Rosiglitazone_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0657553
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0528003
MYH9 myosin, heavy chain 9, non-muscle 0.0457984
ATP13A3 ATPase type 13A3 0.0440198
MSN moesin 0.0361834
SMAD3 SMAD family member 3 0.0361237
TRIO trio Rho guanine nucleotide exchange factor 0.0357082
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0349034
VEGFA vascular endothelial growth factor A 0.0337714
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0298551
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0295147
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0289423
NAV2 neuron navigator 2 0.0276878
INHBA inhibin, beta A 0.026557
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0239282
CLIC4 chloride intracellular channel 4 0.0236014
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0215316
PICALM phosphatidylinositol binding clathrin assembly protein 0.021162
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0209187
PRELID2 PRELI domain containing 2 0.0205057
ADAM9 ADAM metallopeptidase domain 9 0.019763
ADAM17 ADAM metallopeptidase domain 17 0.0193982
ARRDC3 arrestin domain containing 3 0.0183465
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0182174
MAP1B microtubule-associated protein 1B 0.0181507
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0180959
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0179631
SPAG9 sperm associated antigen 9 0.0177345
DPYSL3 dihydropyrimidinase-like 3 0.017564
CD44 CD44 molecule (Indian blood group) 0.0172716
WWTR1 WW domain containing transcription regulator 1 0.0172634
NRIP1 nuclear receptor interacting protein 1 0.0165883
KDM6A lysine (K)-specific demethylase 6A 0.016465
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0163349
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0158417
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0157367
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0156873
CENPF centromere protein F, 350/400kDa 0.0154386
TNIP1 TNFAIP3 interacting protein 1 0.0153892
ARHGAP29 Rho GTPase activating protein 29 0.0153607
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0152932
RPL3 ribosomal protein L3 0.0152923
CNTN5 contactin 5 0.0149709
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0148759
LIMA1 LIM domain and actin binding 1 0.0141415
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0140966
IL1B interleukin 1, beta 0.013717
GRB10 growth factor receptor-bound protein 10 0.0136237
UBA6 ubiquitin-like modifier activating enzyme 6 0.0135771
JAK2 Janus kinase 2 0.0135073
ANXA5 annexin A5 0.0131548
NOTCH2 notch 2 0.0130922
CSF1 colony stimulating factor 1 (macrophage) 0.0128203
RASA2 RAS p21 protein activator 2 0.0127976
NRP2 neuropilin 2 0.0127919
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.012544
CKAP5 cytoskeleton associated protein 5 0.0123989
SHB Src homology 2 domain containing adaptor protein B 0.0121601
PRKD3 protein kinase D3 0.012057
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0119531
USP47 ubiquitin specific peptidase 47 0.0118151
AGFG1 ArfGAP with FG repeats 1 0.0117988
SOD2 superoxide dismutase 2, mitochondrial 0.0116861
KIF16B kinesin family member 16B 0.0116789
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0115039
RB1CC1 RB1-inducible coiled-coil 1 0.0114329
VMP1 vacuole membrane protein 1 0.0112905
CCNL1 cyclin L1 0.0112457
PLSCR1 phospholipid scramblase 1 0.0111766
TMF1 TATA element modulatory factor 1 0.0111407
ITGAV integrin, alpha V 0.0111342
SFPQ splicing factor proline/glutamine-rich 0.0110846
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0109851
SAMD4A sterile alpha motif domain containing 4A 0.0108889
SAMD9 sterile alpha motif domain containing 9 0.0107673
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0106772
PDLIM5 PDZ and LIM domain 5 0.0104995
ANLN anillin, actin binding protein 0.0104374
CEMIP cell migration inducing protein, hyaluronan binding 0.0103819
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0103128
RIPK2 receptor-interacting serine-threonine kinase 2 0.0102804
PTBP2 polypyrimidine tract binding protein 2 0.0102794
GLS2 glutaminase 2 (liver, mitochondrial) 0.0102712
THBS1 thrombospondin 1 0.0102698
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0102435
BZW1 basic leucine zipper and W2 domains 1 0.0100075
KIRREL3 kin of IRRE like 3 (Drosophila) 0.00994467
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00992832
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00991231
PDE10A phosphodiesterase 10A 0.00976238
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00969217
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.00964382
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00959098
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.00957427
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00951767
RNF145 ring finger protein 145 0.00950937
PTEN phosphatase and tensin homolog 0.00949034
HLTF helicase-like transcription factor 0.00948627
LNPEP leucyl/cystinyl aminopeptidase 0.00947567
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00942415

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.357154
NDRG1 N-myc downstream regulated 1 -0.25469
VIM vimentin -0.218065
COL1A1 collagen, type I, alpha 1 -0.203713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.154993
TGFBI transforming growth factor, beta-induced, 68kDa -0.128105
TMSB10 thymosin beta 10 -0.116856
COL1A2 collagen, type I, alpha 2 -0.109378
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107823
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102344
IER3 immediate early response 3 -0.0886109
MT2A metallothionein 2A -0.0825267
CDH13 cadherin 13 -0.0789955
COL5A1 collagen, type V, alpha 1 -0.0755372
FTL ferritin, light polypeptide -0.0711803
LOX lysyl oxidase -0.0670722
CALR calreticulin -0.0667428
COL6A3 collagen, type VI, alpha 3 -0.0666641
RPS8 ribosomal protein S8 -0.0619226
HLA-B major histocompatibility complex, class I, B -0.0607354
RPL35A ribosomal protein L35a -0.0590671
TPM4 tropomyosin 4 -0.0586427
ACTG1 actin gamma 1 -0.0519886
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0513197
LOXL2 lysyl oxidase-like 2 -0.0487927
PTMA prothymosin, alpha -0.0477805
CAVIN1 caveolae associated protein 1 -0.0475898
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0463929
FBN1 fibrillin 1 -0.0455619
MTDH metadherin -0.0455356
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0434769
EIF1 eukaryotic translation initiation factor 1 -0.0432433
TPT1 tumor protein, translationally-controlled 1 -0.0416174
CANX calnexin -0.0411516
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0411378
FN1 fibronectin 1 -0.0390783
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0387525
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0386369
GNAS GNAS complex locus -0.037951
COL6A1 collagen, type VI, alpha 1 -0.0377598
S100A9 S100 calcium binding protein A9 -0.0344736
RPS6 ribosomal protein S6 -0.0338572
PGK1 phosphoglycerate kinase 1 -0.0321668
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0315069
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0312757
TRPS1 trichorhinophalangeal syndrome I -0.0306812
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0304827
RPL8 ribosomal protein L8 -0.0294443
RRBP1 ribosome binding protein 1 -0.0293774
COL6A2 collagen, type VI, alpha 2 -0.0291353
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0289759
LMAN1 lectin, mannose-binding, 1 -0.0289376
PSD3 pleckstrin and Sec7 domain containing 3 -0.0289326
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0289322
RPL28 ribosomal protein L28 -0.0284562
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0278446
S100A10 S100 calcium binding protein A10 -0.0278133
AHNAK AHNAK nucleoprotein -0.0277445
RPL37A ribosomal protein L37a -0.0276958
S100A6 S100 calcium binding protein A6 -0.0273005
RPL30 ribosomal protein L30 -0.0266842
RPLP1 ribosomal protein, large, P1 -0.0263488
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.026164
CLMP CXADR-like membrane protein -0.0261008
RPS19 ribosomal protein S19 -0.0257091
RPL19 ribosomal protein L19 -0.0253792
WSB1 WD repeat and SOCS box containing 1 -0.0252
KPNB1 karyopherin (importin) beta 1 -0.0251293
HLA-A major histocompatibility complex, class I, A -0.0247868
RPL26 ribosomal protein L26 -0.0247848
VDAC1 voltage-dependent anion channel 1 -0.0247322
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0244919
CTSB cathepsin B -0.0239016
LOC112694756 uncharaterized LOC112694756 -0.0232831
RPL12 ribosomal protein L12 -0.0231901
RPL36 ribosomal protein L36 -0.0231116
RPL34 ribosomal protein L34 -0.0226436
RPS24 ribosomal protein S24 -0.0224605
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0223992
LMNA lamin A/C -0.0223709
RPL23 ribosomal protein L23 -0.0222742
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0220448
COL3A1 collagen, type III, alpha 1 -0.0219113
RPS27A ribosomal protein S27a -0.0216576
EHD2 EH-domain containing 2 -0.0215799
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0214868
IFI6 interferon, alpha-inducible protein 6 -0.0213812
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0213654
COL7A1 collagen, type VII, alpha 1 -0.0212993
ARL4C ADP-ribosylation factor-like 4C -0.0211863
RPS20 ribosomal protein S20 -0.0210279
ZBTB20 zinc finger and BTB domain containing 20 -0.0209653
MAP4 microtubule-associated protein 4 -0.0207929
OXR1 oxidation resistance 1 -0.0207422
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0205877
ANXA2 annexin A2 -0.0204301
LAMB3 laminin, beta 3 -0.0203408
RPS3 ribosomal protein S3 -0.0203106
SORBS2 sorbin and SH3 domain containing 2 -0.0201228
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0200579