Roxadustat_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.293923
TRIO trio Rho guanine nucleotide exchange factor 0.168319
COL6A3 collagen, type VI, alpha 3 0.157538
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.123091
ATP13A3 ATPase type 13A3 0.121649
LOXL2 lysyl oxidase-like 2 0.0907768
MYH9 myosin, heavy chain 9, non-muscle 0.088956
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0881255
NDRG1 N-myc downstream regulated 1 0.0866903
AHNAK AHNAK nucleoprotein 0.0815836
LDHA lactate dehydrogenase A 0.0682043
ELL2 elongation factor, RNA polymerase II, 2 0.0673948
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0660702
ARRDC3 arrestin domain containing 3 0.0619142
ENO1 enolase 1, (alpha) 0.0584232
ERRFI1 ERBB receptor feedback inhibitor 1 0.0578484
SMAD3 SMAD family member 3 0.0568051
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0523083
TIMP3 TIMP metallopeptidase inhibitor 3 0.0513934
LTBP1 latent transforming growth factor beta binding protein 1 0.0509226
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0494451
LOX lysyl oxidase 0.0483675
PDE10A phosphodiesterase 10A 0.0479319
PGK1 phosphoglycerate kinase 1 0.044836
SPAG9 sperm associated antigen 9 0.044526
CXCL8 chemokine (C-X-C motif) ligand 8 0.0440104
FNDC3B fibronectin type III domain containing 3B 0.0431568
CADM1 cell adhesion molecule 1 0.042234
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0422121
PRELID2 PRELI domain containing 2 0.0416668
APP amyloid beta (A4) precursor protein 0.040844
NAV2 neuron navigator 2 0.0401008
ZNF292 zinc finger protein 292 0.0400207
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0381983
MTSS1 metastasis suppressor 1 0.0377106
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0359981
ECE1 endothelin converting enzyme 1 0.0348967
TM4SF1 transmembrane 4 L six family member 1 0.0347139
SHB Src homology 2 domain containing adaptor protein B 0.0342094
RLF rearranged L-myc fusion 0.0339521
TNIP1 TNFAIP3 interacting protein 1 0.0334717
RUNX1 runt-related transcription factor 1 0.0327836
BHLHE40 basic helix-loop-helix family, member e40 0.0327151
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0326815
KDM3A lysine (K)-specific demethylase 3A 0.0325406
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0316267
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0312569
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0311647
PLEC plectin 0.0304988
GRB10 growth factor receptor-bound protein 10 0.0299457
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.02952
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0293837
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0289536
JARID2 jumonji, AT rich interactive domain 2 0.0279309
RASA2 RAS p21 protein activator 2 0.0276041
CD109 CD109 molecule 0.027528
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0271301
ESYT2 extended synaptotagmin-like protein 2 0.0269777
SOD2 superoxide dismutase 2, mitochondrial 0.0265336
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0263572
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0259542
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0258355
NAMPT nicotinamide phosphoribosyltransferase 0.0255595
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0253471
CD44 CD44 molecule (Indian blood group) 0.0253238
COL7A1 collagen, type VII, alpha 1 0.0250312
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0246797
YEATS2 YEATS domain containing 2 0.0244844
OGA O-GlcNAcase 0.0244253
KDM7A lysine (K)-specific demethylase 7A 0.0243852
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0242009
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0239954
CAMTA1 calmodulin binding transcription activator 1 0.0238454
FAT1 FAT atypical cadherin 1 0.0236056
AFAP1 actin filament associated protein 1 0.0232449
PFKP phosphofructokinase, platelet 0.0230787
DPYSL3 dihydropyrimidinase-like 3 0.0229425
IER3 immediate early response 3 0.0222001
ADAM9 ADAM metallopeptidase domain 9 0.0218481
UBA6 ubiquitin-like modifier activating enzyme 6 0.0218063
CLIC4 chloride intracellular channel 4 0.0217687
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0215526
UBC ubiquitin C 0.0215466
DLG1 discs, large homolog 1 (Drosophila) 0.0215153
KMT2E lysine (K)-specific methyltransferase 2E 0.0213017
ADAM17 ADAM metallopeptidase domain 17 0.021095
RICTOR RPTOR independent companion of MTOR, complex 2 0.0210627
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210503
MACF1 microtubule-actin crosslinking factor 1 0.0209684
SEPTIN9 septin 9 0.0209338
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0204882
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0203435
ANXA2 annexin A2 0.0203418
MYO10 myosin X 0.0201172
RNF24 ring finger protein 24 0.0200909
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0199414
RBM39 RNA binding motif protein 39 0.0197913
MRTFA myocardin related transcription factor A 0.0197564
AZIN1 antizyme inhibitor 1 0.0195604
ECT2 epithelial cell transforming 2 0.0195602

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.188598
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0929002
VIM vimentin -0.0882861
TMSB10 thymosin beta 10 -0.0642383
MT2A metallothionein 2A -0.0605355
CDH13 cadherin 13 -0.0526753
COL1A2 collagen, type I, alpha 2 -0.0490762
PSD3 pleckstrin and Sec7 domain containing 3 -0.0456891
RPS8 ribosomal protein S8 -0.0451849
FTL ferritin, light polypeptide -0.0416194
ZBTB20 zinc finger and BTB domain containing 20 -0.0387784
DPYD dihydropyrimidine dehydrogenase -0.0385094
RPL35A ribosomal protein L35a -0.0366458
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.036568
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0350192
RPS6 ribosomal protein S6 -0.032338
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0321485
FTH1 ferritin, heavy polypeptide 1 -0.0312661
PDLIM5 PDZ and LIM domain 5 -0.0286888
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0281795
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0270731
S100A9 S100 calcium binding protein A9 -0.0269393
TRPS1 trichorhinophalangeal syndrome I -0.0268282
EGR1 early growth response 1 -0.026725
CALD1 caldesmon 1 -0.0261559
GOLGB1 golgin B1 -0.0261496
GLIS3 GLIS family zinc finger 3 -0.0256236
TTC3 tetratricopeptide repeat domain 3 -0.0232635
RPS12 ribosomal protein S12 -0.0230509
COL1A1 collagen, type I, alpha 1 -0.0228649
RPL28 ribosomal protein L28 -0.0227704
RPS3 ribosomal protein S3 -0.0227143
RPS19 ribosomal protein S19 -0.021712
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0216559
RPL26 ribosomal protein L26 -0.0212007
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0204648
NALF1 NALCN channel auxiliary factor 1 -0.0204
PALLD palladin, cytoskeletal associated protein -0.0203713
RPL36 ribosomal protein L36 -0.0199074
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0198161
NEK10 NIMA-related kinase 10 -0.019761
ACTG1 actin gamma 1 -0.0193022
RPL37A ribosomal protein L37a -0.0192532
RAB2A RAB2A, member RAS oncogene family -0.019181
IARS1 isoleucyl-tRNA synthetase 1 -0.0187191
RACK1 receptor for activated C kinase 1 -0.0186663
RPS13 ribosomal protein S13 -0.0185702
VCL vinculin -0.0183438
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0180658
TPT1 tumor protein, translationally-controlled 1 -0.0180569
VMP1 vacuole membrane protein 1 -0.0180182
PFN1 profilin 1 -0.0180049
OXR1 oxidation resistance 1 -0.0179929
EIF1 eukaryotic translation initiation factor 1 -0.0179373
RPL5 ribosomal protein L5 -0.0179252
HLA-A major histocompatibility complex, class I, A -0.0178453
CYB5R3 cytochrome b5 reductase 3 -0.0178363
RND3 Rho family GTPase 3 -0.0177887
RPLP2 ribosomal protein, large, P2 -0.017773
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0176699
HM13 histocompatibility (minor) 13 -0.0176195
ATM ATM serine/threonine kinase -0.0173145
DGKI diacylglycerol kinase, iota -0.0172824
RPL11 ribosomal protein L11 -0.0172423
RPLP1 ribosomal protein, large, P1 -0.0172076
RPL30 ribosomal protein L30 -0.0167118
RPL9 ribosomal protein L9 -0.0164525
RPL19 ribosomal protein L19 -0.0162501
EFNA5 ephrin-A5 -0.016011
PDIA3 protein disulfide isomerase family A, member 3 -0.0160106
BBS9 Bardet-Biedl syndrome 9 -0.0159978
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0159406
SLC38A2 solute carrier family 38, member 2 -0.0158
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0157894
MBNL1 muscleblind-like splicing regulator 1 -0.0157832
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0155495
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.015492
RPS25 ribosomal protein S25 -0.0153589
RPL18 ribosomal protein L18 -0.0152111
BNC2 basonuclin 2 -0.0151373
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0150118
RPL8 ribosomal protein L8 -0.0148726
INTS6 integrator complex subunit 6 -0.0148597
CDK13 cyclin-dependent kinase 13 -0.014593
PTMA prothymosin, alpha -0.0144603
PDIA5 protein disulfide isomerase family A, member 5 -0.0144146
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0143298
RSU1 Ras suppressor protein 1 -0.0142835
MTDH metadherin -0.0142126
SORBS2 sorbin and SH3 domain containing 2 -0.0141028
COL6A1 collagen, type VI, alpha 1 -0.0140993
AGO3 argonaute RISC catalytic component 3 -0.0139356
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0137358
NABP1 nucleic acid binding protein 1 -0.0137038
RPL12 ribosomal protein L12 -0.0136254
MYADM myeloid-associated differentiation marker -0.0133574
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0133434
ZNF644 zinc finger protein 644 -0.013287
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0131476
RPL23 ribosomal protein L23 -0.013134