Rosiglitazone_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

166 genes differentially expressed following the Rosiglitazone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.279008
AKAP12 A kinase (PRKA) anchor protein 12 0.213316
NAMPT nicotinamide phosphoribosyltransferase 0.197087
FNDC3B fibronectin type III domain containing 3B 0.140404
SPTBN1 spectrin, beta, non-erythrocytic 1 0.121641
AKAP13 A kinase (PRKA) anchor protein 13 0.120092
SQSTM1 sequestosome 1 0.111946
PTMA prothymosin, alpha 0.110668
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.101297
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0955711
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0939462
KTN1 kinectin 1 (kinesin receptor) 0.0915989
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0913931
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0900159
USP9X ubiquitin specific peptidase 9, X-linked 0.0851415
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0812518
ASPH aspartate beta-hydroxylase 0.0765841
ANXA2 annexin A2 0.0761179
GRB10 growth factor receptor-bound protein 10 0.0724265
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0723772
NAP1L1 nucleosome assembly protein 1-like 1 0.0689013
S100A6 S100 calcium binding protein A6 0.0684865
FAM13A family with sequence similarity 13, member A 0.0672641
LMTK2 lemur tyrosine kinase 2 0.0666681
PTK2 protein tyrosine kinase 2 0.0645483
MYH9 myosin, heavy chain 9, non-muscle 0.0636815
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.061733
VEZT vezatin, adherens junctions transmembrane protein 0.0615895
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0614325
B2M beta-2-microglobulin 0.0613989
HELZ helicase with zinc finger 0.0613183
UGCG UDP-glucose ceramide glucosyltransferase 0.0591603
RNF145 ring finger protein 145 0.0575768
ERRFI1 ERBB receptor feedback inhibitor 1 0.0537732
KMT2C lysine (K)-specific methyltransferase 2C 0.0536006
COL8A1 collagen, type VIII, alpha 1 0.0522829
RIOK3 RIO kinase 3 0.0517341
FTH1 ferritin, heavy polypeptide 1 0.0508469
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0506173
RLF rearranged L-myc fusion 0.0492751
ERBIN erbb2 interacting protein 0.0477387
ELL2 elongation factor, RNA polymerase II, 2 0.0477102
ZNF207 zinc finger protein 207 0.044835
LDHA lactate dehydrogenase A 0.0421902
RORA RAR-related orphan receptor A 0.0403739
ATP13A3 ATPase type 13A3 0.0399578
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0398826
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0396976
ZFAND3 zinc finger, AN1-type domain 3 0.0387322
TMSB10 thymosin beta 10 0.0385556
VIM vimentin 0.037765
BZW1 basic leucine zipper and W2 domains 1 0.036775
RUNX1 runt-related transcription factor 1 0.0352631
SBF2 SET binding factor 2 0.0334067
TBC1D12 TBC1 domain family, member 12 0.0319982
FAM107B family with sequence similarity 107, member B 0.0306996
GPHN gephyrin 0.0284406
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.028067
KMT2E lysine (K)-specific methyltransferase 2E 0.0265776
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0259004
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0239085
EPS8 epidermal growth factor receptor pathway substrate 8 0.023493
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0225304
LOC112694756 uncharaterized LOC112694756 0.0220665
DSCAM Down syndrome cell adhesion molecule 0.0211605
NDRG1 N-myc downstream regulated 1 0.0199268
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0176036
UBE2K ubiquitin-conjugating enzyme E2K 0.0172632
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0171534
CXCL8 chemokine (C-X-C motif) ligand 8 0.0171325
DST dystonin 0.0167514
MYO1E myosin IE 0.016401
BIRC6 baculoviral IAP repeat containing 6 0.0159479
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0156358
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0155105
EZR ezrin 0.0138825
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0128171
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0119792
IGF1R insulin-like growth factor 1 receptor 0.0115746
IPO7 importin 7 0.0105935
PRRC2C proline-rich coiled-coil 2C 0.0105884
RBM39 RNA binding motif protein 39 0.0104596
PARD3 par-3 family cell polarity regulator 0.0100376
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00865481
GARS1 glycyl-tRNA synthetase 1 0.00812377
CALR calreticulin 0.00661886
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00604765
FNDC3A fibronectin type III domain containing 3A 0.00530402
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00427222
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00365949
MT2A metallothionein 2A 0.00285052
FTL ferritin, light polypeptide 0.0015934
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00137202

decreased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 -0.206678
TPT1 tumor protein, translationally-controlled 1 -0.124127
HMGA2 high mobility group AT-hook 2 -0.123503
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.113829
VCL vinculin -0.110541
SMYD3 SET and MYND domain containing 3 -0.11025
HDLBP high density lipoprotein binding protein -0.101156
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.100074
LAMB3 laminin, beta 3 -0.0900183
TRIO trio Rho guanine nucleotide exchange factor -0.0896172
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.089486
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0863897
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0821005
DIAPH2 diaphanous-related formin 2 -0.0738565
DOCK4 dedicator of cytokinesis 4 -0.0728501
FN1 fibronectin 1 -0.0711475
STC1 stanniocalcin 1 -0.0703532
PDE10A phosphodiesterase 10A -0.0685509
RBM25 RNA binding motif protein 25 -0.0657831
ZNF292 zinc finger protein 292 -0.0625933
RPL23 ribosomal protein L23 -0.0610281
IGF2 insulin-like growth factor 2 -0.0542609
ENO1 enolase 1, (alpha) -0.0512541
SAMD4A sterile alpha motif domain containing 4A -0.0498308
RPS25 ribosomal protein S25 -0.0485162
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0478383
NALF1 NALCN channel auxiliary factor 1 -0.0472256
LOC102724023 ES1 protein homolog, mitochondrial -0.0425252
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.04133
KIF5B kinesin family member 5B -0.0413011
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0404504
PRKCA protein kinase C, alpha -0.0382722
NAV2 neuron navigator 2 -0.0380131
RPS19 ribosomal protein S19 -0.0341553
GOLGA4 golgin A4 -0.0331547
MORF4L2 mortality factor 4 like 2 -0.0330269
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0323588
IGFBP3 insulin-like growth factor binding protein 3 -0.0318271
EFNA5 ephrin-A5 -0.0308195
TXNIP thioredoxin interacting protein -0.0307793
CDH13 cadherin 13 -0.0307633
RPLP1 ribosomal protein, large, P1 -0.0282056
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0274276
PSD3 pleckstrin and Sec7 domain containing 3 -0.0272575
EEF2 eukaryotic translation elongation factor 2 -0.0266791
ETNK1 ethanolamine kinase 1 -0.0264323
SLTM SAFB-like, transcription modulator -0.0243521
RPL34 ribosomal protein L34 -0.0234953
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0232339
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0220139
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.021306
PDLIM5 PDZ and LIM domain 5 -0.0187512
FLNB filamin B, beta -0.0180752
ANKRD12 ankyrin repeat domain 12 -0.0180359
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0177782
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0161781
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0148693
CANX calnexin -0.0144283
RPLP2 ribosomal protein, large, P2 -0.0113457
MYOF myoferlin -0.010898
RPS6 ribosomal protein S6 -0.0106386
MCL1 myeloid cell leukemia 1 -0.00996434
PKM pyruvate kinase, muscle -0.00987092
VMP1 vacuole membrane protein 1 -0.00834439
POTEF POTE ankyrin domain family, member F -0.00614886
RPS8 ribosomal protein S8 -0.00415411
USP47 ubiquitin specific peptidase 47 -0.00282649
RPL26 ribosomal protein L26 -0.00245877
KYNU kynureninase -0.00245701
RPL11 ribosomal protein L11 -0.0013459
RPS12 ribosomal protein S12 -9.40122E-4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -6.67279E-4
RPL37A ribosomal protein L37a -3.33875E-5