Roxadustat_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.101286
NDRG1 N-myc downstream regulated 1 0.0950858
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0841739
MBNL2 muscleblind-like splicing regulator 2 0.0834159
ZMYND8 zinc finger, MYND-type containing 8 0.0831487
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0802052
ERRFI1 ERBB receptor feedback inhibitor 1 0.0801992
RNF149 ring finger protein 149 0.0753285
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0724951
FNDC3B fibronectin type III domain containing 3B 0.0704994
DSCAM Down syndrome cell adhesion molecule 0.0689329
AHNAK AHNAK nucleoprotein 0.0565041
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0536689
BTBD9 BTB (POZ) domain containing 9 0.0534199
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0523197
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0516743
PGK1 phosphoglycerate kinase 1 0.0473388
TXNIP thioredoxin interacting protein 0.0466008
KDM3A lysine (K)-specific demethylase 3A 0.0431419
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0426915
ZMYM2 zinc finger, MYM-type 2 0.0423934
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0417027
CANX calnexin 0.0392815
FNDC3A fibronectin type III domain containing 3A 0.038831
PTEN phosphatase and tensin homolog 0.0381215
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0377541
MCTP2 multiple C2 domains, transmembrane 2 0.0373478
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0371467
ARRDC3 arrestin domain containing 3 0.0356881
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0348986
FNIP1 folliculin interacting protein 1 0.0346374
PTBP3 polypyrimidine tract binding protein 3 0.0343632
KMT2C lysine (K)-specific methyltransferase 2C 0.0339178
SREBF2 sterol regulatory element binding transcription factor 2 0.033707
OGA O-GlcNAcase 0.0335551
TSC22D2 TSC22 domain family, member 2 0.0331302
SORBS1 sorbin and SH3 domain containing 1 0.0320594
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0318469
ESYT2 extended synaptotagmin-like protein 2 0.0317528
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0313936
IFNGR1 interferon gamma receptor 1 0.0311559
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0310616
NPEPPS aminopeptidase puromycin sensitive 0.0309818
H1-0 H1.0 linker histone 0.0307481
SCARB1 scavenger receptor class B, member 1 0.030352
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0291322
HELZ helicase with zinc finger 0.0288421
PARP4 poly (ADP-ribose) polymerase family, member 4 0.028323
SBF2 SET binding factor 2 0.0283008
LDHA lactate dehydrogenase A 0.028119
WDR45B WD repeat domain 45B 0.0275435
MXI1 MAX interactor 1, dimerization protein 0.0272688
HDLBP high density lipoprotein binding protein 0.027218
GRK3 G protein-coupled receptor kinase 3 0.0270247
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0266239
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0264283
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0261528
MLPH melanophilin 0.0261049
ARHGAP32 Rho GTPase activating protein 32 0.025939
DENND4C DENN/MADD domain containing 4C 0.025748
RBM39 RNA binding motif protein 39 0.0257355
AFF1 AF4/FMR2 family, member 1 0.0254611
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0252013
RLF rearranged L-myc fusion 0.0251726
XPO1 exportin 1 0.0251562
UBC ubiquitin C 0.0248484
MYH9 myosin, heavy chain 9, non-muscle 0.0248064
SEC24D SEC24 family member D 0.0247602
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0241399
GOLGA4 golgin A4 0.0233598
TTC3 tetratricopeptide repeat domain 3 0.023211
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0231664
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0229322
SAMD4A sterile alpha motif domain containing 4A 0.0226835
COG6 component of oligomeric golgi complex 6 0.0225141
TM9SF3 transmembrane 9 superfamily member 3 0.0224815
ADAM17 ADAM metallopeptidase domain 17 0.0223183
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0222903
BHLHE40 basic helix-loop-helix family, member e40 0.0222815
RHOBTB3 Rho-related BTB domain containing 3 0.0222633
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.022189
PDIA3 protein disulfide isomerase family A, member 3 0.0220441
PDIA4 protein disulfide isomerase family A, member 4 0.0220233
KIF16B kinesin family member 16B 0.022014
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0220061
BCLAF1 BCL2-associated transcription factor 1 0.0218697
SUCO SUN domain containing ossification factor 0.0215158
YEATS2 YEATS domain containing 2 0.0214838
PRELID2 PRELI domain containing 2 0.0214408
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0214158
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0213758
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0211824
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0211094
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0209598
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0208602
TMPRSS4 transmembrane protease, serine 4 0.0208181
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0207564
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0206536
USP3 ubiquitin specific peptidase 3 0.0206117
USP34 ubiquitin specific peptidase 34 0.0205039

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.0907299
ANXA2 annexin A2 -0.0807666
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0805739
EPSTI1 epithelial stromal interaction 1 (breast) -0.0774169
INTS6 integrator complex subunit 6 -0.0749212
VCL vinculin -0.0704096
RIGI RNA sensor RIG-I -0.0687427
SP100 SP100 nuclear antigen -0.0652704
MX1 MX dynamin-like GTPase 1 -0.0597424
LMO7 LIM domain 7 -0.0591732
LCN2 lipocalin 2 -0.0543904
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0522715
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0508965
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0507741
RNF213 ring finger protein 213 -0.0507249
MX2 MX dynamin-like GTPase 2 -0.0506573
GMDS GDP-mannose 4,6-dehydratase -0.0490423
TPT1 tumor protein, translationally-controlled 1 -0.0470021
LYZ lysozyme -0.0467757
AREG amphiregulin -0.0455256
B2M beta-2-microglobulin -0.0453305
C6ORF132 chromosome 6 open reading frame 132 -0.0440068
PLSCR1 phospholipid scramblase 1 -0.0438595
RAB7A RAB7A, member RAS oncogene family -0.0438108
STS steroid sulfatase (microsomal), isozyme S -0.040926
ZSWIM6 zinc finger, SWIM-type containing 6 -0.040809
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0404905
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0395495
IFI6 interferon, alpha-inducible protein 6 -0.0384154
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0382995
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.038054
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0375179
VMP1 vacuole membrane protein 1 -0.035522
PLSCR2 phospholipid scramblase 2 -0.0340157
PTMA prothymosin, alpha -0.0332643
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0329178
PERP PERP, TP53 apoptosis effector -0.0325947
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.032385
RABGAP1L RAB GTPase activating protein 1-like -0.032022
EPHB2 EPH receptor B2 -0.031434
TJP1 tight junction protein 1 -0.0314238
TM4SF19 transmembrane 4 L six family member 19 -0.0304422
NPSR1 neuropeptide S receptor 1 -0.0303817
ACTG1 actin gamma 1 -0.0294183
MYO1E myosin IE -0.0293838
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0293651
PMP22 peripheral myelin protein 22 -0.0293519
TSHZ2 teashirt zinc finger homeobox 2 -0.0293507
FTL ferritin, light polypeptide -0.0291831
CATSPERB catsper channel auxiliary subunit beta -0.0286702
TNS4 tensin 4 -0.0271995
IFI27 interferon, alpha-inducible protein 27 -0.0268241
EZR ezrin -0.0266038
XAF1 XIAP associated factor 1 -0.0265657
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0259619
RPS6 ribosomal protein S6 -0.0253902
MCTP1 multiple C2 domains, transmembrane 1 -0.0252335
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0249188
MACC1 metastasis associated in colon cancer 1 -0.0246537
LAMA4 laminin, alpha 4 -0.0245107
GCLC glutamate-cysteine ligase, catalytic subunit -0.0243606
LOC102724023 ES1 protein homolog, mitochondrial -0.0243533
MCL1 myeloid cell leukemia 1 -0.0243263
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.023228
NABP1 nucleic acid binding protein 1 -0.0229155
TMSB10 thymosin beta 10 -0.0224733
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0223051
TMC5 transmembrane channel-like 5 -0.0222377
MAML2 mastermind-like 2 (Drosophila) -0.0217265
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0216843
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0216564
UBAP2 ubiquitin associated protein 2 -0.0213989
ETV6 ets variant 6 -0.0202341
MAP7 microtubule-associated protein 7 -0.019993
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0191449
FBXO39 F-box protein 39 -0.0190927
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0188738
MCU mitochondrial calcium uniporter -0.0188339
ACTN4 actinin, alpha 4 -0.0187786
RPL35A ribosomal protein L35a -0.0187299
RPLP1 ribosomal protein, large, P1 -0.0186372
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0186055
NCKAP5 NCK-associated protein 5 -0.0185706
EFNB2 ephrin-B2 -0.018505
POU2F2 POU class 2 homeobox 2 -0.0183528
NT5C2 5'-nucleotidase, cytosolic II -0.0182153
POF1B premature ovarian failure, 1B -0.0181533
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0180598
RPS19 ribosomal protein S19 -0.0180301
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0177971
FOSL1 FOS-like antigen 1 -0.0177849
NCEH1 neutral cholesterol ester hydrolase 1 -0.0177825
LPP LIM domain containing preferred translocation partner in lipoma -0.0173014
LAP3 leucine aminopeptidase 3 -0.0172701
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0172257
OASL 2'-5'-oligoadenylate synthetase-like -0.0169762
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0167655
TM4SF1 transmembrane 4 L six family member 1 -0.0167174
IFIH1 interferon induced with helicase C domain 1 -0.0165651
ZNFX1 zinc finger, NFX1-type containing 1 -0.0165041