| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.233355 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.169035 |
| AHNAK | AHNAK nucleoprotein | 0.148201 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.122836 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.118786 |
| FBN1 | fibrillin 1 | 0.108459 |
| LOXL2 | lysyl oxidase-like 2 | 0.102628 |
| LOX | lysyl oxidase | 0.10209 |
| NDRG1 | N-myc downstream regulated 1 | 0.0956923 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0831119 |
| PGK1 | phosphoglycerate kinase 1 | 0.074649 |
| FLNB | filamin B, beta | 0.0705066 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0697209 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0692803 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0680512 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.062632 |
| RUNX1 | runt-related transcription factor 1 | 0.0590282 |
| THBS2 | thrombospondin 2 | 0.0551438 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0549279 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0535371 |
| AUTS2 | autism susceptibility candidate 2 | 0.0534169 |
| APP | amyloid beta (A4) precursor protein | 0.0533194 |
| OGA | O-GlcNAcase | 0.053303 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0529311 |
| MYOF | myoferlin | 0.0513954 |
| ATP13A3 | ATPase type 13A3 | 0.0502122 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0477951 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0475937 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0469207 |
| DST | dystonin | 0.0466705 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0460136 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0435611 |
| SPAG9 | sperm associated antigen 9 | 0.0424397 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0422704 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0412622 |
| ZNF292 | zinc finger protein 292 | 0.0399838 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0398967 |
| HELZ | helicase with zinc finger | 0.0387083 |
| SP3 | Sp3 transcription factor | 0.0385314 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.038235 |
| SEPTIN9 | septin 9 | 0.0373976 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0371974 |
| CD109 | CD109 molecule | 0.0370087 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0369021 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0365413 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0355337 |
| LDHA | lactate dehydrogenase A | 0.0351644 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.034069 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0337856 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0337788 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0335467 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0333775 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0333157 |
| RAI1 | retinoic acid induced 1 | 0.0326599 |
| XPO1 | exportin 1 | 0.0321366 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0319902 |
| COL5A2 | collagen, type V, alpha 2 | 0.0319795 |
| NAV2 | neuron navigator 2 | 0.0318712 |
| COL5A1 | collagen, type V, alpha 1 | 0.0317724 |
| YEATS2 | YEATS domain containing 2 | 0.03165 |
| MB21D2 | Mab-21 domain containing 2 | 0.0315113 |
| ARRDC3 | arrestin domain containing 3 | 0.0313041 |
| NBAS | neuroblastoma amplified sequence | 0.0310781 |
| PRELID2 | PRELI domain containing 2 | 0.0310186 |
| WTAP | Wilms tumor 1 associated protein | 0.0309339 |
| SBF2 | SET binding factor 2 | 0.0308632 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0308573 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0308095 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0305953 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0304569 |
| RLF | rearranged L-myc fusion | 0.0304492 |
| GPC6 | glypican 6 | 0.0300233 |
| INSIG2 | insulin induced gene 2 | 0.0298576 |
| C1D | C1D nuclear receptor corepressor | 0.0298402 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0295472 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0293973 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0293053 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0292507 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0292381 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0291062 |
| DENND5A | DENN/MADD domain containing 5A | 0.0291049 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0291017 |
| AFAP1 | actin filament associated protein 1 | 0.0286195 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0284582 |
| FMNL2 | formin-like 2 | 0.0282016 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0281255 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0280491 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0277857 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0276153 |
| COL3A1 | collagen, type III, alpha 1 | 0.0275159 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0274426 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0271828 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0271143 |
| PKM | pyruvate kinase, muscle | 0.0270303 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0269764 |
| RNF24 | ring finger protein 24 | 0.0268852 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0266225 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0264146 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0263117 |
| ENO1 | enolase 1, (alpha) | 0.0259422 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.129453 |
| S100A10 | S100 calcium binding protein A10 | -0.060486 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0549471 |
| PLAT | plasminogen activator, tissue | -0.0482587 |
| SUCNR1 | succinate receptor 1 | -0.046989 |
| MAP1B | microtubule-associated protein 1B | -0.0461084 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0432144 |
| TMSB10 | thymosin beta 10 | -0.0427079 |
| CSTB | cystatin B (stefin B) | -0.0344608 |
| S100A6 | S100 calcium binding protein A6 | -0.0305798 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0249038 |
| TPM4 | tropomyosin 4 | -0.0242176 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0240442 |
| HLA-B | major histocompatibility complex, class I, B | -0.0238912 |
| PTMA | prothymosin, alpha | -0.0228542 |
| LMNA | lamin A/C | -0.0224138 |
| TMSB4X | thymosin beta 4, X-linked | -0.02163 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0214539 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0207417 |
| RPS15 | ribosomal protein S15 | -0.0203013 |
| RPL28 | ribosomal protein L28 | -0.0200355 |
| MX2 | MX dynamin-like GTPase 2 | -0.0198471 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0197175 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0188424 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0187138 |
| S100A4 | S100 calcium binding protein A4 | -0.0180789 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0180686 |
| TBCA | tubulin folding cofactor A | -0.0180346 |
| ACTG1 | actin gamma 1 | -0.0177549 |
| RPS24 | ribosomal protein S24 | -0.0177022 |
| RPL35A | ribosomal protein L35a | -0.0170763 |
| RPS8 | ribosomal protein S8 | -0.016997 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0163368 |
| RPL34 | ribosomal protein L34 | -0.0160609 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0160098 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0159596 |
| CENPF | centromere protein F, 350/400kDa | -0.0157922 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0157112 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.015394 |
| RASAL2 | RAS protein activator like 2 | -0.0150199 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0145268 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0142246 |
| RRBP1 | ribosome binding protein 1 | -0.0140341 |
| RPS5 | ribosomal protein S5 | -0.0139887 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0136532 |
| RPS6 | ribosomal protein S6 | -0.0134829 |
| CBX3 | chromobox homolog 3 | -0.0134288 |
| RPLP1 | ribosomal protein, large, P1 | -0.013417 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0133592 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0133166 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0132515 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0131956 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0131773 |
| FTL | ferritin, light polypeptide | -0.0128471 |
| HLA-C | major histocompatibility complex, class I, C | -0.0125817 |
| HMGB1 | high mobility group box 1 | -0.0124815 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0122571 |
| S100A11 | S100 calcium binding protein A11 | -0.0121528 |
| GNAS | GNAS complex locus | -0.0120173 |
| CCND1 | cyclin D1 | -0.0119415 |
| PFN1 | profilin 1 | -0.0119311 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0118969 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0118909 |
| POTEF | POTE ankyrin domain family, member F | -0.0117895 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.011784 |
| KRT81 | keratin 81, type II | -0.0117124 |
| NUCB2 | nucleobindin 2 | -0.0114556 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0112463 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0112025 |
| RPS23 | ribosomal protein S23 | -0.0111811 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0110317 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0109798 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0107183 |
| EHBP1 | EH domain binding protein 1 | -0.0106723 |
| CCM2 | cerebral cavernous malformation 2 | -0.0106368 |
| RPS14 | ribosomal protein S14 | -0.0105789 |
| DSTN | destrin (actin depolymerizing factor) | -0.0105713 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0105315 |
| HM13 | histocompatibility (minor) 13 | -0.0105086 |
| CYTH3 | cytohesin 3 | -0.0103667 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0103403 |
| BPTF | bromodomain PHD finger transcription factor | -0.0103349 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0102857 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0102819 |
| RPL32 | ribosomal protein L32 | -0.0102701 |
| RPL9 | ribosomal protein L9 | -0.0101929 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0101902 |
| NPR2 | natriuretic peptide receptor 2 | -0.0101687 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0101544 |
| CENPK | centromere protein K | -0.0101504 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0100952 |
| THY1 | Thy-1 cell surface antigen | -0.0100394 |
| RIGI | RNA sensor RIG-I | -0.00993557 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.00987488 |
| RAI14 | retinoic acid induced 14 | -0.00984601 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.00983788 |
| CD151 | CD151 molecule (Raph blood group) | -0.00983718 |
| ASTN2 | astrotactin 2 | -0.00978123 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.00963538 |
| RACK1 | receptor for activated C kinase 1 | -0.00961836 |
