| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ropivacaine (hydrochloride monohydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ropivacaine (hydrochloride monohydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ENO1 | enolase 1, (alpha) | 0.152462 |
| UBC | ubiquitin C | 0.132164 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.130299 |
| NRG3 | neuregulin 3 | 0.114377 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0862972 |
| RPS27A | ribosomal protein S27a | 0.0847835 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0782567 |
| VIM | vimentin | 0.0731854 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0705791 |
| FLNA | filamin A, alpha | 0.070297 |
| ANGPTL4 | angiopoietin-like 4 | 0.070272 |
| FLNB | filamin B, beta | 0.0701333 |
| ASPH | aspartate beta-hydroxylase | 0.067203 |
| RPS3 | ribosomal protein S3 | 0.0669348 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0665024 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0661756 |
| AHNAK | AHNAK nucleoprotein | 0.0631545 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0618292 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0607837 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0604501 |
| TMSB10 | thymosin beta 10 | 0.0588346 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.056067 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0551185 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0550234 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0535548 |
| HDAC4 | histone deacetylase 4 | 0.0510973 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.050331 |
| RUNX1 | runt-related transcription factor 1 | 0.048446 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0476617 |
| SMAD3 | SMAD family member 3 | 0.0458116 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0448363 |
| PTK2 | protein tyrosine kinase 2 | 0.0442408 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0437968 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0419486 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0418498 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0410978 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0410716 |
| CFAP20DC | CFAP20 domain containing | 0.0409059 |
| ATXN1 | ataxin 1 | 0.0403017 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0401602 |
| DST | dystonin | 0.0401335 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0397204 |
| APOD | apolipoprotein D | 0.0397062 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0396141 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0388822 |
| ACTN4 | actinin, alpha 4 | 0.0387797 |
| MSI2 | musashi RNA-binding protein 2 | 0.0383019 |
| PLAT | plasminogen activator, tissue | 0.0382731 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0380024 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0373309 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0367695 |
| SP100 | SP100 nuclear antigen | 0.0364064 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0357105 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0356486 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0355094 |
| PKM | pyruvate kinase, muscle | 0.0354851 |
| NOTCH2 | notch 2 | 0.0354215 |
| PCBP2 | poly(rC) binding protein 2 | 0.0350399 |
| CD109 | CD109 molecule | 0.0346465 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0341246 |
| EHBP1 | EH domain binding protein 1 | 0.0340264 |
| EMP1 | epithelial membrane protein 1 | 0.0340234 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0338943 |
| LDHA | lactate dehydrogenase A | 0.0335362 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0333275 |
| RAD51B | RAD51 paralog B | 0.0332726 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0331108 |
| NAV2 | neuron navigator 2 | 0.0326591 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0315827 |
| ACTN1 | actinin, alpha 1 | 0.0314973 |
| NAV1 | neuron navigator 1 | 0.0309539 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0302422 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0300293 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0297393 |
| CTBP2 | C-terminal binding protein 2 | 0.0295679 |
| RNF144A | ring finger protein 144A | 0.0295133 |
| AMOTL1 | angiomotin like 1 | 0.0294712 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0284653 |
| FHIT | fragile histidine triad | 0.0281547 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0278138 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0276846 |
| MLPH | melanophilin | 0.0274381 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0271012 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.026753 |
| CTTN | cortactin | 0.0266719 |
| HLA-E | major histocompatibility complex, class I, E | 0.0266471 |
| FMNL2 | formin-like 2 | 0.0265239 |
| PRKCE | protein kinase C, epsilon | 0.0264517 |
| MCL1 | myeloid cell leukemia 1 | 0.0264096 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0260135 |
| HDAC9 | histone deacetylase 9 | 0.0259457 |
| MELTF | melanotransferrin | 0.0259094 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.025766 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0257274 |
| INTS6 | integrator complex subunit 6 | 0.0257176 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0254973 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0252272 |
| CERS2 | ceramide synthase 2 | 0.0252165 |
| EFCAB13 | EF-hand calcium binding domain 13 | 0.0251958 |
| MYO9B | myosin IXB | 0.0251485 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.120527 |
| GOLGA4 | golgin A4 | -0.098923 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0909187 |
| RPS6 | ribosomal protein S6 | -0.0887942 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0830144 |
| FMN1 | formin 1 | -0.0828027 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0771548 |
| RPL35A | ribosomal protein L35a | -0.0765173 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0761448 |
| RPLP1 | ribosomal protein, large, P1 | -0.0760194 |
| LSAMP | limbic system-associated membrane protein | -0.0751179 |
| FTL | ferritin, light polypeptide | -0.0737609 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0595291 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0585863 |
| MT2A | metallothionein 2A | -0.053717 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0519598 |
| CLINT1 | clathrin interactor 1 | -0.0507737 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0501317 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0490593 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0484242 |
| SQSTM1 | sequestosome 1 | -0.0482953 |
| SPAG9 | sperm associated antigen 9 | -0.0470766 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0466797 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0439213 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0427575 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0403025 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0388114 |
| PMEL | premelanosome protein | -0.0377749 |
| TXNRD1 | thioredoxin reductase 1 | -0.0364879 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0355577 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0343263 |
| RTN4 | reticulon 4 | -0.0335956 |
| RPL34 | ribosomal protein L34 | -0.0335269 |
| RPS21 | ribosomal protein S21 | -0.0330676 |
| KAZN | kazrin, periplakin interacting protein | -0.0325234 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0323206 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0321255 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0320832 |
| RPS2 | ribosomal protein S2 | -0.0319394 |
| TENM1 | teneurin transmembrane protein 1 | -0.0317625 |
| RPL32 | ribosomal protein L32 | -0.0311786 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0306502 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0302928 |
| RPL12 | ribosomal protein L12 | -0.029954 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0299426 |
| ANXA5 | annexin A5 | -0.0297753 |
| MAP4 | microtubule-associated protein 4 | -0.0293955 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0290008 |
| WDR45B | WD repeat domain 45B | -0.0288195 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0284094 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0283399 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0277815 |
| GNAS | GNAS complex locus | -0.0275454 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0268776 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0263573 |
| CLTC | clathrin, heavy chain (Hc) | -0.0259725 |
| CENPF | centromere protein F, 350/400kDa | -0.025864 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0257415 |
| CALD1 | caldesmon 1 | -0.0256969 |
| MKI67 | marker of proliferation Ki-67 | -0.0255344 |
| HMGA1 | high mobility group AT-hook 1 | -0.0255233 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0255143 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0254952 |
| FSTL5 | follistatin-like 5 | -0.0251966 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0244316 |
| S100A9 | S100 calcium binding protein A9 | -0.0242084 |
| TRAM1 | translocation associated membrane protein 1 | -0.0241863 |
| SFTPA2 | surfactant protein A2 | -0.0239833 |
| SETD5 | SET domain containing 5 | -0.0239764 |
| SNX9 | sorting nexin 9 | -0.0239461 |
| ACTG1 | actin gamma 1 | -0.0237656 |
| PRAME | preferentially expressed antigen in melanoma | -0.0236943 |
| DSTN | destrin (actin depolymerizing factor) | -0.023678 |
| JMJD1C | jumonji domain containing 1C | -0.0236244 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0235656 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0235218 |
| RPS23 | ribosomal protein S23 | -0.0234996 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0234042 |
| TFG | TRK-fused gene | -0.0232629 |
| RPL36A | ribosomal protein L36a | -0.023185 |
| SRP54 | signal recognition particle 54kDa | -0.0230776 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0230274 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0229996 |
| MORF4L2 | mortality factor 4 like 2 | -0.0227866 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0227256 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0226672 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0226279 |
| RPS20 | ribosomal protein S20 | -0.0225318 |
| CCDC88A | coiled-coil domain containing 88A | -0.0225075 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0224636 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0223419 |
| RPL7 | ribosomal protein L7 | -0.0222598 |
| WASF2 | WAS protein family, member 2 | -0.0222044 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0221634 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0215692 |
| TUBB | tubulin, beta class I | -0.0214772 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0213369 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0212677 |
| RPLP0 | ribosomal protein, large, P0 | -0.0212091 |
| CANX | calnexin | -0.0212 |
