Rotigotine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/59227
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Genes

199 proteins with high or low expression in Rotigotine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
WWC2 WW and C2 domain containing 2 0.93
CTNND2 catenin (cadherin-associated protein), delta 2 0.79
RASA4 RAS p21 protein activator 4 0.75
ALPK3 alpha-kinase 3 0.68
F10 coagulation factor X 0.67
ABHD2 abhydrolase domain containing 2 0.65
BOK BCL2-related ovarian killer 0.56
TSPAN3 tetraspanin 3 0.52
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.49
RPGR retinitis pigmentosa GTPase regulator 0.48
TASP1 taspase, threonine aspartase, 1 0.48
TRHDE thyrotropin-releasing hormone degrading enzyme 0.48
CERK ceramide kinase 0.48
H1-0 H1.0 linker histone 0.47
RPGRIP1L RPGRIP1-like 0.45
ZFHX2 zinc finger homeobox 2 0.45
H1-2 H1.2 linker histone, cluster member 0.44
PDLIM3 PDZ and LIM domain 3 0.44
TP73 tumor protein p73 0.44
ANKRD18B ankyrin repeat domain 18B 0.43
C12ORF73 chromosome 12 open reading frame 73 0.43
TPM1 tropomyosin 1 (alpha) 0.43
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.42
PXDN peroxidasin 0.41
SARDH sarcosine dehydrogenase 0.41
SAYSD1 SAYSVFN motif domain containing 1 0.4
SET SET nuclear proto-oncogene 0.39
TUB tubby bipartite transcription factor 0.38
INTU inturned planar cell polarity protein 0.38
C17ORF53 chromosome 17 open reading frame 53 0.37
CYBA cytochrome b-245, alpha polypeptide 0.36
OSER1 oxidative stress responsive serine-rich 1 0.35
C18ORF32 chromosome 18 open reading frame 32 0.35
MCRIP2 MAPK regulated corepressor interacting protein 2 0.35
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.35
KLHL2 kelch-like family member 2 0.35
STC2 stanniocalcin 2 0.34
CREBZF CREB/ATF bZIP transcription factor 0.34
ABHD15 abhydrolase domain containing 15 0.34
FBXL16 F-box and leucine-rich repeat protein 16 0.34
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.34
CYBRD1 cytochrome b reductase 1 0.34
MT2A metallothionein 2A 0.33
CHN1 chimerin 1 0.33
TNXB tenascin XB 0.33
JOSD1 Josephin domain containing 1 0.32
GATA2 GATA binding protein 2 0.32
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.31
COL6A3 collagen, type VI, alpha 3 0.31
ESYT2 extended synaptotagmin-like protein 2 0.31
OSGIN1 oxidative stress induced growth inhibitor 1 0.31
ZWINT ZW10 interacting kinetochore protein 0.31
PRELID1 PRELI domain containing 1 0.31
ZNF268 zinc finger protein 268 0.31
EPN3 epsin 3 0.31
MT1F metallothionein 1F 0.31
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 0.3
PRDM2 PR domain containing 2, with ZNF domain 0.3
SH3RF2 SH3 domain containing ring finger 2 0.3
STOML1 stomatin (EPB72)-like 1 0.3
ATMIN ATM interactor 0.3
STMN1 stathmin 1 0.29
H1-4 H1.4 linker histone, cluster member 0.29
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.29
CLCN6 chloride channel, voltage-sensitive 6 0.29
ZDHHC2 zinc finger, DHHC-type containing 2 0.28
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.28
EXPH5 exophilin 5 0.28
VSIG10 V-set and immunoglobulin domain containing 10 0.28
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.28
NOVA2 neuro-oncological ventral antigen 2 0.28
THBS2 thrombospondin 2 0.28
YAE1 YAE1 maturation factor of ABCE1 0.28
H1-3 H1.3 linker histone, cluster member 0.28
CREG1 cellular repressor of E1A-stimulated genes 1 0.28
ZNF460 zinc finger protein 460 0.28
RNF115 ring finger protein 115 0.28
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.28
FLYWCH1 FLYWCH-type zinc finger 1 0.28
MSH5 mutS homolog 5 0.27
MT1X metallothionein 1X 0.27
CD63 CD63 molecule 0.27
TMEM51 transmembrane protein 51 0.27
KLF3 Kruppel-like factor 3 (basic) 0.27
DERPC DERPC proline and glycine rich nuclear protein 0.27
ZC3H14 zinc finger CCCH-type containing 14 0.27
KLHL24 kelch-like family member 24 0.27
GPR108 G protein-coupled receptor 108 0.27
NOP10 NOP10 ribonucleoprotein 0.27
ZDHHC12 zinc finger, DHHC-type containing 12 0.27
PTTG1 pituitary tumor-transforming 1 0.27
NTSR1 neurotensin receptor 1 (high affinity) 0.27
RPL37 ribosomal protein L37 0.26
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.26
RNF130 ring finger protein 130 0.26
GKAP1 G kinase anchoring protein 1 0.26
GALNS galactosamine (N-acetyl)-6-sulfatase 0.26
DOCK11 dedicator of cytokinesis 11 0.26
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.26
FTH1 ferritin, heavy polypeptide 1 0.26

low expression

Symbol Name Standardized Value
ITGA1 integrin, alpha 1 -1.88
KSR2 kinase suppressor of ras 2 -1.0
VAV1 vav 1 guanine nucleotide exchange factor -0.94
DNAL4 dynein, axonemal, light chain 4 -0.77
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.76
TMC6 transmembrane channel-like 6 -0.75
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils -0.64
S100A2 S100 calcium binding protein A2 -0.62
TLE5 TLE family member 5, transcriptional modulator -0.6
SASH1 SAM and SH3 domain containing 1 -0.59
TCTN3 tectonic family member 3 -0.59
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.58
ZNF669 zinc finger protein 669 -0.56
CD82 CD82 molecule -0.55
JUN jun proto-oncogene -0.53
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 -0.53
LGALSL lectin, galactoside-binding-like -0.53
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.52
TOB1 transducer of ERBB2, 1 -0.51
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -0.51
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 -0.51
CSRNP2 cysteine-serine-rich nuclear protein 2 -0.5
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.5
TOR2A torsin family 2, member A -0.49
MCOLN2 mucolipin 2 -0.48
ARID3B AT rich interactive domain 3B (BRIGHT-like) -0.46
TP53 tumor protein p53 -0.45
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.45
CYTH3 cytohesin 3 -0.44
CCNE1 cyclin E1 -0.43
MTSS2 MTSS I-BAR domain containing 2 -0.43
INVS inversin -0.42
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -0.42
PIP prolactin-induced protein -0.42
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.41
NOS3 nitric oxide synthase 3 (endothelial cell) -0.41
FAM219B family with sequence similarity 219, member B -0.4
PEA15 phosphoprotein enriched in astrocytes 15 -0.4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.4
ALKBH5 AlkB family member 5, RNA demethylase -0.39
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.39
ZSCAN20 zinc finger and SCAN domain containing 20 -0.39
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -0.39
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.39
DPP4 dipeptidyl-peptidase 4 -0.38
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.38
MT-ND5 NADH dehydrogenase, subunit 5 (complex I) -0.38
LZTS1 leucine zipper, putative tumor suppressor 1 -0.37
ANGPTL4 angiopoietin-like 4 -0.37
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.37
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -0.37
VSIR V-set immunoregulatory receptor -0.37
PGBD2 piggyBac transposable element derived 2 -0.37
CKM creatine kinase, muscle -0.36
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.36
FGB fibrinogen beta chain -0.36
LIPA lipase A, lysosomal acid, cholesterol esterase -0.35
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.35
GEM GTP binding protein overexpressed in skeletal muscle -0.35
LMCD1 LIM and cysteine-rich domains 1 -0.34
C19ORF25 chromosome 19 open reading frame 25 -0.34
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -0.34
AXIN1 axin 1 -0.33
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.33
TRAPPC6A trafficking protein particle complex 6A -0.33
GPRC5C G protein-coupled receptor, class C, group 5, member C -0.33
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -0.33
DST dystonin -0.32
PAH phenylalanine hydroxylase -0.32
ZNF267 zinc finger protein 267 -0.32
ARMC7 armadillo repeat containing 7 -0.32
MSL2 male-specific lethal 2 homolog (Drosophila) -0.32
TRMO tRNA methyltransferase O -0.32
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -0.32
ALMS1 Alstrom syndrome protein 1 -0.32
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -0.32
ABRACL ABRA C-terminal like -0.32
TPGS2 tubulin polyglutamylase complex subunit 2 -0.32
ASB8 ankyrin repeat and SOCS box containing 8 -0.31
NFU1 NFU1 iron-sulfur cluster scaffold -0.31
LTN1 listerin E3 ubiquitin protein ligase 1 -0.31
CCDC9B coiled-coil domain containing 9B -0.31
TLCD4 TLC domain containing 4 -0.31
PNKD paroxysmal nonkinesigenic dyskinesia -0.31
XIRP2 xin actin binding repeat containing 2 -0.31
NAAA N-acylethanolamine acid amidase -0.31
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -0.3
TBRG1 transforming growth factor beta regulator 1 -0.3
KLF2 Kruppel-like factor 2 -0.3
TRAM2 translocation associated membrane protein 2 -0.3
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.3
FAM241B family with sequence similarity 241 member B -0.3
TMEM59 transmembrane protein 59 -0.3
MYADM myeloid-associated differentiation marker -0.3
MAGEF1 melanoma antigen family F1 -0.3
DUSP5 dual specificity phosphatase 5 -0.3
ZNF185 zinc finger protein 185 (LIM domain) -0.3
DDTL D-dopachrome tautomerase-like -0.3
CLK4 CDC-like kinase 4 -0.29