Rosiglitazone_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.16157
SLC35F3 solute carrier family 35, member F3 0.0995721
PODXL podocalyxin-like 0.0832841
PLIN2 perilipin 2 0.0784871
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0741764
MSN moesin 0.0714295
PSD3 pleckstrin and Sec7 domain containing 3 0.0692868
FLNB filamin B, beta 0.0646131
ITGA6 integrin, alpha 6 0.0586102
RAI14 retinoic acid induced 14 0.0540188
AKAP13 A kinase (PRKA) anchor protein 13 0.0503087
SQSTM1 sequestosome 1 0.0457826
PLCE1 phospholipase C, epsilon 1 0.043084
SLK STE20-like kinase 0.0414212
STK10 serine/threonine kinase 10 0.0386002
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0368172
BZW1 basic leucine zipper and W2 domains 1 0.0360283
ARHGAP29 Rho GTPase activating protein 29 0.0357048
PDE4D phosphodiesterase 4D, cAMP-specific 0.0348415
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0348148
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0341991
MYO10 myosin X 0.0335196
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0329252
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0323413
ITGAV integrin, alpha V 0.0309585
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0305904
ZEB1 zinc finger E-box binding homeobox 1 0.0302525
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.029738
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0293438
EFNB2 ephrin-B2 0.0289252
GLS2 glutaminase 2 (liver, mitochondrial) 0.0285641
KDM6A lysine (K)-specific demethylase 6A 0.0274702
RNF217 ring finger protein 217 0.0269882
MEF2A myocyte enhancer factor 2A 0.0268684
PICALM phosphatidylinositol binding clathrin assembly protein 0.0263043
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0256126
MPRIP myosin phosphatase Rho interacting protein 0.0253188
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.02492
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0245972
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0245736
FNDC3B fibronectin type III domain containing 3B 0.0245181
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0242364
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.023911
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.023847
TEK TEK tyrosine kinase, endothelial 0.0235759
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0234121
CAPN2 calpain 2, (m/II) large subunit 0.0229267
FOXO1 forkhead box O1 0.0229087
CAPRIN2 caprin family member 2 0.0228649
TNS3 tensin 3 0.0222296
IL1B interleukin 1, beta 0.0221732
ADAM19 ADAM metallopeptidase domain 19 0.0218812
RCOR1 REST corepressor 1 0.0216696
NAV2 neuron navigator 2 0.0214913
DENND4C DENN/MADD domain containing 4C 0.021285
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0209701
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0209221
ANXA5 annexin A5 0.0208326
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0207849
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.020638
FOSL1 FOS-like antigen 1 0.0206283
FA2H fatty acid 2-hydroxylase 0.0198021
LAMC2 laminin, gamma 2 0.0195056
CLIC4 chloride intracellular channel 4 0.0192372
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0192132
NCOR2 nuclear receptor corepressor 2 0.018868
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0186072
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0186011
ANXA11 annexin A11 0.018398
SYPL1 synaptophysin-like 1 0.0183763
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0183161
EREG epiregulin 0.0180758
FTH1 ferritin, heavy polypeptide 1 0.0180193
ARHGAP23 Rho GTPase activating protein 23 0.0179002
KIAA1671 KIAA1671 0.0177297
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0176537
SPAG9 sperm associated antigen 9 0.0172958
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0172901
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.017104
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0169542
CLMB calcimembrin 0.0169075
F3 coagulation factor III (thromboplastin, tissue factor) 0.0168089
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0167664
SERTAD2 SERTA domain containing 2 0.0164315
DLC1 DLC1 Rho GTPase activating protein 0.0164113
ZMIZ1 zinc finger, MIZ-type containing 1 0.0162583
SEPTIN11 septin 11 0.0161789
EFHD2 EF-hand domain family, member D2 0.0160991
CALB1 calbindin 1, 28kDa 0.0160058
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0158563
RABGAP1L RAB GTPase activating protein 1-like 0.0158028
ABLIM3 actin binding LIM protein family, member 3 0.0157242
LAMA4 laminin, alpha 4 0.0156497
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0155385
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0155094
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0153087
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0152265
PCDH1 protocadherin 1 0.0150972
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0150123
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0149017

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174893
TMSB10 thymosin beta 10 -0.149049
NDRG1 N-myc downstream regulated 1 -0.111187
B2M beta-2-microglobulin -0.107095
MT2A metallothionein 2A -0.106038
PTMA prothymosin, alpha -0.10333
UBC ubiquitin C -0.0894202
AHNAK AHNAK nucleoprotein -0.0872605
TPT1 tumor protein, translationally-controlled 1 -0.086115
RPS21 ribosomal protein S21 -0.0848422
HLA-B major histocompatibility complex, class I, B -0.0753017
ENO1 enolase 1, (alpha) -0.0750974
RPS8 ribosomal protein S8 -0.0715005
RPS27A ribosomal protein S27a -0.0709984
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0682097
LOC112694756 uncharaterized LOC112694756 -0.0668261
PGK1 phosphoglycerate kinase 1 -0.0639556
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0631358
H1-0 H1.0 linker histone -0.0618124
CANX calnexin -0.0611113
CD44 CD44 molecule (Indian blood group) -0.0603464
IFITM3 interferon induced transmembrane protein 3 -0.0596893
LMNA lamin A/C -0.0591013
RPLP1 ribosomal protein, large, P1 -0.0558876
S100A10 S100 calcium binding protein A10 -0.0557424
RPLP2 ribosomal protein, large, P2 -0.0554293
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0548665
RPS19 ribosomal protein S19 -0.0542787
MBNL1 muscleblind-like splicing regulator 1 -0.0534367
MBNL2 muscleblind-like splicing regulator 2 -0.0518099
LDHA lactate dehydrogenase A -0.0517158
GNAS GNAS complex locus -0.0503478
IFITM1 interferon induced transmembrane protein 1 -0.0493422
YBX3 Y box binding protein 3 -0.0491958
RPS13 ribosomal protein S13 -0.049092
CLU clusterin -0.0490856
CALR calreticulin -0.0488921
RPL23 ribosomal protein L23 -0.0485211
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0476403
KRT17 keratin 17, type I -0.0464701
FTL ferritin, light polypeptide -0.0444526
RPS24 ribosomal protein S24 -0.0443024
RPS3 ribosomal protein S3 -0.0442458
RPL8 ribosomal protein L8 -0.0428752
DPYD dihydropyrimidine dehydrogenase -0.0419469
RPS25 ribosomal protein S25 -0.0412509
NAP1L1 nucleosome assembly protein 1-like 1 -0.0406247
IFI6 interferon, alpha-inducible protein 6 -0.039521
RPS12 ribosomal protein S12 -0.03946
MTSS1 metastasis suppressor 1 -0.0392157
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0387957
SERINC3 serine incorporator 3 -0.0380164
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0379035
S100A6 S100 calcium binding protein A6 -0.0378447
RBM39 RNA binding motif protein 39 -0.0372734
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0371711
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0366797
HLA-E major histocompatibility complex, class I, E -0.0366609
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0363392
RPL37A ribosomal protein L37a -0.0355179
FOXP1 forkhead box P1 -0.0354269
IFI16 interferon, gamma-inducible protein 16 -0.0354118
ANXA2 annexin A2 -0.035355
RPL19 ribosomal protein L19 -0.0352071
EIF1 eukaryotic translation initiation factor 1 -0.0349153
PKM pyruvate kinase, muscle -0.0347989
CEMIP cell migration inducing protein, hyaluronan binding -0.0344
RPL11 ribosomal protein L11 -0.0343136
TMSB4X thymosin beta 4, X-linked -0.0342804
CD99 CD99 molecule -0.0339024
RPL31 ribosomal protein L31 -0.0336269
TXNIP thioredoxin interacting protein -0.0335179
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0332722
RPL34 ribosomal protein L34 -0.0332302
FSCN1 fascin actin-bundling protein 1 -0.0329881
RPL37 ribosomal protein L37 -0.0327213
MARCKS myristoylated alanine-rich protein kinase C substrate -0.032568
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.032263
HLA-A major histocompatibility complex, class I, A -0.0321179
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0320949
WSB1 WD repeat and SOCS box containing 1 -0.0320772
CAV1 caveolin 1, caveolae protein, 22kDa -0.0314773
RPL12 ribosomal protein L12 -0.0314415
CALU calumenin -0.0310812
ANLN anillin, actin binding protein -0.0308566
LMO7 LIM domain 7 -0.0304697
MT1X metallothionein 1X -0.0304178
MYOF myoferlin -0.030417
SEC31A SEC31 homolog A (S. cerevisiae) -0.0303208
MARCHF6 membrane associated ring-CH-type finger 6 -0.0302729
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0302152
RPS23 ribosomal protein S23 -0.0301716
IER3 immediate early response 3 -0.0301396
RPL27A ribosomal protein L27a -0.0300835
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0300564
S100A9 S100 calcium binding protein A9 -0.030007
RPL5 ribosomal protein L5 -0.0299534
RPL35A ribosomal protein L35a -0.029931
PLEC plectin -0.0296952
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0292771