Rosiglitazone_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rosiglitazone_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.210091
NAMPT nicotinamide phosphoribosyltransferase 0.139179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105019
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0834119
PLIN2 perilipin 2 0.0753902
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0668411
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.062539
TFPI2 tissue factor pathway inhibitor 2 0.0571353
ATP13A3 ATPase type 13A3 0.0530374
ANXA1 annexin A1 0.0526185
BZW1 basic leucine zipper and W2 domains 1 0.0520011
SIK3 SIK family kinase 3 0.0519124
AKAP12 A kinase (PRKA) anchor protein 12 0.0503705
CXCL5 chemokine (C-X-C motif) ligand 5 0.0491661
KDM3A lysine (K)-specific demethylase 3A 0.048512
AKAP13 A kinase (PRKA) anchor protein 13 0.0476916
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0469754
SPAG9 sperm associated antigen 9 0.0468418
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0458697
GOLGA4 golgin A4 0.0458335
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0455408
ZEB2 zinc finger E-box binding homeobox 2 0.0423518
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0423233
ZFAND3 zinc finger, AN1-type domain 3 0.0423191
PID1 phosphotyrosine interaction domain containing 1 0.041764
EREG epiregulin 0.0415833
IL1B interleukin 1, beta 0.040846
FAM13A family with sequence similarity 13, member A 0.0407036
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0403846
STC1 stanniocalcin 1 0.0391172
WAC WW domain containing adaptor with coiled-coil 0.0390494
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0389211
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0381009
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0375558
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0374682
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.036699
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0364771
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0356867
NCKAP1 NCK-associated protein 1 0.0353245
COG5 component of oligomeric golgi complex 5 0.0350148
OXSR1 oxidative stress responsive 1 0.0348659
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0337913
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0333517
FAM20C family with sequence similarity 20, member C 0.0323414
APP amyloid beta (A4) precursor protein 0.0323042
ARHGAP5 Rho GTPase activating protein 5 0.0319856
CCNY cyclin Y 0.0317863
EPS8 epidermal growth factor receptor pathway substrate 8 0.0317647
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0313899
MATR3 matrin 3 0.0309918
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.030621
MAPK8 mitogen-activated protein kinase 8 0.0303726
RNF145 ring finger protein 145 0.0297925
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0296888
ITGAV integrin, alpha V 0.0296485
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0294219
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0294208
CHD1 chromodomain helicase DNA binding protein 1 0.0290599
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0289598
PRRC2C proline-rich coiled-coil 2C 0.0287855
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0285753
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0279604
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0279542
RAB18 RAB18, member RAS oncogene family 0.0279247
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0278742
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.027696
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0275891
CANX calnexin 0.0274766
COPA coatomer protein complex, subunit alpha 0.0273238
RAB8B RAB8B, member RAS oncogene family 0.0273133
TOP2B topoisomerase (DNA) II beta 180kDa 0.0271542
FMNL3 formin-like 3 0.0268334
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0263609
RLF rearranged L-myc fusion 0.0257136
NAP1L1 nucleosome assembly protein 1-like 1 0.0256349
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0255123
ZFP91 ZFP91 zinc finger protein 0.0253715
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0252916
IPO7 importin 7 0.025164
HSPA8 heat shock 70kDa protein 8 0.0251307
KIF5B kinesin family member 5B 0.0244926
ADAM17 ADAM metallopeptidase domain 17 0.024386
RPLP0 ribosomal protein, large, P0 0.0243416
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0242408
OSBPL9 oxysterol binding protein-like 9 0.0242132
CD44 CD44 molecule (Indian blood group) 0.0237189
AMPD3 adenosine monophosphate deaminase 3 0.0235111
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0234105
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0230713
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0230412
CTNNBL1 catenin, beta like 1 0.0229279
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.022899
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0228843
CENPF centromere protein F, 350/400kDa 0.0228802
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0228006
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0227753
RPL14 ribosomal protein L14 0.0224848
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.022482
PEAK1 pseudopodium-enriched atypical kinase 1 0.0223877
KDM1A lysine (K)-specific demethylase 1A 0.0223759

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233948
FN1 fibronectin 1 -0.146177
TMSB10 thymosin beta 10 -0.136797
NDRG1 N-myc downstream regulated 1 -0.111337
MT2A metallothionein 2A -0.0894488
PDE4D phosphodiesterase 4D, cAMP-specific -0.0887231
GPC6 glypican 6 -0.0842834
VIM vimentin -0.0842068
FTL ferritin, light polypeptide -0.0728585
SDK1 sidekick cell adhesion molecule 1 -0.071372
LOX lysyl oxidase -0.0708508
HMGA2 high mobility group AT-hook 2 -0.0689319
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0677768
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0660481
EGR1 early growth response 1 -0.0569098
HMGA1 high mobility group AT-hook 1 -0.0523352
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0515421
RAD51B RAD51 paralog B -0.0487133
PSD3 pleckstrin and Sec7 domain containing 3 -0.0469869
EFNA5 ephrin-A5 -0.0463201
SOS1 son of sevenless homolog 1 (Drosophila) -0.0457732
TRIO trio Rho guanine nucleotide exchange factor -0.0447054
DLG1 discs, large homolog 1 (Drosophila) -0.0440911
SYT1 synaptotagmin I -0.0438407
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0437773
CA12 carbonic anhydrase XII -0.0436812
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0434425
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0432442
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0412712
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0400529
LRMDA leucine rich melanocyte differentiation associated -0.0398201
MAP1B microtubule-associated protein 1B -0.0391515
TXNIP thioredoxin interacting protein -0.0384308
USP34 ubiquitin specific peptidase 34 -0.0382177
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0374176
MRPS6 mitochondrial ribosomal protein S6 -0.0369685
DPYD dihydropyrimidine dehydrogenase -0.0368824
PRKCA protein kinase C, alpha -0.0367302
ZBTB20 zinc finger and BTB domain containing 20 -0.0365442
RPL35A ribosomal protein L35a -0.0359704
IFI6 interferon, alpha-inducible protein 6 -0.0354353
S100A6 S100 calcium binding protein A6 -0.0338293
EGFR epidermal growth factor receptor -0.0333589
MAML2 mastermind-like 2 (Drosophila) -0.0330497
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0329004
ZFP36L1 ZFP36 ring finger protein-like 1 -0.032329
BABAM2 BRISC and BRCA1 A complex member 2 -0.0320791
PTPRR protein tyrosine phosphatase, receptor type, R -0.031674
PRELID2 PRELI domain containing 2 -0.0314639
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0310747
GLCCI1 glucocorticoid induced 1 -0.0308872
IFITM3 interferon induced transmembrane protein 3 -0.0301593
IFI16 interferon, gamma-inducible protein 16 -0.0300517
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0295302
MYADM myeloid-associated differentiation marker -0.0294869
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0294124
DST dystonin -0.0292908
CUX1 cut-like homeobox 1 -0.029212
IGFBP3 insulin-like growth factor binding protein 3 -0.0286591
RPS19 ribosomal protein S19 -0.0278217
C15ORF48 chromosome 15 open reading frame 48 -0.0270178
CHD1L chromodomain helicase DNA binding protein 1-like -0.0267992
RPS29 ribosomal protein S29 -0.026575
HDAC9 histone deacetylase 9 -0.0263473
SEC61G Sec61 gamma subunit -0.0263171
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.026264
TGFB1 transforming growth factor, beta 1 -0.0261385
AKAP9 A kinase (PRKA) anchor protein 9 -0.0259628
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0258334
IER3 immediate early response 3 -0.0251931
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0250506
ATXN1 ataxin 1 -0.0249465
RNF24 ring finger protein 24 -0.0247547
SOD2 superoxide dismutase 2, mitochondrial -0.0239925
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0239635
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0239521
LIMCH1 LIM and calponin homology domains 1 -0.023952
NCOA7 nuclear receptor coactivator 7 -0.023895
WLS wntless Wnt ligand secretion mediator -0.0238508
TAS2R14 taste receptor, type 2, member 14 -0.0238129
SYNJ2 synaptojanin 2 -0.0237959
AOPEP aminopeptidase O (putative) -0.0237564
CMIP c-Maf inducing protein -0.0237518
ECE1 endothelin converting enzyme 1 -0.023471
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0234587
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0233596
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0233423
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.023331
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0232437
LOXL2 lysyl oxidase-like 2 -0.0230878
COL7A1 collagen, type VII, alpha 1 -0.0230324
GREB1L growth regulation by estrogen in breast cancer-like -0.0228519
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0228344
HDAC4 histone deacetylase 4 -0.0228112
YBX3 Y box binding protein 3 -0.0228001
PFKP phosphofructokinase, platelet -0.0226434
RNF213 ring finger protein 213 -0.0225025
MX2 MX dynamin-like GTPase 2 -0.0222553
FNBP1 formin binding protein 1 -0.0222034
RPL36 ribosomal protein L36 -0.0221822