Rosiglitazone_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rosiglitazone perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rosiglitazone_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.173167
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.129829
TRIO trio Rho guanine nucleotide exchange factor 0.0783141
CD109 CD109 molecule 0.0672915
CANX calnexin 0.0647937
CXCL8 chemokine (C-X-C motif) ligand 8 0.0645464
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0613459
FAM13A family with sequence similarity 13, member A 0.0611666
AHR aryl hydrocarbon receptor 0.0556786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0555956
SQSTM1 sequestosome 1 0.0553821
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0543827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0542827
FNDC3B fibronectin type III domain containing 3B 0.0541726
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0515953
MARCHF6 membrane associated ring-CH-type finger 6 0.0498636
ZNF292 zinc finger protein 292 0.0496643
HELZ helicase with zinc finger 0.0463283
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0430104
SEC23A Sec23 homolog A (S. cerevisiae) 0.0427209
TMSB4X thymosin beta 4, X-linked 0.0414083
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0406894
AFDN afadin, adherens junction formation factor 0.0380247
PLIN2 perilipin 2 0.037086
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.036862
CENPF centromere protein F, 350/400kDa 0.0367178
PUM2 pumilio RNA-binding family member 2 0.0353731
OGA O-GlcNAcase 0.0349272
CEP350 centrosomal protein 350kDa 0.0348751
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0346581
SOD2 superoxide dismutase 2, mitochondrial 0.0346241
CLTC clathrin, heavy chain (Hc) 0.0344744
SPAG9 sperm associated antigen 9 0.0342061
SUCO SUN domain containing ossification factor 0.0338893
LCORL ligand dependent nuclear receptor corepressor-like 0.0335562
KDM5B lysine (K)-specific demethylase 5B 0.0334516
PRRC2C proline-rich coiled-coil 2C 0.0332148
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0330909
DENND4C DENN/MADD domain containing 4C 0.0325363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0321475
NRG1 neuregulin 1 0.0312548
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0311411
COPA coatomer protein complex, subunit alpha 0.0306574
PTK2 protein tyrosine kinase 2 0.0306069
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0304079
INSIG2 insulin induced gene 2 0.0301095
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0300507
TPR translocated promoter region, nuclear basket protein 0.0297949
CDC73 cell division cycle 73 0.0297705
IRAK3 interleukin-1 receptor-associated kinase 3 0.0296762
GRB10 growth factor receptor-bound protein 10 0.0294981
APP amyloid beta (A4) precursor protein 0.0292384
RAD21 RAD21 homolog (S. pombe) 0.0291804
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0289759
TENT2 terminal nucleotidyltransferase 2 0.0288262
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0286709
ENO1 enolase 1, (alpha) 0.0286273
RICTOR RPTOR independent companion of MTOR, complex 2 0.0286052
DOCK5 dedicator of cytokinesis 5 0.0282056
SNX13 sorting nexin 13 0.0281599
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0279681
WAC WW domain containing adaptor with coiled-coil 0.027876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0276192
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.02748
SMOX spermine oxidase 0.0274317
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0272015
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0269535
BZW1 basic leucine zipper and W2 domains 1 0.0267205
PRELID2 PRELI domain containing 2 0.0263604
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0259812
QKI QKI, KH domain containing, RNA binding 0.0254913
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.025146
DENND5B DENN/MADD domain containing 5B 0.0250812
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0248614
EFNA5 ephrin-A5 0.0248022
KTN1 kinectin 1 (kinesin receptor) 0.0247708
RUNX2 runt-related transcription factor 2 0.0246495
COG5 component of oligomeric golgi complex 5 0.0245231
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0244796
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024307
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0242202
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0239773
NEK7 NIMA-related kinase 7 0.0239019
TM9SF3 transmembrane 9 superfamily member 3 0.0238211
TTC3 tetratricopeptide repeat domain 3 0.0238053
TFG TRK-fused gene 0.0236834
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0236653
RAB18 RAB18, member RAS oncogene family 0.0235494
TBC1D22A TBC1 domain family, member 22A 0.0232551
PDIA6 protein disulfide isomerase family A, member 6 0.0232399
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0228773
ENAH enabled homolog (Drosophila) 0.022844
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0227233
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0226431
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0225711
RANBP2 RAN binding protein 2 0.0225286
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0223464
TAS2R14 taste receptor, type 2, member 14 0.022283
GOLGA4 golgin A4 0.0222518
XPO1 exportin 1 0.0221998

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.338455
MT2A metallothionein 2A -0.174431
TMSB10 thymosin beta 10 -0.0920891
FTL ferritin, light polypeptide -0.0813147
VCL vinculin -0.0689199
PTMA prothymosin, alpha -0.0670753
NTN4 netrin 4 -0.0574136
FN1 fibronectin 1 -0.0573478
ENO2 enolase 2 (gamma, neuronal) -0.0554651
NDRG1 N-myc downstream regulated 1 -0.055181
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0471805
EGR1 early growth response 1 -0.0433814
TOP1 topoisomerase (DNA) I -0.0419642
RPS19 ribosomal protein S19 -0.0414798
RPS6 ribosomal protein S6 -0.0414169
KSR1 kinase suppressor of ras 1 -0.0391765
RPLP1 ribosomal protein, large, P1 -0.0385002
PELO pelota homolog (Drosophila) -0.0377631
RPL37A ribosomal protein L37a -0.0377099
RPL35A ribosomal protein L35a -0.0375053
NRP1 neuropilin 1 -0.0372229
HLA-B major histocompatibility complex, class I, B -0.0371524
RPL9 ribosomal protein L9 -0.0371158
RPS8 ribosomal protein S8 -0.0370237
RPS12 ribosomal protein S12 -0.0366083
RPL31 ribosomal protein L31 -0.0358991
RPS27 ribosomal protein S27 -0.0343543
EXT1 exostosin glycosyltransferase 1 -0.0335559
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0329614
B2M beta-2-microglobulin -0.0325708
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0317076
RPL36 ribosomal protein L36 -0.0305477
RPL23 ribosomal protein L23 -0.0299555
RPL18 ribosomal protein L18 -0.0297445
VIM vimentin -0.0295184
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0284509
RPS3 ribosomal protein S3 -0.0284418
PKM pyruvate kinase, muscle -0.0280442
RPS16 ribosomal protein S16 -0.0279184
PALLD palladin, cytoskeletal associated protein -0.0273522
RPL12 ribosomal protein L12 -0.0269928
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0269481
YBX3 Y box binding protein 3 -0.0264859
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0260801
IFI27 interferon, alpha-inducible protein 27 -0.025647
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0249316
TPT1 tumor protein, translationally-controlled 1 -0.0248794
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0248453
RPS29 ribosomal protein S29 -0.0245939
VCAN versican -0.0244298
RPL37 ribosomal protein L37 -0.024268
RPL28 ribosomal protein L28 -0.0241988
LOC102724023 ES1 protein homolog, mitochondrial -0.0238245
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0237342
SLC38A2 solute carrier family 38, member 2 -0.0236715
FHL2 four and a half LIM domains 2 -0.0236124
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0233542
IFI6 interferon, alpha-inducible protein 6 -0.0223357
RPL36A ribosomal protein L36a -0.0222465
NDUFA4 NDUFA4, mitochondrial complex associated -0.0219909
RPL19 ribosomal protein L19 -0.0215599
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0214625
RPS27A ribosomal protein S27a -0.0213885
RPLP2 ribosomal protein, large, P2 -0.021141
HLA-A major histocompatibility complex, class I, A -0.0202593
NPAS2 neuronal PAS domain protein 2 -0.0200326
RPS25 ribosomal protein S25 -0.0199344
IFITM3 interferon induced transmembrane protein 3 -0.0196794
TGFB1 transforming growth factor, beta 1 -0.0195064
SYT1 synaptotagmin I -0.019311
TNNC1 troponin C type 1 (slow) -0.0192658
LRP5 low density lipoprotein receptor-related protein 5 -0.0185994
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0184356
TTC19 tetratricopeptide repeat domain 19 -0.018354
FERMT2 fermitin family member 2 -0.018264
PDLIM5 PDZ and LIM domain 5 -0.0177095
ACTN4 actinin, alpha 4 -0.0174024
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0171472
GNAS GNAS complex locus -0.017015
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0168886
RAB31 RAB31, member RAS oncogene family -0.0168835
SOX4 SRY (sex determining region Y)-box 4 -0.0168444
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0167504
GUK1 guanylate kinase 1 -0.0165865
RPL13A ribosomal protein L13a -0.0165276
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0164949
RAB7A RAB7A, member RAS oncogene family -0.0163861
FNBP1 formin binding protein 1 -0.0162467
FAM193A family with sequence similarity 193, member A -0.0161923
ECE1 endothelin converting enzyme 1 -0.016123
RPL35 ribosomal protein L35 -0.0160673
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0160443
RPL11 ribosomal protein L11 -0.0160297
RPS15 ribosomal protein S15 -0.0158767
RPS21 ribosomal protein S21 -0.015823
WSB1 WD repeat and SOCS box containing 1 -0.015702
HMGA1 high mobility group AT-hook 1 -0.0156272
ADAM8 ADAM metallopeptidase domain 8 -0.0155518
ATN1 atrophin 1 -0.0153587
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0152512