| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/77999 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Rosiglitazone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 3.2 |
| MIGA2 | mitoguardin 2 | 2.35 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 1.55 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 1.01 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.79 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.7 |
| FN1 | fibronectin 1 | 0.64 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.53 |
| ZNF431 | zinc finger protein 431 | 0.49 |
| NAGS | N-acetylglutamate synthase | 0.48 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | 0.46 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.43 |
| RPS21 | ribosomal protein S21 | 0.43 |
| TTC14 | tetratricopeptide repeat domain 14 | 0.41 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.4 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.4 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | 0.39 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.39 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.38 |
| ADAM11 | ADAM metallopeptidase domain 11 | 0.38 |
| TRIM16 | tripartite motif containing 16 | 0.37 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.37 |
| PTEN | phosphatase and tensin homolog | 0.37 |
| JUN | jun proto-oncogene | 0.37 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | 0.37 |
| TIGD5 | tigger transposable element derived 5 | 0.36 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.36 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | 0.36 |
| BMP4 | bone morphogenetic protein 4 | 0.36 |
| NAPB | N-ethylmaleimide-sensitive factor attachment protein, beta | 0.35 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.35 |
| SYK | spleen tyrosine kinase | 0.34 |
| GPN1 | GPN-loop GTPase 1 | 0.34 |
| WDR20 | WD repeat domain 20 | 0.33 |
| DENND4B | DENN/MADD domain containing 4B | 0.33 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.33 |
| GPAT4 | glycerol-3-phosphate acyltransferase 4 | 0.33 |
| ESRRA | estrogen-related receptor alpha | 0.32 |
| MDM4 | MDM4, p53 regulator | 0.32 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | 0.32 |
| USP48 | ubiquitin specific peptidase 48 | 0.32 |
| MUC16 | mucin 16, cell surface associated | 0.32 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | 0.32 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | 0.32 |
| MTFP1 | mitochondrial fission process 1 | 0.31 |
| KMT5B | lysine methyltransferase 5B | 0.31 |
| CLTA | clathrin, light chain A | 0.31 |
| RNPEPL1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | 0.31 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.31 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.31 |
| BOK | BCL2-related ovarian killer | 0.31 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.3 |
| OIP5 | Opa interacting protein 5 | 0.3 |
| SNX29 | sorting nexin 29 | 0.3 |
| SPATA2 | spermatogenesis associated 2 | 0.3 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | 0.3 |
| MIEN1 | migration and invasion enhancer 1 | 0.3 |
| EEF1AKMT4-ECE2 | EEF1AKMT4-ECE2 readthrough | 0.3 |
| LRRC8B | leucine rich repeat containing 8 family, member B | 0.3 |
| NADK | NAD kinase | 0.29 |
| RRAGB | Ras-related GTP binding B | 0.29 |
| CRTC3 | CREB regulated transcription coactivator 3 | 0.29 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | 0.29 |
| RNF13 | ring finger protein 13 | 0.29 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.29 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.29 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 0.28 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 0.28 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.28 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | 0.28 |
| SPRTN | SprT-like N-terminal domain | 0.28 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.28 |
| BTBD11 | BTB (POZ) domain containing 11 | 0.28 |
| ANK2 | ankyrin 2, neuronal | 0.27 |
| ACOT11 | acyl-CoA thioesterase 11 | 0.27 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | 0.27 |
| VHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | 0.27 |
| JMJD4 | jumonji domain containing 4 | 0.27 |
| HAS3 | hyaluronan synthase 3 | 0.27 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.27 |
| ANKRD40 | ankyrin repeat domain 40 | 0.27 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.27 |
| TSPAN33 | tetraspanin 33 | 0.27 |
| RIN3 | Ras and Rab interactor 3 | 0.26 |
| KLHL9 | kelch-like family member 9 | 0.26 |
| IRF5 | interferon regulatory factor 5 | 0.26 |
| CCNA1 | cyclin A1 | 0.26 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.25 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.25 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.25 |
| MYT1 | myelin transcription factor 1 | 0.25 |
| ZNF22 | zinc finger protein 22 | 0.25 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.25 |
| MADD | MAP-kinase activating death domain | 0.24 |
| FDPS | farnesyl diphosphate synthase | 0.24 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.24 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | 0.24 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.24 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -1.41 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.16 |
| TCTN2 | tectonic family member 2 | -0.83 |
| KLHL24 | kelch-like family member 24 | -0.8 |
| HPSE | heparanase | -0.63 |
| ZNF776 | zinc finger protein 776 | -0.63 |
| ARG2 | arginase 2 | -0.62 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.62 |
| HSBP1 | heat shock factor binding protein 1 | -0.55 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | -0.52 |
| PLIN2 | perilipin 2 | -0.51 |
| GLI2 | GLI family zinc finger 2 | -0.49 |
| OPTN | optineurin | -0.49 |
| VWDE | von Willebrand factor D and EGF domains | -0.43 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.43 |
| TTN | titin | -0.43 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.42 |
| LMO7 | LIM domain 7 | -0.42 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.41 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | -0.41 |
| BBS2 | Bardet-Biedl syndrome 2 | -0.4 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.39 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | -0.39 |
| TEX15 | testis expressed 15 | -0.39 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.38 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.38 |
| MAGEA2 | melanoma antigen family A2 | -0.38 |
| MYH15 | myosin, heavy chain 15 | -0.37 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.37 |
| RAB37 | RAB37, member RAS oncogene family | -0.36 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | -0.35 |
| NCOA6 | nuclear receptor coactivator 6 | -0.34 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.34 |
| FAM160A1 | family with sequence similarity 160, member A1 | -0.33 |
| STK36 | serine/threonine kinase 36 | -0.33 |
| LINS1 | lines homolog 1 | -0.33 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.33 |
| AMMECR1L | AMMECR1-like | -0.33 |
| MAP2 | microtubule-associated protein 2 | -0.33 |
| RAET1G | retinoic acid early transcript 1G | -0.32 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.32 |
| MCL1 | myeloid cell leukemia 1 | -0.32 |
| SUCO | SUN domain containing ossification factor | -0.32 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -0.32 |
| ABHD18 | abhydrolase domain containing 18 | -0.32 |
| C15ORF40 | chromosome 15 open reading frame 40 | -0.31 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.31 |
| ZNF101 | zinc finger protein 101 | -0.31 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | -0.31 |
| PEX2 | peroxisomal biogenesis factor 2 | -0.31 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.31 |
| ABHD3 | abhydrolase domain containing 3 | -0.31 |
| MYCBP | MYC binding protein | -0.3 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | -0.3 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.3 |
| ABHD5 | abhydrolase domain containing 5 | -0.3 |
| ADIRF | adipogenesis regulatory factor | -0.3 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.29 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.29 |
| RP2 | retinitis pigmentosa 2 (X-linked recessive) | -0.29 |
| SEC61B | Sec61 beta subunit | -0.29 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.29 |
| TROAP | trophinin associated protein | -0.29 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.29 |
| SON | SON DNA binding protein | -0.29 |
| ABLIM2 | actin binding LIM protein family, member 2 | -0.29 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.29 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.29 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.28 |
| H1-0 | H1.0 linker histone | -0.28 |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | -0.28 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.28 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | -0.28 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.28 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.27 |
| MT2A | metallothionein 2A | -0.27 |
| SP110 | SP110 nuclear body protein | -0.27 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.27 |
| MT1X | metallothionein 1X | -0.27 |
| HSH2D | hematopoietic SH2 domain containing | -0.27 |
| MT1F | metallothionein 1F | -0.27 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -0.27 |
| TMEM64 | transmembrane protein 64 | -0.27 |
| MRC2 | mannose receptor, C type 2 | -0.26 |
| MARCKSL1 | MARCKS-like 1 | -0.26 |
| BAIAP3 | BAI1-associated protein 3 | -0.26 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.26 |
| CENPN | centromere protein N | -0.26 |
| WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial | -0.26 |
| C14ORF93 | chromosome 14 open reading frame 93 | -0.26 |
| RYBP | RING1 and YY1 binding protein | -0.26 |
| ZNF580 | zinc finger protein 580 | -0.26 |
| MIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | -0.26 |
| MTRF1 | mitochondrial translational release factor 1 | -0.26 |
| MXRA7 | matrix-remodelling associated 7 | -0.26 |
| PGBD1 | piggyBac transposable element derived 1 | -0.26 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.26 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.26 |
| CSNK1G2 | casein kinase 1, gamma 2 | -0.26 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.26 |
