128327 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0127763 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0127474 |
| YTHDC1 | YTH domain containing 1 | 0.0125966 |
| WAC | WW domain containing adaptor with coiled-coil | 0.012553 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0125064 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0124774 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0124754 |
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 0.012433 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0123804 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0123603 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0123406 |
| USP34 | ubiquitin specific peptidase 34 | 0.0123365 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | 0.0123097 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0122526 |
| CCNY | cyclin Y | 0.0122474 |
| GCN1 | GCN1 activator of EIF2AK4 | 0.012143 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0121286 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0121247 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0120765 |
| TOP1 | topoisomerase (DNA) I | 0.0120748 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0120434 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0120343 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.012011 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0120085 |
| PTK2 | protein tyrosine kinase 2 | 0.0119624 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0119566 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0118001 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.0117647 |
| PRCC | papillary renal cell carcinoma (translocation-associated) | 0.0115185 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0114676 |
| ANLN | anillin, actin binding protein | 0.0114463 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0114097 |
| VGLL4 | vestigial-like family member 4 | 0.011304 |
| NSUN2 | NOP2/Sun RNA methyltransferase family, member 2 | 0.0112963 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.011264 |
| FOXP2 | forkhead box P2 | 0.0111649 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.146672 |
| CALCA | calcitonin-related polypeptide alpha | -0.0966964 |
| NRG1 | neuregulin 1 | -0.0774041 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0707797 |
| GPC6 | glypican 6 | -0.0662377 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0658197 |
| RPS6 | ribosomal protein S6 | -0.0636312 |
| RPS21 | ribosomal protein S21 | -0.0558738 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0548644 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0526121 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.052195 |
| RPS8 | ribosomal protein S8 | -0.0517201 |
| NDRG1 | N-myc downstream regulated 1 | -0.0514605 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0508685 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0489926 |
| ESRRG | estrogen-related receptor gamma | -0.0479262 |
| ACTG1 | actin gamma 1 | -0.0449055 |
| NCKAP5 | NCK-associated protein 5 | -0.0447313 |
| GPC5 | glypican 5 | -0.0438865 |
| PTCHD4 | patched domain containing 4 | -0.0435453 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0429436 |
| SCG2 | secretogranin II | -0.0427932 |
| RPS25 | ribosomal protein S25 | -0.0426543 |
| SMYD3 | SET and MYND domain containing 3 | -0.0403391 |
| MAP1B | microtubule-associated protein 1B | -0.0398519 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0397347 |
| RPL31 | ribosomal protein L31 | -0.039663 |
| RPL11 | ribosomal protein L11 | -0.0392323 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0392232 |
| RPL37A | ribosomal protein L37a | -0.0389481 |
| EGR1 | early growth response 1 | -0.0388288 |
| TENM1 | teneurin transmembrane protein 1 | -0.0386954 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0383774 |
| SNTG1 | syntrophin, gamma 1 | -0.0383287 |
| S100A9 | S100 calcium binding protein A9 | -0.0376841 |
| SYT1 | synaptotagmin I | -0.0374554 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0371758 |
| FTL | ferritin, light polypeptide | -0.0371039 |
| RPL38 | ribosomal protein L38 | -0.0370804 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0367445 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0357597 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0351176 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0340422 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0339813 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.03343 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0333028 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0330018 |
| RPL34 | ribosomal protein L34 | -0.0326586 |
| LSAMP | limbic system-associated membrane protein | -0.0321966 |
| DTNA | dystrobrevin, alpha | -0.0317696 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0314752 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314228 |
| RPS23 | ribosomal protein S23 | -0.0310446 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0310054 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0302127 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0300974 |
| RPL26 | ribosomal protein L26 | -0.0300395 |
| RPS19 | ribosomal protein S19 | -0.0300101 |
| RNF213 | ring finger protein 213 | -0.0300007 |
| RORA | RAR-related orphan receptor A | -0.0298199 |
| RPS27 | ribosomal protein S27 | -0.0297579 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0292404 |
| RAD51B | RAD51 paralog B | -0.0291631 |
| RPL37 | ribosomal protein L37 | -0.029089 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0290427 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0286529 |
| GNAS | GNAS complex locus | -0.028305 |
| FGF14 | fibroblast growth factor 14 | -0.0282824 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0280266 |
| RPS15 | ribosomal protein S15 | -0.0280239 |
| CHGA | chromogranin A | -0.0279984 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0279857 |
| RPL35A | ribosomal protein L35a | -0.0275657 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0269779 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0265368 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.0264077 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0262376 |
| MKI67 | marker of proliferation Ki-67 | -0.0259091 |
| CPE | carboxypeptidase E | -0.0257276 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0253521 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0250924 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0250254 |
| ZNF804A | zinc finger protein 804A | -0.0248509 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0248362 |
| RPS29 | ribosomal protein S29 | -0.0246935 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0244603 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0244224 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0242382 |
| RPL8 | ribosomal protein L8 | -0.0240858 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.023955 |
| RPL36AL | ribosomal protein L36a-like | -0.0239354 |
| SASH1 | SAM and SH3 domain containing 1 | -0.023879 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0236597 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0236587 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0234828 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0234585 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0233804 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0233698 |
| PEG10 | paternally expressed 10 | -0.0231141 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0230809 |
