Rosiglitazone_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.114267
TRIO trio Rho guanine nucleotide exchange factor 0.0973264
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0947673
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0687296
AHNAK AHNAK nucleoprotein 0.0621542
AKAP12 A kinase (PRKA) anchor protein 12 0.0596472
FBN1 fibrillin 1 0.0589296
THBS2 thrombospondin 2 0.0565422
DST dystonin 0.0499798
AUTS2 autism susceptibility candidate 2 0.0480306
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0448027
NAV2 neuron navigator 2 0.0430324
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0426646
OGA O-GlcNAcase 0.0379287
AHNAK2 AHNAK nucleoprotein 2 0.034654
CDH13 cadherin 13 0.0344482
ATP13A3 ATPase type 13A3 0.0333597
ZEB1 zinc finger E-box binding homeobox 1 0.0312981
KDM3A lysine (K)-specific demethylase 3A 0.0308491
MACF1 microtubule-actin crosslinking factor 1 0.0304832
SOD2 superoxide dismutase 2, mitochondrial 0.030314
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0300425
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0297694
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0289416
PODXL podocalyxin-like 0.0287094
MYH9 myosin, heavy chain 9, non-muscle 0.0280954
MSI2 musashi RNA-binding protein 2 0.0279294
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0271295
MYOF myoferlin 0.0267284
FBXL7 F-box and leucine-rich repeat protein 7 0.0266451
COL5A2 collagen, type V, alpha 2 0.0258651
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249883
MMP12 matrix metallopeptidase 12 0.024977
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023785
KLF7 Kruppel-like factor 7 (ubiquitous) 0.023203
COL3A1 collagen, type III, alpha 1 0.0226769
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0223224
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0217155
CD109 CD109 molecule 0.0215465
SLC39A11 solute carrier family 39, member 11 0.0214189
GOLGA4 golgin A4 0.021363
ZC3H11A zinc finger CCCH-type containing 11A 0.0213514
CYLD cylindromatosis (turban tumor syndrome) 0.0210828
FNDC3B fibronectin type III domain containing 3B 0.0209289
IQGAP1 IQ motif containing GTPase activating protein 1 0.020882
CANX calnexin 0.0208209
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0199136
AFDN afadin, adherens junction formation factor 0.0198958
BZW1 basic leucine zipper and W2 domains 1 0.019808
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0194765
DENND5A DENN/MADD domain containing 5A 0.0193537
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.019239
APP amyloid beta (A4) precursor protein 0.0190627
SUCO SUN domain containing ossification factor 0.0189254
SQSTM1 sequestosome 1 0.0189047
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0188875
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0188701
CAVIN1 caveolae associated protein 1 0.0188642
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187941
ANKRD36 ankyrin repeat domain 36 0.0187881
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0186697
DSPP dentin sialophosphoprotein 0.0185778
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0184902
PICALM phosphatidylinositol binding clathrin assembly protein 0.0174493
AFF4 AF4/FMR2 family, member 4 0.0172398
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0172364
TOP2B topoisomerase (DNA) II beta 180kDa 0.0170586
INSIG2 insulin induced gene 2 0.0170542
TNIP1 TNFAIP3 interacting protein 1 0.016533
UBQLN1 ubiquilin 1 0.0163273
MATR3 matrin 3 0.016316
FRMD4A FERM domain containing 4A 0.0162877
MXI1 MAX interactor 1, dimerization protein 0.0161637
MIMS1 mitochondrial inner membrane scaffold 1 0.0160592
USP9X ubiquitin specific peptidase 9, X-linked 0.0158612
BHLHE40 basic helix-loop-helix family, member e40 0.0157295
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0156704
NFE2L1 nuclear factor, erythroid 2-like 1 0.0156335
RAI14 retinoic acid induced 14 0.015605
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0156048
FMNL2 formin-like 2 0.0156029
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0155555
MBNL2 muscleblind-like splicing regulator 2 0.015336
DTNA dystrobrevin, alpha 0.0152844
GLS2 glutaminase 2 (liver, mitochondrial) 0.015282
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0151214
ELL2 elongation factor, RNA polymerase II, 2 0.0150158
EGLN1 egl-9 family hypoxia-inducible factor 1 0.014875
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0148157
SPAG9 sperm associated antigen 9 0.0145853
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0145597
DENND1A DENN/MADD domain containing 1A 0.0145534
BCAP31 B-cell receptor-associated protein 31 0.0145505
MAP4 microtubule-associated protein 4 0.0144583
NAMPT nicotinamide phosphoribosyltransferase 0.0144251
SBF2 SET binding factor 2 0.014328
NT5C2 5'-nucleotidase, cytosolic II 0.0143198
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.01423
NCKAP1 NCK-associated protein 1 0.0140777
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.014041

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.264648
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223249
MT2A metallothionein 2A -0.219
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.212166
VIM vimentin -0.204185
NDRG1 N-myc downstream regulated 1 -0.0884904
B2M beta-2-microglobulin -0.0784106
HLA-B major histocompatibility complex, class I, B -0.0678061
POTEF POTE ankyrin domain family, member F -0.0560635
IGFBP3 insulin-like growth factor binding protein 3 -0.0556954
MARCKS myristoylated alanine-rich protein kinase C substrate -0.054209
IFITM3 interferon induced transmembrane protein 3 -0.0525449
MAP1B microtubule-associated protein 1B -0.0520302
PLAT plasminogen activator, tissue -0.0519182
MT1X metallothionein 1X -0.051439
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0502586
S100A10 S100 calcium binding protein A10 -0.0500161
MYADM myeloid-associated differentiation marker -0.0492671
IFITM1 interferon induced transmembrane protein 1 -0.046645
LMNA lamin A/C -0.0441642
TAGLN2 transgelin 2 -0.0439835
LOC112694756 uncharaterized LOC112694756 -0.0416482
FTL ferritin, light polypeptide -0.0412498
PFN1 profilin 1 -0.038266
HLA-C major histocompatibility complex, class I, C -0.0378219
BSG basigin (Ok blood group) -0.0368846
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0358787
SUCNR1 succinate receptor 1 -0.0345835
PKM pyruvate kinase, muscle -0.0341698
RPS19 ribosomal protein S19 -0.0337478
CD44 CD44 molecule (Indian blood group) -0.0333481
RPL28 ribosomal protein L28 -0.0322512
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313897
S100A6 S100 calcium binding protein A6 -0.0311898
RPL36 ribosomal protein L36 -0.0303577
S100A11 S100 calcium binding protein A11 -0.0302093
CSTB cystatin B (stefin B) -0.0294351
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0287776
RPL35A ribosomal protein L35a -0.0276827
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0270404
RPLP2 ribosomal protein, large, P2 -0.0260488
IFI6 interferon, alpha-inducible protein 6 -0.0259268
HLA-A major histocompatibility complex, class I, A -0.025842
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0255869
SMIM44 small integral membrane protein 44 -0.0255109
RPS6 ribosomal protein S6 -0.0254913
EIF1 eukaryotic translation initiation factor 1 -0.025447
GNAS GNAS complex locus -0.0254453
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0250941
HSPB1 heat shock 27kDa protein 1 -0.0249902
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.024913
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0248129
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0241998
CYB5R3 cytochrome b5 reductase 3 -0.0240661
CD99 CD99 molecule -0.0238972
RBM25 RNA binding motif protein 25 -0.0235977
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0235665
ENO2 enolase 2 (gamma, neuronal) -0.0234914
ACTN4 actinin, alpha 4 -0.0228661
RPL32 ribosomal protein L32 -0.0227537
CD81 CD81 molecule -0.0227456
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0227009
ISG15 ISG15 ubiquitin-like modifier -0.0223829
S100A9 S100 calcium binding protein A9 -0.0223264
RTN4 reticulon 4 -0.022261
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.02205
PLAUR plasminogen activator, urokinase receptor -0.0220119
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0219432
RPLP1 ribosomal protein, large, P1 -0.021937
SEC61G Sec61 gamma subunit -0.0219156
RPL12 ribosomal protein L12 -0.0219091
EGR1 early growth response 1 -0.0212047
TPM4 tropomyosin 4 -0.0211655
TAPBP TAP binding protein (tapasin) -0.0209368
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0206897
TXNIP thioredoxin interacting protein -0.0202073
CCL5 chemokine (C-C motif) ligand 5 -0.0199861
MTDH metadherin -0.019915
S100A4 S100 calcium binding protein A4 -0.0197203
RPL23 ribosomal protein L23 -0.0197085
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0191953
ARL4C ADP-ribosylation factor-like 4C -0.0189626
RPL19 ribosomal protein L19 -0.0187665
BPTF bromodomain PHD finger transcription factor -0.0187661
LY6E lymphocyte antigen 6 complex, locus E -0.0186197
RPL35 ribosomal protein L35 -0.0185977
MRC2 mannose receptor, C type 2 -0.0184772
PRSS23 protease, serine, 23 -0.0184762
TUBB4B tubulin, beta 4B class IVb -0.0184088
RPS3 ribosomal protein S3 -0.0183358
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0183095
UGCG UDP-glucose ceramide glucosyltransferase -0.0177516
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0177349
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0176118
RPL31 ribosomal protein L31 -0.0174585
STC1 stanniocalcin 1 -0.0171641
PRRC2C proline-rich coiled-coil 2C -0.0170807
RPS5 ribosomal protein S5 -0.017001
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0169962
PTMA prothymosin, alpha -0.0168228