| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.11819 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0930249 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0777806 |
| PCBP2 | poly(rC) binding protein 2 | 0.0725544 |
| MED13L | mediator complex subunit 13-like | 0.0707332 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0706358 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0641715 |
| CCNL1 | cyclin L1 | 0.0606927 |
| PUM2 | pumilio RNA-binding family member 2 | 0.057546 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0544694 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0531849 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0527657 |
| RBM39 | RNA binding motif protein 39 | 0.0503464 |
| USP34 | ubiquitin specific peptidase 34 | 0.049804 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0479121 |
| ZNF292 | zinc finger protein 292 | 0.0468748 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0466988 |
| PGK1 | phosphoglycerate kinase 1 | 0.04661 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0449887 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.044896 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0438971 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0425304 |
| TNPO1 | transportin 1 | 0.0417278 |
| OGA | O-GlcNAcase | 0.0411035 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0407384 |
| AHNAK | AHNAK nucleoprotein | 0.0396994 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0392918 |
| NEK7 | NIMA-related kinase 7 | 0.039118 |
| XPO1 | exportin 1 | 0.0383562 |
| MATR3 | matrin 3 | 0.0377925 |
| ZNF217 | zinc finger protein 217 | 0.0370529 |
| TFG | TRK-fused gene | 0.0367747 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0361449 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0359628 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0358976 |
| TMSB10 | thymosin beta 10 | 0.034734 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0345139 |
| NCKAP1 | NCK-associated protein 1 | 0.0341415 |
| CDK17 | cyclin-dependent kinase 17 | 0.0340575 |
| APP | amyloid beta (A4) precursor protein | 0.0340471 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0339784 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0336274 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0333045 |
| MEMO1 | mediator of cell motility 1 | 0.0332713 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0326256 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0325468 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0324175 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0322281 |
| RPS12 | ribosomal protein S12 | 0.0321636 |
| NBAS | neuroblastoma amplified sequence | 0.0320831 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0319175 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0314013 |
| CPOX | coproporphyrinogen oxidase | 0.0312579 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0309612 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.030671 |
| QKI | QKI, KH domain containing, RNA binding | 0.0304952 |
| YBX3 | Y box binding protein 3 | 0.0304145 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0303722 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0303574 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.030106 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0299301 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0299062 |
| THOC1 | THO complex 1 | 0.029751 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0296802 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.029153 |
| ECT2 | epithelial cell transforming 2 | 0.0290466 |
| TMEM41B | transmembrane protein 41B | 0.0289135 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0286404 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0284641 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0284057 |
| NUP58 | nucleoporin 58 | 0.0278322 |
| KLHL24 | kelch-like family member 24 | 0.0273128 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0270331 |
| CDK19 | cyclin-dependent kinase 19 | 0.0269952 |
| PER1 | period circadian clock 1 | 0.0268226 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0267646 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0267493 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0266527 |
| ARRDC3 | arrestin domain containing 3 | 0.026318 |
| SPAG9 | sperm associated antigen 9 | 0.0262566 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0261713 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0259985 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0259397 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0259351 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0259179 |
| RPS3 | ribosomal protein S3 | 0.025742 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0253378 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0250539 |
| RNF145 | ring finger protein 145 | 0.024922 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0246182 |
| YEATS2 | YEATS domain containing 2 | 0.0245354 |
| FBXO11 | F-box protein 11 | 0.0241712 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0241218 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0237331 |
| GASK1B | golgi associated kinase 1B | 0.0237109 |
| CDC73 | cell division cycle 73 | 0.0236758 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0233933 |
| CEP70 | centrosomal protein 70kDa | 0.0229434 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0228996 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.022662 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.288368 |
| VIM | vimentin | -0.209298 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.190798 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.171928 |
| NLGN1 | neuroligin 1 | -0.145961 |
| HMGA2 | high mobility group AT-hook 2 | -0.108442 |
| ACTG1 | actin gamma 1 | -0.0921857 |
| EHBP1 | EH domain binding protein 1 | -0.0858396 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0836677 |
| AREG | amphiregulin | -0.0786726 |
| PCDH7 | protocadherin 7 | -0.0722983 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0680439 |
| EGR1 | early growth response 1 | -0.0629884 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0623793 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0513096 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0511707 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0504339 |
| TUBA1B | tubulin, alpha 1b | -0.0485757 |
| MMP12 | matrix metallopeptidase 12 | -0.0446849 |
| HMGA1 | high mobility group AT-hook 1 | -0.0422777 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0421729 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0419633 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.040245 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0400566 |
| ADIPOR2 | adiponectin receptor 2 | -0.0388938 |
| MKI67 | marker of proliferation Ki-67 | -0.0383634 |
| BCHE | butyrylcholinesterase | -0.0375719 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0368147 |
| BPTF | bromodomain PHD finger transcription factor | -0.0350061 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0349072 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0341922 |
| NHSL1 | NHS-like 1 | -0.034105 |
| ZNF804A | zinc finger protein 804A | -0.0340364 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0335096 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0329879 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0324145 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0307891 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0293154 |
| RASAL2 | RAS protein activator like 2 | -0.0291108 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0287541 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0285639 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0285358 |
| INTS6 | integrator complex subunit 6 | -0.0284534 |
| PFN1 | profilin 1 | -0.0281398 |
| POTEF | POTE ankyrin domain family, member F | -0.0278154 |
| TPM4 | tropomyosin 4 | -0.0272082 |
| MAP1B | microtubule-associated protein 1B | -0.026826 |
| CUX1 | cut-like homeobox 1 | -0.0260579 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0255549 |
| CCND1 | cyclin D1 | -0.0255034 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0254721 |
| TBCA | tubulin folding cofactor A | -0.0252396 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0246625 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0244463 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0240881 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0238778 |
| CCN2 | cellular communication network factor 2 | -0.023845 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.023533 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0234932 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0233639 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0230426 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0228246 |
| CENPF | centromere protein F, 350/400kDa | -0.0227913 |
| NAV3 | neuron navigator 3 | -0.0226232 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0223267 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0221569 |
| MTAP | methylthioadenosine phosphorylase | -0.021873 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0216956 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0213226 |
| COMMD10 | COMM domain containing 10 | -0.0211707 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0209054 |
| RPS8 | ribosomal protein S8 | -0.0207442 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0206732 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0205204 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0204906 |
| LDHB | lactate dehydrogenase B | -0.0204703 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.020412 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0203278 |
| PRDX1 | peroxiredoxin 1 | -0.0202903 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0199298 |
| CANX | calnexin | -0.0196061 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0194957 |
| RPS23 | ribosomal protein S23 | -0.0193538 |
| S100A10 | S100 calcium binding protein A10 | -0.0189878 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0189247 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0188735 |
| TUBA1C | tubulin, alpha 1c | -0.0188649 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0187768 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0187343 |
| CEP112 | centrosomal protein 112kDa | -0.0186392 |
| FSTL5 | follistatin-like 5 | -0.0184132 |
| BRI3BP | BRI3 binding protein | -0.0183673 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0181233 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0179557 |
| PCNX4 | pecanex 4 | -0.0178463 |
| RANBP17 | RAN binding protein 17 | -0.0177616 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0175635 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0172077 |
| RPS2 | ribosomal protein S2 | -0.0170943 |
| GNAS | GNAS complex locus | -0.0167857 |
