Rosiglitazone_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0840053
ASPH aspartate beta-hydroxylase 0.0824884
NEK7 NIMA-related kinase 7 0.0563371
TXNRD1 thioredoxin reductase 1 0.0522841
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0521124
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0506731
FNDC3B fibronectin type III domain containing 3B 0.048198
CXCL8 chemokine (C-X-C motif) ligand 8 0.0475946
TRIO trio Rho guanine nucleotide exchange factor 0.0471186
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.044654
AGFG1 ArfGAP with FG repeats 1 0.038103
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0336865
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.032715
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0326411
RTN4 reticulon 4 0.0300745
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0298719
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0295639
USP9X ubiquitin specific peptidase 9, X-linked 0.0295144
BZW1 basic leucine zipper and W2 domains 1 0.0278133
TNPO1 transportin 1 0.0270715
NRCAM neuronal cell adhesion molecule 0.0268663
MYOF myoferlin 0.0262757
KYNU kynureninase 0.0262019
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0258163
ERRFI1 ERBB receptor feedback inhibitor 1 0.0241063
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0237904
ELL2 elongation factor, RNA polymerase II, 2 0.0234531
KDM6A lysine (K)-specific demethylase 6A 0.0228205
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0223168
WDR43 WD repeat domain 43 0.0222742
TGFBR1 transforming growth factor, beta receptor 1 0.0220215
MATR3 matrin 3 0.0220095
HSPA8 heat shock 70kDa protein 8 0.0219378
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0219276
MSN moesin 0.0217586
SPAG9 sperm associated antigen 9 0.0216941
EZR ezrin 0.0215803
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0213982
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0204924
ZEB2 zinc finger E-box binding homeobox 2 0.0202907
CHD1 chromodomain helicase DNA binding protein 1 0.0202562
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0201087
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0197848
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0197128
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0192955
ATP13A3 ATPase type 13A3 0.0190883
TM9SF3 transmembrane 9 superfamily member 3 0.0188052
NCKAP1 NCK-associated protein 1 0.0186372
CTSC cathepsin C 0.0184518
BCAR3 breast cancer anti-estrogen resistance 3 0.0183117
CUL3 cullin 3 0.0180503
DST dystonin 0.0180435
ZC3H11A zinc finger CCCH-type containing 11A 0.0180409
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0174836
OGA O-GlcNAcase 0.0172133
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0170711
TSC22D2 TSC22 domain family, member 2 0.0168616
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0166435
ENAH enabled homolog (Drosophila) 0.0165432
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0164493
PUM2 pumilio RNA-binding family member 2 0.0163956
IPO7 importin 7 0.0163731
ANXA5 annexin A5 0.0162646
RPL3 ribosomal protein L3 0.0162529
EFNA5 ephrin-A5 0.0161452
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0161345
COL8A1 collagen, type VIII, alpha 1 0.0161234
ADAM17 ADAM metallopeptidase domain 17 0.016121
PCBP3 poly(rC) binding protein 3 0.0161169
ZNF292 zinc finger protein 292 0.0160958
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0160684
ITPRID2 ITPR interacting domain containing 2 0.0159058
NRG1 neuregulin 1 0.0157778
SUCO SUN domain containing ossification factor 0.0153636
USP3 ubiquitin specific peptidase 3 0.0152917
SFPQ splicing factor proline/glutamine-rich 0.0151076
ECPAS Ecm29 proteasome adaptor and scaffold 0.0150922
GDA guanine deaminase 0.0150098
BDNF brain-derived neurotrophic factor 0.0149924
MARCHF7 membrane associated ring-CH-type finger 7 0.014912
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0147365
NBAS neuroblastoma amplified sequence 0.0146983
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0146751
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0146283
RLIM ring finger protein, LIM domain interacting 0.0146046
AHR aryl hydrocarbon receptor 0.0144629
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0142582
SAMD4A sterile alpha motif domain containing 4A 0.0141539
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0141425
TRA2A transformer 2 alpha homolog (Drosophila) 0.0141418
PTEN phosphatase and tensin homolog 0.014128
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0140605
ANO6 anoctamin 6 0.0139195
WAC WW domain containing adaptor with coiled-coil 0.0138187
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.013757
EIF4B eukaryotic translation initiation factor 4B 0.0136942
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0136752
FAT1 FAT atypical cadherin 1 0.0134418
PICALM phosphatidylinositol binding clathrin assembly protein 0.013403
PRKD3 protein kinase D3 0.0133576

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139699
TMSB10 thymosin beta 10 -0.139605
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.138129
VIM vimentin -0.112117
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106165
PTMA prothymosin, alpha -0.0890192
PDE4D phosphodiesterase 4D, cAMP-specific -0.0879242
RPS6 ribosomal protein S6 -0.0791843
RPLP1 ribosomal protein, large, P1 -0.069757
RPL37A ribosomal protein L37a -0.0661447
FTL ferritin, light polypeptide -0.0625795
FN1 fibronectin 1 -0.0602223
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0586359
TPT1 tumor protein, translationally-controlled 1 -0.0573732
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0570529
RPS12 ribosomal protein S12 -0.0548397
MT2A metallothionein 2A -0.0539185
RPL12 ribosomal protein L12 -0.0525748
RPS19 ribosomal protein S19 -0.0525636
RPS3 ribosomal protein S3 -0.0518427
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0512245
RPL19 ribosomal protein L19 -0.0497547
RPS8 ribosomal protein S8 -0.0488722
IGFBP3 insulin-like growth factor binding protein 3 -0.0483405
RPL31 ribosomal protein L31 -0.046674
S100A6 S100 calcium binding protein A6 -0.0452177
RPL35A ribosomal protein L35a -0.0437993
PDE10A phosphodiesterase 10A -0.0431667
RPL26 ribosomal protein L26 -0.0431652
RPL9 ribosomal protein L9 -0.0410626
RPL36 ribosomal protein L36 -0.0390599
RPL23 ribosomal protein L23 -0.0382065
HLA-A major histocompatibility complex, class I, A -0.0374663
RPS29 ribosomal protein S29 -0.0373232
MAML3 mastermind-like 3 (Drosophila) -0.0364973
RPL37 ribosomal protein L37 -0.0364033
P3H2 prolyl 3-hydroxylase 2 -0.0362516
RPLP2 ribosomal protein, large, P2 -0.0360562
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0353219
B2M beta-2-microglobulin -0.0349511
NDRG1 N-myc downstream regulated 1 -0.0341937
RPS24 ribosomal protein S24 -0.0331854
GNAS GNAS complex locus -0.0330426
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0323426
WSB1 WD repeat and SOCS box containing 1 -0.0321929
RPS16 ribosomal protein S16 -0.0316561
RPS27A ribosomal protein S27a -0.0314632
LMNA lamin A/C -0.0313458
RPS27 ribosomal protein S27 -0.0309745
RACK1 receptor for activated C kinase 1 -0.0307587
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0307582
HLA-B major histocompatibility complex, class I, B -0.0306755
RPL34 ribosomal protein L34 -0.0304895
RPL36A ribosomal protein L36a -0.0300261
WARS1 tryptophanyl-tRNA synthetase 1 -0.0299679
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0282413
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0278958
RPL18 ribosomal protein L18 -0.0278589
RPL7A ribosomal protein L7a -0.0278477
RPS13 ribosomal protein S13 -0.026868
TBXT T-box transcription factor T -0.0267116
EGR1 early growth response 1 -0.0264245
SMYD3 SET and MYND domain containing 3 -0.0262936
RPL13A ribosomal protein L13a -0.0260942
RPL11 ribosomal protein L11 -0.0260102
RPS14 ribosomal protein S14 -0.0258458
S100A10 S100 calcium binding protein A10 -0.0255307
EIF1 eukaryotic translation initiation factor 1 -0.0254718
CANX calnexin -0.0254595
RPS23 ribosomal protein S23 -0.0252425
IL6 interleukin 6 -0.0243073
YBX3 Y box binding protein 3 -0.0241241
RPL35 ribosomal protein L35 -0.023695
PFN1 profilin 1 -0.0234775
NALF1 NALCN channel auxiliary factor 1 -0.0231376
MCL1 myeloid cell leukemia 1 -0.0231095
RPS17 ribosomal protein S17 -0.023091
RPS21 ribosomal protein S21 -0.0229941
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0227174
RPL5 ribosomal protein L5 -0.0226842
RPL32 ribosomal protein L32 -0.0226016
SOX4 SRY (sex determining region Y)-box 4 -0.0224742
ISG15 ISG15 ubiquitin-like modifier -0.0222289
RPL28 ribosomal protein L28 -0.0219187
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0218145
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0214511
RGS2 regulator of G-protein signaling 2 -0.0212548
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0212431
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0205381
RPS4X ribosomal protein S4, X-linked -0.0205344
PRKN parkin RBR E3 ubiquitin protein ligase -0.0203328
FNDC3A fibronectin type III domain containing 3A -0.0202568
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0199269
BASP1 brain abundant, membrane attached signal protein 1 -0.0196861
TPI1 triosephosphate isomerase 1 -0.0193391
DDIT4 DNA-damage-inducible transcript 4 -0.0190777
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0190322
SRGN serglycin -0.0188742
DOCK5 dedicator of cytokinesis 5 -0.0188401
CALR calreticulin -0.0188029