Rosiglitazone_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.115454
GOLGA4 golgin A4 0.0975053
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0826831
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0803433
TMSB4X thymosin beta 4, X-linked 0.0704289
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0629729
SAMD4A sterile alpha motif domain containing 4A 0.0613917
SOX6 SRY (sex determining region Y)-box 6 0.0569756
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0520997
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0491399
ELOVL5 ELOVL fatty acid elongase 5 0.0482006
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0461739
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0457966
ZFAND3 zinc finger, AN1-type domain 3 0.0451348
PHF3 PHD finger protein 3 0.0437052
EEF2 eukaryotic translation elongation factor 2 0.0436931
TGFBR3 transforming growth factor, beta receptor III 0.0436549
EZR ezrin 0.0434284
PNISR PNN-interacting serine/arginine-rich protein 0.0433193
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0419536
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0417506
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0404194
TXNRD1 thioredoxin reductase 1 0.0397792
RB1CC1 RB1-inducible coiled-coil 1 0.0394246
MSI2 musashi RNA-binding protein 2 0.0387997
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0375282
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0372913
CRY1 cryptochrome circadian clock 1 0.0372513
TMF1 TATA element modulatory factor 1 0.036913
SRRM2 serine/arginine repetitive matrix 2 0.036544
VMP1 vacuole membrane protein 1 0.0359877
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0348601
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0343706
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0336485
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0336001
TTC3 tetratricopeptide repeat domain 3 0.0331885
APP amyloid beta (A4) precursor protein 0.0323637
EPS8 epidermal growth factor receptor pathway substrate 8 0.0321849
PRRC2C proline-rich coiled-coil 2C 0.0316835
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0310797
TOP1 topoisomerase (DNA) I 0.0310054
ANK2 ankyrin 2, neuronal 0.0307678
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0305571
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0301036
MATR3 matrin 3 0.0300408
KMT2E lysine (K)-specific methyltransferase 2E 0.0297727
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0297611
COG5 component of oligomeric golgi complex 5 0.029535
RPL14 ribosomal protein L14 0.0293381
ZC3H11A zinc finger CCCH-type containing 11A 0.029277
IWS1 IWS1 homolog (S. cerevisiae) 0.0289135
ZEB1 zinc finger E-box binding homeobox 1 0.0285992
CSDE1 cold shock domain containing E1, RNA-binding 0.0284987
CPED1 cadherin-like and PC-esterase domain containing 1 0.0284716
ITSN2 intersectin 2 0.0284653
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282669
RAB2A RAB2A, member RAS oncogene family 0.0281646
NKTR natural killer cell triggering receptor 0.0278969
AHI1 Abelson helper integration site 1 0.027714
THOC2 THO complex 2 0.0275517
SQSTM1 sequestosome 1 0.0275282
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0274287
ARHGAP5 Rho GTPase activating protein 5 0.0274052
EIF4B eukaryotic translation initiation factor 4B 0.0273711
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0273422
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0273221
NARS1 asparaginyl-tRNA synthetase 1 0.0271487
SPAG9 sperm associated antigen 9 0.026364
GIGYF2 GRB10 interacting GYF protein 2 0.0263468
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0259164
FNIP1 folliculin interacting protein 1 0.0258632
HDAC9 histone deacetylase 9 0.0255699
HMGB2 high mobility group box 2 0.025478
ZNF292 zinc finger protein 292 0.0252814
OGA O-GlcNAcase 0.0250509
PLXNA1 plexin A1 0.0247171
SERINC1 serine incorporator 1 0.0246058
CLIP1 CAP-GLY domain containing linker protein 1 0.024419
MAPK8 mitogen-activated protein kinase 8 0.0243816
TARS1 threonyl-tRNA synthetase 1 0.0242078
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0241549
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0240669
BIRC6 baculoviral IAP repeat containing 6 0.024032
SCAF8 SR-related CTD-associated factor 8 0.0239789
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0237407
ANKRD17 ankyrin repeat domain 17 0.0236403
SMNDC1 survival motor neuron domain containing 1 0.0234435
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0234184
KIF5B kinesin family member 5B 0.023209
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0230667
KLF6 Kruppel-like factor 6 0.0226556
GOLGB1 golgin B1 0.0223402
AOPEP aminopeptidase O (putative) 0.0223195
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0222731
CHD7 chromodomain helicase DNA binding protein 7 0.0222386
MDN1 MDN1, midasin homolog (yeast) 0.0221038
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0220718
GOLGA2 golgin A2 0.0220261
CLIP2 CAP-GLY domain containing linker protein 2 0.0220135
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0219354

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.329521
PKM pyruvate kinase, muscle -0.167201
PTMA prothymosin, alpha -0.107459
ACTG1 actin gamma 1 -0.0985116
PFN1 profilin 1 -0.0959441
RPL35A ribosomal protein L35a -0.0850241
BMP10 bone morphogenetic protein 10 -0.0811848
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0694996
RPS19 ribosomal protein S19 -0.0684855
RPL34 ribosomal protein L34 -0.064397
RPLP1 ribosomal protein, large, P1 -0.0637076
FOXP1 forkhead box P1 -0.0600409
AHNAK AHNAK nucleoprotein -0.0594882
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0591521
RPS23 ribosomal protein S23 -0.0558773
TPT1 tumor protein, translationally-controlled 1 -0.0542384
VCL vinculin -0.0539959
ARL4C ADP-ribosylation factor-like 4C -0.0507059
S100A4 S100 calcium binding protein A4 -0.0504243
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0488742
MACROD2 MACRO domain containing 2 -0.0477464
GLI3 GLI family zinc finger 3 -0.0474831
POTEF POTE ankyrin domain family, member F -0.0464043
EGFR epidermal growth factor receptor -0.0458437
HMGA1 high mobility group AT-hook 1 -0.04569
HSPB1 heat shock 27kDa protein 1 -0.045436
RPS8 ribosomal protein S8 -0.0452272
RPS24 ribosomal protein S24 -0.0449479
LOC102724023 ES1 protein homolog, mitochondrial -0.0445224
SMC4 structural maintenance of chromosomes 4 -0.0436831
RPL12 ribosomal protein L12 -0.0428001
RPS21 ribosomal protein S21 -0.0418879
RHOA ras homolog family member A -0.0407882
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0406857
S100A10 S100 calcium binding protein A10 -0.0401917
RPL31 ribosomal protein L31 -0.0399162
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0395251
RPLP2 ribosomal protein, large, P2 -0.039454
CCND1 cyclin D1 -0.0393057
RPS11 ribosomal protein S11 -0.0390418
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0382097
RPS14 ribosomal protein S14 -0.0379532
RPS13 ribosomal protein S13 -0.037727
HEG1 heart development protein with EGF-like domains 1 -0.037423
KPNB1 karyopherin (importin) beta 1 -0.0371469
RPL28 ribosomal protein L28 -0.0365864
SDK1 sidekick cell adhesion molecule 1 -0.0363851
RPS4X ribosomal protein S4, X-linked -0.0361724
FUS FUS RNA binding protein -0.0359872
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0356888
GLI2 GLI family zinc finger 2 -0.0345181
RPL36A ribosomal protein L36a -0.0338995
ASTN2 astrotactin 2 -0.0335459
GSE1 Gse1 coiled-coil protein -0.0332437
S100A9 S100 calcium binding protein A9 -0.0327829
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0327022
RPL19 ribosomal protein L19 -0.0324455
BZW2 basic leucine zipper and W2 domains 2 -0.0319656
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0319358
PDE4D phosphodiesterase 4D, cAMP-specific -0.0317764
RPL36 ribosomal protein L36 -0.0315654
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0313202
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0305816
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0304233
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0303067
PRUNE2 prune homolog 2 (Drosophila) -0.0300073
RPS25 ribosomal protein S25 -0.029744
CAMKMT calmodulin-lysine N-methyltransferase -0.0296207
FTL ferritin, light polypeptide -0.0291617
RPL27A ribosomal protein L27a -0.0290707
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0288725
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.028862
PRDX2 peroxiredoxin 2 -0.0288323
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0288321
DIAPH3 diaphanous-related formin 3 -0.0287078
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0286464
FHIT fragile histidine triad -0.0283879
GNAS GNAS complex locus -0.0282351
RPS15 ribosomal protein S15 -0.0282027
RPS16 ribosomal protein S16 -0.0281894
RPL9 ribosomal protein L9 -0.0281246
XPO1 exportin 1 -0.0278915
TJP1 tight junction protein 1 -0.0278412
MYO5C myosin VC -0.0277697
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0277213
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.027605
TMSB10 thymosin beta 10 -0.0270492
SSBP2 single-stranded DNA binding protein 2 -0.0261551
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0260349
RPL8 ribosomal protein L8 -0.0260284
LOC112694756 uncharaterized LOC112694756 -0.0256599
TAOK1 TAO kinase 1 -0.025583
TSC22D1 TSC22 domain family, member 1 -0.025428
TAS2R14 taste receptor, type 2, member 14 -0.0246613
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0244869
EXOC4 exocyst complex component 4 -0.0239496
RPLP0 ribosomal protein, large, P0 -0.0239087
DENND4C DENN/MADD domain containing 4C -0.0238726
PYGB phosphorylase, glycogen; brain -0.0238477
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0238181