Rosiglitazone_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.260711
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.104303
ANXA1 annexin A1 0.0894159
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0858502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0789641
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0718793
YAP1 Yes-associated protein 1 0.0696424
HMGA2 high mobility group AT-hook 2 0.0630967
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0577291
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0549753
ASPH aspartate beta-hydroxylase 0.0548391
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0542932
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0539073
IPO7 importin 7 0.0507504
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0502909
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0475183
AKAP12 A kinase (PRKA) anchor protein 12 0.046108
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0452957
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.044764
POTEF POTE ankyrin domain family, member F 0.0424231
ENO1 enolase 1, (alpha) 0.0410425
PCBP2 poly(rC) binding protein 2 0.0404635
EEF2 eukaryotic translation elongation factor 2 0.0380653
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0376543
SET SET nuclear proto-oncogene 0.0374865
TPM3 tropomyosin 3 0.0364241
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0364071
RPS2 ribosomal protein S2 0.0356958
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0356893
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0351653
HSPA8 heat shock 70kDa protein 8 0.0345497
ENAH enabled homolog (Drosophila) 0.0342872
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0336424
INTS6 integrator complex subunit 6 0.0324898
GSK3B glycogen synthase kinase 3 beta 0.0322067
MACF1 microtubule-actin crosslinking factor 1 0.032073
RPL3 ribosomal protein L3 0.0310291
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0309592
ZSWIM6 zinc finger, SWIM-type containing 6 0.0307638
RRM2 ribonucleotide reductase M2 0.0307603
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0307433
CLDND1 claudin domain containing 1 0.0296799
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0291715
CCNL1 cyclin L1 0.0289608
ANKRD11 ankyrin repeat domain 11 0.0286766
NLGN1 neuroligin 1 0.0282745
PTMA prothymosin, alpha 0.0278867
PDIA6 protein disulfide isomerase family A, member 6 0.0278342
DIAPH1 diaphanous-related formin 1 0.0274119
ERBB4 erb-b2 receptor tyrosine kinase 4 0.026898
AATF apoptosis antagonizing transcription factor 0.0268439
LDHB lactate dehydrogenase B 0.0266868
RPS12 ribosomal protein S12 0.0264836
EIF4B eukaryotic translation initiation factor 4B 0.0264687
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0263506
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0261071
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0254611
HTATSF1 HIV-1 Tat specific factor 1 0.0253864
DSPP dentin sialophosphoprotein 0.0250619
VCL vinculin 0.0250054
LRRC23 leucine rich repeat containing 23 0.0247969
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0245803
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0235026
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0231591
ADIPOR2 adiponectin receptor 2 0.023034
WDR26 WD repeat domain 26 0.022553
CCN2 cellular communication network factor 2 0.0224773
PDGFC platelet derived growth factor C 0.0224004
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0222195
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.021993
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0219064
WDR43 WD repeat domain 43 0.0216991
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.021598
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0215008
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0214407
RAB10 RAB10, member RAS oncogene family 0.0209631
GDI2 GDP dissociation inhibitor 2 0.0208923
MATR3 matrin 3 0.020646
ZFYVE16 zinc finger, FYVE domain containing 16 0.0206344
EPHA5 EPH receptor A5 0.0203313
APLP2 amyloid beta (A4) precursor-like protein 2 0.0202415
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0201856
SSRP1 structure specific recognition protein 1 0.0200403
TRIP12 thyroid hormone receptor interactor 12 0.0200353
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0198765
HSPH1 heat shock 105kDa/110kDa protein 1 0.0198066
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.019784
UBE3A ubiquitin protein ligase E3A 0.0197788
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0195159
COPA coatomer protein complex, subunit alpha 0.0194814
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0193716
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0192441
DOCK1 dedicator of cytokinesis 1 0.0192272
NCKAP1 NCK-associated protein 1 0.0191781
NHSL1 NHS-like 1 0.0191677
KMT2C lysine (K)-specific methyltransferase 2C 0.0189773
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0189408
MSH6 mutS homolog 6 0.0186059
MGAT4C MGAT4 family, member C 0.0185868
PUM1 pumilio RNA-binding family member 1 0.0185552

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.201135
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181906
TMSB10 thymosin beta 10 -0.175473
MYL12B myosin, light chain 12B, regulatory -0.106629
ANKRD12 ankyrin repeat domain 12 -0.0773121
HMGA1 high mobility group AT-hook 1 -0.0682252
H1-0 H1.0 linker histone -0.0648677
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0573874
CNRIP1 cannabinoid receptor interacting protein 1 -0.0532616
RPL35A ribosomal protein L35a -0.0507107
PFN1 profilin 1 -0.0499415
TPI1 triosephosphate isomerase 1 -0.0483235
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0480607
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0476031
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0467935
FTL ferritin, light polypeptide -0.045391
BIRC3 baculoviral IAP repeat containing 3 -0.0444433
GARS1 glycyl-tRNA synthetase 1 -0.0438084
RPS24 ribosomal protein S24 -0.0429488
SMC4 structural maintenance of chromosomes 4 -0.0426111
YBX3 Y box binding protein 3 -0.0417489
HSPB1 heat shock 27kDa protein 1 -0.0411049
BIRC6 baculoviral IAP repeat containing 6 -0.0403977
TMEM123 transmembrane protein 123 -0.0401246
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0399927
TPT1 tumor protein, translationally-controlled 1 -0.0399268
RPL12 ribosomal protein L12 -0.0394795
AHNAK AHNAK nucleoprotein -0.0376245
NF1 neurofibromin 1 -0.0375106
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.035904
TUBB tubulin, beta class I -0.0349646
NIPSNAP2 nipsnap homolog 2 -0.0347645
WDPCP WD repeat containing planar cell polarity effector -0.0345225
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0336976
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0334089
ZNF217 zinc finger protein 217 -0.0333733
IFIH1 interferon induced with helicase C domain 1 -0.0313559
KLHL24 kelch-like family member 24 -0.0310351
RPS5 ribosomal protein S5 -0.0307569
PCNP PEST proteolytic signal containing nuclear protein -0.0305419
RPS19 ribosomal protein S19 -0.0302659
RPS21 ribosomal protein S21 -0.0301066
RPLP1 ribosomal protein, large, P1 -0.0297794
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0294544
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0292988
PDE4D phosphodiesterase 4D, cAMP-specific -0.0291267
RPL38 ribosomal protein L38 -0.028601
RPL34 ribosomal protein L34 -0.0285449
PCDH7 protocadherin 7 -0.0283497
S100A6 S100 calcium binding protein A6 -0.0282932
RPL19 ribosomal protein L19 -0.0281377
RPS16 ribosomal protein S16 -0.0278942
CXADR coxsackie virus and adenovirus receptor -0.027781
RPS27A ribosomal protein S27a -0.027509
KLF6 Kruppel-like factor 6 -0.0271365
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0271255
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0270888
R3HDM1 R3H domain containing 1 -0.0270733
HMGB1 high mobility group box 1 -0.0261171
USP34 ubiquitin specific peptidase 34 -0.0261077
SLC38A2 solute carrier family 38, member 2 -0.0253939
RPL26 ribosomal protein L26 -0.0250783
FUS FUS RNA binding protein -0.0249685
TAOK1 TAO kinase 1 -0.0248879
CCDC88A coiled-coil domain containing 88A -0.0248677
FBXL20 F-box and leucine-rich repeat protein 20 -0.0248401
CCNI cyclin I -0.0247224
ZNF804A zinc finger protein 804A -0.0244253
TBC1D32 TBC1 domain family, member 32 -0.0243488
SPAG9 sperm associated antigen 9 -0.0241739
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0241303
KIF18B kinesin family member 18B -0.0238891
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0237869
SYT1 synaptotagmin I -0.0231941
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0231703
LOC112694756 uncharaterized LOC112694756 -0.0231354
VDAC1 voltage-dependent anion channel 1 -0.0231239
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0230427
ZFP64 ZFP64 zinc finger protein -0.0228741
NDUFA4 NDUFA4, mitochondrial complex associated -0.0221803
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0220237
RPL8 ribosomal protein L8 -0.0216984
RAD21 RAD21 homolog (S. pombe) -0.021692
TMEM131 transmembrane protein 131 -0.0216092
NEK7 NIMA-related kinase 7 -0.0215677
RPS8 ribosomal protein S8 -0.021562
LCORL ligand dependent nuclear receptor corepressor-like -0.021447
NEMF nuclear export mediator factor -0.0214343
KDM3A lysine (K)-specific demethylase 3A -0.0214007
CEP95 centrosomal protein 95kDa -0.0212924
RPLP0 ribosomal protein, large, P0 -0.0211097
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0210633
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0210497
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0208598
ATAD5 ATPase family, AAA domain containing 5 -0.0205577
RPL32 ribosomal protein L32 -0.0202755
RPL23 ribosomal protein L23 -0.0202407
CEP350 centrosomal protein 350kDa -0.0201951
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0201215
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0201094