Rosiglitazone_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.115992
FNDC3B fibronectin type III domain containing 3B 0.100347
FN1 fibronectin 1 0.0955536
UGCG UDP-glucose ceramide glucosyltransferase 0.0746534
MSN moesin 0.0660164
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0653449
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0638576
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0627469
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0623178
CENPF centromere protein F, 350/400kDa 0.0621171
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0576659
NAV2 neuron navigator 2 0.0571922
PLIN2 perilipin 2 0.0565823
ELL2 elongation factor, RNA polymerase II, 2 0.0554362
RB1CC1 RB1-inducible coiled-coil 1 0.0527934
RTN4 reticulon 4 0.0523478
MKI67 marker of proliferation Ki-67 0.0506187
MYH9 myosin, heavy chain 9, non-muscle 0.0462863
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.045803
USP9X ubiquitin specific peptidase 9, X-linked 0.0413686
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0410661
TNIP1 TNFAIP3 interacting protein 1 0.0405964
ZNF292 zinc finger protein 292 0.0393561
OGA O-GlcNAcase 0.0389234
TENT5A terminal nucleotidyltransferase 5A 0.0382232
SOD2 superoxide dismutase 2, mitochondrial 0.038139
LAMP2 lysosomal-associated membrane protein 2 0.0379356
CCNL1 cyclin L1 0.0369186
SPAG9 sperm associated antigen 9 0.0363654
SBF2 SET binding factor 2 0.0361805
ARRDC3 arrestin domain containing 3 0.0358867
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0352887
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0351882
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0350409
CKAP5 cytoskeleton associated protein 5 0.0345293
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0339124
KDM6A lysine (K)-specific demethylase 6A 0.0331772
DIAPH3 diaphanous-related formin 3 0.0329978
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0319215
PCBP2 poly(rC) binding protein 2 0.0314029
MATR3 matrin 3 0.0312294
ANLN anillin, actin binding protein 0.0312017
UBA6 ubiquitin-like modifier activating enzyme 6 0.0311288
TXNRD1 thioredoxin reductase 1 0.0310344
EZR ezrin 0.0300871
TPX2 TPX2, microtubule-associated 0.0276672
NRIP1 nuclear receptor interacting protein 1 0.0273926
KIF4A kinesin family member 4A 0.0273748
GOLGA4 golgin A4 0.0273098
ARF4 ADP-ribosylation factor 4 0.0272403
FUBP1 far upstream element (FUSE) binding protein 1 0.0266518
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0260864
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0256852
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0252823
TXNIP thioredoxin interacting protein 0.0251538
AHR aryl hydrocarbon receptor 0.0249554
JMJD1C jumonji domain containing 1C 0.0248819
MXI1 MAX interactor 1, dimerization protein 0.0247715
PHIP pleckstrin homology domain interacting protein 0.0246543
BCLAF1 BCL2-associated transcription factor 1 0.0239804
SMC4 structural maintenance of chromosomes 4 0.0239466
PTBP3 polypyrimidine tract binding protein 3 0.0239064
ANXA5 annexin A5 0.0236895
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0233115
TSC22D2 TSC22 domain family, member 2 0.023309
OSMR oncostatin M receptor 0.0229999
SCAF11 SR-related CTD-associated factor 11 0.0229038
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0226583
FBXL5 F-box and leucine-rich repeat protein 5 0.0221037
CDCP1 CUB domain containing protein 1 0.0220916
DSCAM Down syndrome cell adhesion molecule 0.0217178
KIF11 kinesin family member 11 0.0215485
SERINC1 serine incorporator 1 0.0214482
BRWD3 bromodomain and WD repeat domain containing 3 0.0211013
RASA2 RAS p21 protein activator 2 0.0211002
ADAR adenosine deaminase, RNA-specific 0.0210136
IPO7 importin 7 0.0209535
NEK7 NIMA-related kinase 7 0.0209361
CHD1 chromodomain helicase DNA binding protein 1 0.0207836
BIRC2 baculoviral IAP repeat containing 2 0.0205014
TM9SF3 transmembrane 9 superfamily member 3 0.0203418
DENND4C DENN/MADD domain containing 4C 0.0203385
AFDN afadin, adherens junction formation factor 0.020324
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0202403
ADAM17 ADAM metallopeptidase domain 17 0.0201316
FTH1 ferritin, heavy polypeptide 1 0.020127
BIRC6 baculoviral IAP repeat containing 6 0.0198331
RLF rearranged L-myc fusion 0.0198301
SNX3 sorting nexin 3 0.0198263
MAPK14 mitogen-activated protein kinase 14 0.0197545
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0196996
KLF6 Kruppel-like factor 6 0.0196523
DSTN destrin (actin depolymerizing factor) 0.0196366
EEF2 eukaryotic translation elongation factor 2 0.0196115
SYAP1 synapse associated protein 1 0.0195238
MIS18BP1 MIS18 binding protein 1 0.0192485
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.019107
TPM3 tropomyosin 3 0.0190989
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0189973
CKAP2 cytoskeleton associated protein 2 0.0189929

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.227723
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.173483
HLA-B major histocompatibility complex, class I, B -0.151137
GLIS3 GLIS family zinc finger 3 -0.14122
TMSB10 thymosin beta 10 -0.128662
FRMD4A FERM domain containing 4A -0.127646
HMGA2 high mobility group AT-hook 2 -0.113668
IER3 immediate early response 3 -0.111631
IGFBP3 insulin-like growth factor binding protein 3 -0.110451
FTL ferritin, light polypeptide -0.0992702
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0992302
MT2A metallothionein 2A -0.0986429
COL6A3 collagen, type VI, alpha 3 -0.0968657
NDRG1 N-myc downstream regulated 1 -0.0959003
TPT1 tumor protein, translationally-controlled 1 -0.0915583
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0851147
CDH13 cadherin 13 -0.0781908
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0670504
AKAP12 A kinase (PRKA) anchor protein 12 -0.0659309
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0627128
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0592929
RPL37A ribosomal protein L37a -0.0586401
COL5A1 collagen, type V, alpha 1 -0.0583507
RPS12 ribosomal protein S12 -0.0568142
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.056513
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0564988
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0550548
AHNAK AHNAK nucleoprotein -0.0534849
CD44 CD44 molecule (Indian blood group) -0.0533932
INTS6 integrator complex subunit 6 -0.0532672
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0528803
HLA-A major histocompatibility complex, class I, A -0.0514169
TMEM132D transmembrane protein 132D -0.0511705
RPS24 ribosomal protein S24 -0.0511606
RAB7A RAB7A, member RAS oncogene family -0.0509444
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0509158
RPS3 ribosomal protein S3 -0.0486762
EGFR epidermal growth factor receptor -0.0483385
SDK1 sidekick cell adhesion molecule 1 -0.0479846
TGFBI transforming growth factor, beta-induced, 68kDa -0.0475012
RPS8 ribosomal protein S8 -0.0472812
PGK1 phosphoglycerate kinase 1 -0.046785
SFRP1 secreted frizzled-related protein 1 -0.0460679
RAI14 retinoic acid induced 14 -0.0460379
DIAPH2 diaphanous-related formin 2 -0.0459461
RPLP2 ribosomal protein, large, P2 -0.0440951
RPL35A ribosomal protein L35a -0.0440198
RPS6 ribosomal protein S6 -0.0431268
CTSD cathepsin D -0.0428654
PTMA prothymosin, alpha -0.0422249
SQSTM1 sequestosome 1 -0.0418262
SLC38A1 solute carrier family 38, member 1 -0.0417107
HDAC9 histone deacetylase 9 -0.0416882
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0410986
PTPRK protein tyrosine phosphatase, receptor type, K -0.0410258
RPL9 ribosomal protein L9 -0.0406485
CANX calnexin -0.0400278
LOX lysyl oxidase -0.0390809
AFF3 AF4/FMR2 family, member 3 -0.0381799
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0376641
ADAM12 ADAM metallopeptidase domain 12 -0.0370662
SAMD3 sterile alpha motif domain containing 3 -0.0368289
ZMYND8 zinc finger, MYND-type containing 8 -0.0368203
FRMPD4 FERM and PDZ domain containing 4 -0.0367489
BICC1 BicC family RNA binding protein 1 -0.0366466
RND3 Rho family GTPase 3 -0.0365604
EXT1 exostosin glycosyltransferase 1 -0.0365201
CALR calreticulin -0.0364405
SMYD3 SET and MYND domain containing 3 -0.0363453
EPAS1 endothelial PAS domain protein 1 -0.0362344
RPLP1 ribosomal protein, large, P1 -0.0361084
IFITM3 interferon induced transmembrane protein 3 -0.036097
RPL23 ribosomal protein L23 -0.0350886
RPL36 ribosomal protein L36 -0.0349455
EFNA5 ephrin-A5 -0.0347713
MACF1 microtubule-actin crosslinking factor 1 -0.0346829
FBXL7 F-box and leucine-rich repeat protein 7 -0.0339559
TRIO trio Rho guanine nucleotide exchange factor -0.0337709
PRKCA protein kinase C, alpha -0.0334947
BASP1 brain abundant, membrane attached signal protein 1 -0.0330569
GNAS GNAS complex locus -0.0323058
NAP1L1 nucleosome assembly protein 1-like 1 -0.0320494
CTSB cathepsin B -0.0316899
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.031668
RPL19 ribosomal protein L19 -0.0314206
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0313808
MBD5 methyl-CpG binding domain protein 5 -0.0313269
LOC112694756 uncharaterized LOC112694756 -0.031041
PDE10A phosphodiesterase 10A -0.0307783
RPS27A ribosomal protein S27a -0.0306264
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0302821
TENM2 teneurin transmembrane protein 2 -0.0300762
NAV1 neuron navigator 1 -0.0297117
RPL32 ribosomal protein L32 -0.0296743
ARL4C ADP-ribosylation factor-like 4C -0.0293762
NRN1 neuritin 1 -0.0291467
BNC2 basonuclin 2 -0.0290496
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0290347
RPL36A ribosomal protein L36a -0.0289236
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0289062