Rosiglitazone_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0700491
FNDC3B fibronectin type III domain containing 3B 0.0541743
MSN moesin 0.0443058
ATP13A3 ATPase type 13A3 0.0399951
PDE4D phosphodiesterase 4D, cAMP-specific 0.0352908
IL6 interleukin 6 0.032706
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.032589
KDM6A lysine (K)-specific demethylase 6A 0.032193
FNDC3A fibronectin type III domain containing 3A 0.0317733
RNF145 ring finger protein 145 0.0311271
TRIO trio Rho guanine nucleotide exchange factor 0.0286959
CYLD cylindromatosis (turban tumor syndrome) 0.0282949
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0278268
KAZN kazrin, periplakin interacting protein 0.027349
NBAS neuroblastoma amplified sequence 0.0262326
NAMPT nicotinamide phosphoribosyltransferase 0.025928
NAV2 neuron navigator 2 0.0257443
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0256363
EEF2 eukaryotic translation elongation factor 2 0.0254107
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252334
CHD1 chromodomain helicase DNA binding protein 1 0.0242498
KLF7 Kruppel-like factor 7 (ubiquitous) 0.023897
JARID2 jumonji, AT rich interactive domain 2 0.0227432
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0223062
EGFR epidermal growth factor receptor 0.0219365
DSCAM Down syndrome cell adhesion molecule 0.0214865
AFDN afadin, adherens junction formation factor 0.0212338
FLNB filamin B, beta 0.021191
NKTR natural killer cell triggering receptor 0.0205017
MAML2 mastermind-like 2 (Drosophila) 0.0202833
SNX13 sorting nexin 13 0.020231
CCNL1 cyclin L1 0.0200516
KDM4C lysine (K)-specific demethylase 4C 0.0196059
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0195936
ITGA6 integrin, alpha 6 0.0193507
RNF213 ring finger protein 213 0.0192484
GOLGA4 golgin A4 0.0192188
EFNA5 ephrin-A5 0.0187934
TENT2 terminal nucleotidyltransferase 2 0.0182519
RBM26 RNA binding motif protein 26 0.0180849
EZR ezrin 0.0180057
LIMA1 LIM domain and actin binding 1 0.0179887
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0179087
LSAMP limbic system-associated membrane protein 0.0179017
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0176782
MICU1 mitochondrial calcium uptake 1 0.017302
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0172788
ZFP36L1 ZFP36 ring finger protein-like 1 0.0172704
RB1CC1 RB1-inducible coiled-coil 1 0.0171336
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0170707
ARRDC3 arrestin domain containing 3 0.0168198
DENND4C DENN/MADD domain containing 4C 0.0167649
SEC24B SEC24 family member B 0.0167378
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0167219
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0166194
NKD1 naked cuticle homolog 1 (Drosophila) 0.0165854
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0165708
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0164023
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0163652
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0163229
ADAM17 ADAM metallopeptidase domain 17 0.0163024
METTL15 methyltransferase like 15 0.0162605
PDE8A phosphodiesterase 8A 0.016253
TPM3 tropomyosin 3 0.0161913
ZCCHC7 zinc finger, CCHC domain containing 7 0.016186
GLS2 glutaminase 2 (liver, mitochondrial) 0.016162
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0160044
PDIA6 protein disulfide isomerase family A, member 6 0.0159035
SRPK2 SRSF protein kinase 2 0.015882
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0158177
SPNS1 spinster homolog 1 (Drosophila) 0.0157906
ARHGAP24 Rho GTPase activating protein 24 0.0156906
TNPO3 transportin 3 0.0156889
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.015591
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0155124
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.015511
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0154335
HYOU1 hypoxia up-regulated 1 0.0148824
UBXN4 UBX domain protein 4 0.0147595
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.014667
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0146548
BIRC3 baculoviral IAP repeat containing 3 0.0146435
ESYT2 extended synaptotagmin-like protein 2 0.014615
RNF216 ring finger protein 216 0.0145459
SPPL3 signal peptide peptidase like 3 0.0144351
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.014398
PNISR PNN-interacting serine/arginine-rich protein 0.0143695
SEC13 SEC13 homolog (S. cerevisiae) 0.0143369
SETX senataxin 0.0143186
ZMYND8 zinc finger, MYND-type containing 8 0.01428
MMP12 matrix metallopeptidase 12 0.0142082
ITCH itchy E3 ubiquitin protein ligase 0.0141909
ZMYM2 zinc finger, MYM-type 2 0.0141759
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0141492
RBM33 RNA binding motif protein 33 0.0140761
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0140414
PTK2 protein tyrosine kinase 2 0.0140375
RUNX1 runt-related transcription factor 1 0.014031
THOC2 THO complex 2 0.0140246
CEP350 centrosomal protein 350kDa 0.013825

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266605
MT2A metallothionein 2A -0.133694
TMSB10 thymosin beta 10 -0.0993589
HLA-B major histocompatibility complex, class I, B -0.0922645
TGFBI transforming growth factor, beta-induced, 68kDa -0.090448
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0842202
COL6A3 collagen, type VI, alpha 3 -0.0717471
VIM vimentin -0.0687521
LOXL2 lysyl oxidase-like 2 -0.0634639
IGFBP3 insulin-like growth factor binding protein 3 -0.0605311
COL1A1 collagen, type I, alpha 1 -0.0602548
LOC112694756 uncharaterized LOC112694756 -0.0575992
PTMA prothymosin, alpha -0.0572127
FN1 fibronectin 1 -0.0557772
HLA-C major histocompatibility complex, class I, C -0.0541875
SDC4 syndecan 4 -0.052078
COL1A2 collagen, type I, alpha 2 -0.0482857
COL6A2 collagen, type VI, alpha 2 -0.0470149
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0468668
LOX lysyl oxidase -0.0468378
PRSS23 protease, serine, 23 -0.0464172
HLA-A major histocompatibility complex, class I, A -0.0456843
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0447747
HDLBP high density lipoprotein binding protein -0.0393884
CD44 CD44 molecule (Indian blood group) -0.0393155
COL6A1 collagen, type VI, alpha 1 -0.0391381
S100A10 S100 calcium binding protein A10 -0.038606
ELL2 elongation factor, RNA polymerase II, 2 -0.0379104
B2M beta-2-microglobulin -0.0378003
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0374101
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0370862
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0369375
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0347436
AKAP9 A kinase (PRKA) anchor protein 9 -0.0342598
VCL vinculin -0.0342385
LMAN1 lectin, mannose-binding, 1 -0.0333809
EIF1 eukaryotic translation initiation factor 1 -0.0331969
VDAC1 voltage-dependent anion channel 1 -0.032906
ACTG1 actin gamma 1 -0.0317657
SEC24D SEC24 family member D -0.0313562
CAVIN1 caveolae associated protein 1 -0.0306809
CALU calumenin -0.0301234
ANXA2 annexin A2 -0.0299706
RPL28 ribosomal protein L28 -0.0285593
BSG basigin (Ok blood group) -0.0284658
GNAS GNAS complex locus -0.028143
LDHA lactate dehydrogenase A -0.028051
HMGB1 high mobility group box 1 -0.0280489
CAV1 caveolin 1, caveolae protein, 22kDa -0.0278603
FTL ferritin, light polypeptide -0.0278377
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0277433
NAV1 neuron navigator 1 -0.0277003
FUS FUS RNA binding protein -0.0274889
AHNAK AHNAK nucleoprotein -0.027248
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0269615
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0268657
CLIC4 chloride intracellular channel 4 -0.0263971
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0263604
TUBB tubulin, beta class I -0.0260904
MYOF myoferlin -0.0255352
RPS23 ribosomal protein S23 -0.0255159
RPL34 ribosomal protein L34 -0.0255025
ARF1 ADP-ribosylation factor 1 -0.0253443
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.025236
AFF4 AF4/FMR2 family, member 4 -0.0248554
HM13 histocompatibility (minor) 13 -0.0248113
CCNI cyclin I -0.0246115
MT1X metallothionein 1X -0.0244559
FTH1 ferritin, heavy polypeptide 1 -0.0243347
MAP1B microtubule-associated protein 1B -0.0243013
NDRG1 N-myc downstream regulated 1 -0.0242916
S100A9 S100 calcium binding protein A9 -0.0241453
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0239684
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0239579
UBC ubiquitin C -0.0236944
THY1 Thy-1 cell surface antigen -0.0235873
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0234214
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0231618
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0226013
DPYD dihydropyrimidine dehydrogenase -0.0223318
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0222119
KLHDC10 kelch domain containing 10 -0.0220932
SRP54 signal recognition particle 54kDa -0.0218549
EMP1 epithelial membrane protein 1 -0.0217232
ASPH aspartate beta-hydroxylase -0.021299
ZNF217 zinc finger protein 217 -0.0210521
TAS2R14 taste receptor, type 2, member 14 -0.0208533
TPM4 tropomyosin 4 -0.0208208
OGA O-GlcNAcase -0.0208042
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0207079
POTEF POTE ankyrin domain family, member F -0.0205585
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0203584
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0203311
PMM2 phosphomannomutase 2 -0.020256
PSD3 pleckstrin and Sec7 domain containing 3 -0.0202458
TPT1 tumor protein, translationally-controlled 1 -0.020205
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0200453
RBM39 RNA binding motif protein 39 -0.0198975
GLIS3 GLIS family zinc finger 3 -0.0195814
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0195235