Rosiglitazone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.266535
LPIN1 lipin 1 0.103224
FAM13A family with sequence similarity 13, member A 0.0992662
HELZ helicase with zinc finger 0.0896624
NAMPT nicotinamide phosphoribosyltransferase 0.0818486
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0741284
CD36 CD36 molecule (thrombospondin receptor) 0.0713275
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0690354
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0654036
FNDC3B fibronectin type III domain containing 3B 0.0649367
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0606524
DST dystonin 0.0520968
KDM3A lysine (K)-specific demethylase 3A 0.0512918
NRG1 neuregulin 1 0.0502426
NPEPPS aminopeptidase puromycin sensitive 0.0465524
MEF2A myocyte enhancer factor 2A 0.0447052
ZNF292 zinc finger protein 292 0.0441034
WDR45B WD repeat domain 45B 0.0431033
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0422297
MARCHF6 membrane associated ring-CH-type finger 6 0.0417591
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0412923
MATR3 matrin 3 0.0412689
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0411438
KMT2C lysine (K)-specific methyltransferase 2C 0.039812
ADGRG6 adhesion G protein-coupled receptor G6 0.0375771
SPAG9 sperm associated antigen 9 0.0356997
NEK7 NIMA-related kinase 7 0.0339575
OGA O-GlcNAcase 0.0338974
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0338246
WAC WW domain containing adaptor with coiled-coil 0.0332691
HMGB2 high mobility group box 2 0.0327382
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0326777
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0324058
CASC3 cancer susceptibility candidate 3 0.0320012
NIPBL Nipped-B homolog (Drosophila) 0.0312862
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0310174
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0304676
SSBP2 single-stranded DNA binding protein 2 0.030448
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0301732
SOS1 son of sevenless homolog 1 (Drosophila) 0.0301319
BIRC6 baculoviral IAP repeat containing 6 0.0300189
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0293921
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0293362
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0287927
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0281232
CKAP5 cytoskeleton associated protein 5 0.0279544
DENND4C DENN/MADD domain containing 4C 0.027698
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0274431
RAD21 RAD21 homolog (S. pombe) 0.0271689
HSPA8 heat shock 70kDa protein 8 0.0271649
EIF4B eukaryotic translation initiation factor 4B 0.026862
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0268228
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0265587
TM9SF3 transmembrane 9 superfamily member 3 0.0265305
DTNA dystrobrevin, alpha 0.0256549
CD46 CD46 molecule, complement regulatory protein 0.0255996
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0255345
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0253972
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0253441
OXSR1 oxidative stress responsive 1 0.0253255
SLMAP sarcolemma associated protein 0.0251473
SREBF2 sterol regulatory element binding transcription factor 2 0.025037
UBE2O ubiquitin-conjugating enzyme E2O 0.0250251
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0249672
KDM4C lysine (K)-specific demethylase 4C 0.0249518
ZFAND3 zinc finger, AN1-type domain 3 0.0247076
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0246876
SKIC3 SKI3 subunit of superkiller complex 0.0246491
SEC63 SEC63 homolog (S. cerevisiae) 0.0246447
COPA coatomer protein complex, subunit alpha 0.0246359
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0243856
AUTS2 autism susceptibility candidate 2 0.0243578
SBF2 SET binding factor 2 0.0242754
AFDN afadin, adherens junction formation factor 0.0241977
PTK2 protein tyrosine kinase 2 0.0240624
SETD5 SET domain containing 5 0.0239177
EPS8 epidermal growth factor receptor pathway substrate 8 0.0236622
CHD1 chromodomain helicase DNA binding protein 1 0.0236508
FEM1C fem-1 homolog c (C. elegans) 0.0233562
DSCAM Down syndrome cell adhesion molecule 0.0233214
SLITRK6 SLIT and NTRK-like family, member 6 0.023194
FBXL20 F-box and leucine-rich repeat protein 20 0.023161
FCHSD2 FCH and double SH3 domains 2 0.0230334
KDM6A lysine (K)-specific demethylase 6A 0.0227242
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0226355
AHR aryl hydrocarbon receptor 0.022555
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0223779
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0223491
TOP1 topoisomerase (DNA) I 0.0221775
COL3A1 collagen, type III, alpha 1 0.0219213
NUP58 nucleoporin 58 0.0218113
TSC22D2 TSC22 domain family, member 2 0.0216694
POU2F1 POU class 2 homeobox 1 0.0216133
ZEB1 zinc finger E-box binding homeobox 1 0.0214781
UBA6 ubiquitin-like modifier activating enzyme 6 0.0212938
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0212452
ARHGAP5 Rho GTPase activating protein 5 0.0212373
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0211906
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0211385
MSMO1 methylsterol monooxygenase 1 0.0211062

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.313479
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104506
RPS6 ribosomal protein S6 -0.0698218
TMSB10 thymosin beta 10 -0.0686512
RPL35A ribosomal protein L35a -0.0684262
RPLP1 ribosomal protein, large, P1 -0.0605149
FMN1 formin 1 -0.0588792
VCL vinculin -0.0586856
RPL19 ribosomal protein L19 -0.0556824
RPL23 ribosomal protein L23 -0.054769
NALF1 NALCN channel auxiliary factor 1 -0.0532095
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0512194
PTMA prothymosin, alpha -0.0495924
PTPRD protein tyrosine phosphatase, receptor type, D -0.048241
BPTF bromodomain PHD finger transcription factor -0.0452207
SYT1 synaptotagmin I -0.045031
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0412525
DPH6 diphthamine biosynthesis 6 -0.040771
RPS3 ribosomal protein S3 -0.0402612
FTL ferritin, light polypeptide -0.0397107
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0395526
RPS24 ribosomal protein S24 -0.0391247
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0388034
RPL36 ribosomal protein L36 -0.0377867
TPT1 tumor protein, translationally-controlled 1 -0.037571
B2M beta-2-microglobulin -0.0375428
RPS14 ribosomal protein S14 -0.0371738
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0365469
RPS29 ribosomal protein S29 -0.0365315
TPST1 tyrosylprotein sulfotransferase 1 -0.0360167
PACS1 phosphofurin acidic cluster sorting protein 1 -0.035753
COL1A1 collagen, type I, alpha 1 -0.0354542
NDRG1 N-myc downstream regulated 1 -0.035318
EXT1 exostosin glycosyltransferase 1 -0.0352033
RPS8 ribosomal protein S8 -0.0350383
CALD1 caldesmon 1 -0.0346325
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0343366
RPS12 ribosomal protein S12 -0.0342533
GPC5 glypican 5 -0.0334953
RPL31 ribosomal protein L31 -0.0323679
RPL37A ribosomal protein L37a -0.0317199
RSF1 remodeling and spacing factor 1 -0.0315479
EGR1 early growth response 1 -0.030999
RPS27 ribosomal protein S27 -0.0304439
BICD1 bicaudal D homolog 1 (Drosophila) -0.0299341
THSD4 thrombospondin, type I, domain containing 4 -0.0293067
RPS16 ribosomal protein S16 -0.0292356
IGFBP3 insulin-like growth factor binding protein 3 -0.0291655
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0291241
RPL34 ribosomal protein L34 -0.0287742
RPL18 ribosomal protein L18 -0.0287393
SIK2 salt-inducible kinase 2 -0.0286858
RPL26 ribosomal protein L26 -0.0283576
SLC38A2 solute carrier family 38, member 2 -0.0271299
RPL9 ribosomal protein L9 -0.027021
RAB7A RAB7A, member RAS oncogene family -0.0266047
RPS11 ribosomal protein S11 -0.0263489
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0258848
ZBTB20 zinc finger and BTB domain containing 20 -0.025704
PLAT plasminogen activator, tissue -0.0254897
RPTOR regulatory associated protein of MTOR, complex 1 -0.0249208
RPLP2 ribosomal protein, large, P2 -0.0247641
MARCKS myristoylated alanine-rich protein kinase C substrate -0.024743
GLCCI1 glucocorticoid induced 1 -0.024386
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0241586
RPS21 ribosomal protein S21 -0.0239497
GNAS GNAS complex locus -0.0238732
FNBP1 formin binding protein 1 -0.0236692
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0235534
DCAF7 DDB1 and CUL4 associated factor 7 -0.0235295
CSNK1A1 casein kinase 1, alpha 1 -0.0232294
PTPRK protein tyrosine phosphatase, receptor type, K -0.0232077
FHIT fragile histidine triad -0.0230732
NPAS2 neuronal PAS domain protein 2 -0.0230362
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0227597
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0226971
IFI16 interferon, gamma-inducible protein 16 -0.0225421
TIMP2 TIMP metallopeptidase inhibitor 2 -0.022488
SLIT2 slit homolog 2 (Drosophila) -0.0220015
HLA-A major histocompatibility complex, class I, A -0.0216508
BCAS3 breast carcinoma amplified sequence 3 -0.0207456
RPL11 ribosomal protein L11 -0.0207399
SEC31A SEC31 homolog A (S. cerevisiae) -0.0205006
ATRNL1 attractin-like 1 -0.0204686
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0203316
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0202543
UNC5C unc-5 homolog C (C. elegans) -0.0199493
ADGRB3 adhesion G protein-coupled receptor B3 -0.0197677
RNASEH2A ribonuclease H2, subunit A -0.019744
RPS27A ribosomal protein S27a -0.0194478
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0194012
CBX3 chromobox homolog 3 -0.0193758
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0192208
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0191965
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0190306
PDE10A phosphodiesterase 10A -0.0190243
RPL13A ribosomal protein L13a -0.0188121
ENO2 enolase 2 (gamma, neuronal) -0.0186208
VIM vimentin -0.0185897
PNISR PNN-interacting serine/arginine-rich protein -0.0180575