Rosiglitazone_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.170354
AKAP12 A kinase (PRKA) anchor protein 12 0.113616
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0697281
ERRFI1 ERBB receptor feedback inhibitor 1 0.0666644
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0619147
TXNRD1 thioredoxin reductase 1 0.0585407
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0410812
TPM3 tropomyosin 3 0.0397828
BZW1 basic leucine zipper and W2 domains 1 0.0379563
IPO7 importin 7 0.0376333
OGA O-GlcNAcase 0.0371654
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0354798
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0347619
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0334338
CSDE1 cold shock domain containing E1, RNA-binding 0.0327929
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0317981
TOP2B topoisomerase (DNA) II beta 180kDa 0.0315486
SET SET nuclear proto-oncogene 0.030168
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0294638
EIF4B eukaryotic translation initiation factor 4B 0.028645
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0281873
ZFC3H1 zinc finger, C3H1-type containing 0.0278029
CAMTA1 calmodulin binding transcription activator 1 0.0277699
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0276097
LRPPRC leucine-rich pentatricopeptide repeat containing 0.027557
NIPBL Nipped-B homolog (Drosophila) 0.0273649
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0243908
DSPP dentin sialophosphoprotein 0.0240176
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0238837
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0237612
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0237404
ANXA5 annexin A5 0.0234978
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0234233
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0234225
KDM2A lysine (K)-specific demethylase 2A 0.0233075
ANO6 anoctamin 6 0.0229334
NCKAP1 NCK-associated protein 1 0.022712
USP9X ubiquitin specific peptidase 9, X-linked 0.0226791
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0223313
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0222191
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0219932
RTN4 reticulon 4 0.0217961
SPAG9 sperm associated antigen 9 0.0216684
CKAP5 cytoskeleton associated protein 5 0.0216438
MYH9 myosin, heavy chain 9, non-muscle 0.0215024
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0213908
PRPF8 pre-mRNA processing factor 8 0.0210886
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0207724
KDM3A lysine (K)-specific demethylase 3A 0.0204852
SFPQ splicing factor proline/glutamine-rich 0.0203718
TFG TRK-fused gene 0.0201958
FUBP1 far upstream element (FUSE) binding protein 1 0.0200661
ZFAND3 zinc finger, AN1-type domain 3 0.0198249
RPL3 ribosomal protein L3 0.0197492
HSPA8 heat shock 70kDa protein 8 0.0193142
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0191843
MATR3 matrin 3 0.0188144
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0187999
ANKRD36 ankyrin repeat domain 36 0.0184821
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.018365
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0182277
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0182033
TAS2R14 taste receptor, type 2, member 14 0.0180437
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180367
CLTC clathrin, heavy chain (Hc) 0.0180067
NUP58 nucleoporin 58 0.01799
CSNK1A1 casein kinase 1, alpha 1 0.0179483
BCAP31 B-cell receptor-associated protein 31 0.0178491
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0177653
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0177474
RBM39 RNA binding motif protein 39 0.0177134
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0176935
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0176011
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0172128
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.017196
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0169785
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0169408
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0166344
CDC73 cell division cycle 73 0.0166163
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0166121
MORF4L2 mortality factor 4 like 2 0.0165908
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0165638
RAD21 RAD21 homolog (S. pombe) 0.0165515
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0163523
MACF1 microtubule-actin crosslinking factor 1 0.016291
NAMPT nicotinamide phosphoribosyltransferase 0.0162387
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0161732
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0161043
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0159853
BCLAF1 BCL2-associated transcription factor 1 0.0158689
SERINC1 serine incorporator 1 0.0158345
RRM2 ribonucleotide reductase M2 0.015796
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0157682
ETNK1 ethanolamine kinase 1 0.0157017
XPO1 exportin 1 0.0156881
WDR26 WD repeat domain 26 0.0155784
KIF5B kinesin family member 5B 0.0155231
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.015443
THOC1 THO complex 1 0.0154307
ADAM17 ADAM metallopeptidase domain 17 0.0154242

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.236269
TMSB10 thymosin beta 10 -0.144281
EGR1 early growth response 1 -0.100965
YBX3 Y box binding protein 3 -0.0867844
VIM vimentin -0.0730023
MT2A metallothionein 2A -0.0634072
RPL35A ribosomal protein L35a -0.058342
PTMA prothymosin, alpha -0.0573323
TPI1 triosephosphate isomerase 1 -0.0533496
RPLP1 ribosomal protein, large, P1 -0.0521893
PFN1 profilin 1 -0.0494541
RPS3 ribosomal protein S3 -0.0492371
RPS19 ribosomal protein S19 -0.0492287
RPL37 ribosomal protein L37 -0.0464755
RPL37A ribosomal protein L37a -0.0461786
RPS8 ribosomal protein S8 -0.0450349
RPS21 ribosomal protein S21 -0.0428285
RPS29 ribosomal protein S29 -0.042747
RPL23 ribosomal protein L23 -0.0415341
RPL12 ribosomal protein L12 -0.0408475
RPL36 ribosomal protein L36 -0.0388237
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.038461
HLA-B major histocompatibility complex, class I, B -0.0382983
RPL31 ribosomal protein L31 -0.0370117
RPS27 ribosomal protein S27 -0.0356935
RPL34 ribosomal protein L34 -0.0342792
RPL9 ribosomal protein L9 -0.0341722
RPL8 ribosomal protein L8 -0.0338095
GRAMD1B GRAM domain containing 1B -0.0328515
RPL32 ribosomal protein L32 -0.0326561
RPL5 ribosomal protein L5 -0.0320138
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0319166
RPLP2 ribosomal protein, large, P2 -0.0315722
ACTG1 actin gamma 1 -0.0310504
RPL19 ribosomal protein L19 -0.0307994
FTL ferritin, light polypeptide -0.0305367
TFPI2 tissue factor pathway inhibitor 2 -0.0304824
TPT1 tumor protein, translationally-controlled 1 -0.0302636
RPS15 ribosomal protein S15 -0.0287673
IFI6 interferon, alpha-inducible protein 6 -0.0271966
RPS10 ribosomal protein S10 -0.0269137
RPL28 ribosomal protein L28 -0.0268379
MYL12B myosin, light chain 12B, regulatory -0.0261772
RPS27A ribosomal protein S27a -0.0256362
RPL30 ribosomal protein L30 -0.02459
RPL26 ribosomal protein L26 -0.0238668
RPS4X ribosomal protein S4, X-linked -0.0234497
KTN1 kinectin 1 (kinesin receptor) -0.0230515
RPS13 ribosomal protein S13 -0.0228576
TPM2 tropomyosin 2 (beta) -0.0228453
RPL38 ribosomal protein L38 -0.0226379
NACA nascent polypeptide-associated complex alpha subunit -0.022494
AKAP9 A kinase (PRKA) anchor protein 9 -0.0223869
RPS12 ribosomal protein S12 -0.0222603
RPL18 ribosomal protein L18 -0.0219042
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0218132
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0217842
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0216065
RIMS2 regulating synaptic membrane exocytosis 2 -0.0215056
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0214393
BPTF bromodomain PHD finger transcription factor -0.0211337
WSB1 WD repeat and SOCS box containing 1 -0.0209806
RPL27 ribosomal protein L27 -0.0209804
DEK DEK proto-oncogene -0.0209625
RPL35 ribosomal protein L35 -0.0206603
S100A11 S100 calcium binding protein A11 -0.0205122
PKM pyruvate kinase, muscle -0.0202205
GNAS GNAS complex locus -0.0202154
ATP5F1E ATP synthase F1 subunit epsilon -0.0199183
RPS24 ribosomal protein S24 -0.0198983
VDAC1 voltage-dependent anion channel 1 -0.0198777
RPS14 ribosomal protein S14 -0.0198066
EGFR epidermal growth factor receptor -0.0197436
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0197103
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0193832
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0192779
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0191627
RPS25 ribosomal protein S25 -0.0190443
IGF2 insulin-like growth factor 2 -0.0188224
PHF14 PHD finger protein 14 -0.0187396
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0184662
HMGA1 high mobility group AT-hook 1 -0.0183876
RPS23 ribosomal protein S23 -0.0182648
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0182358
EML4 echinoderm microtubule associated protein like 4 -0.018197
MCL1 myeloid cell leukemia 1 -0.018156
EIF5B eukaryotic translation initiation factor 5B -0.0179278
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0179256
PRH1 proline-rich protein HaeIII subfamily 1 -0.0178837
BRD4 bromodomain containing 4 -0.0178516
TAPBP TAP binding protein (tapasin) -0.0178269
MT1X metallothionein 1X -0.0177478
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0176569
POTEF POTE ankyrin domain family, member F -0.0176148
RPS6 ribosomal protein S6 -0.0175493
RPS16 ribosomal protein S16 -0.017418
TUBA1C tubulin, alpha 1c -0.0173637
RPL36A ribosomal protein L36a -0.01731
ATP5F1B ATP synthase F1 subunit beta -0.0170726
SMIM44 small integral membrane protein 44 -0.0170014